LOCUS       NM_001130700            6842 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens interaction protein for cytohesin exchange factors 1
            (IPCEF1), transcript variant 2, mRNA.
ACCESSION   NM_001130700
VERSION     NM_001130700.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6842)
  AUTHORS   Guo,M., Sun,Y., Ding,J., Li,Y., Yang,S., Zhao,Y., Jin,X. and
            Li,S.S.
  TITLE     Circular RNA profiling reveals a potential role of hsa_circ_IPCEF1
            in papillary thyroid carcinoma
  JOURNAL   Mol Med Rep 24 (2) (2021)
   PUBMED   34165176
  REMARK    GeneRIF: Circular RNA profiling reveals a potential role of
            hsa_circ_IPCEF1 in papillary thyroid carcinoma.
REFERENCE   2  (bases 1 to 6842)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 6842)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 6842)
  AUTHORS   Speedy,H.E., Di Bernardo,M.C., Sava,G.P., Dyer,M.J., Holroyd,A.,
            Wang,Y., Sunter,N.J., Mansouri,L., Juliusson,G., Smedby,K.E.,
            Roos,G., Jayne,S., Majid,A., Dearden,C., Hall,A.G.,
            Mainou-Fowler,T., Jackson,G.H., Summerfield,G., Harris,R.J.,
            Pettitt,A.R., Allsup,D.J., Bailey,J.R., Pratt,G., Pepper,C.,
            Fegan,C., Rosenquist,R., Catovsky,D., Allan,J.M. and Houlston,R.S.
  TITLE     A genome-wide association study identifies multiple susceptibility
            loci for chronic lymphocytic leukemia
  JOURNAL   Nat Genet 46 (1), 56-60 (2014)
   PUBMED   24292274
REFERENCE   5  (bases 1 to 6842)
  AUTHORS   Attar,M.A., Salem,J.C., Pursel,H.S. and Santy,L.C.
  TITLE     CNK3 and IPCEF1 produce a single protein that is required for HGF
            dependent Arf6 activation and migration
  JOURNAL   Exp Cell Res 318 (3), 228-237 (2012)
   PUBMED   22085542
  REMARK    GeneRIF: CNK3 and IPCEF1 produce a single protein that is required
            for HGF dependent Arf6 activation and migration.
REFERENCE   6  (bases 1 to 6842)
  AUTHORS   Xie,S.M., Shen,L.J., Yin,C., Ruan,P. and Yao,X.
  TITLE     [Expression of tumor suppressor gene PTEN, PIP3 and cyclin D1 in
            oral squamous cell carcinoma and their correlations]
  JOURNAL   Zhonghua Kou Qiang Yi Xue Za Zhi 41 (7), 407-410 (2006)
   PUBMED   17067457
  REMARK    GeneRIF: PTEN may down-regulate the expression of PIP3, and then
            down-regulate the expression of cyclin D1, which leads to the
            suppression of cell growth.
REFERENCE   7  (bases 1 to 6842)
  AUTHORS   Venkateswarlu,K.
  TITLE     Interaction protein for cytohesin exchange factors 1 (IPCEF1) binds
            cytohesin 2 and modifies its activity
  JOURNAL   J Biol Chem 278 (44), 43460-43469 (2003)
   PUBMED   12920129
  REMARK    GeneRIF: IPCEF1 increases the in vitro and in vivo stimulation of
            ARFGTP formation by cytohesin 2
REFERENCE   8  (bases 1 to 6842)
  AUTHORS   Burmester,T., Ebner,B., Weich,B. and Hankeln,T.
  TITLE     Cytoglobin: a novel globin type ubiquitously expressed in
            vertebrate tissues
  JOURNAL   Mol Biol Evol 19 (4), 416-421 (2002)
   PUBMED   11919282
REFERENCE   9  (bases 1 to 6842)
  AUTHORS   Krugmann,S., Anderson,K.E., Ridley,S.H., Risso,N., McGregor,A.,
            Coadwell,J., Davidson,K., Eguinoa,A., Ellson,C.D., Lipp,P.,
            Manifava,M., Ktistakis,N., Painter,G., Thuring,J.W., Cooper,M.A.,
            Lim,Z.Y., Holmes,A.B., Dove,S.K., Michell,R.H., Grewal,A.,
            Nazarian,A., Erdjument-Bromage,H., Tempst,P., Stephens,L.R. and
            Hawkins,P.T.
  TITLE     Identification of ARAP3, a novel PI3K effector regulating both Arf
            and Rho GTPases, by selective capture on phosphoinositide affinity
            matrices
  JOURNAL   Mol Cell 9 (1), 95-108 (2002)
   PUBMED   11804589
REFERENCE   10 (bases 1 to 6842)
  AUTHORS   Kawada,N., Kristensen,D.B., Asahina,K., Nakatani,K., Minamiyama,Y.,
            Seki,S. and Yoshizato,K.
  TITLE     Characterization of a stellate cell activation-associated protein
            (STAP) with peroxidase activity found in rat hepatic stellate cells
  JOURNAL   J Biol Chem 276 (27), 25318-25323 (2001)
   PUBMED   11320098
  REMARK    Erratum:[J Biol Chem 2001 Dec 14;276(50):47744-5]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL033376.17, AJ310566.1, AK289917.1, AB007863.1, BX647254.1 and
            BU075081.1.
            
            On Aug 13, 2020 this sequence version replaced NM_001130700.1.
            
            Transcript Variant: This variant (2) has an alternate 5' UTR, as
            compared to variant 1. Variants 1, 2, and 4-6 all encode the same
            isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038192.202953.1,
                                           SRR18074968.3555441.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000367220.9/ ENSP00000356189.4
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-37                AL033376.17        44534-44570         c
            38-68               AJ310566.1         2-32
            69-1726             AK289917.1         1-1658
            1727-3138           AB007863.1         1468-2879
            3139-3264           BX647254.1         3142-3267
            3265-6727           AB007863.1         3005-6467
            6728-6842           BU075081.1         14-128              c
FEATURES             Location/Qualifiers
     source          1..6842
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q25.2"
     gene            1..6842
                     /gene="IPCEF1"
                     /gene_synonym="PIP3-E; PIP3E"
                     /note="interaction protein for cytohesin exchange factors
                     1"
                     /db_xref="GeneID:26034"
                     /db_xref="HGNC:HGNC:21204"
                     /db_xref="MIM:619948"
     exon            1..132
                     /gene="IPCEF1"
                     /gene_synonym="PIP3-E; PIP3E"
                     /inference="alignment:Splign:2.1.0"
     exon            133..176
                     /gene="IPCEF1"
                     /gene_synonym="PIP3-E; PIP3E"
                     /inference="alignment:Splign:2.1.0"
     exon            177..229
                     /gene="IPCEF1"
                     /gene_synonym="PIP3-E; PIP3E"
                     /inference="alignment:Splign:2.1.0"
     CDS             194..1510
                     /gene="IPCEF1"
                     /gene_synonym="PIP3-E; PIP3E"
                     /note="isoform 1 is encoded by transcript variant 2;
                     interaction protein for cytohesin exchange factors 1
                     Interaction protein for cytohesin exchange factors 1;
                     interactor protein for cytohesin exchange factors 1;
                     phosphoinositide-binding protein PIP3-E"
                     /codon_start=1
                     /product="interactor protein for cytohesin exchange
                     factors 1 isoform 1"
                     /protein_id="NP_001124172.1"
                     /db_xref="CCDS:CCDS47509.1"
                     /db_xref="GeneID:26034"
                     /db_xref="HGNC:HGNC:21204"
                     /db_xref="MIM:619948"
                     /translation="MTSYMAIDGSALQVPLRQKPRRKTQGFLTMSRRRISCKDLGHAD
                     CQGWLYKKKEKGSFLSNKWKKFWVILKGSSLYWYSNQMAEKADGFVNLPDFTVERASE
                     CKKKHAFKISHPQIKTFYFAAENVQEMNVWLNKLGSAVIHQESTTKDEECYSESEQED
                     PEIAAETPPPPHASQTQSLTAQQASSSSPSLSGTSYSFSSLENTVKTPSSFPSSLSKE
                     RQSLPDTVNSLSAAEDEGQPITFAVQVHSPVPSEAGIHKALENSFVTSESGFLNSLSS
                     DDTSSLSSNHDHLTVPDKPAGSKIMDKEETKVSEDDEMEKLYKSLEQASLSPLGDRRP
                     STKKELRKSFVKRCKNPSINEKLHKIRTLNSTLKCKEHDLAMINQLLDDPKLTARKYR
                     EWKVMNTLLIQDIYQQQRASPAPDDTDDTPQELKKSPSSPSVENSI"
     exon            230..269
                     /gene="IPCEF1"
                     /gene_synonym="PIP3-E; PIP3E"
                     /inference="alignment:Splign:2.1.0"
     exon            270..439
                     /gene="IPCEF1"
                     /gene_synonym="PIP3-E; PIP3E"
                     /inference="alignment:Splign:2.1.0"
     exon            440..513
                     /gene="IPCEF1"
                     /gene_synonym="PIP3-E; PIP3E"
                     /inference="alignment:Splign:2.1.0"
     exon            514..585
                     /gene="IPCEF1"
                     /gene_synonym="PIP3-E; PIP3E"
                     /inference="alignment:Splign:2.1.0"
     exon            586..644
                     /gene="IPCEF1"
                     /gene_synonym="PIP3-E; PIP3E"
                     /inference="alignment:Splign:2.1.0"
     exon            645..730
                     /gene="IPCEF1"
                     /gene_synonym="PIP3-E; PIP3E"
                     /inference="alignment:Splign:2.1.0"
     exon            731..1103
                     /gene="IPCEF1"
                     /gene_synonym="PIP3-E; PIP3E"
                     /inference="alignment:Splign:2.1.0"
     exon            1104..1297
                     /gene="IPCEF1"
                     /gene_synonym="PIP3-E; PIP3E"
                     /inference="alignment:Splign:2.1.0"
     exon            1298..6842
                     /gene="IPCEF1"
                     /gene_synonym="PIP3-E; PIP3E"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6703..6708
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IPCEF1"
                     /gene_synonym="PIP3-E; PIP3E"
                     /note="hexamer: AATAAA"
     polyA_site      6729
                     /gene="IPCEF1"
                     /gene_synonym="PIP3-E; PIP3E"
                     /note="major polyA site"
     regulatory      6817..6822
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IPCEF1"
                     /gene_synonym="PIP3-E; PIP3E"
                     /note="hexamer: AATAAA"
     polyA_site      6842
                     /gene="IPCEF1"
                     /gene_synonym="PIP3-E; PIP3E"
ORIGIN      
        1 agttctgggt tgactgagtt tccagagctg aggctgcttt aagtagaatc ctcaagcttg
       61 gcctcagagt actatgaggc ttctgaatcc aggaataaga ctgctcttgg atttactctc
      121 tttgtattgc atgtcaaagg caacagaact ggaccaagaa aattcataac tttttgcttt
      181 tgtttctact aagatgacat catacatggc tattgatggc agtgctcttc aggttccctt
      241 gcgtcagaag cccaggagga aaactcaagg ttttctcacg atgagtcgga ggaggatatc
      301 gtgtaaagat ctgggccatg ctgactgcca agggtggctg tataagaaaa aggaaaaggg
      361 aagtttccta agcaacaaat ggaaaaagtt ctgggtgata ctgaaggggt cgtcactgta
      421 ctggtatagc aatcaaatgg cagagaaagc tgatggattt gtcaacctgc ctgatttcac
      481 tgtggaaaga gcatctgaat gcaagaaaaa gcatgctttt aagatcagcc atccacagat
      541 caagaccttt tattttgcag ctgagaatgt gcaggaaatg aacgtgtggt taaataaact
      601 tggatcggct gtaatccatc aggaatccac tacaaaggat gaagaatgtt acagtgaaag
      661 tgaacaggaa gatccagaaa tagctgcgga gacaccaccc cctcctcacg cttcccagac
      721 tcagtctttg actgcacagc aggcatcttc atcctcaccc agcctgagtg gaacgtcgta
      781 ttctttctct tccctggaaa atacagtgaa gacacccagc agttttcctt cctccttatc
      841 taaagagaga caatccttgc ctgacacagt taacagtttg tctgctgctg aagatgaggg
      901 acaaccaata acgtttgctg tgcaagttca ttcacctgta ccctcagagg caggcatcca
      961 caaggccctg gaaaacagtt ttgtcacatc agaaagtgga tttttgaact ctttatctag
     1021 tgatgatact tcttcattga gtagcaatca tgaccatctt actgtcccag ataagcctgc
     1081 tggatcaaag atcatggaca aagaagagac aaaagtgtct gaagatgatg aaatggagaa
     1141 gctgtacaaa tcattagagc aagctagtct atctcctctt ggggaccgac gaccttcgac
     1201 taaaaaggag ttgagaaaat cctttgttaa gcggtgtaaa aatccatcta taaacgagaa
     1261 actccacaaa atccgaacat tgaatagcac attaaagtgt aaagaacatg atctggccat
     1321 gattaaccag ttgctggatg acccgaagct gacagccagg aaatacagag agtggaaagt
     1381 catgaacacc ctgctgatcc aggacatcta tcagcagcag cgggcttcgc ctgcccctga
     1441 tgacactgat gacacccccc aggaactcaa gaaatcacct tcttctccct ctgttgaaaa
     1501 ttccatttga gacaaagtca gggttttctc ctcttatatt ttatcacaag caactcttca
     1561 agatgttgca aaagcttaca tttttcctta aaaggaaaac tgaaacccag tccttcaagc
     1621 atcagcttcc catctaaaga tgcacgttag atgaagataa tcaccgaata caccagggct
     1681 cctcatttca gtcgtaacgc atccattgag attggaatga ttgagttcag ttgaaaggcg
     1741 ttttttgtgt tcctactggg agctcacggt gatgtggggc tctagggggg atgtgagaaa
     1801 tgtctcttct gttcattgct ctccagagaa tgctatggac aagaatcaaa ttttaccagg
     1861 agtaattgcc catggaaaca ttctgttttt caaaagaaga atgtacatat tccacttgac
     1921 tgggaagctg tgtggcccaa atcactgttt gagtggagga atgttttcta gagcagtgac
     1981 tggaaggaca aacgtggtgt tgcagaacaa aaattccttg cctttggtat ggaatggtgg
     2041 tgccttttcc atgtgatgag aaatgcttca tagacagtgg catgtgggag agctgaagga
     2101 ggaggcgtgt tccatattcc actcattcaa aggacagctt ggtgttttca cactttatgc
     2161 aggttagggg atctgattaa tgtttccttt ccttacaaca gctagagaaa acatctcatc
     2221 acaattggag acctctactt cctttgagct ttcctactca atggtaggag ataggaatat
     2281 gttccgcaaa gaatgtctac tgctcttgtc cttggctgtg atccctatac atagtgtgaa
     2341 tttatatcca ggtttcccag gatcaatatt gacaagacga ctttggcatc tgaattgttt
     2401 taatatcttt actcaaaaaa acaaaaaaac aaaaacccat ggaagcaaca aaagagttaa
     2461 acatgaggga tttatttttg tatgtttata tgtcacttgt gtgctatgtg aatagctatg
     2521 tttgttattt aaatatattt atagaagttc aaattactag tgtttaaaag atgatatact
     2581 attatatatt gtgcttagta tatatttgat gagtctatac tttttgcttg agaaaaatag
     2641 aaatactatt gattcactgg tgttatgatg ttgcactgtg tctgaggaat gctcaggaaa
     2701 tcttgtggga aaaaaatggg gcatgcattc ataatttttc attttcttcc ccaccccaac
     2761 ccccatgagc tcttaaattt agatttctat ctcttgtaag tcactctttt aaccagcaaa
     2821 ggactttcat cttagattat cctttctatt aaataaactt taagctttgt gccatttatg
     2881 cctgcaaacc ttagaccaaa ggcaacacaa ctaatgtcat cttttcatta aagactaata
     2941 gaaatttaga aatcattgtg ttaaagagag ctatagagaa acaatatgaa agtcttccct
     3001 tactaatcac catgaatatt tctcaccata ggaataacca caacccacca agtacccatg
     3061 ttggccctgc ctacccgtaa caaattgttc acacaaccta ttttgtttta tagcttcaaa
     3121 gtgtggcttg acattcaaat ggaaggaacc acctgaatta tatctgcaaa caaaatggaa
     3181 atagttgttg aatagttccc caagctttac taagaagcct taatactctg taaacaaaca
     3241 aacaaacaaa aaacaacctt agcattaaga aataaaaaca aaaaacaaga agcaagttgt
     3301 actgctagaa acttctctaa gataagaggc caggccagtc agtttggccc agcaaacatg
     3361 tgggtacttc tccacctagg gaagccactg aagatgagtt tgacctgtgg tgacctgaca
     3421 gagagaacat tcagatcctc agattgcacc ctgatgccct ggtttaggaa agcagtgctt
     3481 taaccttttg cccctggaaa ttactgattc tttctgtgat tagcagatac cagaagggaa
     3541 attatttagg attggcaatg taaagagtat tgaaggaaca acaaataaca atagcagaaa
     3601 taacagtgtg acataaagtg cccttccacc tatttttctt tggtttgcaa caccagcctg
     3661 tagacttcca gtttttctta aattgaagag ctccagacac ttttgagcag ggtttgtgaa
     3721 tagctttgaa tgctttcctt tggcttttcg tgaagacata tttccccagc ctttcaactg
     3781 taaactcctt tagtaccatt gaaacttaag gcaaaaaaga tccctgggat tacttagcca
     3841 aggcttaaat ttatttttca aagtcaagaa cattagccta gaagtttttg ctttgctagt
     3901 taaagcttac tttgcagagc ttcccaaagt gaaagggaaa ctgaacttca caattttgca
     3961 cctggctttc tggagcccca ttgcctgctc attcgtgttt ttccccctgt aaattatttt
     4021 gcttttgacc aggttgtgct agaaagtagg gctgcttctg tgagttctca gcctaggctg
     4081 tggccactaa gacgtgggtg gggggataga caggagtgag agggagagtg ggtgacactt
     4141 tccgtgacac ttaatgtagg aagacatggg cttctctctc ttggcctcaa gccacttttc
     4201 tggtccaaag aatattggga aaactggatt actttcagta tatttcttga gaccgggtca
     4261 tctctgaaat gcatttgggg tagtttcctg gggtccaagg gccaattcct atacccagtc
     4321 ctgcagtgtc tgtgagctgt ggaatgagag agaaaaccat ggctgctcag gaaggaagtg
     4381 gagaatctct cagcacacgt agatccaaat ctgtggcacc tgctaaagat taggatttgg
     4441 agaggactcc tctttggggt tgtgaagagg accttttccc tctgttgtta gcctgtagat
     4501 ccagaacgga gcctgatgtg atgccttcac tggttgatat attgcaaata gacactctga
     4561 gccctgcatt gcaagggcgt cttttgcttt aaagaattct tagttttgcc acaacagctc
     4621 aaatctcaga ataggatcaa aggcctagaa agactcctaa agtataggat tacaaagact
     4681 ccaggaagcg taagaaagag attgtgtttg gagtcagatt tcaatgtgaa acccatgcct
     4741 tacatttaca cagcactttg tagtttgcaa attggtgtgt tttcagcccc ctcccgctgc
     4801 cccatgctct gagatgattg tggattatta cagtgaagtg cctggcccgg agcccccagt
     4861 gatgaagcag gaacttgagt ctcaggactc ccagcggctc tctgcccatt tcctcctctc
     4921 cgccccccac ctcgcttcac ctgttacctt gtgaagttgc tgttggcaca tagcccacta
     4981 ggaaaccaag aagtttgact gggagcgtgt gtttcattgc actgggctta gcatacggct
     5041 ggccctggtg gctgtttggc taaattctcc atttgaaacc taaagggccc tctctgtgct
     5101 tgagcacagt ctcctcctag tggtcctgcc tcaacctgct ggcgggctgt ctatggattg
     5161 gggtttcacc taatcatgct gtgtttcctt tcttttcttt ctgtacatta gactacttgg
     5221 gaggtgctgt gtgatccttg gatgaaaaac atatatttaa agaaatggag agtgtttatt
     5281 ttgtttgctt tttgaggcat gtgctgtcaa atgttagaga ccaaacttag tgattagagg
     5341 ttggtccttt gaccttcttc tcttaattgc ttttcatgta atcatgataa tttactcagg
     5401 tagcactcca gtcacaaaca atgtcacaga gatgaaacag attcaaagaa aaaatatttt
     5461 taagtctttt gaaaagaagt gctattcaaa tttaagacat gtttaaattc ataggtacat
     5521 tatctcttag taagaaatac tttttttttt ctttttttag acagagtctt gctctgttgc
     5581 ccaggctgga gtgcagtggc acgattttag ctcactgcaa cctctgcctc cctggttgaa
     5641 gtgattctcc tgcctcagcc tcccgagtag ctgggactac gcccggctaa tttttatatt
     5701 tttagtagag accggggttt accatgttgc ccaggctggt ttcaaactcc tgacctcagg
     5761 tgatctgcct gcctctgcct cccagagtgc tgggattaca ggtgtgagcc accacacctg
     5821 gccgaaagac agtattttga tatagccaca tacatgattt aatgagtaat gttaagtaca
     5881 gaaaagctgc catatccaca tagttttagg gggcatttct tcttcagtct aacaagaata
     5941 tgatatccaa ttgtggtttt ccaatttatt tctcttccaa tttcttttgt atacctcaca
     6001 ggagaaattg aatcctagaa ctgggagatg actgccctgc ccagggtttt gtaatacata
     6061 attgaaaata aaagtccctg aaactaaatg tttgcagcct gtatgaaatg gactgtggaa
     6121 gggggataat ttctctcctc acagaaagcc actcgtctcc ttgaatgagg cattgagcag
     6181 acacacgttt ctctgtgtcg tggggcagga agcaattccc ttgcctcttc agcacatctc
     6241 agttctttcc cacatgaccc cagaaccaca tagaaaacat tgaaaataat ggattcttca
     6301 ttgtatttga attttttttt tttaaccttt agcccaaaag ggaagtgtgc ctcgtggaaa
     6361 gagcaaatgc cgtaaaatag aaaccaggag ttttaatcgc catatatttt aatgtgcttg
     6421 catgatggga atgtgacttt tagcactgca tggtgtttgg gggcaagata ttaatgtgga
     6481 aatcttagct taagttttac tgtgctctca tcctgtgtca gctacccctc taaactgaaa
     6541 aagaggcatg gctcatttct ctcctgcttt atgtttttga ggttgacttg taagataaaa
     6601 ataaaaataa gaaaaaaata tatctaggca aatgacatga aaaaaaagtt gaaatatact
     6661 actggtgttc atttttgtcc tgcagtgttg ctttctcaaa gaaataaaca tgtggctgga
     6721 agtgtttaat ggctgcgttt tgatcgtcta caacaaggtt acagtgccct ctggtggcag
     6781 tcatcaaaat cgcttctaga cttgttttta tttttaaata aaagatctaa ttatattgga
     6841 aa
//
