LOCUS       NM_016291               1746 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens inositol hexakisphosphate kinase 2 (IP6K2), transcript
            variant 1, mRNA.
ACCESSION   NM_016291
VERSION     NM_016291.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1746)
  AUTHORS   Tang,J.Y., Yang,L., Wu,Q.J., Yang,Y., Su,Y.Y., Chen,Y.R. and Mu,J.
  TITLE     Circ-IP6K2 suppresses tumor progression by modulating the
            miR-1292-5p/CAMK2N1 signal in clear cell renal cell carcinoma
  JOURNAL   Funct Integr Genomics 24 (4), 122 (2024)
   PUBMED   38980439
  REMARK    GeneRIF: Circ-IP6K2 suppresses tumor progression by modulating the
            miR-1292-5p/CAMK2N1 signal in clear cell renal cell carcinoma.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1746)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 1746)
  AUTHORS   Nagata,E., Fujii,N., Kohara,S., Okada,C., Satoh,T., Takekoshi,S.,
            Takao,M., Mihara,B. and Takizawa,S.
  TITLE     Inositol hexakisphosphate kinase 2 promotes cell death of anterior
            horn cells in the spinal cord of patients with amyotrophic lateral
            sclerosis
  JOURNAL   Mol Biol Rep 47 (9), 6479-6485 (2020)
   PUBMED   32929655
  REMARK    GeneRIF: Inositol hexakisphosphate kinase 2 promotes cell death of
            anterior horn cells in the spinal cord of patients with amyotrophic
            lateral sclerosis.
REFERENCE   4  (bases 1 to 1746)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 1746)
  AUTHORS   Liang,R. and Tang,Y.
  TITLE     LINC00467 knockdown repressed cell proliferation but stimulated
            cell apoptosis in glioblastoma via miR-339-3p/IP6K2 axis
  JOURNAL   Cancer Biomark 28 (2), 169-180 (2020)
   PUBMED   32176627
  REMARK    GeneRIF: LINC00467 knockdown repressed cell proliferation but
            stimulated cell apoptosis in glioblastoma via miR-339-3p/IP6K2
            axis.
REFERENCE   6  (bases 1 to 1746)
  AUTHORS   Saiardi,A., Nagata,E., Luo,H.R., Snowman,A.M. and Snyder,S.H.
  TITLE     Identification and characterization of a novel inositol
            hexakisphosphate kinase
  JOURNAL   J Biol Chem 276 (42), 39179-39185 (2001)
   PUBMED   11502751
REFERENCE   7  (bases 1 to 1746)
  AUTHORS   Morrison,B.H., Bauer,J.A., Kalvakolanu,D.V. and Lindner,D.J.
  TITLE     Inositol hexakisphosphate kinase 2 mediates growth suppressive and
            apoptotic effects of interferon-beta in ovarian carcinoma cells
  JOURNAL   J Biol Chem 276 (27), 24965-24970 (2001)
   PUBMED   11337497
REFERENCE   8  (bases 1 to 1746)
  AUTHORS   Saiardi,A., Caffrey,J.J., Snyder,S.H. and Shears,S.B.
  TITLE     The inositol hexakisphosphate kinase family. Catalytic flexibility
            and function in yeast vacuole biogenesis
  JOURNAL   J Biol Chem 275 (32), 24686-24692 (2000)
   PUBMED   10827188
REFERENCE   9  (bases 1 to 1746)
  AUTHORS   Saiardi,A., Erdjument-Bromage,H., Snowman,A.M., Tempst,P. and
            Snyder,S.H.
  TITLE     Synthesis of diphosphoinositol pentakisphosphate by a newly
            identified family of higher inositol polyphosphate kinases
  JOURNAL   Curr Biol 9 (22), 1323-1326 (1999)
   PUBMED   10574768
REFERENCE   10 (bases 1 to 1746)
  AUTHORS   White,K.E. and Econs,M.J.
  TITLE     Localization of PiUS, a stimulator of cellular phosphate uptake to
            human chromosome 3p21.3
  JOURNAL   Somat Cell Mol Genet 24 (1), 71-74 (1998)
   PUBMED   9776982
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB039955.1, AK315204.1 and
            AY007091.1.
            
            On Nov 22, 2018 this sequence version replaced NM_016291.3.
            
            Summary: This gene encodes a protein that belongs to the inositol
            phosphokinase (IPK) family. This protein is likely responsible for
            the conversion of inositol hexakisphosphate (InsP6) to
            diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). It may also
            convert 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4 and affect
            the growth suppressive and apoptotic activities of interferon-beta
            in some ovarian cancers. Alternative splicing results in multiple
            transcript variants encoding different isoforms. [provided by
            RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (a). Variants 1 and 2 encode the same isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.134821.1,
                                           SRR3476690.167495.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000328631.10/ ENSP00000331103.5
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-7                 DB039955.1         58-64
            8-1476              AK315204.1         3-1471
            1477-1746           AY007091.1         1457-1726
FEATURES             Location/Qualifiers
     source          1..1746
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p21.31"
     gene            1..1746
                     /gene="IP6K2"
                     /gene_synonym="IHPK2; InsP6K2; PIUS"
                     /note="inositol hexakisphosphate kinase 2"
                     /db_xref="GeneID:51447"
                     /db_xref="HGNC:HGNC:17313"
                     /db_xref="MIM:606992"
     exon            1..65
                     /gene="IP6K2"
                     /gene_synonym="IHPK2; InsP6K2; PIUS"
                     /inference="alignment:Splign:2.1.0"
     exon            66..397
                     /gene="IP6K2"
                     /gene_synonym="IHPK2; InsP6K2; PIUS"
                     /inference="alignment:Splign:2.1.0"
     CDS             196..1476
                     /gene="IP6K2"
                     /gene_synonym="IHPK2; InsP6K2; PIUS"
                     /EC_number="2.7.4.21"
                     /note="isoform a is encoded by transcript variant 1;
                     inositol hexaphosphate kinase 2;
                     ATP:1D-myo-inositol-hexakisphosphate phosphotransferase;
                     insp6 kinase 2; pi uptake stimulator"
                     /codon_start=1
                     /product="inositol hexakisphosphate kinase 2 isoform a"
                     /protein_id="NP_057375.2"
                     /db_xref="CCDS:CCDS2777.1"
                     /db_xref="GeneID:51447"
                     /db_xref="HGNC:HGNC:17313"
                     /db_xref="MIM:606992"
                     /translation="MSPAFRAMDVEPRAKGVLLEPFVHQVGGHSCVLRFNETTLCKPL
                     VPREHQFYETLPAEMRKFTPQYKGVVSVRFEEDEDRNLCLIAYPLKGDHGIVDIVDNS
                     DCEPKSKLLRWTTNKKHHVLETEKTPKDWVRQHRKEEKMKSHKLEEEFEWLKKSEVLY
                     YTVEKKGNISSQLKHYNPWSMKCHQQQLQRMKENAKHRNQYKFILLENLTSRYEVPCV
                     LDLKMGTRQHGDDASEEKAANQIRKCQQSTSAVIGVRVCGMQVYQAGSGQLMFMNKYH
                     GRKLSVQGFKEALFQFFHNGRYLRRELLGPVLKKLTELKAVLERQESYRFYSSSLLVI
                     YDGKERPEVVLDSDAEDLEDLSEESADESAGAYAYKPIGASSVDVRMIDFAHTTCRLY
                     GEDTVVHEGQDAGYIFGLQSLIDIVTEISEESGE"
     exon            398..623
                     /gene="IP6K2"
                     /gene_synonym="IHPK2; InsP6K2; PIUS"
                     /inference="alignment:Splign:2.1.0"
     exon            624..799
                     /gene="IP6K2"
                     /gene_synonym="IHPK2; InsP6K2; PIUS"
                     /inference="alignment:Splign:2.1.0"
     exon            800..975
                     /gene="IP6K2"
                     /gene_synonym="IHPK2; InsP6K2; PIUS"
                     /inference="alignment:Splign:2.1.0"
     exon            976..1746
                     /gene="IP6K2"
                     /gene_synonym="IHPK2; InsP6K2; PIUS"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1722..1727
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IP6K2"
                     /gene_synonym="IHPK2; InsP6K2; PIUS"
                     /note="hexamer: AATACA"
     polyA_site      1746
                     /gene="IP6K2"
                     /gene_synonym="IHPK2; InsP6K2; PIUS"
                     /note="major polyA site"
ORIGIN      
        1 gcagccattt tggtgcgaga gaaacaatag gacggaaacg ccgaggaacc cggctgaggc
       61 ggcagcagag catcctggcc agaacaagcc aaggagccaa gacgagaggg acacacggac
      121 aaacaacaga cagaagacgt actggccgct ggactccgct gcctccccca tctccccgcc
      181 atctgcgccc ggaggatgag cccagccttc agggccatgg atgtggagcc ccgcgccaaa
      241 ggcgtccttc tggagccctt tgtccaccag gtcggggggc actcatgcgt gctccgcttc
      301 aatgagacaa ccctgtgcaa gcccctggtc ccaagggaac atcagttcta cgagaccctc
      361 cctgctgaga tgcgcaaatt cactccccag tacaaaggtg tggtatctgt gcgctttgaa
      421 gaagatgaag acaggaactt gtgtctaata gcatatccat tgaaagggga ccatggaatt
      481 gtggacattg tagataattc agactgtgaa ccaaaaagta agctcctaag gtggacaaca
      541 aacaaaaaac atcatgtctt agaaacagaa aagaccccta aggactgggt gcgtcagcac
      601 cgtaaagagg agaaaatgaa gagccataag ttagaagaag aatttgagtg gctaaagaaa
      661 tctgaagtct tgtactacac tgtagagaag aaggggaata taagttccca gcttaaacac
      721 tataaccctt ggagcatgaa atgtcaccag caacagttac agagaatgaa ggagaatgca
      781 aagcatcgga accagtacaa atttatctta ctggaaaacc tgacttcccg ctacgaggtg
      841 ccttgtgtcc ttgacctcaa gatgggcaca cgacaacatg gtgatgatgc ttcagaggag
      901 aaggcagcca accagatccg aaaatgtcag cagagcacat ctgcagtcat tggtgtgcgt
      961 gtgtgtggca tgcaggtgta ccaagcaggc agtgggcagc tcatgttcat gaacaagtac
     1021 catggacgga agctatcggt gcagggcttc aaggaggcac ttttccagtt cttccacaat
     1081 gggcggtacc tgcgccgtga actcctgggc cctgtgctca agaagctgac tgagctcaag
     1141 gcagtgttgg agcgacagga gtcctaccgc ttctactcaa gctccctgct ggtcatttat
     1201 gatggcaagg agcggcccga agtggtcctg gactcagatg ctgaggattt ggaggacctg
     1261 tcagaggaat cagctgatga gtctgctggt gcctatgcct acaaacccat cggcgccagc
     1321 tctgtagatg tgcgcatgat cgactttgca cacaccacct gcaggctgta tggcgaggac
     1381 accgtggtgc atgagggcca ggatgctggc tatatcttcg ggctccagag cctgatagac
     1441 attgtcacag agataagtga ggagagtggg gagtgagctt gctagctgct ccagtacttg
     1501 agagcgactc tgtgtcccag gcacagctgt gctgcgtcag ggaggaagcc agtatggcca
     1561 ggtggtggct cctgcagcct ggagctgatg tgcagtggcc tctgtgagcc ccagcctgag
     1621 ccagtcccag ctgtgcttgg agtctttatt tattttaact atttcttcaa cattccacat
     1681 ttgatgatga tacctctttc ttccctgagt gtatatgttc taatacaaat ctttttgttt
     1741 attgta
//
