LOCUS       NM_153273               4471 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens inositol hexakisphosphate kinase 1 (IP6K1), transcript
            variant 1, mRNA.
ACCESSION   NM_153273
VERSION     NM_153273.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4471)
  AUTHORS   Shah,A. and Bhandari,R.
  TITLE     IP6K1 upregulates the formation of processing bodies by influencing
            protein-protein interactions on the mRNA cap
  JOURNAL   J Cell Sci 134 (24) (2021)
   PUBMED   34841428
  REMARK    GeneRIF: IP6K1 upregulates the formation of processing bodies by
            influencing protein-protein interactions on the mRNA cap.
REFERENCE   2  (bases 1 to 4471)
  AUTHORS   Mukherjee,S., Chakraborty,M., Ulmasov,B., McCommis,K., Zhang,J.,
            Carpenter,D., Msengi,E.N., Haubner,J., Guo,C., Pike,D.P.,
            Ghoshal,S., Ford,D.A., Neuschwander-Tetri,B.A. and Chakraborty,A.
  TITLE     Pleiotropic actions of IP6K1 mediate hepatic metabolic dysfunction
            to promote nonalcoholic fatty liver disease and steatohepatitis
  JOURNAL   Mol Metab 54, 101364 (2021)
   PUBMED   34757046
  REMARK    GeneRIF: Pleiotropic actions of IP6K1 mediate hepatic metabolic
            dysfunction to promote nonalcoholic fatty liver disease and
            steatohepatitis.
REFERENCE   3  (bases 1 to 4471)
  AUTHORS   Minini,M., Senni,A., He,X., Proietti,S., Liguoro,D., Catizone,A.,
            Giuliani,A., Mancini,R., Fuso,A., Cucina,A., Cao,Y. and Bizzarri,M.
  TITLE     miR-125a-5p impairs the metastatic potential in breast cancer via
            IP6K1 targeting
  JOURNAL   Cancer Lett 520, 48-56 (2021)
   PUBMED   34229060
  REMARK    GeneRIF: miR-125a-5p impairs the metastatic potential in breast
            cancer via IP6K1 targeting.
REFERENCE   4  (bases 1 to 4471)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 4471)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 4471)
  AUTHORS   Saiardi,A., Nagata,E., Luo,H.R., Snowman,A.M. and Snyder,S.H.
  TITLE     Identification and characterization of a novel inositol
            hexakisphosphate kinase
  JOURNAL   J Biol Chem 276 (42), 39179-39185 (2001)
   PUBMED   11502751
REFERENCE   7  (bases 1 to 4471)
  AUTHORS   Saiardi,A., Caffrey,J.J., Snyder,S.H. and Shears,S.B.
  TITLE     The inositol hexakisphosphate kinase family. Catalytic flexibility
            and function in yeast vacuole biogenesis
  JOURNAL   J Biol Chem 275 (32), 24686-24692 (2000)
   PUBMED   10827188
REFERENCE   8  (bases 1 to 4471)
  AUTHORS   Schell,M.J., Letcher,A.J., Brearley,C.A., Biber,J., Murer,H. and
            Irvine,R.F.
  TITLE     PiUS (Pi uptake stimulator) is an inositol hexakisphosphate kinase
  JOURNAL   FEBS Lett 461 (3), 169-172 (1999)
   PUBMED   10567691
REFERENCE   9  (bases 1 to 4471)
  AUTHORS   Saiardi,A., Erdjument-Bromage,H., Snowman,A.M., Tempst,P. and
            Snyder,S.H.
  TITLE     Synthesis of diphosphoinositol pentakisphosphate by a newly
            identified family of higher inositol polyphosphate kinases
  JOURNAL   Curr Biol 9 (22), 1323-1326 (1999)
   PUBMED   10574768
REFERENCE   10 (bases 1 to 4471)
  AUTHORS   White,K.E. and Econs,M.J.
  TITLE     Localization of PiUS, a stimulator of cellular phosphate uptake to
            human chromosome 3p21.3
  JOURNAL   Somat Cell Mol Genet 24 (1), 71-74 (1998)
   PUBMED   9776982
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC139451.7, BG720032.1,
            AL561521.3, D87452.2, CB152138.1, BE387671.1 and AC099668.2.
            
            On Nov 22, 2018 this sequence version replaced NM_153273.3.
            
            Summary: This gene encodes a member of the inositol phosphokinase
            family. The encoded protein may be responsible for the conversion
            of inositol hexakisphosphate (InsP6) to diphosphoinositol
            pentakisphosphate (InsP7/PP-InsP5). It may also convert
            1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4. Alternatively
            spliced transcript variants have been described. [provided by
            RefSeq, Jun 2011].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1). Variants 1 and 3
            encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.50167.1,
                                           SRR1803614.65183.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145774 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000321599.9/ ENSP00000323780.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2                 AC139451.7         82701-82702
            3-12                BG720032.1         8-17
            13-15               AL561521.3         11-13
            16-2855             D87452.2           1-2840
            2856-2865           CB152138.1         544-553
            2866-3532           D87452.2           2851-3517
            3533-3540           BE387671.1         200-207
            3541-4470           D87452.2           3526-4455
            4471-4471           AC099668.2         11979-11979
FEATURES             Location/Qualifiers
     source          1..4471
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p21.31"
     gene            1..4471
                     /gene="IP6K1"
                     /gene_synonym="IHPK1; PiUS"
                     /note="inositol hexakisphosphate kinase 1"
                     /db_xref="GeneID:9807"
                     /db_xref="HGNC:HGNC:18360"
                     /db_xref="MIM:606991"
     exon            1..189
                     /gene="IP6K1"
                     /gene_synonym="IHPK1; PiUS"
                     /inference="alignment:Splign:2.1.0"
     exon            190..540
                     /gene="IP6K1"
                     /gene_synonym="IHPK1; PiUS"
                     /inference="alignment:Splign:2.1.0"
     CDS             318..1643
                     /gene="IP6K1"
                     /gene_synonym="IHPK1; PiUS"
                     /EC_number="2.7.4.21"
                     /note="isoform 1 is encoded by transcript variant 1;
                     inositol hexaphosphate kinase 1; Pi uptake stimulator;
                     insP6 kinase 1; ATP:1D-myo-inositol-hexakisphosphate
                     phosphotransferase"
                     /codon_start=1
                     /product="inositol hexakisphosphate kinase 1 isoform 1"
                     /protein_id="NP_695005.1"
                     /db_xref="CCDS:CCDS33760.1"
                     /db_xref="GeneID:9807"
                     /db_xref="HGNC:HGNC:18360"
                     /db_xref="MIM:606991"
                     /translation="MCVCQTMEVGQYGKNASRAGDRGVLLEPFIHQVGGHSSMMRYDD
                     HTVCKPLISREQRFYESLPPEMKEFTPEYKGVVSVCFEGDSDGYINLVAYPYVESETV
                     EQDDTTEREQPRRKHSRRSLHRSGSGSDHKEEKASLSLETSESSQEAKSPKVELHSHS
                     EVPFQMLDGNSGLSSEKISHNPWSLRCHKQQLSRMRSESKDRKLYKFLLLENVVHHFK
                     YPCVLDLKMGTRQHGDDASAEKAARQMRKCEQSTSATLGVRVCGMQVYQLDTGHYLCR
                     NKYYGRGLSIEGFRNALYQYLHNGLDLRRDLFEPILSKLRGLKAVLERQASYRFYSSS
                     LLVIYDGKECRAESCLDRRSEMRLKHLDMVLPEVASSCGPSTSPSNTSPEAGPSSQPK
                     VDVRMIDFAHSTFKGFRDDPTVHDGPDRGYVFGLENLISIMEQMRDENQ"
     exon            541..751
                     /gene="IP6K1"
                     /gene_synonym="IHPK1; PiUS"
                     /inference="alignment:Splign:2.1.0"
     exon            752..933
                     /gene="IP6K1"
                     /gene_synonym="IHPK1; PiUS"
                     /inference="alignment:Splign:2.1.0"
     exon            934..1109
                     /gene="IP6K1"
                     /gene_synonym="IHPK1; PiUS"
                     /inference="alignment:Splign:2.1.0"
     exon            1110..4471
                     /gene="IP6K1"
                     /gene_synonym="IHPK1; PiUS"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4451..4456
                     /regulatory_class="polyA_signal_sequence"
                     /gene="IP6K1"
                     /gene_synonym="IHPK1; PiUS"
                     /note="hexamer: AATAAA"
     polyA_site      4471
                     /gene="IP6K1"
                     /gene_synonym="IHPK1; PiUS"
                     /note="major polyA site"
ORIGIN      
        1 agccgccatc ttgttgttga tccgtaccca gtgggcagcg ccgggagctg gaccaagcgg
       61 ccggtgagag gccgctgtag cggtgctcag ccacctgtgc tgcctgccag ggggcgggcc
      121 gaaacctgga ggcccggggg gcccagctcc cgtagggagc cgtgggcgct cggtgcccgg
      181 gccgggcagg acagaataat aagctgaata gaatctgacc attggctttc acctggccag
      241 gaccttctat gtagctctcc ttttgtggcc catgtgctgc atcctctgcc ctcagtgtgc
      301 aactggcccc caacgcaatg tgtgtttgtc aaaccatgga agtggggcag tatggcaaga
      361 atgcaagtcg ggctggagac cggggagtcc tcctggagcc cttcatccac caagtaggcg
      421 gacacagcag catgatgcgt tacgacgatc acactgtgtg caagcccctc atctcccggg
      481 aacagcgctt ttacgagtcc ctccctcccg aaatgaagga gttcacccct gaatacaaag
      541 gcgtggtatc tgtctgtttt gagggggaca gtgatggtta catcaactta gtggcctatc
      601 cttatgtgga aagtgagact gtggaacagg atgacacaac agaacgggag caacctcggc
      661 gcaaacactc ccgccggagc ctgcaccggt caggcagtgg cagtgaccac aaggaggaga
      721 aagccagcct gtcccttgag acctctgaga gctcacagga ggcaaagagt ccgaaggtgg
      781 agctgcacag ccactcagag gtccctttcc agatgctaga tggcaacagt ggcttgagtt
      841 ctgagaagat cagccacaac ccctggagcc tgcgttgtca caagcagcag ctgagccgca
      901 tgcgctccga gtccaaggac cgaaagctct acaagttcct cctgcttgag aacgtggtgc
      961 accacttcaa gtacccctgc gtgttggacc tgaagatggg cacgcggcag catggcgatg
     1021 acgcgtcagc tgagaaggca gcccggcaga tgcggaaatg cgagcagagc acatcagcca
     1081 cgctgggcgt cagggtctgc ggcatgcagg tgtaccagct ggacacaggg cattacctct
     1141 gcaggaacaa gtactatggc cgtgggctct ccattgaagg cttccgcaat gccctctatc
     1201 aatatctgca caatggcctg gacctgcgac gtgacctgtt tgagcctatc ctgagcaaac
     1261 tgcggggcct gaaagctgtg ctggagcggc aggcctctta ccgcttctac tccagttccc
     1321 tgcttgtcat ctatgatggc aaggagtgcc gggctgagtc ctgcctggac cgccggtctg
     1381 agatgcgtct caagcacctg gacatggtgc tccctgaggt ggcgtcatcc tgtggcccca
     1441 gcaccagccc cagcaacacc agccccgagg cgggtccctc ctctcagccc aaggtggatg
     1501 tccgcatgat tgactttgca cacagcacat tcaagggctt ccgggatgac cccaccgtgc
     1561 atgatgggcc agacagaggc tacgtgtttg gcctggagaa cctcatcagc atcatggaac
     1621 agatgcggga cgagaaccag taggccctgt tctgggcccc cagaacccct tcctctccac
     1681 tgcaggcagg gaccattgtt ctgaacttgc cgtgaggaca cacagacttg cttttaaagg
     1741 gttatatttc tctttggtgt aaactaaaag aaatgttttt agctgtagcc tggaatccat
     1801 atatataaag tgaaggaggg cagaccacac gccctctcag ccaggctcct cagctttgtg
     1861 gctctgactg gtgtgtccag gctgccttag gaaggaagag gtgcccctgg tgggcttggc
     1921 agcagggaca gggtgccctt ggacattggt ttctcttgtc tagatctttg agatctgtgg
     1981 ctgcagggcc ctgctgattg taaggtaaag ccctgggctg gtgcagggcc cctccacgcc
     2041 cactcttccc ttgttcccca gaagtagagg gctctgggtg cccatttctt gggggctttc
     2101 cagtcttatg ctgtgggtgt cagctagctc tttaataggt gccctcaggg caccacaggg
     2161 ctgactgcac aaagctggac ccatccttcg gtctgacctt agcatggggc tagattaatg
     2221 aagctgggct gaggccaact tatggcagag ggcggcgcct gggttcccca ggcacctgtt
     2281 ggcacgtgac aggttggcac ctgtcctatt cctgaaacag cctctctcac caagttccct
     2341 tgcctaagaa ggccactccc tcccacccca ctgaagtggg ggatagtcgg tgtcctagca
     2401 ggcctcaggg cctctggtgg ctctggccca gacagtattt gcagttcttg tgctatgggt
     2461 gggagtcttc ttcctcaagt ttcggcagct gtgctgctgc tggatgggct gctcctccca
     2521 gggctcaagg gctgtggtcc gctcagggtc tcatttcccc aggccaagtt caaggcagca
     2581 gccctttgtg aggcgctctt ggccctgggc ctggagggag aactttaagc ttttttgctc
     2641 acagggacgt ggtatgggcc ctgggtgcag gtgcccacat tctgctaatg agagctttgt
     2701 ctgatcagtc ctgggtccat cagtttgtcc atgtgtccgg ctgccagccc gtcccttggg
     2761 atccttcccc tggggtgtag ccttgttcat tagtatatac tcattccttc atgctttcct
     2821 cagcagaaca cttccacttc tgaggtgagc ttttgcccca tgcccttcct ccacaggtgt
     2881 tgccttttta taaagacctg atagcagaat aaattggtgt ttccctgttg acccagcacc
     2941 atttctgtgg gcctagaata tggccctcaa cccttagagt ggggcagtga gggcttgagg
     3001 agtgaccctt cctttctcat ggttttagtc attttggctg ccagccctta atggcacaga
     3061 tctgctgctt ctaacagatg gccaggaggt gacaccgatt tcagccattg ccaaggttag
     3121 caccctctcc tttgagccta gggccacact gttcattgtc actttaggca agtgcctgtt
     3181 tggctttaaa ggtaagcctg ccagctgtga gaagccttgg taactgatgg actcatttcc
     3241 tggtccttaa agatgcagcc tcttaagggc tccttgatgg atgccatctc tcctagcccc
     3301 cagccctggt gccactggtg ggcaggttcc cattctttgg ggctgggagg gacagcttgc
     3361 ctgtttctgg tcacaaatta cagtcttctc tcctgtacca ttctgtggct tcagccatgg
     3421 gggcagtagc ccttcattag tgtagatagt cattccctgg tagggtggag ggtaagacat
     3481 agggtctgga actgtttggg accttttggg gatgtcctgt gcctcccaga ttcctcgatt
     3541 ctgggaggag aggctgccgc attctgctgc tcctcacagc gagcaaagct gcacccactt
     3601 acattcagta ttttcctggc actacaaaga gtgggaaggc ctgggatttg ctgctgctcc
     3661 cttagagcag ggcccctctt ttcagcactt tggacacctg gagacccagc cctgttattt
     3721 aatggtagtg ggcaagtgtg tgtgcatact gtctgccact gctttctccc tgccccatgc
     3781 cagagagccc tgtccctgcc aggcccagcc ttcttagccc caacttggga acaaagtgca
     3841 acatgggatc atgggttggg gtgctcaggt gagccctctc tatagtgctt ccctgggcca
     3901 agctgacacc agcccctgag ggtggggtgg gacgggtggt gcttaaaaga ggaaggggac
     3961 cagtgtagca acttgccagg gaccccaccc ctccctctct gggcctgtgc agtgagcatg
     4021 gggattccca tcaaggggcc tggcacctgt gctagttacg tagccgctgc tcacgcgctc
     4081 actcctgacc acatgcacgt tccctagatg cagactgctt tgaactttaa agctgtacaa
     4141 tttggttatg tttgtgctga cttaaaatat attttaatga ggaaaaaata atggagaacc
     4201 ctgggaagga cctggttctt ttgcttctcg gggaactgta agccctcgcg ttctgggaat
     4261 cgctctctgc tgctctttcc tggaagctaa gcctgtctcc accgcccgag gcctgcgccg
     4321 gtggctcccg ccgcagttgc gtttgctttg gaccttgcgt gcgggggagg gggtgctcgg
     4381 tccgagcccg ctcctttctg tacacctagc gctgcccgcc ccgcttgtgt ctgaggtcgt
     4441 gtatgtcaaa aataaagccg ctagaaacgg a
//
