LOCUS       NM_015693              13208 bp    mRNA    linear   PRI 07-FEB-2025
DEFINITION  Homo sapiens inturned planar cell polarity protein (INTU), mRNA.
ACCESSION   NM_015693 XM_371707
VERSION     NM_015693.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 13208)
  AUTHORS   Wang,S., Liu,A., Su,Y. and Dong,Z.
  TITLE     Deficiency of the Planar Cell Polarity Protein Intu Delays Kidney
            Repair and Suppresses Renal Fibrosis after Acute Kidney Injury
  JOURNAL   Am J Pathol 193 (3), 275-285 (2023)
   PUBMED   36586478
  REMARK    GeneRIF: Deficiency of the Planar Cell Polarity Protein Intu Delays
            Kidney Repair and Suppresses Renal Fibrosis after Acute Kidney
            Injury.
REFERENCE   2  (bases 1 to 13208)
  AUTHORS   Chan,H.Y.E. and Chen,Z.S.
  TITLE     Multifaceted investigation underlies diverse mechanisms
            contributing to the downregulation of Hedgehog pathway-associated
            genes INTU and IFT88 in lung adenocarcinoma and uterine corpus
            endometrial carcinoma
  JOURNAL   Aging (Albany NY) 14 (19), 7794-7823 (2022)
   PUBMED   36084949
  REMARK    GeneRIF: Multifaceted investigation underlies diverse mechanisms
            contributing to the downregulation of Hedgehog pathway-associated
            genes INTU and IFT88 in lung adenocarcinoma and uterine corpus
            endometrial carcinoma.
REFERENCE   3  (bases 1 to 13208)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 13208)
  AUTHORS   Chou,Y.C., Chen,M.J., Chen,P.H., Chang,C.W., Yu,M.H., Chen,Y.J.,
            Tsai,E.M., Tsai,S.F., Kuo,W.S. and Tzeng,C.R.
  TITLE     Integration of genome-wide association study and expression
            quantitative trait locus mapping for identification of
            endometriosis-associated genes
  JOURNAL   Sci Rep 11 (1), 478 (2021)
   PUBMED   33436679
  REMARK    GeneRIF: Integration of genome-wide association study and
            expression quantitative trait locus mapping for identification of
            endometriosis-associated genes.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 13208)
  AUTHORS   Toriyama,M., Lee,C., Taylor,S.P., Duran,I., Cohn,D.H., Bruel,A.L.,
            Tabler,J.M., Drew,K., Kelly,M.R., Kim,S., Park,T.J., Braun,D.A.,
            Pierquin,G., Biver,A., Wagner,K., Malfroot,A., Panigrahi,I.,
            Franco,B., Al-Lami,H.A., Yeung,Y., Choi,Y.J., Duffourd,Y.,
            Faivre,L., Riviere,J.B., Chen,J., Liu,K.J., Marcotte,E.M.,
            Hildebrandt,F., Thauvin-Robinet,C., Krakow,D., Jackson,P.K. and
            Wallingford,J.B.
  CONSRTM   University of Washington Center for Mendelian Genomics
  TITLE     The ciliopathy-associated CPLANE proteins direct basal body
            recruitment of intraflagellar transport machinery
  JOURNAL   Nat Genet 48 (6), 648-656 (2016)
   PUBMED   27158779
  REMARK    Erratum:[Nat Genet. 2016 Jul 27;48(8):970. doi:
            10.1038/ng0816-970b.. PMID: 27463398]
REFERENCE   6  (bases 1 to 13208)
  AUTHORS   Boldt,K., van Reeuwijk,J., Lu,Q., Koutroumpas,K., Nguyen,T.M.,
            Texier,Y., van Beersum,S.E., Horn,N., Willer,J.R., Mans,D.A.,
            Dougherty,G., Lamers,I.J., Coene,K.L., Arts,H.H., Betts,M.J.,
            Beyer,T., Bolat,E., Gloeckner,C.J., Haidari,K., Hetterschijt,L.,
            Iaconis,D., Jenkins,D., Klose,F., Knapp,B., Latour,B.,
            Letteboer,S.J., Marcelis,C.L., Mitic,D., Morleo,M., Oud,M.M.,
            Riemersma,M., Rix,S., Terhal,P.A., Toedt,G., van Dam,T.J., de
            Vrieze,E., Wissinger,Y., Wu,K.M., Apic,G., Beales,P.L.,
            Blacque,O.E., Gibson,T.J., Huynen,M.A., Katsanis,N., Kremer,H.,
            Omran,H., van Wijk,E., Wolfrum,U., Kepes,F., Davis,E.E., Franco,B.,
            Giles,R.H., Ueffing,M., Russell,R.B. and Roepman,R.
  CONSRTM   UK10K Rare Diseases Group
  TITLE     An organelle-specific protein landscape identifies novel diseases
            and molecular mechanisms
  JOURNAL   Nat Commun 7, 11491 (2016)
   PUBMED   27173435
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 13208)
  AUTHORS   Yasunaga,T., Hoff,S., Schell,C., Helmstadter,M., Kretz,O.,
            Kuechlin,S., Yakulov,T.A., Engel,C., Muller,B., Bensch,R.,
            Ronneberger,O., Huber,T.B., Lienkamp,S.S. and Walz,G.
  TITLE     The polarity protein Inturned links NPHP4 to Daam1 to control the
            subapical actin network in multiciliated cells
  JOURNAL   J Cell Biol 211 (5), 963-973 (2015)
   PUBMED   26644512
REFERENCE   8  (bases 1 to 13208)
  AUTHORS   Al-Balool,H.H., Weber,D., Liu,Y., Wade,M., Guleria,K., Nam,P.L.,
            Clayton,J., Rowe,W., Coxhead,J., Irving,J., Elliott,D.J.,
            Hall,A.G., Santibanez-Koref,M. and Jackson,M.S.
  TITLE     Post-transcriptional exon shuffling events in humans can be
            evolutionarily conserved and abundant
  JOURNAL   Genome Res 21 (11), 1788-1799 (2011)
   PUBMED   21948523
REFERENCE   9  (bases 1 to 13208)
  AUTHORS   Heydeck,W. and Liu,A.
  TITLE     PCP effector proteins inturned and fuzzy play nonredundant roles in
            the patterning but not convergent extension of mammalian neural
            tube
  JOURNAL   Dev Dyn 240 (8), 1938-1948 (2011)
   PUBMED   21761479
REFERENCE   10 (bases 1 to 13208)
  AUTHORS   Park,T.J., Haigo,S.L. and Wallingford,J.B.
  TITLE     Ciliogenesis defects in embryos lacking inturned or fuzzy function
            are associated with failure of planar cell polarity and Hedgehog
            signaling
  JOURNAL   Nat Genet 38 (3), 303-311 (2006)
   PUBMED   16493421
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB195553.1, BC130611.1, DB302901.1 and AC093591.3.
            
            On Nov 22, 2018 this sequence version replaced NM_015693.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.73433.1, AB033110.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000335251.11/ ENSP00000334003.5
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-9                 DB195553.1         26-34
            10-2950             BC130611.1         1-2941
            2951-3250           DB302901.1         1-300               c
            3251-13208          AC093591.3         20482-30439
FEATURES             Location/Qualifiers
     source          1..13208
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q28.1"
     gene            1..13208
                     /gene="INTU"
                     /gene_synonym="CPLANE4; INT; OFD17; PDZD6; PDZK6; SRTD20"
                     /note="inturned planar cell polarity protein"
                     /db_xref="GeneID:27152"
                     /db_xref="HGNC:HGNC:29239"
                     /db_xref="MIM:610621"
     exon            1..224
                     /gene="INTU"
                     /gene_synonym="CPLANE4; INT; OFD17; PDZD6; PDZK6; SRTD20"
                     /inference="alignment:Splign:2.1.0"
     CDS             79..2907
                     /gene="INTU"
                     /gene_synonym="CPLANE4; INT; OFD17; PDZD6; PDZK6; SRTD20"
                     /note="PDZ domain containing 6; PDZ domain-containing
                     protein 6; inturned planar cell polarity effector homolog;
                     ciliogenesis and planar polarity effector 4; ciliogenesis
                     and planar polarity effector complex subunit 4"
                     /codon_start=1
                     /product="protein inturned"
                     /protein_id="NP_056508.2"
                     /db_xref="CCDS:CCDS34061.1"
                     /db_xref="GeneID:27152"
                     /db_xref="HGNC:HGNC:29239"
                     /db_xref="MIM:610621"
                     /translation="MASVASCDSRPSSDELPGDPSSQEEDEDYDFEDRVSDSGSYSSA
                     SSDYDDLEPEWLDSVQKNGELFYLELSEDEEESLLPETPTVNHVRFSENEIIIEDDYK
                     ERKKYEPKLKQFTKILRRKRLLPKRCNKKNSNDNGPVSILKHQSNQKTGVIVQQRYKD
                     VNVYVNPKKLTVIKAKEQLKLLEVLVGIIHQTKWSWRRTGKQGDGERLVVHGLLPGGS
                     AMKSGQVLIGDVLVAVNDVDVTTENIERVLSCIPGPMQVKLTFENAYDVKRETSHPRQ
                     KKTQSNTSDLVKLLWGEEVEGIQQSGLNTPHIIMYLTLQLDSETSKEEQEILYHYPMS
                     EASQKLKSVRGIFLTLCDMLENVTGTQVTSSSLLLNGKQIHVAYWKESDKLLLIGLPA
                     EEVPLPRLRNMIENVIQTLKFMYGSLDSAFCQIENVPRLDHFFNLFFQRALQPAKLHS
                     SASPSAQQYDASSAVLLDNLPGVRWLTLPLEIKMELDMALSDLEAADFAELSEDYYDM
                     RRLYTILGSSLFYKGYLICSHLPKDDLIDIAVYCRHYCLLPLAAKQRIGQLIIWREVF
                     PQHHLRPLADSSTEVFPEPEGRYFLLVVGLKHYMLCVLLEAGGCASKAIGSPGPDCVY
                     VDQVKTTLHQLDGVDSRIDERLASSPVPCLSCADWFLTGSREKTDSLTTSPILSRLQG
                     TSKVATSPTCRRTLFGDYSLKTRKPSPSCSSGGSDNGCEGGEDDGFSPHTTPDAVRKQ
                     RESQGSDGLEESGTLLKVTKKKSTLPNPFHLGNLKKDLPEKELEIYNTVKLTSGPENT
                     LFHYVALETVQGIFITPTLEEVAQLSGSIHPQLIKNFHQCCLSIRAVFQQTLVEEKKK
                     GLNSGDHSDSAKSVSSLNPVKEHGVLFECSPGNWTDQKKAPPVMAYWVVGRLFLHPKP
                     QELYVCFHDSVTEIAIEIAFKLFFGLTL"
     exon            225..760
                     /gene="INTU"
                     /gene_synonym="CPLANE4; INT; OFD17; PDZD6; PDZK6; SRTD20"
                     /inference="alignment:Splign:2.1.0"
     exon            761..846
                     /gene="INTU"
                     /gene_synonym="CPLANE4; INT; OFD17; PDZD6; PDZK6; SRTD20"
                     /inference="alignment:Splign:2.1.0"
     exon            847..1050
                     /gene="INTU"
                     /gene_synonym="CPLANE4; INT; OFD17; PDZD6; PDZK6; SRTD20"
                     /inference="alignment:Splign:2.1.0"
     exon            1051..1169
                     /gene="INTU"
                     /gene_synonym="CPLANE4; INT; OFD17; PDZD6; PDZK6; SRTD20"
                     /inference="alignment:Splign:2.1.0"
     exon            1170..1259
                     /gene="INTU"
                     /gene_synonym="CPLANE4; INT; OFD17; PDZD6; PDZK6; SRTD20"
                     /inference="alignment:Splign:2.1.0"
     exon            1260..1337
                     /gene="INTU"
                     /gene_synonym="CPLANE4; INT; OFD17; PDZD6; PDZK6; SRTD20"
                     /inference="alignment:Splign:2.1.0"
     exon            1338..1527
                     /gene="INTU"
                     /gene_synonym="CPLANE4; INT; OFD17; PDZD6; PDZK6; SRTD20"
                     /inference="alignment:Splign:2.1.0"
     exon            1528..1581
                     /gene="INTU"
                     /gene_synonym="CPLANE4; INT; OFD17; PDZD6; PDZK6; SRTD20"
                     /inference="alignment:Splign:2.1.0"
     exon            1582..1644
                     /gene="INTU"
                     /gene_synonym="CPLANE4; INT; OFD17; PDZD6; PDZK6; SRTD20"
                     /inference="alignment:Splign:2.1.0"
     exon            1645..1866
                     /gene="INTU"
                     /gene_synonym="CPLANE4; INT; OFD17; PDZD6; PDZK6; SRTD20"
                     /inference="alignment:Splign:2.1.0"
     exon            1867..2349
                     /gene="INTU"
                     /gene_synonym="CPLANE4; INT; OFD17; PDZD6; PDZK6; SRTD20"
                     /inference="alignment:Splign:2.1.0"
     exon            2350..2447
                     /gene="INTU"
                     /gene_synonym="CPLANE4; INT; OFD17; PDZD6; PDZK6; SRTD20"
                     /inference="alignment:Splign:2.1.0"
     exon            2448..2637
                     /gene="INTU"
                     /gene_synonym="CPLANE4; INT; OFD17; PDZD6; PDZK6; SRTD20"
                     /inference="alignment:Splign:2.1.0"
     exon            2638..2795
                     /gene="INTU"
                     /gene_synonym="CPLANE4; INT; OFD17; PDZD6; PDZK6; SRTD20"
                     /inference="alignment:Splign:2.1.0"
     exon            2796..13208
                     /gene="INTU"
                     /gene_synonym="CPLANE4; INT; OFD17; PDZD6; PDZK6; SRTD20"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3218..3223
                     /regulatory_class="polyA_signal_sequence"
                     /gene="INTU"
                     /gene_synonym="CPLANE4; INT; OFD17; PDZD6; PDZK6; SRTD20"
                     /note="hexamer: AATATA"
     polyA_site      3247
                     /gene="INTU"
                     /gene_synonym="CPLANE4; INT; OFD17; PDZD6; PDZK6; SRTD20"
                     /note="major polyA site"
     regulatory      13180..13185
                     /regulatory_class="polyA_signal_sequence"
                     /gene="INTU"
                     /gene_synonym="CPLANE4; INT; OFD17; PDZD6; PDZK6; SRTD20"
                     /note="hexamer: AATAAA"
     polyA_site      13208
                     /gene="INTU"
                     /gene_synonym="CPLANE4; INT; OFD17; PDZD6; PDZK6; SRTD20"
                     /note="major polyA site"
ORIGIN      
        1 agaggcaaca tggcggcctt agcaagctat agctgcgaga tttgaattac tccactcgta
       61 gctattgcat tcctgacgat ggcctctgtg gcttcgtgcg attcgcgtcc gagctcagac
      121 gagctccctg gagacccctc ttcacaagaa gaagatgagg actatgattt tgaagatcgg
      181 gtcagcgact cgggttcata ttcctcagcg agtagcgatt atgatgatct tgagcctgaa
      241 tggctggaca gtgtgcagaa aaatggagag ctgttttatt tggaattgag tgaggatgaa
      301 gaagaaagcc tccttcctga gacaccaact gtgaaccatg tcaggttcag tgaaaatgag
      361 attatcattg aagatgacta caaagaaaga aaaaagtatg aacccaaact caagcagttt
      421 accaaaattt taagaaggaa aagactttta cccaagcgct gcaataaaaa aaatagcaat
      481 gacaatggac cagtatccat tctaaagcat cagtccaatc agaagacagg agtcattgtc
      541 caacagcgat acaaagatgt gaatgtttat gtaaacccca aaaagctaac tgttatcaaa
      601 gccaaagagc agctcaagct tctggaagtg ctggttggaa ttattcatca gaccaagtgg
      661 agctggagaa gaaccggaaa gcagggtgat ggagagaggc ttgtggttca tggcctgctg
      721 ccagggggat ctgctatgaa gagcggtcag gtactcattg gtgatgtcct tgttgctgtg
      781 aatgatgtcg atgttactac tgaaaacatc gagagagttc tgtcttgcat tcctggacct
      841 atgcaggtga aactgacatt tgaaaatgca tatgatgtga aaagggagac gtcccatcca
      901 agacagaaaa agacacagtc caacacaagt gatttagtca agcttctctg gggagaagag
      961 gttgaaggta tccagcagag tggcctaaac actcctcata tcattatgta tctcacacta
     1021 cagctcgact cagaaacctc aaaggaagag caggaaattc tttatcatta tccaatgtct
     1081 gaagcatctc agaaacttaa aagtgtgaga gggatttttc tcacactctg tgacatgctg
     1141 gaaaacgtaa ctgggacaca agttactagt tcatccctcc ttttaaatgg aaaacaaatt
     1201 catgtggctt attggaaaga atctgacaag ttgttgctaa ttggcctgcc tgctgaagaa
     1261 gttcctcttc ctcgtctaag gaacatgata gaaaatgtca tccaaacctt aaaatttatg
     1321 tatggttctt tagatagtgc cttttgccag attgagaatg ttcctcgttt ggatcatttt
     1381 tttaacttgt tctttcaaag agcacttcag cctgcgaaac tgcattccag cgccagtccc
     1441 agtgctcagc agtacgatgc ttccagtgca gtacttttag acaacctccc tggagtccgg
     1501 tggctcacac ttccactgga aatcaagatg gaattagaca tggcattaag tgacttggag
     1561 gctgcagatt ttgcagaact gtccgaggat tactatgaca tgaggcggct gtatacaatt
     1621 ttggggtctt ctctatttta caagggttat ttgatatgca gtcatttgcc caaggatgat
     1681 cttattgata ttgccgtata ctgtcgccac tattgcctgc tgcctttagc agcaaaacaa
     1741 agaattggtc agttgatcat atggagagaa gtgtttcctc agcatcacct ccgacctttg
     1801 gcagactcaa gcactgaagt ctttccggaa cctgaaggaa gatatttttt gctagttgtt
     1861 ggcttgaaac attatatgct atgtgtacta ttagaagctg gaggttgcgc atccaaagct
     1921 attgggagtc ctggaccaga ctgtgtatat gtggatcaag tcaaaacaac tcttcaccag
     1981 ctggatggag tagattctcg catagatgaa cggctagcat cttctccagt cccctgtttg
     2041 tcttgtgctg actggttcct tactggatca cgtgaaaaaa cagatagctt gaccacttcg
     2101 cctattctca gtaggctaca aggtacttcc aaagtagcaa cttctccaac atgcagaaga
     2161 acgctttttg gtgactattc cttaaagaca cgcaagccta gtccttcctg tagtagtgga
     2221 ggatctgaca atggttgtga aggtggagaa gatgatggct ttagccccca tactacaccg
     2281 gatgcagtac ggaagcaaag agaatctcag ggctctgatg gtttagaaga aagtgggacc
     2341 ttgcttaagg tcactaaaaa gaagtctact cttccaaatc catttcattt gggaaacttg
     2401 aaaaaggacc ttccagaaaa agaattagaa atatataaca cagtgaaact gacatctggt
     2461 cctgagaaca cacttttcca ctacgttgcc ttagaaacag tgcaaggaat ctttattact
     2521 cctacccttg aagaggtggc acagctaagt ggctctatcc accctcagct aataaagaat
     2581 ttccatcagt gttgtctttc cattcgtgca gttttccaac agacattggt ggaagagaaa
     2641 aagaaaggac taaatagtgg agaccattca gattctgcaa agtcagtgtc ttctcttaac
     2701 cctgttaaag aacatggtgt gttgtttgaa tgttcacctg gaaactggac tgatcagaaa
     2761 aaagcaccac cagttatggc ttactgggta gtagggagac tttttcttca tccaaaacct
     2821 caagaacttt atgtctgttt tcatgactca gtcacagaaa ttgccattga aatagctttt
     2881 aaattgttct ttgggttaac cttgtagctg tgctttcttg atgcgtagaa acacgtgcat
     2941 ggaggatcaa acactgtcag aattgctgaa atcaatacac aaagagataa agtttagctt
     3001 ctttttacta ttcaatattg aacataatat tgttaaatat tgagatgaaa tgctgttgga
     3061 tttgatacat taaatcttaa tgtaatattg taagactttt gagaatatac ttgattaaaa
     3121 tgtgaaagaa gggattgtta acttattgct attttggtat ataatgttaa tttattgact
     3181 agtttgaaat aatgtgaagt gttttttata tcagattaat ataggaaatg tttattcttg
     3241 aaaaatactc aatttgttgt tgtttatttt tctcaaaatt catactgata tctgatgaaa
     3301 tgattatgaa attgggagca ggtgaccagg tgctgtaact aagtagtgct atgaccatga
     3361 gcaagttttt gtacctctct aagctcagag ttttcatgta aaatgagatg attgcattga
     3421 ggtttcaaaa atacctctta agtaaaatgt gcttttattt tattttagtt ttagttttag
     3481 ttctggggta catgtgcagg atgtgcaggt tcgttacata ggtaaacatg tgccatggcg
     3541 gtttgctcca cctatcaacc catcacctag gtattaagcc tagcatgcat tagctatttt
     3601 tcctaatact ctccctaccc ccacaacagg ccctggtgtg cattgttccc ctccctttgt
     3661 ccatgtgttc tcatggtcag ctcccactta taagtgagaa cctacagtgt ttggttttct
     3721 gttcctgcat tagtttgctg aggataatgg cttccagctt catccatgtc cctgcagagg
     3781 acatgatctc ataccttttt gtggctgcat agtattccat ggtgtatgtg taccacattt
     3841 tctttatcca gtctattgct gatgggcatt tgggttgatt ccatgtcttt gctattgtaa
     3901 atagtgcttc aatgaacata tgtgtgcata tatatttgta attgaatgat ttatattact
     3961 ttgagtataa acccagtaat gggattgctg ggtcaaatgg catttctggt tctagatctt
     4021 tgaagaatca ccacactgtc ttccacaatg gttgaactaa ttcacattcc caccaacagt
     4081 gtaaaagcgt tcctatttcc tcacagcctc gccagcatct gttatttctt gactttttaa
     4141 taatagccac tctgactggt gtgagatgat atctcattgt ggttttgatt tgcatttctc
     4201 taacaatcag tgatattgag cttttttttc atatgtttgt tggctgcatg aatgtcttct
     4261 tttgagaagt gtctgttcat gtcctttgcc cagtttttaa tgcggttcta ttttttcttg
     4321 taacttggtt tgagttcctt gtagatcctg gatatcagat cattgttgga tgaatagatt
     4381 gccaaaattt tctcccactc tgtaggttgc ctgttcactc tgatgatagt ttcttttgct
     4441 gtgcagaagg tctttaattt aactagatcc catttgtcaa gttttgcttt tgttgcagtt
     4501 gcttttgtga tttcatcatg aaatctttgc ccatgctcat gtcttaaatg gtattgccta
     4561 gattttcttc tagggatttt atagttttgg gctttacatt taagccttta ttctatctta
     4621 attttttgta taaggtatga ggaatgggtc cagtttctat tttctgcata tggatagcta
     4681 gttctcccag caccatttat taaataagga atcctttccc cattgcttgt ttttctcagg
     4741 tttgttgaag atcagatggt tgtagatgtg caatcttatt tctgagttct ctattctatt
     4801 ccattggtct atgtgtcagt ttttgtacca gtaccatgat gttttggtta ttgtaccctt
     4861 acagtacagt ttgaagtttg gtagtgtgat gcctccagct ttgatctttt ggcttaggat
     4921 tgccttggct atacaggctc tttttttggt tccatataaa ttttaaaata gttttttcta
     4981 attctatgaa gaatatcaat ggtagtttaa tgggaataac attgactcta taaattactt
     5041 tgggcagtat ggctattttc atgatattga ttcttactgt ctgtgagcat ggaatatttt
     5101 tccatttgtt tgtgtcctct ctggtttcct tgagccgtgg tttgtagttc tccttgaaga
     5161 ggtccttcac ttcccttgtt agctgtattc ctaggtattt tattctcttt gaagcaattg
     5221 tgagtaggag ttcattcatg atttggatct ctgcttgcct gttgttggtg tataggaatg
     5281 ctggtgactt ctgcacaatg attttgtatc ttgagacttt gctgaagttg cttatcagct
     5341 taagaagctt ttgggctgag acaatggggt tttctagata taggataatg tcctctgcaa
     5401 acaaagacat tttgacttcc tctcttcttc tttgaatacc ctttatttct ttctcttgcc
     5461 tgattgccct ggccaggact tccaatacta tgttgaatag tggtgagaga ggtcatcctt
     5521 gtcttgtgct ggttttcaag gggagtgctt ccagcttttg cccattcggt atgatattgg
     5581 ctgtgagtct gtcataaatg gctcttatta ttttgaagta tgttccttca atacctagtt
     5641 tattgagagt ttttaacatg aaaggatgtt gaattttatt gaaggtgttt tctgcatcta
     5701 ttgagttaat catgtggtct ttgtctttag ttctgtttgt gtgatgaatt aagtttattg
     5761 atttgcatat gttgaaccag cctcacatcc cgggaatgaa gccaacttga tcgtggtgga
     5821 taagcttttt gatgtgctgc tggattcagt ttgccagtgt tttattgaga atttttacat
     5881 tgatgttcat cagggatatt ggtctgaagt tttctttttt tgttgtatct ctgccaggtt
     5941 ttgatatcag gatgatgctg gccttataga atgagttagg gaggagtctc tccttttcat
     6001 ttgtttggaa tagtttcaga agaagtggta tcagcttctt tttgtatttc tggcagaatt
     6061 cagctgtaga tccatctggt cctgggcttt ttttggttgg tagcctatta attactgcct
     6121 caatttcaga acttgttatt ggtctattca gtgattcaac ttcttcctgg ttcagtcttg
     6181 ggagggtgta tgtgtccagg aatttatcca tttcttctag attttcgagt ttatttgcac
     6241 cgagctgtta tagtattgtc tgatggttgt ttatatttcc atgggatcag tggtaatatc
     6301 ccctttatca ttttttattg tgtctatttg gttcttctct cttttcttct ttattagtct
     6361 agctaatagt ctattttgtt aatattttca aaaaaaagca gcccctggat tcatttattt
     6421 tttgaagggt ttttcatgtc tctagctcct tcatttccac tctgattttg gttacttttt
     6481 gtcttctgct ggcttttggg tttgtttgct cttggttcac tagttctttt agttgtgata
     6541 ctagggtgtc gatttgagat ctttctagct ttttgatgtg ggcatttagt gctataaatt
     6601 tccctcttaa cactgcttta gctatgcccc agagattctg gtacattgtc tctttgtttt
     6661 cattggtttc aaagaacttc ttgatttctc tcttaatttc attatttacc caggagtcat
     6721 tcaggagcag gttgttcaat ttccacgtag ttttgtggtt ttgagtgact ttcttactct
     6781 tgagttccaa tttgattgcg ctgtgatctg agagactgtt tgttattact tcagttcttt
     6841 agcatttgct gaggagtgct ttacttctaa ttgtgtgatc aattttagag taagtaccat
     6901 gtggcactga gaagaatata tattctgttg tttgggggtg gaaagatgtc tagatattta
     6961 tcaggtccca cttgatccag agctgaggtc aagtcctgaa taactttgtt aattttctgt
     7021 ctcgatgatc taatattgac agtggggtgt taaagtctcc cactattatt gtgtggaaat
     7081 ctaagtctct ttttgggtct ctaagaactt gttttatgaa tctgagtgct cctatattag
     7141 gtgcatatat atttaggata gttagctctt cttgttgaat tgaccccttt accagtatgt
     7201 aatgcctttg tctttttttt aatctttatt cgtttaaagt ctttgtcaga aactaggatt
     7261 gcagcctctc ctttttctgt tttccttttg cttggtagat tttccttcat ccttttattt
     7321 tgagtctatg tgtgtccttg catgtgagat gggtctcttg aatacagcac actgatagag
     7381 tttgactcta tccagcttgc cactctgcgt cttttatttg gggcatttag tgcatttaca
     7441 tttaaggtta atattgttat gtgtgaattt tatcctgaca tcatgatgct agttgattat
     7501 tttgcagact tgtttatgtt tttgcttcat agtgttactg atctgtgtat ttcaatgtgt
     7561 tttttgtagc ggctggtaac agtttttcct ttccatattg agtgcttcct tcaggagcac
     7621 ttgcaaggca ggcctggtgg tgacgaattc cctcagcatt tgcttgtctg aaaaagattt
     7681 tatttctcct tcacttatga agcttagttc agccagatat gaaattctag gttggaaatt
     7741 ctttccttta agaatgttga aaattggccc ccaacctctt ccagcttata aggtttctgc
     7801 tgagaggtct gctgttagtc tgatgggctt ccctttataa gtgacctggc ctatctctct
     7861 gactgccctt aacatttttt ccttcatttc agtcttggag aatctgatga ttatgtgtct
     7921 tggggttgat ctcatggagt attgtattgg ggttctctgg atttcctgaa tttgaatgtt
     7981 ggcctgtctt gctaggttgg ggaagttttc ctggatgata tccagaagtg tgttttccaa
     8041 cttggttcca ttcttctgtc tctttcaggt atatctacca gtcgtaggtt cagtctttta
     8101 acataatccc atagttctca gaggtttcat tcattccttt tcattctttt ttctctaatc
     8161 ttgtctgcct gccttatttc agcaagatag tcttcaaact ctgatatcct ttcttccact
     8221 tagtctattt ggctatggat acttgtgttt ccattataaa gttctcatgt ttttcagctc
     8281 catcagatca tttacgttcc tctccaaact ggttattctg tttaacagct cctataatgt
     8341 tttattatgg ttcttagctt ctttgcagtg agttagaaca tattccctta gcttggtgaa
     8401 gttcgttatt tcccatcttg gatggatgat tgacattcat ccatctcagc ctcagcccag
     8461 ttctgtgccc ttgctagaga catgttgcaa tcttttggag gagaagaggc actctggctt
     8521 tctgagtttt ccgtatcctt gcattctttc tcatcttcat gggtttatct acctttgatc
     8581 tttgagtctg ctgacttttg gatgaggttt ttgtggtgtc ttttttgttg atgttgttgc
     8641 attctgtttt tctttagtag tcaggcccct cttctgcaga gctgctgcag tttgcctggg
     8701 gtccactcta gaccctattc gcctgggtct ctcgtcttcc aggagatatc accagtggag
     8761 gctgcagacc agcaaagatg gcagcctgct ccttcctctg ggagctctgt cccagagggg
     8821 cactggcctg atgctagccg gaatgctcct gtatgaagtg tctggagact cctgttggga
     8881 ggtctcagtc agaaggagcg gggtcagaga accacttaaa taagcagtct gtctgcccct
     8941 tgacagggtg ggtgtgctac actgggggga atccccctca tctggactgc cttgactctc
     9001 cagagccagc aggcagagaa gactaagatc actgatccat gatacttcag ccatccttcc
     9061 tcctaggggc tcctcttggg gttatcagcg ttttgtccat aaacccctgg ctggggatgc
     9121 tgagattccc acagggaggc cctgtccagt gaagaggagt gaatctgggt tccaccccat
     9181 ctcgccggcg ctagcagcaa gggaaagtgg ccaattgaag ccgcagtgat ggcggcctcc
     9241 cctcccttct cccccctctc cttccccact tccagaactc agtcgtctta ggcagtttct
     9301 agctggtggg ggaggattcc aagccagtgg gttttagctt atagagttct gtgagagcaa
     9361 ggctgcttgg ctccctggct tcagccccct ccccatgaga gtggacagat ctcctgcctc
     9421 acgggagttc ccagagccgg agtatgcaaa tactccagtg tctcagtgcc tgctcaaagc
     9481 ggctgcccac ccaagcagag atttgtgctt gggacccaaa gctctggtag cattggctca
     9541 ggagggaacc tcctgatcta caagttgcaa ggatctgtgg gaaaagcctg gttttcaggg
     9601 aggggaagca aaatccttca ccatctccct tggctggacg agggagttca ctttgctgcg
     9661 tgcagttcct ggatgggatc ttgctccacc ctgtttgctt gctctccgtg ggtcatgcca
     9721 gccacctagc agtcccaata agagaacttc agtatctcaa ctgaagatgc agagttgact
     9781 cacagttttc ttccttcttg gtgggagctg cagagcagag ctgcctctct ttgaccatct
     9841 gggctctctg ttctactttt tttttttttt tttttgcctc ttgcatgttg gtcacctcct
     9901 aaattagtaa tgtccaagta cttattcctt atcagatact tttcgttaat ttaactatcc
     9961 tagtacatac ctcactgtgg ggaaaggggg aaagatgaaa attaaactta ctttttattt
    10021 atttgattct ctttaagttt caggtaagct caattttgac taggatatat atatgtgtgt
    10081 gtgtgtatat atatgtattt tttaaactat ttgtcaactt tatttttttt tgtttgtttt
    10141 tgttaaaata cattcagcgg ctgggcttag tggctcacgc ctgtaatctc aacactttgg
    10201 gaggctgagg caggtggatc acttgagtcc aggagttcaa gaccagcctg agcaacatag
    10261 caaaaactcc atctctacaa aaacaccaaa attagccggg tgtggtagca ctctctttta
    10321 acagtcccag atacctggga ggctgaggtg ggaagatcac ctgagctcag tcggttgagg
    10381 ctgcagtgag ctatgatcat gccactgcac tctagcctgg gcaacacagt gagaccctgt
    10441 ctcaaaaaaa aaaatcacat tcaagtatat ttcacatgca ttttatataa ttcatgaatt
    10501 tcaggaaagc tgcatgtaaa tcttttttta aagctaaatc atgttaaaga cactgaaaaa
    10561 gttaactaaa attctatggt gacttctttt ataaaatact aatttttggc cgggcacggt
    10621 ggtggctcac gcctgtaatc ccagcacttt gggaggccga ggcaggtgga tcatgaggtc
    10681 aggaattcga gaccagcctg accaacatgg tgaaacccca tctctactaa aaatacaaaa
    10741 attagctggg cgtggtggtg tgcacctgta atcctagcta cctaggaggc tgaggcagga
    10801 gaatcgcttg aacccaggaa gcagaggttg cagtgagcca agatcacacc accgcacttc
    10861 tgcctgtgga acagaatgag actccgtctc aaaaaaaaaa aaaaaaatac taacttttat
    10921 cttagaaata tagatcatta tgcattgggt tttttcaaag ggggaacact ttagtgaaca
    10981 atagtttact tgacctttag ttggaaaaga aaactaatgg tggagaattt tctttggctg
    11041 ggagaatttg gtagattgag agaaaggaag aacatcaata ctgcattttt acttgacatt
    11101 taccctgtag atcctcctag aggttcgatg cccccaagac attccaacac tgagctgttt
    11161 cttctccagg tcttaagctt tgaatacaag ctataccagc acatctaaaa tcggtctcta
    11221 catttttcca tcttaaatat gagctgtcca gcttagtcaa aactaactgc aaaacactgg
    11281 gtgtaccatt tgagtcattt ggtcttaaaa gaaacactat tatcactgtg tcacagtttg
    11341 agagattttc acttaagcat ttaagttgca aaccactaca tatttgtccc attagtgact
    11401 agtgggcctt aattttggca ttcaaattag ggtaaaaaac cttggttctt gaaatgctac
    11461 agaaaatagc ttgaggccag gcacagttgc tcacacctgt aactccagca ctttggaagg
    11521 ctgaggcagg cagatcactt gaggtcaggc gtttgagacc aggctggtca acatggtgaa
    11581 accctgtctc tactaaaaat actaaaaaaa aaaaaaaaaa aaaaaaaatt agccgggcat
    11641 ggtggcaggt gcctgaagtc ccagctactt gggaggctga ggcaggagaa tcacttgaac
    11701 ccaggaagca gaggctgcag tgagcctagc tcgtgccact gccactccag cctgggcaac
    11761 agaacgaggc tctgtttaaa aaacaaaaaa gcttgaaata ccttcccctt aagatcacaa
    11821 tattgtcata tgctaccatt tgactcacaa ctgctgtctt aggactgctt atttacatat
    11881 atatgtatta agacactttg gttaaaacaa tttattaaat gtcttaaatt tctggatatg
    11941 tccctgaaaa taccatgaac tacttctaat actgataatt atgaataaac gtagctgttg
    12001 atcacctcag gttttcatac aaactgaact aaggtagggt tttatcatag gggacttttt
    12061 gtttcattta atgaaatttt gatgtgttga actgctttcc tggtgtcaga gaaacatgag
    12121 accatcgctc aataatggaa ataaaaaggc agagcagact actgatctta ataaaaggaa
    12181 aattatttgc tgtatcgtag atgtgcactg taatttccat gttaaagagg cactgcattt
    12241 ttaagaaata aaatcacaca tcttattttt tcatttctaa atggatattg aactaagctc
    12301 tgaaggcaaa cttagctgcc tatttttcca aatatgttca gaatcacatc tgaaacatca
    12361 aactgattat cagacaataa agtgcctgtt actttattaa ataaaggggg acaggatgac
    12421 agtgcagata tcctagaaat atgctttaga agacatagaa acgttgttaa attggatttt
    12481 attagtatgc aaatgttccc ttccaccaac aactattaat gtgaaaaact atatatagct
    12541 agcatttttt aaaatatcaa atactgtctc attatcatat gtttagcccc cccaaaatta
    12601 cattttagac tcttactttc tctccctctc ccctttcttt agctcttgtt tgtgtcttgc
    12661 caaagaagtg tacctagtaa gggaatgttt cttatttgtg ccaagggact attgatgatg
    12721 ctgtataatg gcaagatagc attttgtaat acctgctttt ttatatttct aatacaaatg
    12781 ggcaaagctg tgaaaccaat ttactaggtt tttctgcttt ggacataatt gtatgtgtta
    12841 attctctcta aacagtgcct ggcacatatt acatgctata aaagtgttag ctactactgc
    12901 taccatttat tattatcatt attaaatatc cattggttga aaaaccaagt agtcagctaa
    12961 atcatacctg ctactgtaca aaatgtaggg gaaaagctga gaaaaatcat ttatcaataa
    13021 acagttttca gaacaagaat ttatactttg gatattttta aattgttaaa tgttattgaa
    13081 actttatgca ccaaaactgt atgaaataat ttaattttgc agttgtgttt ctatattcta
    13141 tgtaattaaa gctactttta tactatattg atagttttaa ataaaactgg tttggaggtt
    13201 tgtttgca
//
