LOCUS       NM_017864               4645 bp    mRNA    linear   PRI 07-FEB-2025
DEFINITION  Homo sapiens integrator complex subunit 8 (INTS8), transcript
            variant 1, mRNA.
ACCESSION   NM_017864
VERSION     NM_017864.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4645)
  AUTHORS   Lin,M.H., Jensen,M.K., Elrod,N.D., Chu,H.F., Haseley,M., Beam,A.C.,
            Huang,K.L., Chiang,W., Russell,W.K., Williams,K., Proschel,C.,
            Wagner,E.J. and Tong,L.
  TITLE     Cytoplasmic binding partners of the Integrator endonuclease INTS11
            and its paralog CPSF73 are required for their nuclear function
  JOURNAL   Mol Cell 84 (15), 2900-2917 (2024)
   PUBMED   39032490
REFERENCE   2  (bases 1 to 4645)
  AUTHORS   Zhou,Q., Ji,L., Shi,X., Deng,D., Guo,F., Wang,Z., Liu,W., Zhang,J.,
            Xia,S. and Shang,D.
  TITLE     INTS8 is a therapeutic target for intrahepatic cholangiocarcinoma
            via the integration of bioinformatics analysis and experimental
            validation
  JOURNAL   Sci Rep 11 (1), 23649 (2021)
   PUBMED   34880328
  REMARK    GeneRIF: INTS8 is a therapeutic target for intrahepatic
            cholangiocarcinoma via the integration of bioinformatics analysis
            and experimental validation.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4645)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 4645)
  AUTHORS   Pfleiderer,M.M. and Galej,W.P.
  TITLE     Structure of the catalytic core of the Integrator complex
  JOURNAL   Mol Cell 81 (6), 1246-1259 (2021)
   PUBMED   33548203
REFERENCE   5  (bases 1 to 4645)
  AUTHORS   Huang,K.L., Jee,D., Stein,C.B., Elrod,N.D., Henriques,T.,
            Mascibroda,L.G., Baillat,D., Russell,W.K., Adelman,K. and
            Wagner,E.J.
  TITLE     Integrator Recruits Protein Phosphatase 2A to Prevent Pause Release
            and Facilitate Transcription Termination
  JOURNAL   Mol Cell 80 (2), 345-358 (2020)
   PUBMED   32966759
  REMARK    GeneRIF: Integrator Recruits Protein Phosphatase 2A to Prevent
            Pause Release and Facilitate Transcription Termination.
REFERENCE   6  (bases 1 to 4645)
  AUTHORS   Beckedorff,F., Blumenthal,E., daSilva,L.F., Aoi,Y., Cingaram,P.R.,
            Yue,J., Zhang,A., Dokaneheifard,S., Valencia,M.G., Gaidosh,G.,
            Shilatifard,A. and Shiekhattar,R.
  TITLE     The Human Integrator Complex Facilitates Transcriptional Elongation
            by Endonucleolytic Cleavage of Nascent Transcripts
  JOURNAL   Cell Rep 32 (3), 107917 (2020)
   PUBMED   32697989
REFERENCE   7  (bases 1 to 4645)
  AUTHORS   Sabath,K., Staubli,M.L., Marti,S., Leitner,A., Moes,M. and Jonas,S.
  TITLE     INTS10-INTS13-INTS14 form a functional module of Integrator that
            binds nucleic acids and the cleavage module
  JOURNAL   Nat Commun 11 (1), 3422 (2020)
   PUBMED   32647223
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 4645)
  AUTHORS   Oegema,R., Baillat,D., Schot,R., van Unen,L.M., Brooks,A.,
            Kia,S.K., Hoogeboom,A.J.M., Xia,Z., Li,W., Cesaroni,M.,
            Lequin,M.H., van Slegtenhorst,M., Dobyns,W.B., de Coo,I.F.M.,
            Verheijen,F.W., Kremer,A., van der Spek,P.J., Heijsman,D.,
            Wagner,E.J., Fornerod,M. and Mancini,G.M.S.
  TITLE     Human mutations in integrator complex subunits link transcriptome
            integrity to brain development
  JOURNAL   PLoS Genet 13 (5), e1006809 (2017)
   PUBMED   28542170
  REMARK    GeneRIF: Mutations INTS8 cause a severe neurodevelopmental
            syndrome.  INTS8 mutations lead in vitro to instability of the
            complex and impaired function.
            Erratum:[PLoS Genet. 2017 Aug 1;13(8):e1006923. doi:
            10.1371/journal.pgen.1006923.. PMID: 28763441]
            Publication Status: Online-Only
REFERENCE   9  (bases 1 to 4645)
  AUTHORS   Ng,M.C., Shriner,D., Chen,B.H., Li,J., Chen,W.M., Guo,X., Liu,J.,
            Bielinski,S.J., Yanek,L.R., Nalls,M.A., Comeau,M.E.,
            Rasmussen-Torvik,L.J., Jensen,R.A., Evans,D.S., Sun,Y.V., An,P.,
            Patel,S.R., Lu,Y., Long,J., Armstrong,L.L., Wagenknecht,L.,
            Yang,L., Snively,B.M., Palmer,N.D., Mudgal,P., Langefeld,C.D.,
            Keene,K.L., Freedman,B.I., Mychaleckyj,J.C., Nayak,U., Raffel,L.J.,
            Goodarzi,M.O., Chen,Y.D., Taylor,H.A. Jr., Correa,A., Sims,M.,
            Couper,D., Pankow,J.S., Boerwinkle,E., Adeyemo,A., Doumatey,A.,
            Chen,G., Mathias,R.A., Vaidya,D., Singleton,A.B., Zonderman,A.B.,
            Igo,R.P. Jr., Sedor,J.R., Kabagambe,E.K., Siscovick,D.S.,
            McKnight,B., Rice,K., Liu,Y., Hsueh,W.C., Zhao,W., Bielak,L.F.,
            Kraja,A., Province,M.A., Bottinger,E.P., Gottesman,O., Cai,Q.,
            Zheng,W., Blot,W.J., Lowe,W.L., Pacheco,J.A., Crawford,D.C.,
            Grundberg,E., Rich,S.S., Hayes,M.G., Shu,X.O., Loos,R.J.,
            Borecki,I.B., Peyser,P.A., Cummings,S.R., Psaty,B.M., Fornage,M.,
            Iyengar,S.K., Evans,M.K., Becker,D.M., Kao,W.H., Wilson,J.G.,
            Rotter,J.I., Sale,M.M., Liu,S., Rotimi,C.N. and Bowden,D.W.
  CONSRTM   FIND Consortium; eMERGE Consortium; DIAGRAM Consortium; MuTHER
            Consortium; MEta-analysis of type 2 DIabetes in African Americans
            Consortium
  TITLE     Meta-analysis of genome-wide association studies in African
            Americans provides insights into the genetic architecture of type 2
            diabetes
  JOURNAL   PLoS Genet 10 (8), e1004517 (2014)
   PUBMED   25102180
  REMARK    Publication Status: Online-Only
REFERENCE   10 (bases 1 to 4645)
  AUTHORS   Baillat,D., Hakimi,M.A., Naar,A.M., Shilatifard,A., Cooch,N. and
            Shiekhattar,R.
  TITLE     Integrator, a multiprotein mediator of small nuclear RNA
            processing, associates with the C-terminal repeat of RNA polymerase
            II
  JOURNAL   Cell 123 (2), 265-276 (2005)
   PUBMED   16239144
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AP003692.2, DA644524.1,
            AB161944.1 and BC136754.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_017864.3.
            
            Summary: This gene encodes a subunit of the Integrator complex
            which is involved in the cleavage of small nuclear RNAs U1 and U2
            within the nucleus. The encoded protein associates with RNA
            polymerase II and is recruited to the U1 and U2 small nuclear RNA
            genes. Alternative splicing results in multiple transcript
            variants. [provided by RefSeq, Nov 2012].
            
            Transcript Variant: This variant (1) represents the shortest
            transcript and encodes the functional protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803613.257055.1,
                                           SRR1803611.172737.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000523731.6/ ENSP00000430338.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3                 AP003692.2         87620-87622
            4-19                DA644524.1         1-16
            20-2274             AB161944.1         1-2255
            2275-3163           BC136754.1         2186-3074
            3164-3392           AB161944.1         3145-3373
            3393-4645           AP003692.2         144827-146079
FEATURES             Location/Qualifiers
     source          1..4645
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q22.1"
     gene            1..4645
                     /gene="INTS8"
                     /gene_synonym="C8orf52; INT8; NEDCHS"
                     /note="integrator complex subunit 8"
                     /db_xref="GeneID:55656"
                     /db_xref="HGNC:HGNC:26048"
                     /db_xref="MIM:611351"
     exon            1..275
                     /gene="INTS8"
                     /gene_synonym="C8orf52; INT8; NEDCHS"
                     /inference="alignment:Splign:2.1.0"
     CDS             146..3133
                     /gene="INTS8"
                     /gene_synonym="C8orf52; INT8; NEDCHS"
                     /note="protein kaonashi-1"
                     /codon_start=1
                     /product="integrator complex subunit 8"
                     /protein_id="NP_060334.2"
                     /db_xref="CCDS:CCDS34925.1"
                     /db_xref="GeneID:55656"
                     /db_xref="HGNC:HGNC:26048"
                     /db_xref="MIM:611351"
                     /translation="MSAEAADREAATSSRPCTPPQTCWFEFLLEESLLEKHLRKPCPD
                     PAPVQLIVQFLEQASKPSVNEQNQVQPPPDNKRNRILKLLALKVAAHLKWDLDILEKS
                     LSVPVLNMLLNELLCISKVPPGTKHVDMDLATLPPTTAMAVLLYNRWAIRTIVQSSFP
                     VKQAKPGPPQLSVMNQMQQEKELTENILKVLKEQAADSILVLEAALKLNKDLYVHTMR
                     TLDLLAMEPGMVNGETESSTAGLKVKTEEMQCQVCYDLGAAYFQQGSTNSAVYENARE
                     KFFRTKELIAEIGSLSLHCTIDEKRLAGYCQACDVLVPSSDSTSQQLTPYSQVHICLR
                     SGNYQEVIQIFIEDNLTLSLPVQFRQSVLRELFKKAQQGNEALDEICFKVCACNTVRD
                     ILEGRTISVQFNQLFLRPNKEKIDFLLEVCSRSVNLEKASESLKGNMAAFLKNVCLGL
                     EDLQYVFMISSHELFITLLKDEERKLLVDQMRKRSPRVNLCIKPVTSFYDIPASASVN
                     IGQLEHQLILSVDPWRIRQILIELHGMTSERQFWTVSNKWEVPSVYSGVILGIKDNLT
                     RDLVYILMAKGLHCSTVKDFSHAKQLFAACLELVTEFSPKLRQVMLNEMLLLDIHTHE
                     AGTGQAGERPPSDLISRVRGYLEMRLPDIPLRQVIAEECVAFMLNWRENEYLTLQVPA
                     FLLQSNPYVKLGQLLAATCKELPGPKESRRTAKDLWEVVVQICSVSSQHKRGNDGRVS
                     LIKQRESTLGIMYRSELLSFIKKLREPLVLTIILSLFVKLHNVREDIVNDITAEHISI
                     WPSSIPNLQSVDFEAVAITVKELVRYTLSINPNNHSWLIIQADIYFATNQYSAALHYY
                     LQAGAVCSDFFNKAVPPDVYTDQVIKRMIKCCSLLNCHTQVAILCQFLREIDYKTAFK
                     SLQEQNSHDAMDSYYDYIWDVTILEYLTYLHHKRGETDKRQIAIKAIGQTELNASNPE
                     EVLQLAAQRRKKKFLQAMAKLYF"
     exon            276..450
                     /gene="INTS8"
                     /gene_synonym="C8orf52; INT8; NEDCHS"
                     /inference="alignment:Splign:2.1.0"
     exon            451..591
                     /gene="INTS8"
                     /gene_synonym="C8orf52; INT8; NEDCHS"
                     /inference="alignment:Splign:2.1.0"
     exon            592..663
                     /gene="INTS8"
                     /gene_synonym="C8orf52; INT8; NEDCHS"
                     /inference="alignment:Splign:2.1.0"
     exon            664..715
                     /gene="INTS8"
                     /gene_synonym="C8orf52; INT8; NEDCHS"
                     /inference="alignment:Splign:2.1.0"
     exon            716..898
                     /gene="INTS8"
                     /gene_synonym="C8orf52; INT8; NEDCHS"
                     /inference="alignment:Splign:2.1.0"
     exon            899..1006
                     /gene="INTS8"
                     /gene_synonym="C8orf52; INT8; NEDCHS"
                     /inference="alignment:Splign:2.1.0"
     exon            1007..1162
                     /gene="INTS8"
                     /gene_synonym="C8orf52; INT8; NEDCHS"
                     /inference="alignment:Splign:2.1.0"
     exon            1163..1263
                     /gene="INTS8"
                     /gene_synonym="C8orf52; INT8; NEDCHS"
                     /inference="alignment:Splign:2.1.0"
     exon            1264..1405
                     /gene="INTS8"
                     /gene_synonym="C8orf52; INT8; NEDCHS"
                     /inference="alignment:Splign:2.1.0"
     exon            1406..1476
                     /gene="INTS8"
                     /gene_synonym="C8orf52; INT8; NEDCHS"
                     /inference="alignment:Splign:2.1.0"
     exon            1477..1652
                     /gene="INTS8"
                     /gene_synonym="C8orf52; INT8; NEDCHS"
                     /inference="alignment:Splign:2.1.0"
     exon            1653..1786
                     /gene="INTS8"
                     /gene_synonym="C8orf52; INT8; NEDCHS"
                     /inference="alignment:Splign:2.1.0"
     exon            1787..1897
                     /gene="INTS8"
                     /gene_synonym="C8orf52; INT8; NEDCHS"
                     /inference="alignment:Splign:2.1.0"
     exon            1898..2099
                     /gene="INTS8"
                     /gene_synonym="C8orf52; INT8; NEDCHS"
                     /inference="alignment:Splign:2.1.0"
     exon            2100..2221
                     /gene="INTS8"
                     /gene_synonym="C8orf52; INT8; NEDCHS"
                     /inference="alignment:Splign:2.1.0"
     exon            2222..2406
                     /gene="INTS8"
                     /gene_synonym="C8orf52; INT8; NEDCHS"
                     /inference="alignment:Splign:2.1.0"
     exon            2407..2440
                     /gene="INTS8"
                     /gene_synonym="C8orf52; INT8; NEDCHS"
                     /inference="alignment:Splign:2.1.0"
     exon            2441..2497
                     /gene="INTS8"
                     /gene_synonym="C8orf52; INT8; NEDCHS"
                     /inference="alignment:Splign:2.1.0"
     exon            2498..2559
                     /gene="INTS8"
                     /gene_synonym="C8orf52; INT8; NEDCHS"
                     /inference="alignment:Splign:2.1.0"
     exon            2560..2678
                     /gene="INTS8"
                     /gene_synonym="C8orf52; INT8; NEDCHS"
                     /inference="alignment:Splign:2.1.0"
     exon            2679..2782
                     /gene="INTS8"
                     /gene_synonym="C8orf52; INT8; NEDCHS"
                     /inference="alignment:Splign:2.1.0"
     exon            2783..2833
                     /gene="INTS8"
                     /gene_synonym="C8orf52; INT8; NEDCHS"
                     /inference="alignment:Splign:2.1.0"
     exon            2834..2907
                     /gene="INTS8"
                     /gene_synonym="C8orf52; INT8; NEDCHS"
                     /inference="alignment:Splign:2.1.0"
     exon            2908..2972
                     /gene="INTS8"
                     /gene_synonym="C8orf52; INT8; NEDCHS"
                     /inference="alignment:Splign:2.1.0"
     exon            2973..3016
                     /gene="INTS8"
                     /gene_synonym="C8orf52; INT8; NEDCHS"
                     /inference="alignment:Splign:2.1.0"
     exon            3017..4645
                     /gene="INTS8"
                     /gene_synonym="C8orf52; INT8; NEDCHS"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3189..3194
                     /regulatory_class="polyA_signal_sequence"
                     /gene="INTS8"
                     /gene_synonym="C8orf52; INT8; NEDCHS"
                     /note="hexamer: ATTAAA"
     polyA_site      3213
                     /gene="INTS8"
                     /gene_synonym="C8orf52; INT8; NEDCHS"
                     /note="major polyA site"
     regulatory      3363..3368
                     /regulatory_class="polyA_signal_sequence"
                     /gene="INTS8"
                     /gene_synonym="C8orf52; INT8; NEDCHS"
                     /note="hexamer: AATAAA"
     polyA_site      3392
                     /gene="INTS8"
                     /gene_synonym="C8orf52; INT8; NEDCHS"
     regulatory      3485..3490
                     /regulatory_class="polyA_signal_sequence"
                     /gene="INTS8"
                     /gene_synonym="C8orf52; INT8; NEDCHS"
                     /note="hexamer: AATAAA"
     polyA_site      3503
                     /gene="INTS8"
                     /gene_synonym="C8orf52; INT8; NEDCHS"
     regulatory      3934..3939
                     /regulatory_class="polyA_signal_sequence"
                     /gene="INTS8"
                     /gene_synonym="C8orf52; INT8; NEDCHS"
                     /note="hexamer: AATAAA"
     polyA_site      3954
                     /gene="INTS8"
                     /gene_synonym="C8orf52; INT8; NEDCHS"
ORIGIN      
        1 gccattttgg attgtgtgag tttccgggac gttcggaggg tggcctctct cccaccgggt
       61 tccgcatacc ccaggcaccg gcccgcatcc aagtgtcagg ttggagccgg gaagcggccc
      121 tggtggtagc ggcggcgggg gcaggatgag cgcggaggcg gcggaccggg aggcggccac
      181 ctccagccgg ccctgcaccc cgccgcagac ctgctggttt gagtttctgc tggaggagtc
      241 actgttggag aaacatctgc gcaagccctg cccggatcct gcaccagttc aacttatagt
      301 tcagtttttg gaacaggctt ccaaaccttc agttaatgaa caaaaccaag ttcaacctcc
      361 gcctgataac aagagaaatc gtattttaaa actacttgct cttaaagttg ctgcacattt
      421 gaagtgggac ttagacatat tagagaaaag tttgtctgtt ccagtattga atatgctact
      481 aaatgaacta ctctgcatca gtaaagttcc tcctgggaca aagcatgtag acatggatct
      541 ggccacttta cctccgacca ctgccatggc tgtacttctc tataatagat gggcaattag
      601 gacaattgtt caaagtagtt ttccagtcaa acaggcaaaa cccggacccc ctcagttaag
      661 tgttatgaat caaatgcaac aggaaaaaga gctaacagaa aacattttga aagtgctcaa
      721 agaacaagct gctgattcta ttttggtact agaagcagcc ctaaaattaa acaaggatct
      781 ttatgtccat acgatgagaa ctctagattt attggccatg gaaccaggca tggtaaatgg
      841 agaaactgag agttctactg ctggattgaa agtcaaaacc gaagaaatgc agtgccaggt
      901 gtgctatgat ttgggcgcag catacttcca gcaaggctcc acaaattcag ctgtctatga
      961 aaatgccagg gaaaaatttt ttagaaccaa agaactaatt gcagagatag gttcattatc
     1021 tcttcattgt accatagatg agaagcggtt agctggctat tgtcaagcat gtgatgttct
     1081 tgtaccttct tctgatagta catctcaaca gttgactcca tatagtcaag tccatatttg
     1141 tttgagatct ggcaactatc aggaggtaat acagattttc attgaagaca acttaacctt
     1201 gagtttacct gtccagttcc gacagtcagt cctaagagaa ctctttaaga aagctcaaca
     1261 gggaaatgaa gctctagatg aaatctgttt taaagtttgt gcctgtaata cagtccgtga
     1321 tatactggaa ggcagaacaa ttagtgttca atttaaccag ctatttctta gaccaaataa
     1381 agagaaaata gactttcttc ttgaggtatg ttcaagatca gtaaatttag aaaaagcttc
     1441 agagtctttg aaaggaaaca tggctgcttt tctaaagaat gtgtgtctgg ggttggaaga
     1501 tctgcagtat gttttcatga tttcttcaca tgagcttttc attacattgt tgaaagatga
     1561 agaacgaaag ctacttgttg atcagatgag gaagagatcc cctagagtaa atctgtgcat
     1621 taaacctgta acttcatttt atgatatccc agcttcagca agtgtcaaca ttggtcagtt
     1681 agagcatcaa cttatattgt cagtggatcc ttggaggatt agacaaattt taattgaatt
     1741 acatggtatg acttcagagc gccagttctg gacagtgtct aataagtggg aagtaccttc
     1801 tgtctatagt ggtgttatcc tgggaattaa agacaattta acaagagatt tggtttatat
     1861 tcttatggcc aaaggtttgc actgcagtac tgttaaggac ttttcccatg ctaaacagct
     1921 ctttgctgct tgtttggagt tggtaacaga gttctcaccg aagcttcgtc aggtcatgct
     1981 gaatgagatg ttgcttttgg atattcatac acacgaagct gggacagggc aggcaggaga
     2041 gagaccgcca tccgacctta taagtagagt acgaggctat ctggaaatga ggcttcctga
     2101 tattcctctt cgtcaagtta tagctgagga atgtgttgcc tttatgttaa actggagaga
     2161 aaatgaatac cttacactcc aagttcctgc atttttgctt cagagtaatc catatgtaaa
     2221 gcttggacag cttttagcag ctacatgcaa agaacttcca ggccctaaag aaagtagacg
     2281 gactgccaaa gacctttggg aagttgttgt tcaaatctgt agtgtgtcca gtcagcacaa
     2341 acgaggaaat gatggcagag ttagtttaat aaaacagagg gaatctacgt taggtatcat
     2401 gtatcggagt gaactgcttt cttttatcaa aaaattacga gaaccactcg ttttgactat
     2461 tattttatca ctctttgtga aacttcacaa tgttcgggag gacattgtga atgatattac
     2521 agctgaacac atttctattt ggccatcttc cattcccaac ctccagtctg tggactttga
     2581 agctgtggca atcacagtga aagagctagt tcgatataca ctcagtataa atccaaataa
     2641 ccattcttgg ttaattatcc aggcagatat ttactttgca acgaatcagt attcagcagc
     2701 tcttcactat tacctccagg caggagctgt gtgttctgac ttctttaaca aggctgtgcc
     2761 ccctgatgtt tatacagacc aggtaataaa acgaatgata aaatgttgtt ctttgctgaa
     2821 ttgccacaca caggtggcca ttttatgtca gttcctcaga gaaattgact acaaaacagc
     2881 gtttaaatct ctgcaagaac aaaacagtca tgatgctatg gactcctact acgactacat
     2941 atgggatgtt accattttgg aatacttgac ttatcttcat cataaaagag gagaaacaga
     3001 taaaagacaa attgcaatca aagccatcgg ccagacagag ttgaatgcaa gcaatccaga
     3061 agaagtgtta cagctggcag cgcagagaag gaaaaaaaag tttctccaag caatggcaaa
     3121 actttacttt taagcagtta aattttttta acttttattt tttaaacaat gggctaaaaa
     3181 taaacagtat taaaaggtta agtttatata atacatatgt acacaattag tggtgttttc
     3241 ttttcagaca aaatactgaa acaaatatta gtttaaaaac aaactataca gaagacttca
     3301 taccgtaaca ataaatgtat agtttcttca aagggagaag agattcacat atctgataac
     3361 aaaataaact agcaatctag ttttctaatc tactttatga ggctggattt tttttttaga
     3421 aaagctaatt taaaatattt agaaatagct agcctatgta cagcaagttt tcatgtcttt
     3481 ttttaataaa tagatttcta ggagtcagta tatatttaat actcttcttc cttaagaaaa
     3541 tagaagttta ggtcaagtgt taagctttat cactttgaca ctgtccttat ctcacaatgg
     3601 aggaatttag aaaggacctt aacagtttca caaacataaa taaagcctta gtcacactaa
     3661 attaaaaaaa aaaattcctt agggatatct tagagtagta aagtgacttc ctcatataaa
     3721 tagtttgaaa gggtacttaa gtttttcacc caaattgtga tatacaaaaa ggttattacc
     3781 aagcaaccta catgtcaaga aagccccagt taggaaggag ccacagcatt tatcttgttt
     3841 ataatttctt tggtactccc actgtttaga gcacaggttg aacaccatgt tcatctaagc
     3901 cttattagtt aaaaaatgtg ttatggcaag gcaaataaac tagtttaaaa aacattaaat
     3961 ttcaccattt gtagaaattc aagttttata atagcttgct atagcagcta tagataaatt
     4021 agtcacctta ttacaaaact aaacctttgt aaacaagttt aaatttaatt ttcaagaacc
     4081 aaattgcact agtcaagagt gtaggaattt tgagaatcta acaactagat tcaaagtact
     4141 gtatcactta gtataccctt taaggtagca cttatccagt ccaaaactcc agtgacaaaa
     4201 ttcctagttt atcaagataa acacagtaac actggattaa aggaaaaaca ttgctatggt
     4261 atagactgtg gttggcttct atccagtaac cttgggaatg aagacatctt tgtaaacaag
     4321 tcctgctgtt tctttaacag ctaacatagg aaataattaa atgtattctt tagtgccaat
     4381 tgtaagtttt aaaatcagaa tggcagtgta acttgtgaat tggctagggc aatcaatcac
     4441 agcactactt tctgtaaaac tttagtagtt cagtgatacc agttctaccc aatcttggtg
     4501 aattccaact tgtttgctta gttatcttct ttagtgtttt cctggtggtt tttcagtgct
     4561 cttcggtggt gtcataatgc ctccattgca cactggtgac aactgtcccc cttttctgaa
     4621 ggtgtttatg taatttactt cctcc
//
