LOCUS       NM_015434               4430 bp    mRNA    linear   PRI 18-NOV-2024
DEFINITION  Homo sapiens integrator complex subunit 7 (INTS7), transcript
            variant 1, mRNA.
ACCESSION   NM_015434
VERSION     NM_015434.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4430)
  AUTHORS   Lin,M.H., Jensen,M.K., Elrod,N.D., Chu,H.F., Haseley,M., Beam,A.C.,
            Huang,K.L., Chiang,W., Russell,W.K., Williams,K., Proschel,C.,
            Wagner,E.J. and Tong,L.
  TITLE     Cytoplasmic binding partners of the Integrator endonuclease INTS11
            and its paralog CPSF73 are required for their nuclear function
  JOURNAL   Mol Cell 84 (15), 2900-2917 (2024)
   PUBMED   39032490
REFERENCE   2  (bases 1 to 4430)
  AUTHORS   Pfleiderer,M.M. and Galej,W.P.
  TITLE     Structure of the catalytic core of the Integrator complex
  JOURNAL   Mol Cell 81 (6), 1246-1259 (2021)
   PUBMED   33548203
REFERENCE   3  (bases 1 to 4430)
  AUTHORS   Beckedorff,F., Blumenthal,E., daSilva,L.F., Aoi,Y., Cingaram,P.R.,
            Yue,J., Zhang,A., Dokaneheifard,S., Valencia,M.G., Gaidosh,G.,
            Shilatifard,A. and Shiekhattar,R.
  TITLE     The Human Integrator Complex Facilitates Transcriptional Elongation
            by Endonucleolytic Cleavage of Nascent Transcripts
  JOURNAL   Cell Rep 32 (3), 107917 (2020)
   PUBMED   32697989
REFERENCE   4  (bases 1 to 4430)
  AUTHORS   Sabath,K., Staubli,M.L., Marti,S., Leitner,A., Moes,M. and Jonas,S.
  TITLE     INTS10-INTS13-INTS14 form a functional module of Integrator that
            binds nucleic acids and the cleavage module
  JOURNAL   Nat Commun 11 (1), 3422 (2020)
   PUBMED   32647223
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4430)
  AUTHORS   Sahni,N., Yi,S., Taipale,M., Fuxman Bass,J.I.,
            Coulombe-Huntington,J., Yang,F., Peng,J., Weile,J., Karras,G.I.,
            Wang,Y., Kovacs,I.A., Kamburov,A., Krykbaeva,I., Lam,M.H.,
            Tucker,G., Khurana,V., Sharma,A., Liu,Y.Y., Yachie,N., Zhong,Q.,
            Shen,Y., Palagi,A., San-Miguel,A., Fan,C., Balcha,D., Dricot,A.,
            Jordan,D.M., Walsh,J.M., Shah,A.A., Yang,X., Stoyanova,A.K.,
            Leighton,A., Calderwood,M.A., Jacob,Y., Cusick,M.E.,
            Salehi-Ashtiani,K., Whitesell,L.J., Sunyaev,S., Berger,B.,
            Barabasi,A.L., Charloteaux,B., Hill,D.E., Hao,T., Roth,F.P.,
            Xia,Y., Walhout,A.J.M., Lindquist,S. and Vidal,M.
  TITLE     Widespread macromolecular interaction perturbations in human
            genetic disorders
  JOURNAL   Cell 161 (3), 647-660 (2015)
   PUBMED   25910212
REFERENCE   6  (bases 1 to 4430)
  AUTHORS   Greenwood,T.A., Akiskal,H.S., Akiskal,K.K. and Kelsoe,J.R.
  CONSRTM   Bipolar Genome Study
  TITLE     Genome-wide association study of temperament in bipolar disorder
            reveals significant associations with three novel Loci
  JOURNAL   Biol Psychiatry 72 (4), 303-310 (2012)
   PUBMED   22365631
REFERENCE   7  (bases 1 to 4430)
  AUTHORS   Cotta-Ramusino,C., McDonald,E.R. 3rd, Hurov,K., Sowa,M.E.,
            Harper,J.W. and Elledge,S.J.
  TITLE     A DNA damage response screen identifies RHINO, a 9-1-1 and TopBP1
            interacting protein required for ATR signaling
  JOURNAL   Science 332 (6035), 1313-1317 (2011)
   PUBMED   21659603
REFERENCE   8  (bases 1 to 4430)
  AUTHORS   Egloff,S., Szczepaniak,S.A., Dienstbier,M., Taylor,A., Knight,S.
            and Murphy,S.
  TITLE     The integrator complex recognizes a new double mark on the RNA
            polymerase II carboxyl-terminal domain
  JOURNAL   J Biol Chem 285 (27), 20564-20569 (2010)
   PUBMED   20457598
REFERENCE   9  (bases 1 to 4430)
  AUTHORS   Nakagawa,H., Tategu,M., Yamauchi,R., Sasaki,K., Sekimachi,S. and
            Yoshida,K.
  TITLE     Transcriptional regulation of an evolutionary conserved intergenic
            region of CDT2-INTS7
  JOURNAL   PLoS One 3 (1), e1484 (2008)
   PUBMED   18213392
  REMARK    Publication Status: Online-Only
REFERENCE   10 (bases 1 to 4430)
  AUTHORS   Baillat,D., Hakimi,M.A., Naar,A.M., Shilatifard,A., Cooch,N. and
            Shiekhattar,R.
  TITLE     Integrator, a multiprotein mediator of small nuclear RNA
            processing, associates with the C-terminal repeat of RNA polymerase
            II
  JOURNAL   Cell 123 (2), 265-276 (2005)
   PUBMED   16239144
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB062625.1, AK001598.1,
            AC092814.2 and BC009918.2.
            
            On Nov 23, 2018 this sequence version replaced NM_015434.3.
            
            Summary: This gene encodes a subunit of the integrator complex. The
            integrator complex associates with the C-terminal domain of RNA
            polymerase II and mediates 3'-end processing of the small nuclear
            RNAs U1 and U2. Alternatively spliced transcript variants encoding
            multiple isoforms have been observed for this gene. [provided by
            RefSeq, Dec 2010].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BK005725.1, AK001598.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000366994.8/ ENSP00000355961.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-15                DB062625.1         104-118
            16-3477             AK001598.1         1-3462
            3478-4180           AC092814.2         51809-52511         c
            4181-4430           BC009918.2         4194-4443
FEATURES             Location/Qualifiers
     source          1..4430
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q32.3"
     gene            1..4430
                     /gene="INTS7"
                     /gene_synonym="C1orf73; INT7"
                     /note="integrator complex subunit 7"
                     /db_xref="GeneID:25896"
                     /db_xref="HGNC:HGNC:24484"
                     /db_xref="MIM:611350"
     exon            1..214
                     /gene="INTS7"
                     /gene_synonym="C1orf73; INT7"
                     /inference="alignment:Splign:2.1.0"
     CDS             121..3009
                     /gene="INTS7"
                     /gene_synonym="C1orf73; INT7"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="integrator complex subunit 7 isoform 1"
                     /protein_id="NP_056249.1"
                     /db_xref="CCDS:CCDS1501.1"
                     /db_xref="GeneID:25896"
                     /db_xref="HGNC:HGNC:24484"
                     /db_xref="MIM:611350"
                     /translation="MASNSTKSFLADAGYGEQELDANSALMELDKGLRSGKLGEQCEA
                     VVRFPRLFQKYPFPILINSAFLKLADVFRVGNNFLRLCVLKVTQQSEKHLEKILNVDE
                     FVKRIFSVIHSNDPVARAITLRMLGSLASIIPERKNAHHSIRQSLDSHDNVEVEAAVF
                     AAANFSAQSKDFAVGICNKISEMIQGLATPVDLKLKLIPILQHMHHDAILASSARQLL
                     QQLVTSYPSTKMVIVSLHTFTLLAASSLVDTPKQIQLLLQYLKNDPRKAVKRLAIQDL
                     KLLANKTPHTWSRENIQALCECALQTPYDSLKLGMLSVLSTLSGTIAIKHYFSIVPGN
                     VSSSPRSSDLVKLAQECCYHNNRGIAAHGVRVLTNITVSCQEKDLLALEQDAVFGLES
                     LLVLCSQDDSPGAQATLKIALNCMVKLAKGRPHLSQSVVETLLTQLHSAQDAARILMC
                     HCLAAIAMQLPVLGDGMLGDLMELYKVIGRSATDKQQELLVSLATVIFVASQKALSVE
                     SKAVIKQQLESVSNGWTVYRIARQASRMGNHDMAKELYQSLLTQVASEHFYFWLNSLK
                     EFSHAEQCLTGLQEENYSSALSCIAESLKFYHKGIASLTAASTPLNPLSFQCEFVKLR
                     IDLLQAFSQLICTCNSLKTSPPPAIATTIAMTLGNDLQRCGRISNQMKQSMEEFRSLA
                     SRYGDLYQASFDADSATLRNVELQQQSCLLISHAIEALILDPESASFQEYGSTGTAHA
                     DSEYERRMMSVYNHVLEEVESLNRKYTPVSYMHTACLCNAIIALLKVPLSFQRYFFQK
                     LQSTSIKLALSPSPRNPAEPIAVQNNQQLALKVEGVVQHGSKPGLFRKIQSVCLNVSS
                     TLQSKSGQDYKIPIDNMTNEMEQRVEPHNDYFSTQFLLNFAILGTHNITVESSVKDAN
                     GIVWKTGPRTTIFVKSLEDPYSQQIRLQQQQAQQPLQQQQQRNAYTRF"
     exon            215..344
                     /gene="INTS7"
                     /gene_synonym="C1orf73; INT7"
                     /inference="alignment:Splign:2.1.0"
     exon            345..491
                     /gene="INTS7"
                     /gene_synonym="C1orf73; INT7"
                     /inference="alignment:Splign:2.1.0"
     exon            492..629
                     /gene="INTS7"
                     /gene_synonym="C1orf73; INT7"
                     /inference="alignment:Splign:2.1.0"
     exon            630..676
                     /gene="INTS7"
                     /gene_synonym="C1orf73; INT7"
                     /inference="alignment:Splign:2.1.0"
     exon            677..876
                     /gene="INTS7"
                     /gene_synonym="C1orf73; INT7"
                     /inference="alignment:Splign:2.1.0"
     exon            877..999
                     /gene="INTS7"
                     /gene_synonym="C1orf73; INT7"
                     /inference="alignment:Splign:2.1.0"
     exon            1000..1117
                     /gene="INTS7"
                     /gene_synonym="C1orf73; INT7"
                     /inference="alignment:Splign:2.1.0"
     exon            1118..1252
                     /gene="INTS7"
                     /gene_synonym="C1orf73; INT7"
                     /inference="alignment:Splign:2.1.0"
     exon            1253..1350
                     /gene="INTS7"
                     /gene_synonym="C1orf73; INT7"
                     /inference="alignment:Splign:2.1.0"
     exon            1351..1590
                     /gene="INTS7"
                     /gene_synonym="C1orf73; INT7"
                     /inference="alignment:Splign:2.1.0"
     exon            1591..1728
                     /gene="INTS7"
                     /gene_synonym="C1orf73; INT7"
                     /inference="alignment:Splign:2.1.0"
     exon            1729..1935
                     /gene="INTS7"
                     /gene_synonym="C1orf73; INT7"
                     /inference="alignment:Splign:2.1.0"
     exon            1936..2130
                     /gene="INTS7"
                     /gene_synonym="C1orf73; INT7"
                     /inference="alignment:Splign:2.1.0"
     exon            2131..2234
                     /gene="INTS7"
                     /gene_synonym="C1orf73; INT7"
                     /inference="alignment:Splign:2.1.0"
     exon            2235..2303
                     /gene="INTS7"
                     /gene_synonym="C1orf73; INT7"
                     /inference="alignment:Splign:2.1.0"
     exon            2304..2436
                     /gene="INTS7"
                     /gene_synonym="C1orf73; INT7"
                     /inference="alignment:Splign:2.1.0"
     exon            2437..2535
                     /gene="INTS7"
                     /gene_synonym="C1orf73; INT7"
                     /inference="alignment:Splign:2.1.0"
     exon            2536..2721
                     /gene="INTS7"
                     /gene_synonym="C1orf73; INT7"
                     /inference="alignment:Splign:2.1.0"
     exon            2722..4430
                     /gene="INTS7"
                     /gene_synonym="C1orf73; INT7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3090..3095
                     /regulatory_class="polyA_signal_sequence"
                     /gene="INTS7"
                     /gene_synonym="C1orf73; INT7"
                     /note="hexamer: ATTAAA"
     polyA_site      3115
                     /gene="INTS7"
                     /gene_synonym="C1orf73; INT7"
                     /note="major polyA site"
     regulatory      3463..3468
                     /regulatory_class="polyA_signal_sequence"
                     /gene="INTS7"
                     /gene_synonym="C1orf73; INT7"
                     /note="hexamer: AATACA"
     polyA_site      3485
                     /gene="INTS7"
                     /gene_synonym="C1orf73; INT7"
                     /note="major polyA site"
     regulatory      4409..4414
                     /regulatory_class="polyA_signal_sequence"
                     /gene="INTS7"
                     /gene_synonym="C1orf73; INT7"
                     /note="hexamer: AATAAA"
     polyA_site      4430
                     /gene="INTS7"
                     /gene_synonym="C1orf73; INT7"
ORIGIN      
        1 gtaacagggc ttgacagcgc gcggaagaaa aaccagcaag aaggcggcgg gggaagatgg
       61 cggtcctggg gtagagtttg caagctttct gactaggcta gtcgagtaac tattcgggtc
      121 atggcgtcaa actcaactaa gtctttcctg gcagatgccg gctatggcga acaggaactg
      181 gatgccaact ctgcccttat ggaattggac aaaggcctaa gatctggcaa acttggtgaa
      241 cagtgtgaag cagttgttcg ctttcccaga ctttttcaga agtatccatt ccctattctt
      301 atcaattctg cattcctaaa gttagctgat gttttcagag ttggaaataa tttcctgagg
      361 ctatgtgttc ttaaagttac ccaacaaagt gagaaacatt tggagaagat tctaaatgtg
      421 gatgaatttg tgaagagaat tttttctgtg attcatagta atgatcctgt ggcaagagcc
      481 atcaccctcc ggatgttggg aagtctggca tcaataattc ctgagaggaa gaatgctcat
      541 catagtattc gtcagagttt agattcacat gataatgtag aagttgaagc tgctgttttt
      601 gctgctgcaa acttctctgc acagtcaaag gattttgctg taggaatctg taacaaaatc
      661 agtgaaatga ttcaaggttt agcgacacca gtagacttga agctaaaatt gatacccatt
      721 ctacagcaca tgcaccatga tgcaatcttg gcttccagtg ctcgtcagct tttacaacag
      781 ctggtcacat cctatccgtc caccaaaatg gtgattgtgt ctttgcacac tttcactctg
      841 cttgcagcgt catctttggt tgatacacct aagcagattc agcttctgtt gcagtatttg
      901 aagaatgatc ccaggaaggc agtaaagaga cttgctattc aagatctgaa attacttgct
      961 aataaaacac cacatacttg gagtagggag aatattcagg cactttgtga gtgtgccctc
     1021 cagactcctt atgacagctt aaaactaggg atgttgtctg tcctttccac actatcaggg
     1081 accatcgcca tcaaacatta cttcagtata gttccaggaa atgtgagttc ttctcccaga
     1141 tcttctgatt tagtcaaatt agcccaagag tgctgttacc ataataacag gggcattgca
     1201 gctcatggag ttagagtcct aactaatata actgtttctt gtcaagaaaa ggatcttttg
     1261 gcactggaac aagatgctgt ctttggcctg gaatccctac tggtactttg tagtcaagat
     1321 gatagtccag gtgctcaggc cactttaaag attgctctaa actgtatggt gaagttggcc
     1381 aagggcaggc cccatcttag ccagtcagta gttgagacct tgttgactca attgcacagt
     1441 gctcaagacg ctgcccggat tttgatgtgc cattgcctgg cagccattgc catgcaactg
     1501 ccggtgctgg gtgatgggat gcttggtgac ctcatggagc tgtacaaggt gattggacga
     1561 tcagccacag acaagcaaca agaacttctg gtgagtttgg ctactgtgat ttttgttgca
     1621 agtcagaagg cattgtctgt ggaaagtaag gcagtaatta agcagcagct tgaaagtgtc
     1681 tccaatggat ggactgtata ccgtattgcc agacaggctt ccagaatggg taatcatgac
     1741 atggccaaag agctttatca gagtttgctg actcaggttg cctcagaaca tttctacttc
     1801 tggctaaata gtttgaagga gttttcacat gcagaacagt gtctcactgg gttgcaagag
     1861 gaaaattata gttcagcact ttcttgcatt gctgaatctt taaaattcta tcacaaaggg
     1921 attgcttcct taacagcagc tagtacacca ctgaatcctt taagctttca gtgtgaattt
     1981 gtaaaactca ggattgacct tttacaagcc ttctctcaac ttatctgtac ttgtaatagc
     2041 ctgaagacaa gcccaccacc tgcaattgcc acaacaattg ccatgacctt aggaaatgac
     2101 ctccagaggt gtggtcgcat ctccaatcag atgaaacagt ccatggaaga atttcgaagc
     2161 cttgcttctc gatatggaga tctttaccag gcatcttttg atgctgactc agcaactttg
     2221 aggaatgttg aactacagca gcagagctgt ttactgatat ctcatgcaat agaagccctg
     2281 attttggatc cagaatcagc aagtttccag gaatatggat ctactggaac agcccatgct
     2341 gatagtgaat atgaaagaag aatgatgtct gtatataatc atgtcttgga ggaggtagaa
     2401 tcactcaatc ggaaatatac ccctgtttct tatatgcaca cagcatgcct ctgcaatgcc
     2461 atcattgctt tgctgaaagt tcccctttct ttccagagat attttttcca gaaactacag
     2521 tctaccagca tcaagcttgc tctgtcacca tcgccccgga atcctgcaga gcccattgct
     2581 gtccagaata accagcagct ggcgctaaag gtagagggag tggttcagca cggatctaaa
     2641 ccaggactct tccgcaaaat tcagtctgtc tgtctgaatg tttcttccac actgcagagt
     2701 aaatctggac aagactacaa gatacccatt gacaacatga ccaatgagat ggagcaaagg
     2761 gttgaacctc ataatgatta cttcagtact caatttctgt tgaactttgc tatccttgga
     2821 acacacaaca ttacagtgga atcttctgtg aaagatgcca atggtatagt atggaagact
     2881 ggtcccagaa ctaccatatt tgtaaaatcc ctggaagacc cttattccca gcaaattcgc
     2941 ttacaacagc agcaagccca gcagccatta cagcagcagc agcaacgcaa tgcctacaca
     3001 cggttttaac catggaatga atgcactgca gactctcaag agatcaatca aattgccaga
     3061 aacagtttgg tttttcatat ggaataagta ttaaagttac agtgtagttc atttattcat
     3121 tgatttttgt aatgtaatat tctggaaaaa attttgtttt cttaaaaatt ttgtctgaca
     3181 gctgggcgtg gttgctcacg cctgtaatcc cagcactttg ggaggctgag gtgggcggct
     3241 cacgaggaga tcaagaccat cctggctaac acagtgaaac cccgtctcca ctaaaaaata
     3301 caaaaaaatt agccaagcat ggtggcaggc gcctgtagtc ccagctactt gggaggctga
     3361 ggcaggagaa tggtgtgaac ctgggaggcg gagcttgcag tgagccgaga ctgtgctcca
     3421 gcctgggcga cagagcgaga ctccgtctca aaaaaataaa taaatacatt ttgtctgaaa
     3481 aataactggg atcctggcca gaaagattgt tctttcttgt tttattatta gttttttctg
     3541 ttgccaagct tttttttctt tcaagaatag tcacatgttg agatcactga attggtaaat
     3601 ttgaccgcta ctcttccaaa atacatcatt tgctgcctga cttagaccta ggattctgag
     3661 ttgttcattg ggaggttctg accagtcact acaaggttta tccatggtag cagaacctga
     3721 gtccttctgt agatggactt gaaagtgttc cgtgcaacat ccagccttct ggattatgaa
     3781 agcccacagt ctaacagtat tgaaacatcc tgctgtatta gttcaaccac atatttatct
     3841 cttcctgtgc taaagcagtc tttattattt tcatatttaa ttgaaacaaa gagcagctag
     3901 caatttcata gaaaattaat ttgttttttc tgatgtgtct gcaactgtgt ataatacaga
     3961 catttcacat tgtttccaaa agtgaagaac actcatttaa tatcttcaat gttttaagtt
     4021 agaaggggtg gatcttttcc tttggttggt gattggtttg gtttatactt gatgagttat
     4081 gctagactga ttgtttagag agagcagtct ctttattaca caggctcagt ttgttgggat
     4141 gctcagggaa cagagttttc tggttagcca gaaaaccccc ttttttccta ttttaattct
     4201 ggttgaaaac catgataaaa tagactttct tagcacagta tggtagatat aacttaactg
     4261 ctttttgatt ggggatcatt tagggcttca ggatcacgat ttctaaacat cagggatcat
     4321 atggttgcag atgccgatgc tataagtaat ttggccggat gcagctccta aggtaaagca
     4381 gggtactttc cctggaattt cctttttaaa taaatatctg tttctttgct
//
