LOCUS       NM_001351601            3904 bp    mRNA    linear   PRI 09-JUN-2024
DEFINITION  Homo sapiens integrator complex subunit 6 like (INTS6L), transcript
            variant 2, mRNA.
ACCESSION   NM_001351601 XM_005262394
VERSION     NM_001351601.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3904)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL357834.16 and AL391380.14.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 21, 2020 this sequence version replaced NM_001351601.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803617.158445.1,
                                           SRR14038196.2677762.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000639893.2/ ENSP00000491427.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-444               AL357834.16        2336-2779
            445-522             AL357834.16        2917-2994
            523-672             AL357834.16        27099-27248
            673-762             AL357834.16        28056-28145
            763-946             AL357834.16        28378-28561
            947-1075            AL357834.16        28813-28941
            1076-1239           AL391380.14        352-515
            1240-1392           AL391380.14        2704-2856
            1393-1525           AL391380.14        6878-7010
            1526-1620           AL391380.14        20047-20141
            1621-1731           AL391380.14        21146-21256
            1732-1950           AL391380.14        23525-23743
            1951-2074           AL391380.14        24649-24772
            2075-2217           AL391380.14        25794-25936
            2218-2452           AL391380.14        27903-28137
            2453-2827           AL391380.14        30498-30872
            2828-2921           AL391380.14        31760-31853
            2922-3904           AL391380.14        32238-33220
FEATURES             Location/Qualifiers
     source          1..3904
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq26.3"
     gene            1..3904
                     /gene="INTS6L"
                     /gene_synonym="DDX26B"
                     /note="integrator complex subunit 6 like"
                     /db_xref="GeneID:203522"
                     /db_xref="HGNC:HGNC:27334"
     exon            1..444
                     /gene="INTS6L"
                     /gene_synonym="DDX26B"
                     /inference="alignment:Splign:2.1.0"
     CDS             334..3030
                     /gene="INTS6L"
                     /gene_synonym="DDX26B"
                     /note="isoform 2 is encoded by transcript variant 2;
                     protein DDX26B; DEAD/H (Asp-Glu-Ala-Asp/His) box
                     polypeptide 26B"
                     /codon_start=1
                     /product="integrator complex subunit 6-like isoform 2"
                     /protein_id="NP_001338530.1"
                     /db_xref="CCDS:CCDS87784.1"
                     /db_xref="GeneID:203522"
                     /db_xref="HGNC:HGNC:27334"
                     /translation="MPILLFLIDTSASMNQRTDLGTSYLDIAKGAVELFLKLRARDPA
                     SRGDRYMLVTYDEPPYCIKAGWKENHATFMSELKNLQASGLTTLGQALRSSFDLLNLN
                     RLISGIDNYGQGRNPFFLEPSILITITDGNKLTSTAGVQEELHLPLNSPLPGSELTKE
                     PFRWDQRLFALVLRLPGVASTEPEQLGSVPTDESAITQMCEVTGGRSYCVRTQRMLNQ
                     CLESLVQKVQSGVVINFEKTGPDPLPIGEDGLMDSSRPSNSFAAQPWHSCHKLIYVRP
                     NSKTGVPVGHWPIPESFWPDQNLPSLPPRTSHPVVRFSCVDCEPMVIDKLPFDKYELE
                     PSPLTQYILERKSPHTCWQVFVTSSGKYNELGYPFGYLKASTTLTCVNLFVMPYNYPV
                     LLPLLDDLFKVHKLKPNLKWRQAFDSYLKTLPPYYLLPLKKALRMMGAPNLISDNLDC
                     GLSYSVISYLKKLSQQTKLESERILASVGKKPPQEIGIKVKNHSGGGMSLTHNKNFRK
                     LLKEITGETALRLTELNTKEFAGFQIGLLNKDLKPQTYRNAYDIPRRGLLDQLTRMRS
                     NLLKTHKFIVGQDEDSLHSVPVAQMGNYQEYLKTLASPLREIDPDQPKRLHTFGNPFK
                     QDKKGMMIDEADEFVAGPQNKVKRPGEPNSPMSSKRRRSMSLLLRKPQTPPTVTNHVG
                     GKGPPSASWFPSYPNLIKPTLVHTDATIIHDGHEEKMENGQITPDGFLSKSAPSELIN
                     MTGDLMPPNQVDSLSDDFTSLSKDGLIQKPGSNAFVGGAKNCSLSVDDQKDPVASTLG
                     AMPNTLQITPAMAQGINADIKHQLMKEVRKFGRKYERIFILLEEVQGPLEMKKQFVEF
                     TIKEAARFKRRVLIQYLEKVLEKINSHHLHNNISHINSRSSC"
     exon            445..522
                     /gene="INTS6L"
                     /gene_synonym="DDX26B"
                     /inference="alignment:Splign:2.1.0"
     exon            523..672
                     /gene="INTS6L"
                     /gene_synonym="DDX26B"
                     /inference="alignment:Splign:2.1.0"
     exon            673..762
                     /gene="INTS6L"
                     /gene_synonym="DDX26B"
                     /inference="alignment:Splign:2.1.0"
     exon            763..946
                     /gene="INTS6L"
                     /gene_synonym="DDX26B"
                     /inference="alignment:Splign:2.1.0"
     exon            947..1075
                     /gene="INTS6L"
                     /gene_synonym="DDX26B"
                     /inference="alignment:Splign:2.1.0"
     exon            1076..1239
                     /gene="INTS6L"
                     /gene_synonym="DDX26B"
                     /inference="alignment:Splign:2.1.0"
     exon            1240..1392
                     /gene="INTS6L"
                     /gene_synonym="DDX26B"
                     /inference="alignment:Splign:2.1.0"
     exon            1393..1525
                     /gene="INTS6L"
                     /gene_synonym="DDX26B"
                     /inference="alignment:Splign:2.1.0"
     exon            1526..1620
                     /gene="INTS6L"
                     /gene_synonym="DDX26B"
                     /inference="alignment:Splign:2.1.0"
     exon            1621..1731
                     /gene="INTS6L"
                     /gene_synonym="DDX26B"
                     /inference="alignment:Splign:2.1.0"
     exon            1732..1950
                     /gene="INTS6L"
                     /gene_synonym="DDX26B"
                     /inference="alignment:Splign:2.1.0"
     exon            1951..2074
                     /gene="INTS6L"
                     /gene_synonym="DDX26B"
                     /inference="alignment:Splign:2.1.0"
     exon            2075..2217
                     /gene="INTS6L"
                     /gene_synonym="DDX26B"
                     /inference="alignment:Splign:2.1.0"
     exon            2218..2452
                     /gene="INTS6L"
                     /gene_synonym="DDX26B"
                     /inference="alignment:Splign:2.1.0"
     exon            2453..2827
                     /gene="INTS6L"
                     /gene_synonym="DDX26B"
                     /inference="alignment:Splign:2.1.0"
     exon            2828..2921
                     /gene="INTS6L"
                     /gene_synonym="DDX26B"
                     /inference="alignment:Splign:2.1.0"
     exon            2922..3904
                     /gene="INTS6L"
                     /gene_synonym="DDX26B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3873..3878
                     /regulatory_class="polyA_signal_sequence"
                     /gene="INTS6L"
                     /gene_synonym="DDX26B"
                     /note="hexamer: AATAAA"
     polyA_site      3904
                     /gene="INTS6L"
                     /gene_synonym="DDX26B"
                     /note="major polyA site"
ORIGIN      
        1 agtctggggc gagcgctcta gtgagcgcgg acggatgctt aggcagtagt cctggcagcg
       61 gcagtagtgg tggcagcaga agagaggaag ggggagggcc ccgagggcta cacacgctca
      121 cactttcaag ttcccttgga gggagaggag gtggggctgc agaaagagga ggccaggagc
      181 ggtcccatcc gtcccgtccc gtcccgtctc cccctcttcc tcttgctcct tgctccccgg
      241 ctctgcgaga gttgagggtt caggtggccg tacgcggcag tgagggcaag agggccggga
      301 gagtggggag cggaggcagg agtgcggggg aagatgccca tcctgctgtt cctcatagac
      361 acgtccgcct ctatgaacca gcgcactgac ctgggcacct cttatttgga cattgccaaa
      421 ggcgctgtgg agttattctt gaagctgcgc gcccgggacc cggccagccg tggagacagg
      481 tacatgctgg tcacctacga cgaacccccg tactgcatca aggctggttg gaaggaaaat
      541 catgcaacat tcatgagcga actaaaaaat cttcaggctt ctggactgac tactctcggt
      601 caggctctaa gatcctcatt tgatttgtta aatctcaata gattaatatc tggaatagac
      661 aattatggac aggggagaaa tccatttttt ttagaaccat ctattttaat taccatcaca
      721 gatggaaaca agttaacaag tactgctggt gttcaagaag agctccatct tcctttgaat
      781 tcccctctgc ctggaagtga actaaccaaa gaaccttttc gttgggatca aaggttattt
      841 gccctggtgt tgcgtttgcc tggagtggct tctaccgaac cagagcaact agggagcgta
      901 ccaactgatg aatctgccat cacacagatg tgtgaagtca caggaggtcg ctcctactgt
      961 gtgagaacac aaagaatgtt gaatcaatgt ttagaatctc tagttcaaaa agttcagagt
     1021 ggtgtagtta ttaattttga aaaaacagga ccagatccac ttcctattgg agaagatgga
     1081 cttatggatt catccaggcc aagcaattca tttgctgctc agccatggca tagttgtcat
     1141 aaactcattt atgtacgacc taactctaaa actggtgttc ctgttggaca ttggccaatt
     1201 ccagaatctt tttggccaga tcagaattta ccttcactac ctccacgaac atctcatcct
     1261 gttgtgaggt tctcctgtgt agattgtgag ccaatggtaa tagacaaact tccttttgac
     1321 aaatatgaac ttgaaccttc gcccttaact cagtatatct tggaacgaaa gtctccccat
     1381 acctgctggc aggtatttgt tactagcagt ggaaagtaca atgaacttgg atatccattt
     1441 ggttatttaa aagccagtac aactttaact tgtgtaaacc tctttgtgat gccttacaac
     1501 tacccagttt tacttcctct tttagatgac ttgtttaaag ttcacaagct taagccaaat
     1561 ctgaagtggc gacaggcttt tgacagctac ttaaaaactc tgcctccata ctacctatta
     1621 ccattaaaga aagcactaag gatgatggga gctccaaatc tgatatcaga taatttagat
     1681 tgtggactta gttacagtgt tatctcttac cttaaaaaac tcagccaaca gaccaaacta
     1741 gagtcagaac gaatactagc atcagtgggg aagaaacctc cccaggaaat tggaattaaa
     1801 gtgaaaaatc attctggagg tggcatgtcc ttgactcaca ataaaaattt tagaaaacta
     1861 ttgaaagaaa tcacagggga aactgcactt agactgacag aattgaacac caaagaattt
     1921 gctggcttcc aaattgggct cttaaacaag gatttgaaac ctcagacata cagaaatgct
     1981 tatgatattc cccgtagagg tcttttagac cagctgacca gaatgagatc caatctgctg
     2041 aaaacgcaca agtttattgt tggacaagat gaagattccc ttcatagtgt tccagttgca
     2101 caaatgggta actatcagga atatctgaag acattggctt ctccactgcg agagattgat
     2161 ccagaccaac ccaaaagact gcatactttt ggcaatccgt ttaaacaaga taagaaggga
     2221 atgatgattg atgaagcaga tgagtttgta gcagggccac aaaacaaagt gaaacgtcca
     2281 ggggaaccca acagtcctat gtcatctaag agaaggcgga gtatgtccct gctgttgagg
     2341 aaaccacaaa caccacctac tgtaactaac catgtgggcg gaaagggacc accctcagcc
     2401 tcgtggttcc catcttatcc aaacctcata aaacccaccc ttgtacatac agatgctact
     2461 atcattcacg atggccatga ggagaagatg gaaaatggtc agatcacacc tgatggcttc
     2521 ctgtcaaaat ctgctccatc agagcttata aatatgacag gagatcttat gccacccaac
     2581 caagtggatt ctctgtctga cgacttcaca agtctcagca aagatgggct gattcaaaaa
     2641 cctggtagta acgcatttgt aggaggagcc aaaaactgca gtctctccgt agatgaccaa
     2701 aaagacccag tagcatctac tttgggagct atgccaaata cattacaaat cactcctgct
     2761 atggcacaag gaatcaatgc tgatataaaa catcaattaa tgaaggaagt tcgaaagttt
     2821 ggtcgaaaat atgaaagaat tttcattttg cttgaagaag tgcaaggacc tctggagatg
     2881 aagaaacagt ttgttgaatt taccatcaag gaagccgcaa ggtttaaaag acgagtccta
     2941 attcagtacc ttgagaaggt actagaaaaa ataaattccc accaccttca caacaacatt
     3001 agtcacatca acagcagatc atcatgttag tgcaaagacc agtgagaaaa aaatgacaag
     3061 ttttctgtgc tgtaggatgg aacaggatat tgttgaagcc tcctggaatg tttgagtcaa
     3121 gggaattgct ttccagatgc taagaagcag cagtggggct tttgaatttt atgattatct
     3181 ggcagtgaaa gctgggcttt tgccttaata attttttaaa gtatgaattg ttttgttttg
     3241 ttttcctcaa ttgaggaagc tgatgttatt aattcacagg ctaaattcgg taaacaccac
     3301 tgcccctacc acgggtaatg agaggtcact cacttgaact ttgccattcc aggcattctc
     3361 agagtggcga ggggccacct gcaagtggag cacaacttgg tgctcttact gtgtccttca
     3421 gaaagaatag gtgtacagaa aggaaatggc aatcttatgt gtgctgaaca aagttttcaa
     3481 caattcctag ttgtgccttt taaaccatgc aatattcagg atagtttgaa tcaaagaagt
     3541 aagaagctgc tatttgggta acttatttct ctgtgggaag gggcagggag agtcaccaaa
     3601 caatctacct ccaactctct tctcttttgt ctagagacat tacaaagtgc acttgaggct
     3661 gcccccaacc tctgacattt gttcttgcat gtgatgatag aaagtcttca gatggactta
     3721 tacattctgt gctttggaag cacaagaaga acaaaatatg tgtatatttc ctttaatgtt
     3781 tatacaaaag tttatatgga gcagtattgt tatgtttgta tgaatttgca aaaattaaag
     3841 tgtacaaaga gattttgatt ttgcatatat aaaataaatc attttattga ttttcacaag
     3901 ttca
//
