LOCUS       NM_012141               7350 bp    mRNA    linear   PRI 18-NOV-2024
DEFINITION  Homo sapiens integrator complex subunit 6 (INTS6), transcript
            variant 1, mRNA.
ACCESSION   NM_012141
VERSION     NM_012141.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7350)
  AUTHORS   Lin,M.H., Jensen,M.K., Elrod,N.D., Chu,H.F., Haseley,M., Beam,A.C.,
            Huang,K.L., Chiang,W., Russell,W.K., Williams,K., Proschel,C.,
            Wagner,E.J. and Tong,L.
  TITLE     Cytoplasmic binding partners of the Integrator endonuclease INTS11
            and its paralog CPSF73 are required for their nuclear function
  JOURNAL   Mol Cell 84 (15), 2900-2917 (2024)
   PUBMED   39032490
REFERENCE   2  (bases 1 to 7350)
  AUTHORS   Ding,X., Chen,T., Shi,Q., Nan,P., Wang,X., Xie,D. and Li,J.
  TITLE     INTS6 promotes colorectal cancer progression by activating of AKT
            and ERK signaling
  JOURNAL   Exp Cell Res 407 (2), 112826 (2021)
   PUBMED   34508742
  REMARK    GeneRIF: INTS6 promotes colorectal cancer progression by activating
            of AKT and ERK signaling.
REFERENCE   3  (bases 1 to 7350)
  AUTHORS   Vervoort,S.J., Welsh,S.A., Devlin,J.R., Barbieri,E., Knight,D.A.,
            Offley,S., Bjelosevic,S., Costacurta,M., Todorovski,I.,
            Kearney,C.J., Sandow,J.J., Fan,Z., Blyth,B., McLeod,V.,
            Vissers,J.H.A., Pavic,K., Martin,B.P., Gregory,G., Demosthenous,E.,
            Zethoven,M., Kong,I.Y., Hawkins,E.D., Hogg,S.J., Kelly,M.J.,
            Newbold,A., Simpson,K.J., Kauko,O., Harvey,K.F., Ohlmeyer,M.,
            Westermarck,J., Gray,N., Gardini,A. and Johnstone,R.W.
  TITLE     The PP2A-Integrator-CDK9 axis fine-tunes transcription and can be
            targeted therapeutically in cancer
  JOURNAL   Cell 184 (12), 3143-3162 (2021)
   PUBMED   34004147
  REMARK    GeneRIF: The PP2A-Integrator-CDK9 axis fine-tunes transcription and
            can be targeted therapeutically in cancer.
REFERENCE   4  (bases 1 to 7350)
  AUTHORS   Pfleiderer,M.M. and Galej,W.P.
  TITLE     Structure of the catalytic core of the Integrator complex
  JOURNAL   Mol Cell 81 (6), 1246-1259 (2021)
   PUBMED   33548203
REFERENCE   5  (bases 1 to 7350)
  AUTHORS   Beckedorff,F., Blumenthal,E., daSilva,L.F., Aoi,Y., Cingaram,P.R.,
            Yue,J., Zhang,A., Dokaneheifard,S., Valencia,M.G., Gaidosh,G.,
            Shilatifard,A. and Shiekhattar,R.
  TITLE     The Human Integrator Complex Facilitates Transcriptional Elongation
            by Endonucleolytic Cleavage of Nascent Transcripts
  JOURNAL   Cell Rep 32 (3), 107917 (2020)
   PUBMED   32697989
REFERENCE   6  (bases 1 to 7350)
  AUTHORS   Wieland,I., Sell,C., Weidle,U.H. and Wieacker,P.
  TITLE     Ectopic expression of DICE1 suppresses tumor cell growth
  JOURNAL   Oncol Rep 12 (2), 207-211 (2004)
   PUBMED   15254679
  REMARK    GeneRIF: DICE1 has a growth-suppressing activity and interferes
            with anchorage-independent growth of IGF-IR transformed tumor cells
            dependent upon IGF-I signaling
REFERENCE   7  (bases 1 to 7350)
  AUTHORS   Dunham,A., Matthews,L.H., Burton,J., Ashurst,J.L., Howe,K.L.,
            Ashcroft,K.J., Beare,D.M., Burford,D.C., Hunt,S.E.,
            Griffiths-Jones,S., Jones,M.C., Keenan,S.J., Oliver,K., Scott,C.E.,
            Ainscough,R., Almeida,J.P., Ambrose,K.D., Andrews,D.T.,
            Ashwell,R.I., Babbage,A.K., Bagguley,C.L., Bailey,J., Bannerjee,R.,
            Barlow,K.F., Bates,K., Beasley,H., Bird,C.P., Bray-Allen,S.,
            Brown,A.J., Brown,J.Y., Burrill,W., Carder,C., Carter,N.P.,
            Chapman,J.C., Clamp,M.E., Clark,S.Y., Clarke,G., Clee,C.M.,
            Clegg,S.C., Cobley,V., Collins,J.E., Corby,N., Coville,G.J.,
            Deloukas,P., Dhami,P., Dunham,I., Dunn,M., Earthrowl,M.E.,
            Ellington,A.G., Faulkner,L., Frankish,A.G., Frankland,J.,
            French,L., Garner,P., Garnett,J., Gilbert,J.G., Gilson,C.J.,
            Ghori,J., Grafham,D.V., Gribble,S.M., Griffiths,C., Hall,R.E.,
            Hammond,S., Harley,J.L., Hart,E.A., Heath,P.D., Howden,P.J.,
            Huckle,E.J., Hunt,P.J., Hunt,A.R., Johnson,C., Johnson,D., Kay,M.,
            Kimberley,A.M., King,A., Laird,G.K., Langford,C.J., Lawlor,S.,
            Leongamornlert,D.A., Lloyd,D.M., Lloyd,C., Loveland,J.E.,
            Lovell,J., Martin,S., Mashreghi-Mohammadi,M., McLaren,S.J.,
            McMurray,A., Milne,S., Moore,M.J., Nickerson,T., Palmer,S.A.,
            Pearce,A.V., Peck,A.I., Pelan,S., Phillimore,B., Porter,K.M.,
            Rice,C.M., Searle,S., Sehra,H.K., Shownkeen,R., Skuce,C.D.,
            Smith,M., Steward,C.A., Sycamore,N., Tester,J., Thomas,D.W.,
            Tracey,A., Tromans,A., Tubby,B., Wall,M., Wallis,J.M., West,A.P.,
            Whitehead,S.L., Willey,D.L., Wilming,L., Wray,P.W., Wright,M.W.,
            Young,L., Coulson,A., Durbin,R., Hubbard,T., Sulston,J.E., Beck,S.,
            Bentley,D.R., Rogers,J. and Ross,M.T.
  TITLE     The DNA sequence and analysis of human chromosome 13
  JOURNAL   Nature 428 (6982), 522-528 (2004)
   PUBMED   15057823
REFERENCE   8  (bases 1 to 7350)
  AUTHORS   Li,W.J., Hu,N., Su,H., Wang,C., Goldstein,A.M., Wang,Y.,
            Emmert-Buck,M.R., Roth,M.J., Guo,W.J. and Taylor,P.R.
  TITLE     Allelic loss on chromosome 13q14 and mutation in deleted in cancer
            1 gene in esophageal squamous cell carcinoma
  JOURNAL   Oncogene 22 (2), 314-318 (2003)
   PUBMED   12527901
  REMARK    GeneRIF: Somatic mutations were identified in three patients (3/56,
            5%), and one novel polymorphism was identified in 3% of ESCC
            patients (4/136) and 3% of healthy individuals (6/232). We conclude
            that DICE1 mutations occur in ESCC but are infrequent.
REFERENCE   9  (bases 1 to 7350)
  AUTHORS   Wieland,I., Ropke,A., Stumm,M., Sell,C., Weidle,U.H. and
            Wieacker,P.F.
  TITLE     Molecular characterization of the DICE1 (DDX26) tumor suppressor
            gene in lung carcinoma cells
  JOURNAL   Oncol Res 12 (11-12), 491-500 (2001)
   PUBMED   11939413
  REMARK    GeneRIF: Molecular characterization of the tumor suppressor gene in
            lung carcinoma cells
REFERENCE   10 (bases 1 to 7350)
  AUTHORS   Wieland,I., Arden,K.C., Michels,D., Klein-Hitpass,L., Bohm,M.,
            Viars,C.S. and Weidle,U.H.
  TITLE     Isolation of DICE1: a gene frequently affected by LOH and
            downregulated in lung carcinomas
  JOURNAL   Oncogene 18 (32), 4530-4537 (1999)
   PUBMED   10467397
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL833524.1, AL354820.18,
            AF097645.1 and AL137780.10.
            
            On Nov 23, 2018 this sequence version replaced NM_012141.2.
            
            Summary: DEAD box proteins, characterized by the conserved motif
            Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. The protein
            encoded by this gene is a DEAD box protein that is part of a
            complex that interacts with the C-terminus of RNA polymerase II and
            is involved in 3' end processing of snRNAs. In addition, this gene
            is a candidate tumor suppressor and is located in the critical
            region of loss of heterozygosity (LOH). Multiple transcript
            variants encoding different isoforms have been found for this gene.
            [provided by RefSeq, Apr 2015].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803615.136347.1,
                                           SRR1803613.77251.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000311234.9/ ENSP00000310260.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-44                AL833524.1         172-215
            45-622              AL354820.18        41926-42503         c
            623-700             AL354820.18        41489-41566         c
            701-850             AL354820.18        40536-40685         c
            851-3231            AF097645.1         816-3196
            3232-7350           AL137780.10        59603-63721         c
FEATURES             Location/Qualifiers
     source          1..7350
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="13"
                     /map="13q14.3"
     gene            1..7350
                     /gene="INTS6"
                     /gene_synonym="DBI-1; DDX26; DDX26A; DICE1; HDB; INT6;
                     Notchl2"
                     /note="integrator complex subunit 6"
                     /db_xref="GeneID:26512"
                     /db_xref="HGNC:HGNC:14879"
                     /db_xref="MIM:604331"
     exon            1..622
                     /gene="INTS6"
                     /gene_synonym="DBI-1; DDX26; DDX26A; DICE1; HDB; INT6;
                     Notchl2"
                     /inference="alignment:Splign:2.1.0"
     CDS             512..3175
                     /gene="INTS6"
                     /gene_synonym="DBI-1; DDX26; DDX26A; DICE1; HDB; INT6;
                     Notchl2"
                     /note="isoform a is encoded by transcript variant 1; DEAD
                     box protein; DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide
                     26; RNA helicase HDB; protein deleted in cancer 1"
                     /codon_start=1
                     /product="integrator complex subunit 6 isoform a"
                     /protein_id="NP_036273.1"
                     /db_xref="CCDS:CCDS9428.1"
                     /db_xref="GeneID:26512"
                     /db_xref="HGNC:HGNC:14879"
                     /db_xref="MIM:604331"
                     /translation="MPILLFLIDTSASMNQRSHLGTTYLDTAKGAVETFMKLRARDPA
                     SRGDRYMLVTFEEPPYAIKAGWKENHATFMNELKNLQAEGLTTLGQSLRTAFDLLNLN
                     RLVTGIDNYGQGRNPFFLEPAIIITITDGSKLTTTSGVQDELHLPLNSPLPGSELTKE
                     PFRWDQRLFALVLRLPGTMSVESEQLTGVPLDDSAITPMCEVTGGRSYSVCSPRMLNQ
                     CLESLVQKVQSGVVINFEKAGPDPSPVEDGQPDISRPFGSQPWHSCHKLIYVRPNPKT
                     GVPIGHWPVPESFWPDQNSPTLPPRTSHPVVKFSCTDCEPMVIDKLPFDKYELEPSPL
                     TQFILERKSPQTCWQVYVSNSAKYSELGHPFGYLKASTALNCVNLFVMPYNYPVLLPL
                     LDDLFKVHKAKPTLKWRQSFESYLKTMPPYYLGPLKKAVRMMGAPNLIADSMEYGLSY
                     SVISYLKKLSQQAKIESDRVIGSVGKKVVQETGIKVRSRSHGLSMAYRKDFQQLLQGI
                     SEDVPHRLLDLNMKEYTGFQVALLNKDLKPQTFRNAYDIPRRNLLDHLTRMRSNLLKS
                     TRRFLKGQDEDQVHSVPIAQMGNYQEYLKQVPSPLRELDPDQPRRLHTFGNPFKLDKK
                     GMMIDEADEFVAGPQNKHKRPGEPNMQGIPKRRRCMSPLLRGRQQNPVVNNHIGGKGP
                     PAPTTQAQPDLIKPLPLHKISETTNDSIIHDVVENHVADQLSSDITPNAMDTEFSASS
                     PASLLERPTNHMEALGHDHLGTNDLTVGGFLENHEEPRDKEQCAEENIPASSLNKGKK
                     LMHCRSHEEVNTELKAQIMKEIRKPGRKYERIFTLLKHVQGSLQTRLIFLQNVIKEAS
                     RFKKRMLIEQLENFLDEIHRRANQINHINSN"
     exon            623..700
                     /gene="INTS6"
                     /gene_synonym="DBI-1; DDX26; DDX26A; DICE1; HDB; INT6;
                     Notchl2"
                     /inference="alignment:Splign:2.1.0"
     exon            701..850
                     /gene="INTS6"
                     /gene_synonym="DBI-1; DDX26; DDX26A; DICE1; HDB; INT6;
                     Notchl2"
                     /inference="alignment:Splign:2.1.0"
     exon            851..940
                     /gene="INTS6"
                     /gene_synonym="DBI-1; DDX26; DDX26A; DICE1; HDB; INT6;
                     Notchl2"
                     /inference="alignment:Splign:2.1.0"
     exon            941..1124
                     /gene="INTS6"
                     /gene_synonym="DBI-1; DDX26; DDX26A; DICE1; HDB; INT6;
                     Notchl2"
                     /inference="alignment:Splign:2.1.0"
     exon            1125..1250
                     /gene="INTS6"
                     /gene_synonym="DBI-1; DDX26; DDX26A; DICE1; HDB; INT6;
                     Notchl2"
                     /inference="alignment:Splign:2.1.0"
     exon            1251..1405
                     /gene="INTS6"
                     /gene_synonym="DBI-1; DDX26; DDX26A; DICE1; HDB; INT6;
                     Notchl2"
                     /inference="alignment:Splign:2.1.0"
     exon            1406..1558
                     /gene="INTS6"
                     /gene_synonym="DBI-1; DDX26; DDX26A; DICE1; HDB; INT6;
                     Notchl2"
                     /inference="alignment:Splign:2.1.0"
     exon            1559..1691
                     /gene="INTS6"
                     /gene_synonym="DBI-1; DDX26; DDX26A; DICE1; HDB; INT6;
                     Notchl2"
                     /inference="alignment:Splign:2.1.0"
     exon            1692..1786
                     /gene="INTS6"
                     /gene_synonym="DBI-1; DDX26; DDX26A; DICE1; HDB; INT6;
                     Notchl2"
                     /inference="alignment:Splign:2.1.0"
     exon            1787..1897
                     /gene="INTS6"
                     /gene_synonym="DBI-1; DDX26; DDX26A; DICE1; HDB; INT6;
                     Notchl2"
                     /inference="alignment:Splign:2.1.0"
     exon            1898..2113
                     /gene="INTS6"
                     /gene_synonym="DBI-1; DDX26; DDX26A; DICE1; HDB; INT6;
                     Notchl2"
                     /inference="alignment:Splign:2.1.0"
     exon            2114..2240
                     /gene="INTS6"
                     /gene_synonym="DBI-1; DDX26; DDX26A; DICE1; HDB; INT6;
                     Notchl2"
                     /inference="alignment:Splign:2.1.0"
     exon            2241..2383
                     /gene="INTS6"
                     /gene_synonym="DBI-1; DDX26; DDX26A; DICE1; HDB; INT6;
                     Notchl2"
                     /inference="alignment:Splign:2.1.0"
     exon            2384..2615
                     /gene="INTS6"
                     /gene_synonym="DBI-1; DDX26; DDX26A; DICE1; HDB; INT6;
                     Notchl2"
                     /inference="alignment:Splign:2.1.0"
     exon            2616..2987
                     /gene="INTS6"
                     /gene_synonym="DBI-1; DDX26; DDX26A; DICE1; HDB; INT6;
                     Notchl2"
                     /inference="alignment:Splign:2.1.0"
     exon            2988..3081
                     /gene="INTS6"
                     /gene_synonym="DBI-1; DDX26; DDX26A; DICE1; HDB; INT6;
                     Notchl2"
                     /inference="alignment:Splign:2.1.0"
     exon            3082..7350
                     /gene="INTS6"
                     /gene_synonym="DBI-1; DDX26; DDX26A; DICE1; HDB; INT6;
                     Notchl2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3683..3688
                     /regulatory_class="polyA_signal_sequence"
                     /gene="INTS6"
                     /gene_synonym="DBI-1; DDX26; DDX26A; DICE1; HDB; INT6;
                     Notchl2"
                     /note="hexamer: AATAAA"
     polyA_site      3700
                     /gene="INTS6"
                     /gene_synonym="DBI-1; DDX26; DDX26A; DICE1; HDB; INT6;
                     Notchl2"
                     /note="major polyA site"
     regulatory      6234..6239
                     /regulatory_class="polyA_signal_sequence"
                     /gene="INTS6"
                     /gene_synonym="DBI-1; DDX26; DDX26A; DICE1; HDB; INT6;
                     Notchl2"
                     /note="hexamer: AATAAA"
     polyA_site      6266
                     /gene="INTS6"
                     /gene_synonym="DBI-1; DDX26; DDX26A; DICE1; HDB; INT6;
                     Notchl2"
     regulatory      7268..7273
                     /regulatory_class="polyA_signal_sequence"
                     /gene="INTS6"
                     /gene_synonym="DBI-1; DDX26; DDX26A; DICE1; HDB; INT6;
                     Notchl2"
                     /note="hexamer: ATTAAA"
     polyA_site      7296
                     /gene="INTS6"
                     /gene_synonym="DBI-1; DDX26; DDX26A; DICE1; HDB; INT6;
                     Notchl2"
     regulatory      7328..7333
                     /regulatory_class="polyA_signal_sequence"
                     /gene="INTS6"
                     /gene_synonym="DBI-1; DDX26; DDX26A; DICE1; HDB; INT6;
                     Notchl2"
                     /note="hexamer: AATAAA"
     polyA_site      7350
                     /gene="INTS6"
                     /gene_synonym="DBI-1; DDX26; DDX26A; DICE1; HDB; INT6;
                     Notchl2"
ORIGIN      
        1 gcttcagtag cgagaggggc tgagaaagtg gtgacaccgc cggggtgcgg agggagtccc
       61 tgaaacttct cccaacagcc ccagggccaa tcttccctca gcccactccc ctcttcgcca
      121 gctcccaggt ccccactcct gtaccggggg tggggtgggg agccaggccc gtctcccgct
      181 gggacacaca caggggccgg gagcggggac gggacccccg aggcgggggg gacgaaccga
      241 cagacagacg gctgggcgcc cgccccagcg ggcaggcagg caggaggagg cggaggcggg
      301 ggtacgacgg ggagcactgg gtctggggag tttcctctca actatcgggg gagaaactcc
      361 ccgcagccgg aggaaagacc cagacagtgt tttcctcccg ggggccgtgc tcccccgccc
      421 cgcgtagcgg cggtcgccgc caccggcgcc tccacctcta ccatctcctc tttctccacc
      481 acctcgggcc ccggtgtccc cggccagcac tatgcccatc ttactgttcc tgatagacac
      541 gtctgcctct atgaaccagc gcagccatct gggcaccacc tacctggaca cggccaaagg
      601 cgcggtagag accttcatga agctccgtgc ccgggaccct gccagcagag gagacaggta
      661 tatgctggtc actttcgaag agccgcccta tgctatcaag gctggatgga aagaaaacca
      721 tgcaacgttt atgaatgaat tgaaaaacct tcaggctgaa ggacttacga ctcttggcca
      781 atccctaagg acagcttttg atttattaaa tttaaataga ttagtaactg gcatagacaa
      841 ctatgggcag ggaagaaacc cttttttctt ggagccagca ataattatca caattactga
      901 tgggagcaag ttgactacca ccagtggagt ccaggatgag cttcatttac ctcttaattc
      961 tcctttgcct ggaagtgaat tgaccaagga accttttcgt tgggatcaga gactctttgc
     1021 attagtgttg cggttgcctg gcaccatgtc agtagaatca gaacagttga caggtgtgcc
     1081 tttagatgac tctgcaatca caccaatgtg tgaagtgaca ggcggccgtt catattctgt
     1141 gtgttctcca agaatgctta atcagtgtct ggagtccttg gtgcagaaag tacaaagtgg
     1201 ggtggtaata aactttgaaa aagcaggacc agatccttcc cctgtagaag atgggcagcc
     1261 agatatatca aggccttttg gatctcagcc ttggcatagc tgtcacaaac tcatatatgt
     1321 cagaccaaat cctaaaactg gggttcctat aggtcattgg cctgttccag agtctttttg
     1381 gccagatcaa aattcgccaa cactaccacc tcgtacatct catcctgtag tgaagttttc
     1441 ctgtacagac tgtgaaccaa tggttattga taaacttcct tttgacaaat atgagttgga
     1501 accttcacca ctgactcaat ttatcctgga aaggaaatct cctcaaacat gttggcaggt
     1561 gtacgtgagc aatagtgcaa aatacagtga acttggtcat ccttttggtt acttgaaagc
     1621 cagtacagca ctgaactgtg tcaacttatt tgtgatgcct tacaattatc cagtccttct
     1681 tcccctctta gatgacttgt ttaaagtgca taaagcaaaa ccaacattga agtggagaca
     1741 gtcatttgaa agttatttga agacaatgcc tccctactat cttgggccct tgaagaaagc
     1801 tgttaggatg atgggagcac ctaacctaat agcagacagt atggaatatg gacttagtta
     1861 cagtgtcatt tcatacctca aaaaactgag tcaacaggcc aaaatagaat ctgatcgagt
     1921 cattggatct gtaggcaaaa aagtagtaca ggagactgga ataaaagtcc ggagccgatc
     1981 acatggttta tcaatggcat ataggaaaga ttttcaacaa ctcctccagg gaatttcaga
     2041 ggatgtccct cacagactgc tagaccttaa tatgaaggaa tacactgggt tccaagttgc
     2101 tttgctgaat aaggatttga agccacagac atttagaaat gcttatgaca taccaagacg
     2161 aaatcttttg gatcacttaa caagaatgag atctaatctt ttgaagagca ctcgcagatt
     2221 tctgaaagga caggacgaag atcaagtgca cagtgttcct atagcacaaa tggggaacta
     2281 ccaggaatac ctcaagcaag taccttctcc actaagagaa cttgatcctg atcagccacg
     2341 aaggttgcat acatttggca acccctttaa gctggataag aagggtatga tgatagatga
     2401 agcagatgaa tttgtggctg gacctcaaaa taaacataaa cgacccggag aaccaaatat
     2461 gcaagggatc cctaaaagac gtcggtgtat gtctccacta ctaagaggca gacagcagaa
     2521 tcctgttgta aacaatcata ttgggggaaa aggaccacct gcacctacaa ctcaagcaca
     2581 gccagatctt attaaacctc ttcctcttca taaaatttca gaaaccacta atgattcgat
     2641 aatacatgat gtggttgaaa atcatgttgc agaccaactt tcatcagaca ttacaccaaa
     2701 tgctatggat acggaatttt cagcatcttc tccagccagt ttactggaac ggccaaccaa
     2761 tcatatggag gctcttggtc atgaccattt aggaaccaat gacctcactg ttggtggatt
     2821 tttagaaaat catgaggagc caagagataa agaacaatgt gctgaagaga acataccagc
     2881 atcttcactc aacaaaggaa agaaattgat gcattgcaga agccatgaag aggtcaatac
     2941 tgaactaaaa gcacaaataa tgaaagagat ccgaaagcca ggaagaaaat atgaaagaat
     3001 cttcacttta ctgaagcatg tgcaaggcag tttacaaaca agactaatat ttttacaaaa
     3061 tgtcattaaa gaagcatcaa ggtttaaaaa acgaatgcta atagaacaac tggagaactt
     3121 cttggatgaa attcatcgaa gagccaatca gatcaaccat attaatagca attaaaagaa
     3181 aatagaatgt ggccacttat ttcactatct tcttcaaata caaagtaaat acaagactgt
     3241 tgtgatcttg cattcatttt ctgacatgca ttgttggcta tttgaaatac taaaagcaaa
     3301 tctacagatc ctttttccat cattttacag tgaccttttc ttcattttgg tttatttttg
     3361 taatgtgaaa agtatcactc taaaaaacat ttttaattta acaaactaaa aatattcctc
     3421 caaatctctt gcttgtcatt gactcttgcg tgtcaatttc cctcaggttc tattttctta
     3481 aaccaacctt taaaattgtc acctctgtta aggttgaact ttgccaaaaa aaaaagaagt
     3541 tactttgtaa tttttgggga aaaaagcaca tacattaaaa ctaggtaatg ttttgtatat
     3601 acagttattt tggatatatt attgtaagtt gtacaaatgt attttgaaga atatttaaga
     3661 aaagcacttt tgttattcca tcaataaatg ctctatttta ctcttgtgtg gtttaggaaa
     3721 taatcacatt taaagtaatc atttaaaaac atcctaagat aatggaattt taaaggcctt
     3781 gctttttagc attggaaaaa tacaccactt gaagttcatg tttgttaagc ctaactgtaa
     3841 ttacatgtta cataatctgc attgcctttt tactatatgt tcgtagtttt tgttggccat
     3901 gccaacatac tcccatttct gcctagatta tgggaatgac tttgtatggg gcagatagac
     3961 agatacttta aaagctattt aaaaagcaaa caactttgga tattattggt ttccttactt
     4021 caacaccttt tcctttatca ctaggattgt ggatggcacg aagctgaagc tgttagggag
     4081 tggtaggttt ggagtacagt acatgctctg aaatatctag cctttagcag cttcatgcca
     4141 tgcttgcaaa agcccacaac aaattggagg cctccttgtt ctgctctgct gttctcacac
     4201 ttaaactctg ttttatttat aagctaaatg gaaaggaaac acctttaaga tgactttgct
     4261 cattttgcat cccccctgag tttcacagga taaggaaaac cacgctattc attctccacc
     4321 ctcaattcaa catggcctag agtatccgta ctgaggaagc aatcttatgg cctgactcac
     4381 tcaccattca tgatcactgc tgtgcctttt agtggtttgg ggggtaagca gtagaaaaga
     4441 aggtcaaaat agatttggat taagagtagg caaaataaac ttataacatt taaaaactga
     4501 agtattttta ggtttataat attgaaaatc acataccctt agctttttac actttatcag
     4561 acattttttt aaatttcaag ggtatagcaa aatgaaatta taactttatg aagaaaagca
     4621 ttgatgaaag tggagaacat gcatttagtc taggggattt gaaactctcc caatactgaa
     4681 gacaaaccct gtcaagaaaa agaagaattt aatattatat agtattttca tatgcagttc
     4741 tttaagcttt gtttacttct atacaaatac ttttaagtaa tgcaagataa catttaatag
     4801 atggaattgt taaggtaatt gcctgtagtc acattgctaa attcattgag agttacacaa
     4861 aatccagaat atattgtctg ttcctaaatt atatatattt agattctgga attactagga
     4921 ggaattagaa gtcattcaga taaaaattca tacttaacaa gagtatctag gaaagagatt
     4981 cagcccatcc caatattgag cagctttcct tatcagaaag ttttattttc tgtttcacag
     5041 attgctcatg acctttaata catttttctg aatgaaccct ggagggaggt gagaagtagc
     5101 agttttgttc atctcttctt tttgtccttt atctctctgc cactgttctc acctcatcct
     5161 aaaacctggt caggagggtt tgaaacctat cagaactaaa ggttaatatc tcatctccct
     5221 caggcttttt tcatttaaaa aaaaaatggg tatattagtt aaattagaat acttgttgta
     5281 gaattattgt caaaggggaa gggaaataca tctaggggaa acatcatgtc ttttaggccc
     5341 tttatgtcac tgaatgactt aaggctcgac aaatgatatt cttggaaagt ttaatcttga
     5401 ggttttcaaa tctttttttt taatgtctcc catgtttctc atttgctgat tgattcatta
     5461 gttgctctta gtaagatttg tcagttggaa ataatgaagg ctgagactca tttctaaact
     5521 cttccataac catcaccaga agagcagcca ctgtgttgtg tgatgtaggc taatgcctcc
     5581 cagatagagg taaagtcaca aggactatta gaattccagt ggattgtgga actggttttg
     5641 gattatcctt atattttcat tctgattact gaggcagttc tgaaaactcc taccattgaa
     5701 atagtggtgt gtcttttcct tgtttaagga ttttacatca tttttatgca cttgaattcc
     5761 aaaatcagaa tctctctttt acctatcaac ctttattggc tattggcttt tggcaatgac
     5821 ctttctgttc aaatgtagtc ctgtctcttt gtttccttag ggagtagaac ctgtcctttt
     5881 tctcatcttt catttttttg acgtgtcctt tctaagagaa ggctctctgc cgcctgttct
     5941 gggtgataag tgatattttc atctaatcgt tatgtggttg ggatgatcat ggtgaaatac
     6001 taggaagaca tactctgttg atggactttt tctctccaaa taatcccaaa tagattattt
     6061 tctagtgaat ggtttatatc tttctcgtca caaaaatgtt cctttgattt ctagcacaag
     6121 gtacagcagg atgcaaatga ttctcagata aaatgatgtt gacagtattt ccttaacaat
     6181 ttatgtaaaa ctatgcataa ttttcattct aacttttgac atttttctcc ataaataaaa
     6241 gtaatgcctg atgtttagtt aaagtagatc cacctttgct tgattttatt agtcttgttc
     6301 tatcctattt ctttttaata cactgtttag acttgccaac aactcttaac tgagaatctc
     6361 ttttccttcc taggctaagt aattgtgagt gggggaggaa gaacattaag agaaataatc
     6421 taaagacttt gttcaatatt gtcgaagcct aagaatattt gtgtgtcctt ctgatgtact
     6481 gaggctttgc cggtaccaca ccatctttgg attaccataa ggttatgtag taggacttaa
     6541 aagtactagg gcaaacattt gatttttgag aaagatcaac agaacagtat agaaatccag
     6601 gtgcattcat tagaatacta ggatcacaag aggactactc tggtgtactc tagtgacctg
     6661 aaaaaactct aaaatgataa gaaagctagg ggacaaaggg aaaaaagggc aagatttata
     6721 atttatttta ctttcatgat ttttccaagt gtcttcagaa gtagaaacct atagcattaa
     6781 aaaaaaaaat ctacattaac tatatatgag ctgagagaat gagaaggtaa aaaacatgga
     6841 ggataagttt cctttgtact tacgaaatag tcccctttct taggatagaa gatagcaact
     6901 gggtagcttc tgaagcacca taaaaacagc tagaaagaat gcttattttt gaggggatag
     6961 tggacaaatg agcccttgtt gctagagaga cactgataaa ttatctgaat cctgtcaaaa
     7021 aatactgtaa tacctgtgtt aggttctctc aggaaataga tgaatggccg atctgcttta
     7081 aaaataggaa tccgagacct tttcaataac aacagagctg caggaaagaa agaaaaattc
     7141 cattgcattt tctgtgcatt tttaagaaaa taactattgg ttatgaagta agttaatttt
     7201 ttaagaaatc aaagcatcct aatggcattt gattgtttac tgttgtgatg ggggtgcaga
     7261 tgggaaaatt aaagagaaaa gatgccattt agccaatcct gtctcctgtt ttcaacacat
     7321 tccatggaat aaattcctta ttgaaggtaa
//
