LOCUS       NM_030628               3285 bp    mRNA    linear   PRI 18-NOV-2024
DEFINITION  Homo sapiens integrator complex subunit 5 (INTS5), mRNA.
ACCESSION   NM_030628 XM_290519
VERSION     NM_030628.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3285)
  AUTHORS   Lin,M.H., Jensen,M.K., Elrod,N.D., Chu,H.F., Haseley,M., Beam,A.C.,
            Huang,K.L., Chiang,W., Russell,W.K., Williams,K., Proschel,C.,
            Wagner,E.J. and Tong,L.
  TITLE     Cytoplasmic binding partners of the Integrator endonuclease INTS11
            and its paralog CPSF73 are required for their nuclear function
  JOURNAL   Mol Cell 84 (15), 2900-2917 (2024)
   PUBMED   39032490
REFERENCE   2  (bases 1 to 3285)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 3285)
  AUTHORS   Pfleiderer,M.M. and Galej,W.P.
  TITLE     Structure of the catalytic core of the Integrator complex
  JOURNAL   Mol Cell 81 (6), 1246-1259 (2021)
   PUBMED   33548203
REFERENCE   4  (bases 1 to 3285)
  AUTHORS   Beckedorff,F., Blumenthal,E., daSilva,L.F., Aoi,Y., Cingaram,P.R.,
            Yue,J., Zhang,A., Dokaneheifard,S., Valencia,M.G., Gaidosh,G.,
            Shilatifard,A. and Shiekhattar,R.
  TITLE     The Human Integrator Complex Facilitates Transcriptional Elongation
            by Endonucleolytic Cleavage of Nascent Transcripts
  JOURNAL   Cell Rep 32 (3), 107917 (2020)
   PUBMED   32697989
REFERENCE   5  (bases 1 to 3285)
  AUTHORS   Sabath,K., Staubli,M.L., Marti,S., Leitner,A., Moes,M. and Jonas,S.
  TITLE     INTS10-INTS13-INTS14 form a functional module of Integrator that
            binds nucleic acids and the cleavage module
  JOURNAL   Nat Commun 11 (1), 3422 (2020)
   PUBMED   32647223
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3285)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   7  (bases 1 to 3285)
  AUTHORS   Jodoin,J.N., Sitaram,P., Albrecht,T.R., May,S.B., Shboul,M.,
            Lee,E., Reversade,B., Wagner,E.J. and Lee,L.A.
  TITLE     Nuclear-localized Asunder regulates cytoplasmic dynein localization
            via its role in the integrator complex
  JOURNAL   Mol Biol Cell 24 (18), 2954-2965 (2013)
   PUBMED   23904267
REFERENCE   8  (bases 1 to 3285)
  AUTHORS   Baillat,D., Hakimi,M.A., Naar,A.M., Shilatifard,A., Cooch,N. and
            Shiekhattar,R.
  TITLE     Integrator, a multiprotein mediator of small nuclear RNA
            processing, associates with the C-terminal repeat of RNA polymerase
            II
  JOURNAL   Cell 123 (2), 265-276 (2005)
   PUBMED   16239144
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC060841.1.
            
            On Nov 22, 2018 this sequence version replaced NM_030628.1.
            
            Summary: The Integrator complex is a complex that associates with
            the C-terminal domain of RNA polymerase II large subunit. This
            complex is brought to U1 and U2 small nuclear RNA genes, where it
            is involved in the transcription and processing of their
            transcripts. The protein encoded by this gene represents a subunit
            of the Integrator complex. [provided by RefSeq, Aug 2016].
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC060841.1, BK005724.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000330574.2/ ENSP00000327889.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3285              BC060841.1         1-3285
FEATURES             Location/Qualifiers
     source          1..3285
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q12.3"
     gene            1..3285
                     /gene="INTS5"
                     /gene_synonym="INT5; KIAA1698"
                     /note="integrator complex subunit 5"
                     /db_xref="GeneID:80789"
                     /db_xref="HGNC:HGNC:29352"
                     /db_xref="MIM:611349"
     exon            1..133
                     /gene="INTS5"
                     /gene_synonym="INT5; KIAA1698"
                     /inference="alignment:Splign:2.1.0"
     CDS             54..3113
                     /gene="INTS5"
                     /gene_synonym="INT5; KIAA1698"
                     /codon_start=1
                     /product="integrator complex subunit 5"
                     /protein_id="NP_085131.1"
                     /db_xref="CCDS:CCDS8027.1"
                     /db_xref="GeneID:80789"
                     /db_xref="HGNC:HGNC:29352"
                     /db_xref="MIM:611349"
                     /translation="MSALCDPPGAPGPPGPAPATHGPAPLSAQELSQEIKAFLTGVDP
                     ILGHQLSAREHARCGLLLLRSLPPARAAVLDHLRGVFDESVRAHLAALDETPVAGPPH
                     LRPPPPSHVPAGGPGLEDVVQEVQQVLSEFIRANPKAWAPVISAWSIDLMGQLSSTYS
                     GQHQRVPHATGALNELLQLWMGCRATRTLMDIYVQCLSALIGSCPDACVDALLDTSVQ
                     HSPHFDWVVAHIGSSFPGTIISRVLSCGLKDFCVHGGAGGGAGSSGGSSSQTPSTDPF
                     PGSPAIPAEKRVPKIASVVGILGHLASRHGDSIRRELLRMFHDSLAGGSGGRSGDPSL
                     QATVPFLLQLAVMSPALLGTVSGELVDCLKPPAVLSQLQQHLQGFPREELDNMLNLAV
                     HLVSQASGAGAYRLLQFLVDTAMPASVITTQGLAVPDTVREACDRLIQLLLLHLQKLV
                     HHRGGSPGEGVLGPPPPPRLVPFLDALKNHVGELCGETLRLERKRFLWQHQLLGLLSV
                     YTRPSCGPEALGHLLSRARSPEELSLATQLYAGLVVSLSGLLPLAFRSCLARVHAGTL
                     QPPFTARFLRNLALLVGWEQQGGEGPAALGAHFGESASAHLSDLAPLLLHPEEEVAEA
                     AASLLAICPFPSEALSPSQLLGLVRAGVHRFFASLRLHGPPGVASACQLLTRLSQTSP
                     AGLKAVLQLLVEGALHRGNTELFGGQVDGDNETLSVVSASLASASLLDTNRRHTAAVP
                     GPGGIWSVFHAGVIGRGLKPPKFVQSRNQQEVIYNTQSLLSLLVHCCSAPGGTECGEC
                     WGAPILSPEAAKAVAVTLVESVCPDAAGAELAWPPEEHARATVERDLRIGRRFREQPL
                     LFELLKLVAAAPPALCYCSVLLRGLLAALLGHWEASRHPDTTHSPWHLEASCTLVAVM
                     AEGSLLPPALGNMHEVFSQLAPFEVRLLLLSVWGFLREHGPLPQKFIFQSERGRFIRD
                     FSREGGGEGGPHLAVLHSVLHRNIDRLGLFSGRFQAPSPSTLLRQGT"
     exon            134..3285
                     /gene="INTS5"
                     /gene_synonym="INT5; KIAA1698"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3258..3263
                     /regulatory_class="polyA_signal_sequence"
                     /gene="INTS5"
                     /gene_synonym="INT5; KIAA1698"
                     /note="hexamer: AATAAA"
     polyA_site      3285
                     /gene="INTS5"
                     /gene_synonym="INT5; KIAA1698"
                     /note="major polyA site"
ORIGIN      
        1 atgcgccgcc tgcgctccgc cgctcgcgcc tcgggctcgg ctcgggctcc gggatgtccg
       61 cgctgtgcga ccctcccggg gccccagggc cacctgggcc tgccccggcc acccacggtc
      121 ccgcgcctct cagtgctcag gagctgtccc aggaaatcaa ggcttttctg actggcgtag
      181 accccattct gggccaccaa ctctcagccc gggaacatgc tcgctgtggt cttctcctgc
      241 tccgttcttt gccacctgct cgggctgctg tgcttgacca cttgagaggt gtctttgatg
      301 agagtgtccg ggcccacctg gctgccctgg atgaaacccc tgtggctggt ccacctcacc
      361 tccgtccacc tccaccctct catgtccctg ctggtggacc tggtctagag gatgtggttc
      421 aggaagtgca gcaggtgctg tctgagttta tccgggccaa cccaaaggcc tgggcacctg
      481 tgattagtgc atggtccatt gacctcatgg ggcaactgag cagcacgtac tcaggccagc
      541 accagcgtgt tccccacgct actggcgctc ttaatgaact gctacagctg tggatgggtt
      601 gtagggccac gcgtacatta atggacatct atgtgcagtg cctctcggct ctcattggta
      661 gctgcccaga tgcgtgtgtg gatgccttgc tggatacctc tgttcagcat tctccacact
      721 ttgactgggt tgtggcacat attggctcct cttttcctgg caccatcatt tcccgggttc
      781 tctcctgtgg ccttaaggac ttttgtgtcc atggtggggc tggaggtgga gctggcagta
      841 gtggtggaag ctcttctcag accccctcta cagacccctt ccctggatct cctgccattc
      901 ctgcggagaa acgggtgccc aagattgcct cagttgtagg catcctaggt cacctggcct
      961 cccgccacgg agatagcatc cgacgggagc tcctgcgaat gttccatgat agcctggcag
     1021 ggggatctgg aggccgcagt ggggacccct cccttcaggc cacggttccg ttcctactgc
     1081 agctggcagt catgtcacca gctttgctgg gcactgtctc tggagagctt gtggattgcc
     1141 tcaagccccc agctgtgctg agccagctgc agcaacacct tcaaggattc ccccgagagg
     1201 agctggacaa catgttgaac ctggctgtgc acctggtgag ccaggcctct ggggcaggtg
     1261 cctaccgctt gctgcagttc ctggtggaca cagctatgcc tgcttcggtc attaccaccc
     1321 agggcctggc tgtgccagac accgtgcgtg aggcttgtga ccggctaatc cagctgctgc
     1381 tgctgcacct gcaaaaactg gttcatcacc ggggagggtc tcctggggaa ggggtgctag
     1441 gcccgccccc acctccccgc ttggtgccct ttttagatgc gctcaaaaac catgttggag
     1501 agctgtgtgg agagacgtta cgattggaac ggaagcgctt cctctggcag caccagctct
     1561 tgggcctgct gtctgtctat acccggccta gctgtggacc tgaggccttg ggccatctgc
     1621 tgagccgagc ccgaagccct gaagagttga gtttggccac ccagttatat gcagggctag
     1681 tggtcagcct ctctggcctc ctgcccctgg ctttccgaag ctgtctggct cgggtgcatg
     1741 cagggacatt acagcctccc ttcacggccc ggttcctgcg caacttggca ctgctagtag
     1801 ggtgggaaca gcagggtggc gagggccctg cagccctagg ggcgcacttt ggggaatctg
     1861 cctcagccca tctgtctgac ctggctcctc tcctgctaca tcctgaggag gaagtagctg
     1921 aagctgctgc ctctctcctg gccatttgtc cctttccttc tgaagcctta tccccctccc
     1981 agctcctggg actggtaagg gctggggtgc accgcttctt tgcctctctg aggctgcatg
     2041 gacccccagg tgtggcctca gcctgtcagc ttctcacccg cctgtctcag acatccccag
     2101 ctgggctcaa ggctgtcctg cagctgctgg ttgaaggagc cttacatcga ggcaacacag
     2161 aactgtttgg tgggcaagta gatggggaca atgagactct ctcagttgtt tcagcttctt
     2221 tggcttctgc ctccctgttg gacactaacc ggaggcacac tgcagctgtg ccaggtcctg
     2281 gagggatttg gtcagttttc catgctggag tcatcggccg tggcttaaag ccacccaagt
     2341 ttgtccagtc acgaaatcag caggaagtga tctataacac ccagagcctc ctcagcctcc
     2401 tggttcactg ctgcagtgcc ccagggggca ctgaatgtgg ggaatgctgg ggggcaccca
     2461 tcttgagtcc agaggcagcc aaagcagtgg cagtgacctt ggtggagagt gtgtgtcccg
     2521 atgcagctgg tgcagagctg gcctggcccc ccgaggaaca cgcccgggcc accgtggagc
     2581 gggatctccg cattggccgg cgcttccgcg aacagcccct gctctttgag ctgttaaagc
     2641 tggtagcagc tgcaccccca gccctgtgct actgttccgt gctgcttcgg gggctgctgg
     2701 ccgccctctt gggccattgg gaagcctctc gccaccctga cacgacccac tccccctggc
     2761 acctggaggc atcctgcacc ttagtggctg tcatggctga gggaagcctc ctgcctccgg
     2821 ccctgggtaa tatgcatgaa gtatttagcc aactggcacc tttcgaggtg cgtctgctgc
     2881 tgctcagtgt ctggggtttt ctccgggagc atgggccctt gcctcagaag ttcatcttcc
     2941 aatcagagcg gggtcgcttc attcgggact tctccaggga gggtggaggt gagggtggac
     3001 cccatctggc tgtgctgcac agtgtcctcc accgcaacat cgaccgccta ggtcttttct
     3061 ctggccgttt ccaggcacct tcaccgtcca ctctccttcg acaggggacg tagccttttc
     3121 ttgctctgga agcccaggga ggttgagcag tgagagaggg aagggactaa cgtgctccgg
     3181 aagggtggag gtttctcttc taagtccttg gtctaaagag cgctgtcact tttttctctc
     3241 ccactttttt ttttctaaat aaaatttgcc aacttgagaa aacca
//
