LOCUS       NM_023015               5252 bp    mRNA    linear   PRI 18-NOV-2024
DEFINITION  Homo sapiens integrator complex subunit 3 (INTS3), transcript
            variant 1, mRNA.
ACCESSION   NM_023015
VERSION     NM_023015.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5252)
  AUTHORS   Lin,M.H., Jensen,M.K., Elrod,N.D., Chu,H.F., Haseley,M., Beam,A.C.,
            Huang,K.L., Chiang,W., Russell,W.K., Williams,K., Proschel,C.,
            Wagner,E.J. and Tong,L.
  TITLE     Cytoplasmic binding partners of the Integrator endonuclease INTS11
            and its paralog CPSF73 are required for their nuclear function
  JOURNAL   Mol Cell 84 (15), 2900-2917 (2024)
   PUBMED   39032490
REFERENCE   2  (bases 1 to 5252)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 5252)
  AUTHORS   Pfleiderer,M.M. and Galej,W.P.
  TITLE     Structure of the catalytic core of the Integrator complex
  JOURNAL   Mol Cell 81 (6), 1246-1259 (2021)
   PUBMED   33548203
REFERENCE   4  (bases 1 to 5252)
  AUTHORS   Beckedorff,F., Blumenthal,E., daSilva,L.F., Aoi,Y., Cingaram,P.R.,
            Yue,J., Zhang,A., Dokaneheifard,S., Valencia,M.G., Gaidosh,G.,
            Shilatifard,A. and Shiekhattar,R.
  TITLE     The Human Integrator Complex Facilitates Transcriptional Elongation
            by Endonucleolytic Cleavage of Nascent Transcripts
  JOURNAL   Cell Rep 32 (3), 107917 (2020)
   PUBMED   32697989
REFERENCE   5  (bases 1 to 5252)
  AUTHORS   Sabath,K., Staubli,M.L., Marti,S., Leitner,A., Moes,M. and Jonas,S.
  TITLE     INTS10-INTS13-INTS14 form a functional module of Integrator that
            binds nucleic acids and the cleavage module
  JOURNAL   Nat Commun 11 (1), 3422 (2020)
   PUBMED   32647223
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5252)
  AUTHORS   Li,Y., Bolderson,E., Kumar,R., Muniandy,P.A., Xue,Y., Richard,D.J.,
            Seidman,M., Pandita,T.K., Khanna,K.K. and Wang,W.
  TITLE     HSSB1 and hSSB2 form similar multiprotein complexes that
            participate in DNA damage response
  JOURNAL   J Biol Chem 284 (35), 23525-23531 (2009)
   PUBMED   19605351
REFERENCE   7  (bases 1 to 5252)
  AUTHORS   Huang,J., Gong,Z., Ghosal,G. and Chen,J.
  TITLE     SOSS complexes participate in the maintenance of genomic stability
  JOURNAL   Mol Cell 35 (3), 384-393 (2009)
   PUBMED   19683501
  REMARK    GeneRIF: INTS3 is part of an ssDNA-binding heterotrimeric complex,
            SOSS which is involved in the maintenance of genome stability.
REFERENCE   8  (bases 1 to 5252)
  AUTHORS   Richard,D.J., Bolderson,E., Cubeddu,L., Wadsworth,R.I., Savage,K.,
            Sharma,G.G., Nicolette,M.L., Tsvetanov,S., McIlwraith,M.J.,
            Pandita,R.K., Takeda,S., Hay,R.T., Gautier,J., West,S.C.,
            Paull,T.T., Pandita,T.K., White,M.F. and Khanna,K.K.
  TITLE     Single-stranded DNA-binding protein hSSB1 is critical for genomic
            stability
  JOURNAL   Nature 453 (7195), 677-681 (2008)
   PUBMED   18449195
REFERENCE   9  (bases 1 to 5252)
  AUTHORS   Inagaki,Y., Yasui,K., Endo,M., Nakajima,T., Zen,K., Tsuji,K.,
            Minami,M., Tanaka,S., Taniwaki,M., Itoh,Y., Arii,S. and Okanoue,T.
  TITLE     CREB3L4, INTS3, and SNAPAP are targets for the 1q21 amplicon
            frequently detected in hepatocellular carcinoma
  JOURNAL   Cancer Genet Cytogenet 180 (1), 30-36 (2008)
   PUBMED   18068530
REFERENCE   10 (bases 1 to 5252)
  AUTHORS   Baillat,D., Hakimi,M.A., Naar,A.M., Shilatifard,A., Cooch,N. and
            Shiekhattar,R.
  TITLE     Integrator, a multiprotein mediator of small nuclear RNA
            processing, associates with the C-terminal repeat of RNA polymerase
            II
  JOURNAL   Cell 123 (2), 265-276 (2005)
   PUBMED   16239144
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL513523.33.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_023015.4.
            
            Summary: The protein encoded by this gene can form a complex with
            human single-strand DNA binding proteins 1 or 2 (hSSB1 and hSSB2)
            and other proteins to mediate genome stability and the DNA damage
            response. The encoded protein is also part of a multiprotein
            complex that interacts with the C-terminal domain of RNA polymerase
            II large subunit to help regulate processing of U1 and U2 small
            nuclear RNAs. [provided by RefSeq, May 2016].
            
            Transcript Variant: This variant (1) encodes the longer transcript.
            Variants 1 and 2 both encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BX640950.1, BC116458.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000318967.7/ ENSP00000318641.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-735               AL513523.33        12478-13212
            736-819             AL513523.33        25079-25162
            820-903             AL513523.33        25713-25796
            904-1017            AL513523.33        31385-31498
            1018-1102           AL513523.33        31707-31791
            1103-1169           AL513523.33        33117-33183
            1170-1314           AL513523.33        35523-35667
            1315-1444           AL513523.33        36707-36836
            1445-1542           AL513523.33        39070-39167
            1543-1734           AL513523.33        42000-42191
            1735-1822           AL513523.33        43954-44041
            1823-1902           AL513523.33        44739-44818
            1903-1994           AL513523.33        45255-45346
            1995-2101           AL513523.33        45998-46104
            2102-2221           AL513523.33        47156-47275
            2222-2351           AL513523.33        47661-47790
            2352-2406           AL513523.33        48260-48314
            2407-2510           AL513523.33        48546-48649
            2511-2555           AL513523.33        49118-49162
            2556-2675           AL513523.33        49372-49491
            2676-2829           AL513523.33        52102-52255
            2830-2898           AL513523.33        53321-53389
            2899-2974           AL513523.33        54197-54272
            2975-3088           AL513523.33        54626-54739
            3089-3137           AL513523.33        55113-55161
            3138-3305           AL513523.33        56224-56391
            3306-3406           AL513523.33        56768-56868
            3407-3479           AL513523.33        57067-57139
            3480-3636           AL513523.33        57353-57509
            3637-5252           AL513523.33        57621-59236
FEATURES             Location/Qualifiers
     source          1..5252
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q21.3"
     gene            1..5252
                     /gene="INTS3"
                     /gene_synonym="C1orf193; C1orf60; INT3; SOSS-A; SOSSA"
                     /note="integrator complex subunit 3"
                     /db_xref="GeneID:65123"
                     /db_xref="HGNC:HGNC:26153"
                     /db_xref="MIM:611347"
     exon            1..735
                     /gene="INTS3"
                     /gene_synonym="C1orf193; C1orf60; INT3; SOSS-A; SOSSA"
                     /inference="alignment:Splign:2.1.0"
     CDS             586..3714
                     /gene="INTS3"
                     /gene_synonym="C1orf193; C1orf60; INT3; SOSS-A; SOSSA"
                     /note="SOSS complex subunit A; sensor of ssDNA subunit A;
                     sensor of single-strand DNA complex subunit A"
                     /codon_start=1
                     /product="integrator complex subunit 3"
                     /protein_id="NP_075391.3"
                     /db_xref="CCDS:CCDS1052.1"
                     /db_xref="GeneID:65123"
                     /db_xref="HGNC:HGNC:26153"
                     /db_xref="MIM:611347"
                     /translation="MELQKGKGAAAAAAASGAAGGGGGGAGAGAPGGGRLLLSTSLDA
                     KDELEERLERCMSIVTSMTAGVSEREANDALNAYVCKGLPQHEEICLGLFTLILTEPA
                     QAQKCYRDLALVSRDGMNIVLNKINQILMEKYLKLQDTCRTQLVWLVRELVKSGVLGA
                     DGVCMTFMKQIAGGDVTAKNIWLAESVLDILTEQREWVLKSSILIAMAVYTYLRLIVD
                     HHGTAQLQALRQKEVDFCISLLRERFMECLMIGRDLVRLLQNVARIPEFELLWKDIIH
                     NPQALSPQFTGILQLLQSRTSRKFLACRLTPDMETKLLFMTSRVRFGQQKRYQDWFQR
                     QYLSTPDSQSLRCDLIRYICGVVHPSNEVLSSDILPRWAIIGWLLTTCTSNVAASNAK
                     LALFYDWLFFSPDKDSIMNIEPAILVMHHSMKPHPAITATLLDFMCRIIPNFYPPLEG
                     HVRQGVFSSLNHIVEKRVLAHLAPLFDNPKLDKELRAMLREKFPEFCSSPSPPVEVKI
                     EEPVSMEMDNHMSDKDESCYDNAEAAFSDDEEDLNSKGKKREFRFHPIKETVVEEPVD
                     ITPYLDQLDESLRDKVLQLQKGSDTEAQCEVMQEIVDQVLEEDFDSEQLSVLASCLQE
                     LFKAHFRGEVLPEEITEESLEESVGKPLYLIFRNLCQMQEDNSSFSLLLDLLSELYQK
                     QPKIGYHLLYYLRASKAAAGKMNLYESFAQATQLGDLHTCLMMDMKACQEDDVRLLCH
                     LTPSIYTEFPDETLRSGELLNMIVAVIDSAQLQELVCHVMMGNLVMFRKDSVLNILIQ
                     SLDWETFEQYCAWQLFLAHNIPLETIIPILQHLKYKEHPEALSCLLLQLRREKPSEEM
                     VKMVLSRPCHPDDQFTTSILRHWCMKHDELLAEHIKSLLIKNNSLPRKRQSLRSSSSK
                     LAQLTLEQILEHLDNLRLNLTNTKQNFFSQTPILQALQHVQASCDEAHKMKFSDLFSL
                     AEEYEDSSTKPPKSRRKAALSSPRSRKNATQPPNAEEESGSSSASEEEDTKPKPTKRK
                     RKGSSAVGSDSD"
     exon            736..819
                     /gene="INTS3"
                     /gene_synonym="C1orf193; C1orf60; INT3; SOSS-A; SOSSA"
                     /inference="alignment:Splign:2.1.0"
     exon            820..903
                     /gene="INTS3"
                     /gene_synonym="C1orf193; C1orf60; INT3; SOSS-A; SOSSA"
                     /inference="alignment:Splign:2.1.0"
     exon            904..1017
                     /gene="INTS3"
                     /gene_synonym="C1orf193; C1orf60; INT3; SOSS-A; SOSSA"
                     /inference="alignment:Splign:2.1.0"
     exon            1018..1102
                     /gene="INTS3"
                     /gene_synonym="C1orf193; C1orf60; INT3; SOSS-A; SOSSA"
                     /inference="alignment:Splign:2.1.0"
     exon            1103..1169
                     /gene="INTS3"
                     /gene_synonym="C1orf193; C1orf60; INT3; SOSS-A; SOSSA"
                     /inference="alignment:Splign:2.1.0"
     exon            1170..1314
                     /gene="INTS3"
                     /gene_synonym="C1orf193; C1orf60; INT3; SOSS-A; SOSSA"
                     /inference="alignment:Splign:2.1.0"
     exon            1315..1444
                     /gene="INTS3"
                     /gene_synonym="C1orf193; C1orf60; INT3; SOSS-A; SOSSA"
                     /inference="alignment:Splign:2.1.0"
     exon            1445..1542
                     /gene="INTS3"
                     /gene_synonym="C1orf193; C1orf60; INT3; SOSS-A; SOSSA"
                     /inference="alignment:Splign:2.1.0"
     exon            1543..1734
                     /gene="INTS3"
                     /gene_synonym="C1orf193; C1orf60; INT3; SOSS-A; SOSSA"
                     /inference="alignment:Splign:2.1.0"
     exon            1735..1822
                     /gene="INTS3"
                     /gene_synonym="C1orf193; C1orf60; INT3; SOSS-A; SOSSA"
                     /inference="alignment:Splign:2.1.0"
     exon            1823..1902
                     /gene="INTS3"
                     /gene_synonym="C1orf193; C1orf60; INT3; SOSS-A; SOSSA"
                     /inference="alignment:Splign:2.1.0"
     exon            1903..1994
                     /gene="INTS3"
                     /gene_synonym="C1orf193; C1orf60; INT3; SOSS-A; SOSSA"
                     /inference="alignment:Splign:2.1.0"
     exon            1995..2101
                     /gene="INTS3"
                     /gene_synonym="C1orf193; C1orf60; INT3; SOSS-A; SOSSA"
                     /inference="alignment:Splign:2.1.0"
     exon            2102..2221
                     /gene="INTS3"
                     /gene_synonym="C1orf193; C1orf60; INT3; SOSS-A; SOSSA"
                     /inference="alignment:Splign:2.1.0"
     exon            2222..2351
                     /gene="INTS3"
                     /gene_synonym="C1orf193; C1orf60; INT3; SOSS-A; SOSSA"
                     /inference="alignment:Splign:2.1.0"
     exon            2352..2406
                     /gene="INTS3"
                     /gene_synonym="C1orf193; C1orf60; INT3; SOSS-A; SOSSA"
                     /inference="alignment:Splign:2.1.0"
     exon            2407..2510
                     /gene="INTS3"
                     /gene_synonym="C1orf193; C1orf60; INT3; SOSS-A; SOSSA"
                     /inference="alignment:Splign:2.1.0"
     exon            2511..2555
                     /gene="INTS3"
                     /gene_synonym="C1orf193; C1orf60; INT3; SOSS-A; SOSSA"
                     /inference="alignment:Splign:2.1.0"
     exon            2556..2675
                     /gene="INTS3"
                     /gene_synonym="C1orf193; C1orf60; INT3; SOSS-A; SOSSA"
                     /inference="alignment:Splign:2.1.0"
     exon            2676..2829
                     /gene="INTS3"
                     /gene_synonym="C1orf193; C1orf60; INT3; SOSS-A; SOSSA"
                     /inference="alignment:Splign:2.1.0"
     exon            2830..2898
                     /gene="INTS3"
                     /gene_synonym="C1orf193; C1orf60; INT3; SOSS-A; SOSSA"
                     /inference="alignment:Splign:2.1.0"
     exon            2899..2974
                     /gene="INTS3"
                     /gene_synonym="C1orf193; C1orf60; INT3; SOSS-A; SOSSA"
                     /inference="alignment:Splign:2.1.0"
     exon            2975..3088
                     /gene="INTS3"
                     /gene_synonym="C1orf193; C1orf60; INT3; SOSS-A; SOSSA"
                     /inference="alignment:Splign:2.1.0"
     exon            3089..3137
                     /gene="INTS3"
                     /gene_synonym="C1orf193; C1orf60; INT3; SOSS-A; SOSSA"
                     /inference="alignment:Splign:2.1.0"
     exon            3138..3305
                     /gene="INTS3"
                     /gene_synonym="C1orf193; C1orf60; INT3; SOSS-A; SOSSA"
                     /inference="alignment:Splign:2.1.0"
     exon            3306..3406
                     /gene="INTS3"
                     /gene_synonym="C1orf193; C1orf60; INT3; SOSS-A; SOSSA"
                     /inference="alignment:Splign:2.1.0"
     exon            3407..3479
                     /gene="INTS3"
                     /gene_synonym="C1orf193; C1orf60; INT3; SOSS-A; SOSSA"
                     /inference="alignment:Splign:2.1.0"
     exon            3480..3636
                     /gene="INTS3"
                     /gene_synonym="C1orf193; C1orf60; INT3; SOSS-A; SOSSA"
                     /inference="alignment:Splign:2.1.0"
     exon            3637..5252
                     /gene="INTS3"
                     /gene_synonym="C1orf193; C1orf60; INT3; SOSS-A; SOSSA"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4503..4508
                     /regulatory_class="polyA_signal_sequence"
                     /gene="INTS3"
                     /gene_synonym="C1orf193; C1orf60; INT3; SOSS-A; SOSSA"
                     /note="hexamer: AATAAA"
     polyA_site      4523
                     /gene="INTS3"
                     /gene_synonym="C1orf193; C1orf60; INT3; SOSS-A; SOSSA"
                     /note="major polyA site"
     regulatory      5231..5236
                     /regulatory_class="polyA_signal_sequence"
                     /gene="INTS3"
                     /gene_synonym="C1orf193; C1orf60; INT3; SOSS-A; SOSSA"
                     /note="hexamer: ATTAAA"
     polyA_site      5252
                     /gene="INTS3"
                     /gene_synonym="C1orf193; C1orf60; INT3; SOSS-A; SOSSA"
ORIGIN      
        1 gccttcccac cccccgccct tccactatgg ccgcttctgt gtggtgtggg gagacgctgg
       61 tcctccccgt cctcccatag cgcttattgc ctcaccctca ccccctaggg gccggatcca
      121 aaggcgctgc actccccaag ccttggggca tcagccagga aggtttccta cctcctaatt
      181 caggggcagg actcctcttt tccccccacg gggaaaagag gcagaaactt aggggtttcc
      241 ctcctttctt agggtcagac gctcttaggg tccacttctt caggggcgga agcctctcct
      301 acccttccca tagggacaca ggcctttacc ccactgtact tcggagccaa cgcctttccc
      361 tcagcactgc caccccagag tcaggaccca gaggactgtg ccttcgcccc caacgcaggc
      421 gcggcctttt ggagaggagg gaggagtgga gaggacaggg gcccttgctc tcccctcccc
      481 aacttgttcc tcttgccccc cagtccctgg caatccagag atcccgatat ctaggactgt
      541 ccatccatcc actccctgac cttttcccgg ctcctggctg cagccatgga gttgcagaag
      601 ggaaaagggg cggcagcagc agcagctgct tcgggagcag cgggaggtgg aggaggagga
      661 gcgggagcag gagccccagg aggggggagg ctgctacttt caaccagttt ggatgccaag
      721 gatgagttag aggagagatt ggaaaggtgt atgagcattg tgacatcgat gactgctggt
      781 gtctcggaga gagaagccaa tgatgccctc aatgcgtatg tgtgcaaagg cctcccccag
      841 catgaagaaa tctgcctggg cctgtttact ctcatcctca ctgaacctgc ccaagcccag
      901 aagtgttacc gggacttagc tctggtgagt cgtgatggca tgaatattgt cctgaataaa
      961 atcaaccaga tacttatgga gaagtacctg aagctgcagg atacctgccg tactcagttg
     1021 gtgtggttgg tacgggaact ggtgaagagt ggggttctgg gagccgatgg tgtttgtatg
     1081 acgtttatga agcagattgc aggtggagat gttacagcca aaaatatctg gttggcagaa
     1141 agtgttctgg atatcctgac agagcaaagg gagtgggtcc tgaagagcag catcctcatt
     1201 gccatggctg tttacacgta cctccgcctc atcgtggacc accatgggac tgcccagctc
     1261 caggccctgc gacagaagga agtagacttc tgcatctcac tgcttcggga acggttcatg
     1321 gaatgtctga tgattggtcg ggatctcgta agactacttc agaatgttgc taggatacca
     1381 gaatttgaac tgctttggaa agatattatc cataatcctc aggccttgag tcctcagttc
     1441 acaggtatcc tacagcttct tcagtcaaga acatcccgaa aattcctagc atgtcgtcta
     1501 accccggaca tggagactaa actcctcttc atgacatccc gggtgcgatt tggtcaacaa
     1561 aagcgatacc aagattggtt ccagcgccag tacctgtcaa ctccagatag tcagtctctg
     1621 cgctgtgacc tcattcgcta catctgtggg gtagtccacc cttctaatga agtactgagt
     1681 tcagatatct tgccccggtg ggccatcatt ggttggctcc tgacaacgtg cacgtcaaat
     1741 gtcgctgcct ccaatgccaa gctggctttg ttttatgact ggctgttctt tagtccagac
     1801 aaggatagca ttatgaacat agaaccagcc atcctggtca tgcaccactc catgaagccc
     1861 cacccagcca tcactgccac actcctggac ttcatgtgcc gcatcattcc caacttctat
     1921 ccaccattgg agggccacgt gcggcagggt gtcttttcct ccctcaacca cattgtggag
     1981 aaacgggtct tggcacacct agctcccctg tttgacaacc ctaagttgga taaggagctg
     2041 cgggcaatgc tgagagagaa gtttcctgag ttctgcagct caccctcccc acctgtggaa
     2101 gtcaaaattg aggagccagt ttccatggag atggacaacc atatgtcgga taaggatgag
     2161 agttgctatg acaatgcaga ggcagccttc agtgacgatg aagaggatct caacagcaaa
     2221 ggaaagaaga gggagtttcg cttccaccct atcaaggaga cagttgtgga ggagccagtt
     2281 gatatcaccc cttaccttga ccagttggat gagtccctga gggacaaagt actccagcta
     2341 cagaagggga gtgatacgga ggcccagtgt gaggtcatgc aggaaattgt ggaccaggtc
     2401 ctggaggaag actttgactc ggagcagctg tctgtccttg cttcctgcct acaggagctc
     2461 ttcaaggccc actttcgagg ggaggtcctg cctgaggaga ttactgagga gtccctggag
     2521 gagtctgtag gaaagcctct gtacctaata tttaggaacc tatgtcagat gcaggaagac
     2581 aacagcagct tctctctact tctagacctt ctctccgagc tatatcagaa gcagcccaag
     2641 attggctacc acctgctcta ctacctgagg gccagcaaag ccgccgcagg gaagatgaac
     2701 ctgtacgagt catttgccca ggctacccag ctgggcgatc tgcacacctg cctgatgatg
     2761 gacatgaagg cctgccagga ggacgatgtg cggctcctgt gccacctcac gccctccatc
     2821 tacacagagt ttccagatga aaccttgagg agcggagagc tgctgaacat gatcgtggct
     2881 gttattgact ctgcacagct ccaggagctg gtctgccacg tgatgatggg taacctggtt
     2941 atgtttcgaa aagactcagt tctcaacata ctcattcaga gcctagactg ggagaccttt
     3001 gagcagtatt gtgcctggca gctctttctg gcccacaata ttcccctgga gaccataatc
     3061 cccatcctgc agcacctcaa atacaaggag cacccagagg ccctgtcctg cctactgctt
     3121 caactccgaa gagaaaagcc cagcgaggag atggtgaaga tggtgctgag ccggccctgc
     3181 catcctgacg accagttcac caccagcatc ctgcggcact ggtgcatgaa acatgacgag
     3241 ctgctggccg agcacatcaa gtccctgctc atcaagaaca acagcctgcc tcgcaagaga
     3301 cagagcctga ggagctctag cagcaagctg gcccagctga ctctggagca gatcctggag
     3361 cacttggaca atctgcggct caacctgacc aacaccaagc agaacttttt tagccagacg
     3421 ccaattctcc aggcgctgca gcatgtccaa gcgagctgtg acgaagccca caagatgaaa
     3481 ttcagtgatc tcttctccct ggcggaggaa tatgaggact cttccaccaa gccacccaag
     3541 agccggcgaa aagcagctct gtccagccct cgaagtcgaa agaatgccac acagcccccc
     3601 aatgccgaag aagagtcggg ctccagcagt gcttcagaag aggaagacac gaaaccgaag
     3661 cctaccaagc ggaaacgaaa agggtcctct gcagtgggct ctgacagtga ctgaggccct
     3721 gcattcccca tcccaccccc ggctggactg ccctctcctt cttggtgatt caaaggttaa
     3781 tagaggctga ggagattgca ggggaaacac ccttgctgca tccccaagct cccccggtgg
     3841 aaggaggagc tttctcctct ggctgagttt gagaagctgc catgcagccc ctagcccctt
     3901 ccctcctcct ggggcctcca gcccctcaca ctgctgttcc cagtgatatt tgggatctga
     3961 ctgaagccag aggctctgta aaatcagacc atagtggaag tcctcagccc cctggcccct
     4021 tccgcaatct cctcccccag tctcccaaag agccatttca acagagaagg gaaatgacaa
     4081 aggggcagct ggccagataa gctaggatga gagcagagac tcagtgtgtg ggtgtccctt
     4141 cctgcttccc cttcaggtct tggtttgttc tgaagggacg ttttatagtc actatccaca
     4201 tgccagtgtg aaatgggcat ctatgacgtg gtcagggtgt ccattcctaa tcatggggca
     4261 gatgccacaa gcattcagaa aggagtctga aagggtggcc acagccccac gtggtgtgcc
     4321 ctggaggctt aggttggtct gaggttggca cctcaatcta caccagagcc cagggagtcc
     4381 cagaggcaag tttcacagaa ttgtcaaatg atcccatttc cttgagtctg tttttttttt
     4441 tgtttttttt tgtttttttt ttggcagaga taatcgtgtc ttaaaagttg tttttaaatg
     4501 acaataaaac aagccagaat gtcttttgtg ctggagtgtc tgctggcatt tgccccgtgc
     4561 atgtatagct tggtcttgat ttgattggca cccctacttg taaccgcaga acatccccct
     4621 ttcccttcct gttctgcccc cacttttgtc tagagcagaa gggacttggc tttggccact
     4681 acccatcctt cctgctgcca ctggaggtgg gagccaggca ctgatctgtc tatgcagaac
     4741 catcccccgt aggatgaggc ctgtccttac tcatttctca agaaacaaga tgcttccaaa
     4801 aggtctgtca tcctccagtt gaagtctgtg tgcctaccaa gaatggccgg aggactcgct
     4861 gcttgacggg agggatgctc cagcttggtc tccagggaca actgtacctg gagataaagt
     4921 ctggatacca gggagggaca gagatgctct tccttccaca gtgtggccac ttgctgggcc
     4981 atgtgaacca gcagaggaga gttccttggc tatgctgttg ttcccccgct gtccagggag
     5041 aatggaggtg gactgaggag tgaagtttgg gcgaactgca cagagctgct cctcttcacc
     5101 ccgaaaattt gtctttttac agaatccagg ttctcccctc cctcatcact gctgttgctt
     5161 cctttgaaag tctaaaccac tggaggcttc tttttccttc ctctctcctt ccccagtttc
     5221 ctctgtccca attaaaacca ggatggagag ca
//
