LOCUS       NM_001351695            6128 bp    mRNA    linear   PRI 18-NOV-2024
DEFINITION  Homo sapiens integrator complex subunit 2 (INTS2), transcript
            variant 2, mRNA.
ACCESSION   NM_001351695 NR_026641
VERSION     NM_001351695.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6128)
  AUTHORS   Lin,M.H., Jensen,M.K., Elrod,N.D., Chu,H.F., Haseley,M., Beam,A.C.,
            Huang,K.L., Chiang,W., Russell,W.K., Williams,K., Proschel,C.,
            Wagner,E.J. and Tong,L.
  TITLE     Cytoplasmic binding partners of the Integrator endonuclease INTS11
            and its paralog CPSF73 are required for their nuclear function
  JOURNAL   Mol Cell 84 (15), 2900-2917 (2024)
   PUBMED   39032490
REFERENCE   2  (bases 1 to 6128)
  AUTHORS   Pfleiderer,M.M. and Galej,W.P.
  TITLE     Structure of the catalytic core of the Integrator complex
  JOURNAL   Mol Cell 81 (6), 1246-1259 (2021)
   PUBMED   33548203
REFERENCE   3  (bases 1 to 6128)
  AUTHORS   Beckedorff,F., Blumenthal,E., daSilva,L.F., Aoi,Y., Cingaram,P.R.,
            Yue,J., Zhang,A., Dokaneheifard,S., Valencia,M.G., Gaidosh,G.,
            Shilatifard,A. and Shiekhattar,R.
  TITLE     The Human Integrator Complex Facilitates Transcriptional Elongation
            by Endonucleolytic Cleavage of Nascent Transcripts
  JOURNAL   Cell Rep 32 (3), 107917 (2020)
   PUBMED   32697989
REFERENCE   4  (bases 1 to 6128)
  AUTHORS   Sabath,K., Staubli,M.L., Marti,S., Leitner,A., Moes,M. and Jonas,S.
  TITLE     INTS10-INTS13-INTS14 form a functional module of Integrator that
            binds nucleic acids and the cleavage module
  JOURNAL   Nat Commun 11 (1), 3422 (2020)
   PUBMED   32647223
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6128)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 6128)
  AUTHORS   Rienzo,M. and Casamassimi,A.
  TITLE     Integrator complex and transcription regulation: Recent findings
            and pathophysiology
  JOURNAL   Biochim Biophys Acta 1859 (10), 1269-1280 (2016)
   PUBMED   27427483
  REMARK    Review article
REFERENCE   7  (bases 1 to 6128)
  AUTHORS   Lim,B., Kim,C., Kim,J.H., Kwon,W.S., Lee,W.S., Kim,J.M., Park,J.Y.,
            Kim,H.S., Park,K.H., Kim,T.S., Park,J.L., Chung,H.C., Rha,S.Y. and
            Kim,S.Y.
  TITLE     Genetic alterations and their clinical implications in gastric
            cancer peritoneal carcinomatosis revealed by whole-exome sequencing
            of malignant ascites
  JOURNAL   Oncotarget 7 (7), 8055-8066 (2016)
   PUBMED   26811494
  REMARK    GeneRIF: Mutation in INTS2 gene is associated with gastric cancer
            peritoneal carcinomatosis.
REFERENCE   8  (bases 1 to 6128)
  AUTHORS   Baillat,D. and Wagner,E.J.
  TITLE     Integrator: surprisingly diverse functions in gene expression
  JOURNAL   Trends Biochem Sci 40 (5), 257-264 (2015)
   PUBMED   25882383
  REMARK    Review article
REFERENCE   9  (bases 1 to 6128)
  AUTHORS   Jodoin,J.N., Sitaram,P., Albrecht,T.R., May,S.B., Shboul,M.,
            Lee,E., Reversade,B., Wagner,E.J. and Lee,L.A.
  TITLE     Nuclear-localized Asunder regulates cytoplasmic dynein localization
            via its role in the integrator complex
  JOURNAL   Mol Biol Cell 24 (18), 2954-2965 (2013)
   PUBMED   23904267
REFERENCE   10 (bases 1 to 6128)
  AUTHORS   Baillat,D., Hakimi,M.A., Naar,A.M., Shilatifard,A., Cooch,N. and
            Shiekhattar,R.
  TITLE     Integrator, a multiprotein mediator of small nuclear RNA
            processing, associates with the C-terminal repeat of RNA polymerase
            II
  JOURNAL   Cell 123 (2), 265-276 (2005)
   PUBMED   16239144
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC060798.10.
            
            On Jun 2, 2019 this sequence version replaced NM_001351695.1.
            
            Summary: INTS2 is a subunit of the Integrator complex, which
            associates with the C-terminal domain of RNA polymerase II large
            subunit (POLR2A; MIM 180660) and mediates 3-prime end processing of
            small nuclear RNAs U1 (RNU1; MIM 180680) and U2 (RNU2; MIM 180690)
            (Baillat et al., 2005 [PubMed 16239144]).[supplied by OMIM, Mar
            2008].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR11853567.13597.1,
                                           SRR14038193.581439.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000251334.7/ ENSP00000251334.6
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-329               AC060798.10        113264-113592       c
            330-640             AC060798.10        111962-112272       c
            641-779             AC060798.10        110571-110709       c
            780-882             AC060798.10        107335-107437       c
            883-996             AC060798.10        105010-105123       c
            997-1127            AC060798.10        97550-97680         c
            1128-1301           AC060798.10        97130-97303         c
            1302-1528           AC060798.10        93018-93244         c
            1529-1654           AC060798.10        90070-90195         c
            1655-1726           AC060798.10        83278-83349         c
            1727-1841           AC060798.10        83079-83193         c
            1842-1910           AC060798.10        80925-80993         c
            1911-2045           AC060798.10        79375-79509         c
            2046-2222           AC060798.10        77123-77299         c
            2223-2331           AC060798.10        75396-75504         c
            2332-2436           AC060798.10        70511-70615         c
            2437-2601           AC060798.10        66617-66781         c
            2602-2803           AC060798.10        63497-63698         c
            2804-2929           AC060798.10        60523-60648         c
            2930-3125           AC060798.10        57875-58070         c
            3126-3377           AC060798.10        55347-55598         c
            3378-3485           AC060798.10        54883-54990         c
            3486-3591           AC060798.10        54644-54749         c
            3592-3768           AC060798.10        53443-53619         c
            3769-6128           AC060798.10        50977-53336         c
FEATURES             Location/Qualifiers
     source          1..6128
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q23.2"
     gene            1..6128
                     /gene="INTS2"
                     /gene_synonym="INT2; KIAA1287"
                     /note="integrator complex subunit 2"
                     /db_xref="GeneID:57508"
                     /db_xref="HGNC:HGNC:29241"
                     /db_xref="MIM:611346"
     exon            1..329
                     /gene="INTS2"
                     /gene_synonym="INT2; KIAA1287"
                     /inference="alignment:Splign:2.1.0"
     exon            330..640
                     /gene="INTS2"
                     /gene_synonym="INT2; KIAA1287"
                     /inference="alignment:Splign:2.1.0"
     CDS             348..3938
                     /gene="INTS2"
                     /gene_synonym="INT2; KIAA1287"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /codon_start=1
                     /product="integrator complex subunit 2 isoform 2"
                     /protein_id="NP_001338624.2"
                     /db_xref="CCDS:CCDS82181.1"
                     /db_xref="GeneID:57508"
                     /db_xref="HGNC:HGNC:29241"
                     /db_xref="MIM:611346"
                     /translation="MTECTSLQFVSPFAFEAMQKVDVVCLASLSDPELRLLLPCLVRM
                     ALCAPADQSQSWAQDKKLILRLLSGVEAVNSIVALLSVDFHALEQDASKEQQLRHKLG
                     GGSGESILVSQLQHGLTLEFEHSDSPRRLRLVLSELLAIMNKVSESNGEFFFKSSELF
                     ESPVYLEEAADVLCILQAELPSLLPIVDVAEALLHVRNGAWFLCLLVANVPDSFNEVC
                     RGLIKNGERQDEESLGGRRRTDALRFLCKMNPSQALKVRGMVVEECHLPGLGVALTLD
                     HTKNEACEDGVSDLVCFVSGLLLGTNAKVRTWFGTFIRNGQQRKRETSSSVLWQMRRQ
                     LLLELMGILPTVRSTRIVEEADVDMEPNVSVYSGLKEEHVVKASALLRLYCALMGIAG
                     LKPTEEEAEQLLQLMTSRPPATPAGVRFVSLSFCMLLAFSTLVSTPEQEQLMVVWLSW
                     MIKEEAYFESTSGVSASFGEMLLLVAMYFHSNQLSAIIDLVCSTLGMKIVIKPSSLSR
                     MKTIFTQEIFTEQVVTAHAVRVPVTSNLSANITGFLPIHCIYQLLRSRSFTKHKVSIK
                     DWIYRQLCETSTPLHPQLLPLIDVYINSILTPASKSNPEATNQPVTEQEILNIFQGVI
                     GGDNIRLNQRFSITAQLLVLYYILSYEEALLANTKTLAAMQRKPKSYSSSLMDQIPIK
                     FLIRQAQGLQQELGGLHSALLRLLATNYPHLCIVDDWICEEEITGTDALLRRMLLTNN
                     AKNHSPKQLQEAFSAVPVNNTQVMQIIEHLTLLSASELIPYAEVLTSNMSQLLNSGVP
                     RRILQTVNKLWMVLNTVMPRRLWVMTVNALQPSIKFVRQQKYTQNDLMIDPLIVLRCD
                     QRVHRCPPLMDITLHMLNGYLLASKAYLSAHLKETEQDRPSQNNTIGLVGQTDAPEVT
                     REELKNALLAAQDSAAVQILLEICLPTEEEKANGVNPDSLLRNVQSVITTSAPNKGME
                     EGEDNLLCNLREVQCLICCLLHQMYIADPNIAKLVHFQGYPCELLPLTVAGIPSMHIC
                     LDFIPELIAQPELEKQIFAIQLLSHLCIQYALPKSLSVARLAVNVMGTLLTVLTQAKR
                     YAFFMPTLPSLVSFCRAFPPLYEDIMSLLIQIGQVCASDVATQTRDIDPIITRLQQIK
                     EKPSGWSQICKDSSYKNGSRDTGSMDPDVQLCHCIERTVIEIINMSVSGI"
     exon            641..779
                     /gene="INTS2"
                     /gene_synonym="INT2; KIAA1287"
                     /inference="alignment:Splign:2.1.0"
     exon            780..882
                     /gene="INTS2"
                     /gene_synonym="INT2; KIAA1287"
                     /inference="alignment:Splign:2.1.0"
     exon            883..996
                     /gene="INTS2"
                     /gene_synonym="INT2; KIAA1287"
                     /inference="alignment:Splign:2.1.0"
     exon            997..1127
                     /gene="INTS2"
                     /gene_synonym="INT2; KIAA1287"
                     /inference="alignment:Splign:2.1.0"
     exon            1128..1301
                     /gene="INTS2"
                     /gene_synonym="INT2; KIAA1287"
                     /inference="alignment:Splign:2.1.0"
     exon            1302..1528
                     /gene="INTS2"
                     /gene_synonym="INT2; KIAA1287"
                     /inference="alignment:Splign:2.1.0"
     exon            1529..1654
                     /gene="INTS2"
                     /gene_synonym="INT2; KIAA1287"
                     /inference="alignment:Splign:2.1.0"
     exon            1655..1726
                     /gene="INTS2"
                     /gene_synonym="INT2; KIAA1287"
                     /inference="alignment:Splign:2.1.0"
     exon            1727..1841
                     /gene="INTS2"
                     /gene_synonym="INT2; KIAA1287"
                     /inference="alignment:Splign:2.1.0"
     exon            1842..1910
                     /gene="INTS2"
                     /gene_synonym="INT2; KIAA1287"
                     /inference="alignment:Splign:2.1.0"
     exon            1911..2045
                     /gene="INTS2"
                     /gene_synonym="INT2; KIAA1287"
                     /inference="alignment:Splign:2.1.0"
     exon            2046..2222
                     /gene="INTS2"
                     /gene_synonym="INT2; KIAA1287"
                     /inference="alignment:Splign:2.1.0"
     exon            2223..2331
                     /gene="INTS2"
                     /gene_synonym="INT2; KIAA1287"
                     /inference="alignment:Splign:2.1.0"
     exon            2332..2436
                     /gene="INTS2"
                     /gene_synonym="INT2; KIAA1287"
                     /inference="alignment:Splign:2.1.0"
     exon            2437..2601
                     /gene="INTS2"
                     /gene_synonym="INT2; KIAA1287"
                     /inference="alignment:Splign:2.1.0"
     exon            2602..2803
                     /gene="INTS2"
                     /gene_synonym="INT2; KIAA1287"
                     /inference="alignment:Splign:2.1.0"
     exon            2804..2929
                     /gene="INTS2"
                     /gene_synonym="INT2; KIAA1287"
                     /inference="alignment:Splign:2.1.0"
     exon            2930..3125
                     /gene="INTS2"
                     /gene_synonym="INT2; KIAA1287"
                     /inference="alignment:Splign:2.1.0"
     exon            3126..3377
                     /gene="INTS2"
                     /gene_synonym="INT2; KIAA1287"
                     /inference="alignment:Splign:2.1.0"
     exon            3378..3485
                     /gene="INTS2"
                     /gene_synonym="INT2; KIAA1287"
                     /inference="alignment:Splign:2.1.0"
     exon            3486..3591
                     /gene="INTS2"
                     /gene_synonym="INT2; KIAA1287"
                     /inference="alignment:Splign:2.1.0"
     exon            3592..3768
                     /gene="INTS2"
                     /gene_synonym="INT2; KIAA1287"
                     /inference="alignment:Splign:2.1.0"
     exon            3769..6128
                     /gene="INTS2"
                     /gene_synonym="INT2; KIAA1287"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6099..6104
                     /regulatory_class="polyA_signal_sequence"
                     /gene="INTS2"
                     /gene_synonym="INT2; KIAA1287"
                     /note="hexamer: TATAAA"
     polyA_site      6128
                     /gene="INTS2"
                     /gene_synonym="INT2; KIAA1287"
                     /note="major polyA site"
ORIGIN      
        1 agaccagtac ggtggccgac gggagtcaga cgctggggat gaatgaaggt gctgggtgca
       61 ggttgaaaaa gtctcccgct tttccgttcc tacagtcccg gttctgcctt tgtgtggtgc
      121 ccccatcctt cccactttgt atcgacaacc cggttggtcc cggcgtctga gttcttggtg
      181 tccgagtcga ctcgaggcac aactagggtt tggggttccg gatatcgcct aggcccaaca
      241 tcggaccgcg ctctcgattt ctgccgcgtc ccgcctctag gacgcggagt ccgtgtgcgg
      301 ttccgtgagg ctggagggta gatcttaagg atcaacaaac agtaataatg actgaatgta
      361 caagtcttca gtttgtcagc ccttttgctt ttgaggcaat gcagaaggtg gatgttgttt
      421 gcctggcatc tttaagtgat ccagaattaa gacttcttct gccctgtttg gtacggatgg
      481 cactttgtgc acctgctgac cagagccaaa gctgggctca ggataagaaa ctcatccttc
      541 gccttctttc tggagtggaa gctgtcaact ccattgttgc attgttgtcc gtggactttc
      601 atgctttaga acaagatgcc agcaaagaac agcagcttag gcataaactt ggaggaggca
      661 gtggagagag catcctggta tcacagcttc agcatggact gacgttagag tttgaacaca
      721 gtgattcacc tcgtcgattg cgtcttgtgc ttagtgaact gttggcaatt atgaacaagg
      781 tgtctgagtc caacggagaa ttttttttca agtcttctga actttttgag agtccagtat
      841 atttggagga agctgcagat gtactttgta ttttacaagc agagctccct tccttgctcc
      901 ctatagttga tgtagctgaa gctttgctac atgttagaaa tggtgcctgg ttcttgtgtc
      961 tcttggtggc caatgttcct gatagtttta atgaagtttg taggggcctg ataaaaaatg
     1021 gagaacgaca agatgaagaa agtcttggag gaaggcgcag gacagatgcc ttacgcttct
     1081 tgtgtaaaat gaatccttct caggccctca aggtccgagg catggtggtg gaagaatgtc
     1141 acttgccagg ccttggtgtg gctttgacat tggatcatac taaaaatgaa gcttgtgagg
     1201 atggagtgag tgacttggtt tgttttgtaa gtggtttgct tcttggaaca aatgcgaaag
     1261 tccggacttg gtttggaact tttatccgaa atggacagca gagaaaaaga gagaccagca
     1321 gttctgtcct ttggcagatg agaaggcagc ttcttctgga gttgatgggc attcttccca
     1381 cagtaagaag cacccgaatt gtggaagaag ctgatgtgga tatggagccc aatgtgtctg
     1441 tgtattcggg gctgaaagaa gagcatgttg tgaaagccag tgcactctta cgtctgtact
     1501 gtgctttgat ggggatcgct ggactcaaac caactgaaga agaagctgag caattactgc
     1561 agttgatgac gagccgtcct cctgctacgc cagctggggt tcgctttgtt tcactttcct
     1621 tttgtatgct actggccttt tctacacttg tcagtacacc tgaacaggag cagctgatgg
     1681 tggtgtggct aagttggatg ataaaagaag aagcgtattt tgagagtact tcaggcgtct
     1741 ctgcttcttt tggggagatg ttattattgg tggctatgta ctttcacagc aaccagctta
     1801 gtgctatcat tgacttggtc tgttccactt tggggatgaa gattgtaatt aagccaagct
     1861 ccttgagcag gatgaagaca atcttcacac aggaaatttt tactgagcag gttgtcacag
     1921 ctcatgcagt tcgggtccct gtcaccagca acctgagtgc caacattact ggatttttgc
     1981 ctattcattg tatttaccag cttctcagga gccgttcctt taccaagcac aaagtgtcaa
     2041 taaaagattg gatttataga cagctgtgtg aaacctctac tccacttcat cctcaattac
     2101 ttcctttgat tgatgtgtac ataaattcta tacttactcc tgcgtcgaaa tctaatccag
     2161 aagccacaaa tcagccagtc acagaacagg agatactcaa tattttccaa ggagtcattg
     2221 ggggtgacaa catccgcctt aatcagcgtt tcagtatcac agcacagctt ttggtgctct
     2281 actatatact gtcttatgaa gaggctcttc tagcaaacac gaagacttta gctgccatgc
     2341 aaagaaagcc caaatcatat tcttcttctt taatggatca gattcctatc aaattcctta
     2401 ttcgacaggc tcaagggctg cagcaggagt tgggagggtt gcattcagct ttactacgtc
     2461 tccttgctac taactaccca catttatgta ttgtggatga ctggatttgt gaagaagaaa
     2521 tcacagggac tgatgccctg ctacggcgaa tgctcctgac taataatgct aaaaatcatt
     2581 ctcccaaaca actccaagaa gcattttcag ctgtcccagt aaataacaca caagtgatgc
     2641 agattataga acacttgact ctactctctg ccagtgaact tataccatat gcggaagtgt
     2701 taacatccaa tatgagccag ctattgaatt caggggttcc acggagaatt ctgcaaacag
     2761 tcaataaact atggatggtt cttaatactg tgatgcctag aaggctatgg gtaatgacgg
     2821 ttaatgcact tcagccttca ataaagtttg tacgacaaca aaagtatact cagaatgacc
     2881 tgatgataga tcctctcatt gtcctaaggt gtgatcagag ggttcacaga tgccccccac
     2941 tgatggatat taccctacac atgttgaatg gatatcttct tgcatctaaa gcctacctta
     3001 gtgctcatct gaaggaaaca gagcaagata ggccttccca gaataataca attggtttag
     3061 ttggacaaac tgatgctccg gaagttacca gggaagaatt gaaaaatgca ttactggccg
     3121 ctcaggatag tgcagctgtc cagattctct tagagatttg cctacctact gaagaggaga
     3181 aagcaaatgg tgtcaatcca gatagcttgt taagaaatgt tcaaagtgtt attaccacca
     3241 gcgctccaaa taagggaatg gaggaaggag aagacaattt gctctgtaac cttcgagaag
     3301 ttcagtgcct tatctgttgt ctcttgcacc aaatgtacat tgcagatccc aacattgcta
     3361 agcttgttca ctttcagggt tatccatgtg aacttttgcc tctgacggtc gcaggtattc
     3421 catctatgca catctgtcta gatttcatac ctgagcttat tgcacagcca gaacttgaga
     3481 aacagatatt tgctatccag ttgctttctc acttgtgtat acaatatgca ttaccaaagt
     3541 cacttagtgt ggctcgttta gctgtcaatg tcatgggaac tttgttaaca gttttaacac
     3601 aggctaagcg gtatgctttt tttatgccaa ctctgccaag tttggtctct ttttgtcgag
     3661 catttcctcc attgtatgag gatattatgt ctttgctgat ccaaataggg caagtttgtg
     3721 cctctgatgt tgccactcag acaagagaca ttgatccaat tattacacgt cttcaacaaa
     3781 taaaggagaa accaagtgga tggtctcaaa tctgtaaaga ttcatcttat aaaaatggat
     3841 ccagggacac tggaagcatg gatcctgatg tacagctctg tcactgtatt gaaagaacag
     3901 taattgaaat aataaatatg agtgttagtg gaatttaaaa caaaatttaa aacaacaaaa
     3961 agttgtttgc tgcatatacc caacatgaat ctgcatatta gtaacaactc taaactgaat
     4021 gggaacagta aagtattgtc ttggaatcac taaaacaatt caattcaaca tgagtatagt
     4081 ttagaacttt atgagaatta tgcttgcttg tttctgattg gcacatcttt ggatctactt
     4141 tgctgatatg tttctattgt agcagctgag cttttttttt ttccactggg aacacatgta
     4201 agaaactcat tattggaaag ggaatttggc cttgtattta gcttttgaag tgaagactgc
     4261 catgccttta atttcttata aaaatgagtc tgtgggtagc cctagtgttt attttaactg
     4321 tgagcttgta acagaatgtg acaaagatgc aaagatggga gaggaaaaaa gggtaaaggg
     4381 aaaggagaat taaggaaata ataggagtta aaaacacaag tagaaatctc aaagatttgc
     4441 agtgcaagta atagtaatgc aagttggaat tctagttctc aagaaagagt attgagaaga
     4501 cttttaaaaa ggcaagtagc ttttgtaaat gatttctgtg gaaatacaga tgaggattta
     4561 aagatttcac atatttgctt caatttttat taatatatga agccatatgt ttaaagagat
     4621 acttgaataa tttggaattt taagatactg gtgtaaaagt gtttacagaa acatctttgt
     4681 tcaaagaaga acctgagaga tctcatttag ttttatgttt taaatttatt tttataatgc
     4741 tttattaact tacctaatgc tcagaggggg gaaatatgta tcaaattaaa tgaaggtaga
     4801 gcaataaaac ccactggatt aaagagctct tggtttgtca tcaggattat aattcatatc
     4861 ttactttgag aagatctttg agtaagaaaa tgcagtgttt gaacctgagg aaaagttaaa
     4921 gtgtagaaaa tattgtcttg ccgaaggatt ttgcagtcct ctgtcagtaa cttccattga
     4981 ttaggcagac atattcaggt aaaccctaat cattaaaaaa aaattatcaa tgtagaaagt
     5041 aattcccttt tttctctctg agatatacct caatcacaca cttccccacc cccacttgaa
     5101 acagacctct tcacttgtgt tttttttttt tttttcctga ggtggagtct tcccctgttg
     5161 cccaggctgg agtgcagtgg gatgatcttg gctcactgca acttctgcca cctgggttca
     5221 agggattctc gtgcctcaac ctcctgagta gctgggactg caggcacgcg ccacctgtat
     5281 ttttgtattt ttagtaaaga cgggggtttg ccatgttgcc cagactggtt ttgaactcct
     5341 ggcctcaggt gatctgccca ccttggcctc ccaaagtgct gggattacag gtgtgagcca
     5401 ccgcacctgg ccagaccgct tcacttgtaa aagaaattag gctaataaga aggtgtagtt
     5461 tttgagaaat gaaatttaac tttagccttt tcactagtaa atagtcacat ctcattttct
     5521 tcctttgtaa aatggggtta ctactggccc tacctcatat tctatgagaa tgagtttgta
     5581 gctgtttcaa atcatgaagt gcatagtatc acatgtgata gaatatttat aactttttat
     5641 tagatgctta atgttcaatt aagtaatttt gatgtgaaaa ataaaagtaa taaaagtatc
     5701 ttaaaaatag cataagaatt ttcatatttt taaacaaggc agttttgtag tcccttaaga
     5761 ttaaatacaa ctgctccttt tttttttaaa ctgaggcctt gcgatatttt gtgtgaatag
     5821 atatgcccta ggagttcaga aaaagttaaa agtatgtttt ctaattaaat gcagtgcaca
     5881 ttcctggatc aatattcaaa gactggtcat aacctgctgt gttaaaataa tcacatatgc
     5941 tctttttcat cagatttgtt gatgatgtaa ataaaatgtg taaatatatt agtaaatgtt
     6001 aatattcatg tattttaagt taaggttata aaatttgtca caatgtgttt ttttattcaa
     6061 gtgaaaacag atgtgtgcag ctattttgaa tattggttta taaacattca tattctttat
     6121 caaacgaa
//
