LOCUS       NM_024067               2178 bp    mRNA    linear   PRI 18-NOV-2024
DEFINITION  Homo sapiens integrator complex subunit 15 (INTS15), transcript
            variant 1, mRNA.
ACCESSION   NM_024067
VERSION     NM_024067.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2178)
  AUTHORS   Lin,M.H., Jensen,M.K., Elrod,N.D., Chu,H.F., Haseley,M., Beam,A.C.,
            Huang,K.L., Chiang,W., Russell,W.K., Williams,K., Proschel,C.,
            Wagner,E.J. and Tong,L.
  TITLE     Cytoplasmic binding partners of the Integrator endonuclease INTS11
            and its paralog CPSF73 are required for their nuclear function
  JOURNAL   Mol Cell 84 (15), 2900-2917 (2024)
   PUBMED   39032490
REFERENCE   2  (bases 1 to 2178)
  AUTHORS   Azuma,N., Yokoi,T., Tanaka,T., Matsuzaka,E., Saida,Y., Nishina,S.,
            Terao,M., Takada,S., Fukami,M., Okamura,K., Maehara,K.,
            Yamasaki,T., Hirayama,J., Nishina,H., Handa,H. and Yamaguchi,Y.
  TITLE     Integrator complex subunit 15 controls mRNA splicing and is
            critical for eye development
  JOURNAL   Hum Mol Genet 32 (12), 2032-2045 (2023)
   PUBMED   36851842
  REMARK    GeneRIF: Integrator complex subunit 15 controls mRNA splicing and
            is critical for eye development.
REFERENCE   3  (bases 1 to 2178)
  AUTHORS   Drew,K., Wallingford,J.B. and Marcotte,E.M.
  TITLE     hu.MAP 2.0: integration of over 15,000 proteomic experiments builds
            a global compendium of human multiprotein assemblies
  JOURNAL   Mol Syst Biol 17 (5), e10016 (2021)
   PUBMED   33973408
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BI599533.1, AK056149.1, CA454040.1 and BM977018.1.
            
            On Nov 23, 2018 this sequence version replaced NM_024067.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.330641.1,
                                           SRR3476690.782506.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000344417.10/ ENSP00000340220.5
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-247               BI599533.1         6-252
            248-263             BI599533.1         254-269
            264-1558            AK056149.1         1-1295
            1559-1559           CA454040.1         723-723
            1560-2003           AK056149.1         1297-1740
            2004-2178           BM977018.1         18-192              c
FEATURES             Location/Qualifiers
     source          1..2178
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7p22.1"
     gene            1..2178
                     /gene="INTS15"
                     /gene_synonym="C7orf26"
                     /note="integrator complex subunit 15"
                     /db_xref="GeneID:79034"
                     /db_xref="HGNC:HGNC:21702"
     exon            1..455
                     /gene="INTS15"
                     /gene_synonym="C7orf26"
                     /inference="alignment:Splign:2.1.0"
     CDS             264..1613
                     /gene="INTS15"
                     /gene_synonym="C7orf26"
                     /note="isoform 1 is encoded by transcript variant 1;
                     uncharacterized protein C7orf26"
                     /codon_start=1
                     /product="integrator complex subunit 15 isoform 1"
                     /protein_id="NP_076972.2"
                     /db_xref="CCDS:CCDS5353.1"
                     /db_xref="GeneID:79034"
                     /db_xref="HGNC:HGNC:21702"
                     /translation="MSDIRHSLLRRDALSAAKEVLYHLDIYFSSQLQSAPLPIVDKGP
                     VELLEEFVFQVPKERSAQPKRLNSLQELQLLEIMCNYFQEQTKDSVRQIIFSSLFSPQ
                     GNKADDSRMSLLGKLVSMAVAVCRIPVLECAASWLQRTPVVYCVRLAKALVDDYCCLV
                     PGSIQTLKQIFSASPRFCCQFITSVTALYDLSSDDLIPPMDLLEMIVTWIFEDPRLIL
                     ITFLNTPIAANLPIGFLELTPLVGLIRWCVKAPLAYKRKKKPPLSNGHVSNKVTKDPG
                     VGMDRDSHLLYSKLHLSVLQVLMTLQLHLTEKNLYGRLGLILFDHMVPLVEEINRLAD
                     ELNPLNASQEIELSLDRLAQALQVAMASGALLCTRDDLRTLCSRLPHNNLLQLVISGP
                     VQQSPHAALPPGFYPHIHTPPLGYGAVPAHPAAHPALPTHPGHTFISGVTFPFRPIR"
     exon            456..677
                     /gene="INTS15"
                     /gene_synonym="C7orf26"
                     /inference="alignment:Splign:2.1.0"
     exon            678..843
                     /gene="INTS15"
                     /gene_synonym="C7orf26"
                     /inference="alignment:Splign:2.1.0"
     exon            844..1371
                     /gene="INTS15"
                     /gene_synonym="C7orf26"
                     /inference="alignment:Splign:2.1.0"
     exon            1372..1411
                     /gene="INTS15"
                     /gene_synonym="C7orf26"
                     /inference="alignment:Splign:2.1.0"
     exon            1412..2178
                     /gene="INTS15"
                     /gene_synonym="C7orf26"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2157..2162
                     /regulatory_class="polyA_signal_sequence"
                     /gene="INTS15"
                     /gene_synonym="C7orf26"
                     /note="hexamer: AATAAA"
     polyA_site      2178
                     /gene="INTS15"
                     /gene_synonym="C7orf26"
                     /note="major polyA site"
ORIGIN      
        1 attcggccgc tgttcggctg cgcggcggca gctcccggcg gctcctggcg gcgccgcagt
       61 cggaccttcg ggcgcctgct ggccggcggc agcagcgatg gccccctgag caggcaggga
      121 gcaggcggcg gcaggcgggc aagcgggcgg gtgccgcagc ccaggcccgg gtcgcgcctc
      181 tttgtttcca cgggtagcgg cgcagtcccg ggccccgggc ggaagtgaga cgcgctcggc
      241 gcgggggccg cggcggccgc accatgagcg acatccgcca ctcgctgctg cgccgcgatg
      301 cgctgagcgc cgccaaggag gtgttgtacc acctggacat ctacttcagc agccagctgc
      361 agagcgcgcc gctgcccatc gtggacaagg gccccgtgga gctgctggag gagttcgtgt
      421 tccaggtgcc caaggagcgc agcgcgcagc ccaagagact gaattccctt caggagcttc
      481 aacttcttga aatcatgtgc aattatttcc aggagcaaac caaggactct gttcggcaga
      541 ttattttttc atcccttttc agccctcaag ggaacaaagc cgatgacagc cggatgagct
      601 tgttgggaaa actggtctcc atggcggtgg ctgtgtgtcg aatcccggtg ttggagtgtg
      661 ctgcctcctg gcttcagcgg acgcccgtgg tttactgtgt gaggttagcc aaggcccttg
      721 tagatgacta ctgctgtttg gtgccgggat ccattcagac gctgaagcag atattcagtg
      781 ccagcccgag attctgctgc cagttcatca cctccgttac cgcgctctat gacctgtcat
      841 cagatgacct cattccacct atggacttgc ttgaaatgat tgtcacctgg atttttgagg
      901 acccaaggtt gattctcatc acttttttaa atactccgat tgcggccaat ctgccaatag
      961 gattcttaga gctcaccccg ctcgttggat tgatccgctg gtgcgtgaag gcacccctgg
     1021 cttataaaag gaaaaagaag ccccccttat ccaatggcca tgtcagcaac aaggtcacaa
     1081 aggacccggg cgtggggatg gacagagact cccacctctt gtactcaaaa ctccacctca
     1141 gcgtcctgca agtgctcatg acgctgcagc tgcacctgac cgagaagaat ctgtatgggc
     1201 gcctggggct gatcctcttc gaccacatgg tcccgctggt agaggagatc aacaggttgg
     1261 cggatgaact gaaccccctc aacgcctccc aggagattga gctctcgctg gaccggctgg
     1321 cgcaggctct gcaggtggcc atggcctcag gagctctgct gtgcacgaga gatgacctga
     1381 gaaccttgtg ctccaggctg ccccataata acctcctcca gctggtgatc tcgggtcccg
     1441 tgcagcagtc gcctcacgcc gcgctccccc cggggttcta cccccacatc cacacgcccc
     1501 cgctgggcta cggggctgtc ccggcccacc ccgccgccca ccccgccctg cccacgcatc
     1561 ccggccacac cttcatctcc ggcgtgacct ttcccttcag gcccatccgc taggctggcc
     1621 cgtgtgtgcc ttctgcgctc tcgctggacg aagcctttcg agatggaagg ggtggccgga
     1681 ctcccagaag agaacctcgg ggaaggggtc gggcagcccc tccccgccgg cagaaccgtc
     1741 ttggtgtcac ggagtccagg tgcttcccac ccggtcgcat tctttgacat gcagattgga
     1801 tggtggaggg aagagtccag cctctgccga gagcctgctg cgtgcatttt taaaagatgc
     1861 cgatcctggg agcctctgtt ctctgcgcat ttcagacaca gcctgtgtgg cgaggagtgt
     1921 gacggcagga gccacgggtg caagcccgtg tgtctggcct ctttcctcgt gaagacgatg
     1981 tgtccccgcc agaaaaagtg ggctccttct gcagccccgt gagctgagcc caggctgcgt
     2041 agtgaccaca agcttatgtg cagcactgct cagggaggct gtcaggaatt cccctcacct
     2101 cggaaaggaa cttctcagtt ttattggggg tgtctaaatt tcctttcata tgttcaaata
     2161 aatttttcta aacagtca
//
