LOCUS       NM_001394796            2304 bp    mRNA    linear   PRI 18-NOV-2024
DEFINITION  Homo sapiens integrator complex subunit 14 (INTS14), transcript
            variant 6, mRNA.
ACCESSION   NM_001394796
VERSION     NM_001394796.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2304)
  AUTHORS   Lin,M.H., Jensen,M.K., Elrod,N.D., Chu,H.F., Haseley,M., Beam,A.C.,
            Huang,K.L., Chiang,W., Russell,W.K., Williams,K., Proschel,C.,
            Wagner,E.J. and Tong,L.
  TITLE     Cytoplasmic binding partners of the Integrator endonuclease INTS11
            and its paralog CPSF73 are required for their nuclear function
  JOURNAL   Mol Cell 84 (15), 2900-2917 (2024)
   PUBMED   39032490
REFERENCE   2  (bases 1 to 2304)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 2304)
  AUTHORS   Pfleiderer,M.M. and Galej,W.P.
  TITLE     Structure of the catalytic core of the Integrator complex
  JOURNAL   Mol Cell 81 (6), 1246-1259 (2021)
   PUBMED   33548203
REFERENCE   4  (bases 1 to 2304)
  AUTHORS   Beckedorff,F., Blumenthal,E., daSilva,L.F., Aoi,Y., Cingaram,P.R.,
            Yue,J., Zhang,A., Dokaneheifard,S., Valencia,M.G., Gaidosh,G.,
            Shilatifard,A. and Shiekhattar,R.
  TITLE     The Human Integrator Complex Facilitates Transcriptional Elongation
            by Endonucleolytic Cleavage of Nascent Transcripts
  JOURNAL   Cell Rep 32 (3), 107917 (2020)
   PUBMED   32697989
REFERENCE   5  (bases 1 to 2304)
  AUTHORS   Sabath,K., Staubli,M.L., Marti,S., Leitner,A., Moes,M. and Jonas,S.
  TITLE     INTS10-INTS13-INTS14 form a functional module of Integrator that
            binds nucleic acids and the cleavage module
  JOURNAL   Nat Commun 11 (1), 3422 (2020)
   PUBMED   32647223
  REMARK    GeneRIF: INTS10-INTS13-INTS14 form a functional module of
            Integrator that binds nucleic acids and the cleavage module.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2304)
  AUTHORS   Hein,M.Y., Hubner,N.C., Poser,I., Cox,J., Nagaraj,N., Toyoda,Y.,
            Gak,I.A., Weisswange,I., Mansfeld,J., Buchholz,F., Hyman,A.A. and
            Mann,M.
  TITLE     A human interactome in three quantitative dimensions organized by
            stoichiometries and abundances
  JOURNAL   Cell 163 (3), 712-723 (2015)
   PUBMED   26496610
REFERENCE   7  (bases 1 to 2304)
  AUTHORS   Marcon,E., Ni,Z., Pu,S., Turinsky,A.L., Trimble,S.S., Olsen,J.B.,
            Silverman-Gavrila,R., Silverman-Gavrila,L., Phanse,S., Guo,H.,
            Zhong,G., Guo,X., Young,P., Bailey,S., Roudeva,D., Zhao,D.,
            Hewel,J., Li,J., Graslund,S., Paduch,M., Kossiakoff,A.A.,
            Lupien,M., Emili,A., Wodak,S.J. and Greenblatt,J.
  TITLE     Human-chromatin-related protein interactions identify a demethylase
            complex required for chromosome segregation
  JOURNAL   Cell Rep 8 (1), 297-310 (2014)
   PUBMED   24981860
REFERENCE   8  (bases 1 to 2304)
  AUTHORS   Kamatani,Y., Matsuda,K., Okada,Y., Kubo,M., Hosono,N., Daigo,Y.,
            Nakamura,Y. and Kamatani,N.
  TITLE     Genome-wide association study of hematological and biochemical
            traits in a Japanese population
  JOURNAL   Nat Genet 42 (3), 210-215 (2010)
   PUBMED   20139978
REFERENCE   9  (bases 1 to 2304)
  AUTHORS   Baillat,D., Hakimi,M.A., Naar,A.M., Shilatifard,A., Cooch,N. and
            Shiekhattar,R.
  TITLE     Integrator, a multiprotein mediator of small nuclear RNA
            processing, associates with the C-terminal repeat of RNA polymerase
            II
  JOURNAL   Cell 123 (2), 265-276 (2005)
   PUBMED   16239144
REFERENCE   10 (bases 1 to 2304)
  AUTHORS   Simpson,J.C., Wellenreuther,R., Poustka,A., Pepperkok,R. and
            Wiemann,S.
  TITLE     Systematic subcellular localization of novel proteins identified by
            large-scale cDNA sequencing
  JOURNAL   EMBO Rep 1 (3), 287-292 (2000)
   PUBMED   11256614
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC027220.10.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK027475.1, BC007991.2 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000313182.7/ ENSP00000326379.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-34                AC027220.10        62574-62607         c
            35-318              AC027220.10        58635-58918         c
            319-426             AC027220.10        56605-56712         c
            427-582             AC027220.10        51250-51405         c
            583-701             AC027220.10        50348-50466         c
            702-844             AC027220.10        49797-49939         c
            845-937             AC027220.10        47209-47301         c
            938-1082            AC027220.10        44904-45048         c
            1083-1216           AC027220.10        43074-43207         c
            1217-1335           AC027220.10        36246-36364         c
            1336-1401           AC027220.10        33430-33495         c
            1402-2304           AC027220.10        30233-31135         c
FEATURES             Location/Qualifiers
     source          1..2304
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q22.31"
     gene            1..2304
                     /gene="INTS14"
                     /gene_synonym="C15orf44; VWA9"
                     /note="integrator complex subunit 14"
                     /db_xref="GeneID:81556"
                     /db_xref="HGNC:HGNC:25372"
                     /db_xref="MIM:620878"
     exon            1..34
                     /gene="INTS14"
                     /gene_synonym="C15orf44; VWA9"
                     /inference="alignment:Splign:2.1.0"
     exon            35..318
                     /gene="INTS14"
                     /gene_synonym="C15orf44; VWA9"
                     /inference="alignment:Splign:2.1.0"
     CDS             97..1653
                     /gene="INTS14"
                     /gene_synonym="C15orf44; VWA9"
                     /note="isoform 2 is encoded by transcript variant 6;
                     UPF0464 protein C15orf44; von Willebrand factor A
                     domain-containing protein 9; von Willebrand factor A
                     domain containing 9"
                     /codon_start=1
                     /product="integrator complex subunit 14 isoform 2"
                     /protein_id="NP_001381725.1"
                     /db_xref="CCDS:CCDS10211.1"
                     /db_xref="GeneID:81556"
                     /db_xref="HGNC:HGNC:25372"
                     /db_xref="MIM:620878"
                     /translation="MPTVVVMDVSLSMTRPVSIEGSEEYQRKHLAAHGLTMLFEHMAT
                     NYKLEFTALVVFSSLWELMVPFTRDYNTLQEALSNMDDYDKTCLESALVGVCNIVQQE
                     WGGAIPCQVVLVTDGCLGIGRGSLRHSLATQNQRSESNRFPLPFPFPSKLYIMCMANL
                     EELQSTDSLECLERLIDLNNGEGQIFTIDGPLCLKNVQSMFGKLIDLAYTPFHAVLKC
                     GHLTADVQVFPRPEPFVVDEEIDPIPKVINTDLEIVGFIDIADISSPPVLSRHLVLPI
                     ALNKEGDEVGTGITDDNEDENSANQIAGKIPNFCVLLHGSLKVEGMVAIVQLGPEWHG
                     MLYSQADSKKKSNLMMSLFEPGPEPLPWLGKMAQLGPISDAKENPYGEDDNKSPFPLQ
                     PKNKRSYAQNVTVWIKPSGLQTDVQKILRNARKLPEKTQTFYKELNRLRKAALAFGFL
                     DLLKGVADMLERECTLLPETAHPDAAFQLTHAAQQLKLASTGTSEYAAYDQNITPLHT
                     DFSGSSTERI"
     exon            319..426
                     /gene="INTS14"
                     /gene_synonym="C15orf44; VWA9"
                     /inference="alignment:Splign:2.1.0"
     exon            427..582
                     /gene="INTS14"
                     /gene_synonym="C15orf44; VWA9"
                     /inference="alignment:Splign:2.1.0"
     exon            583..701
                     /gene="INTS14"
                     /gene_synonym="C15orf44; VWA9"
                     /inference="alignment:Splign:2.1.0"
     exon            702..844
                     /gene="INTS14"
                     /gene_synonym="C15orf44; VWA9"
                     /inference="alignment:Splign:2.1.0"
     exon            845..937
                     /gene="INTS14"
                     /gene_synonym="C15orf44; VWA9"
                     /inference="alignment:Splign:2.1.0"
     exon            938..1082
                     /gene="INTS14"
                     /gene_synonym="C15orf44; VWA9"
                     /inference="alignment:Splign:2.1.0"
     exon            1083..1216
                     /gene="INTS14"
                     /gene_synonym="C15orf44; VWA9"
                     /inference="alignment:Splign:2.1.0"
     exon            1217..1335
                     /gene="INTS14"
                     /gene_synonym="C15orf44; VWA9"
                     /inference="alignment:Splign:2.1.0"
     exon            1336..1401
                     /gene="INTS14"
                     /gene_synonym="C15orf44; VWA9"
                     /inference="alignment:Splign:2.1.0"
     exon            1402..2304
                     /gene="INTS14"
                     /gene_synonym="C15orf44; VWA9"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2258..2263
                     /regulatory_class="polyA_signal_sequence"
                     /gene="INTS14"
                     /gene_synonym="C15orf44; VWA9"
                     /note="hexamer: AATAAA"
     polyA_site      2283
                     /gene="INTS14"
                     /gene_synonym="C15orf44; VWA9"
                     /note="major polyA site"
     polyA_site      2304
                     /gene="INTS14"
                     /gene_synonym="C15orf44; VWA9"
ORIGIN      
        1 atgccgacgg actgtgtccg gcgatgggca cgggcatttc ttcgtttata gctgtctgtt
       61 tgcattctga ttgggaacac tgggatcatt ttcatcatgc cgacagtggt ggtaatggat
      121 gtatcccttt ccatgacccg acctgtgtct attgaggggt ccgaggaata ccagcgtaag
      181 cacctagcag cccatggttt aacgatgctg tttgagcaca tggccacaaa ttacaagctt
      241 gaatttacag cacttgtggt tttttcatca ctttgggagt tgatggtccc cttcacgaga
      301 gattataata ccctacagga agcactaagt aatatggatg attatgacaa aacctgcttg
      361 gagtctgcat tagttggtgt ttgcaatatc gttcagcaag aatggggtgg tgcaattcct
      421 tgccaggttg tcctggtgac agacggctgt cttggcattg gtagagggtc actgcgacat
      481 tccctagcca ctcaaaatca acgaagtgag agcaacaggt ttccactacc ttttcctttc
      541 ccatctaagt tatatatcat gtgcatggcg aatttggagg agctccagag caccgattcc
      601 ttggaatgcc ttgaacgtct catagattta aacaatggtg aagggcagat ttttactatt
      661 gatggccccc tgtgcttgaa gaatgtacag tctatgtttg gaaaactgat agatttggca
      721 tatacgcctt tccatgctgt tctcaagtgt ggccacctaa ctgctgatgt acaagtcttc
      781 cccaggccag aaccttttgt tgtagatgaa gaaattgatc ctatccctaa agtcattaac
      841 acagatttgg aaatagtggg atttattgat atagctgata tttcaagtcc cccagttctg
      901 tccagacatc tggtcttacc tatagcactt aacaaagaag gtgatgaggt gggtactggc
      961 atcactgatg acaatgaaga tgaaaattca gccaatcaga ttgcaggcaa aatacccaac
     1021 ttttgtgtcc tgctccatgg tagcctaaaa gtggaaggaa tggtagcgat tgttcaatta
     1081 ggtcctgaat ggcatggaat gctctactcc caagctgaca gcaagaagaa atcaaacctc
     1141 atgatgtctc tctttgagcc tggcccagaa cctctcccat ggctagggaa aatggcacag
     1201 ttgggtccta tttcagatgc taaagaaaac ccttatggcg aggatgacaa taagagtcca
     1261 ttccccctgc agcccaaaaa caaacgcagt tatgcccaga atgtgactgt ctggatcaaa
     1321 cccagcggcc tgcagacaga tgtacagaag attttaagaa atgcaaggaa actacctgaa
     1381 aaaacacaga cattctataa ggagctgaac cgtttgcgaa aggccgctct agcctttggt
     1441 ttcctggacc tgctgaaagg ggtggctgac atgctggaaa gggaatgcac actgctgcct
     1501 gagacagccc accctgatgc tgcattccag ctgacccatg ctgcccagca gctcaagctg
     1561 gccagtaccg gcacctctga gtatgccgct tatgaccaga acatcacacc tttgcacacg
     1621 gacttctctg ggagcagcac tgaaagaatt tgaaactgac ttttggagct ttccttcttt
     1681 tttcatttca actgaaaatg ctttaggtaa aaacctttcc agtatgttca cctctagaat
     1741 agccacccaa agaccttcct gaggctgcct cagaagcacc acttgctgtt ttgaatgact
     1801 ctactagtat gagaaggatg tgaaggtggt tggctggttg ggctttaact tcctgggatt
     1861 cataattttt aagcttggaa gatagctgct gttcccatga tgggcacatt tcctgagaag
     1921 cttgaatgac tgatgagcat agagcacccc tgccttcctc aggaaacctg accggcaggg
     1981 gctctctggc ttcctgaaag cttcacctct tccctcgttt atatctcaac tgtaagggca
     2041 ttttcaagct tctgttcatg gaatgagcaa ctcagactgt ctggagcttg ctgagtacaa
     2101 acacaccacc actaagtttc agaactttcc ttagaacttg ggcaaaatgt ggtggtaact
     2161 cttaagtgct tttggtatct cttgagattc taacttttaa agagcaacca ttaatgtgta
     2221 aaatgattcc tattattcaa ggtttttttt taatgaaaat aaaatatttg attttctaga
     2281 aaatggtttc actatgaaac taaa
//
