LOCUS       NM_018164               2634 bp    mRNA    linear   PRI 18-NOV-2024
DEFINITION  Homo sapiens integrator complex subunit 13 (INTS13), mRNA.
ACCESSION   NM_018164
VERSION     NM_018164.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2634)
  AUTHORS   Lin,M.H., Jensen,M.K., Elrod,N.D., Chu,H.F., Haseley,M., Beam,A.C.,
            Huang,K.L., Chiang,W., Russell,W.K., Williams,K., Proschel,C.,
            Wagner,E.J. and Tong,L.
  TITLE     Cytoplasmic binding partners of the Integrator endonuclease INTS11
            and its paralog CPSF73 are required for their nuclear function
  JOURNAL   Mol Cell 84 (15), 2900-2917 (2024)
   PUBMED   39032490
REFERENCE   2  (bases 1 to 2634)
  AUTHORS   Mascibroda,L.G., Shboul,M., Elrod,N.D., Colleaux,L., Hamamy,H.,
            Huang,K.L., Peart,N., Singh,M.K., Lee,H., Merriman,B., Jodoin,J.N.,
            Sitaram,P., Lee,L.A., Fathalla,R., Al-Rawashdeh,B., Ababneh,O.,
            El-Khateeb,M., Escande-Beillard,N., Nelson,S.F., Wu,Y., Tong,L.,
            Kenney,L.J., Roy,S., Russell,W.K., Amiel,J., Reversade,B. and
            Wagner,E.J.
  TITLE     INTS13 variants causing a recessive developmental ciliopathy
            disrupt assembly of the Integrator complex
  JOURNAL   Nat Commun 13 (1), 6054 (2022)
   PUBMED   36229431
  REMARK    GeneRIF: INTS13 variants causing a recessive developmental
            ciliopathy disrupt assembly of the Integrator complex.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2634)
  AUTHORS   Pfleiderer,M.M. and Galej,W.P.
  TITLE     Structure of the catalytic core of the Integrator complex
  JOURNAL   Mol Cell 81 (6), 1246-1259 (2021)
   PUBMED   33548203
REFERENCE   4  (bases 1 to 2634)
  AUTHORS   Beckedorff,F., Blumenthal,E., daSilva,L.F., Aoi,Y., Cingaram,P.R.,
            Yue,J., Zhang,A., Dokaneheifard,S., Valencia,M.G., Gaidosh,G.,
            Shilatifard,A. and Shiekhattar,R.
  TITLE     The Human Integrator Complex Facilitates Transcriptional Elongation
            by Endonucleolytic Cleavage of Nascent Transcripts
  JOURNAL   Cell Rep 32 (3), 107917 (2020)
   PUBMED   32697989
REFERENCE   5  (bases 1 to 2634)
  AUTHORS   Sabath,K., Staubli,M.L., Marti,S., Leitner,A., Moes,M. and Jonas,S.
  TITLE     INTS10-INTS13-INTS14 form a functional module of Integrator that
            binds nucleic acids and the cleavage module
  JOURNAL   Nat Commun 11 (1), 3422 (2020)
   PUBMED   32647223
  REMARK    GeneRIF: INTS10-INTS13-INTS14 form a functional module of
            Integrator that binds nucleic acids and the cleavage module.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2634)
  AUTHORS   Anderson,M.A., Jodoin,J.N., Lee,E., Hales,K.G., Hays,T.S. and
            Lee,L.A.
  TITLE     Asunder is a critical regulator of dynein-dynactin localization
            during Drosophila spermatogenesis
  JOURNAL   Mol Biol Cell 20 (11), 2709-2721 (2009)
   PUBMED   19357193
REFERENCE   7  (bases 1 to 2634)
  AUTHORS   Baillat,D., Hakimi,M.A., Naar,A.M., Shilatifard,A., Cooch,N. and
            Shiekhattar,R.
  TITLE     Integrator, a multiprotein mediator of small nuclear RNA
            processing, associates with the C-terminal repeat of RNA polymerase
            II
  JOURNAL   Cell 123 (2), 265-276 (2005)
   PUBMED   16239144
REFERENCE   8  (bases 1 to 2634)
  AUTHORS   Lee,L.A., Lee,E., Anderson,M.A., Vardy,L., Tahinci,E., Ali,S.M.,
            Kashevsky,H., Benasutti,M., Kirschner,M.W. and Orr-Weaver,T.L.
  TITLE     Drosophila genome-scale screen for PAN GU kinase substrates
            identifies Mat89Bb as a cell cycle regulator
  JOURNAL   Dev Cell 8 (3), 435-442 (2005)
   PUBMED   15737938
REFERENCE   9  (bases 1 to 2634)
  AUTHORS   Lee,S.Y., Obata,Y., Yoshida,M., Stockert,E., Williamson,B.,
            Jungbluth,A.A., Chen,Y.T., Old,L.J. and Scanlan,M.J.
  TITLE     Immunomic analysis of human sarcoma
  JOURNAL   Proc Natl Acad Sci U S A 100 (5), 2651-2656 (2003)
   PUBMED   12601173
REFERENCE   10 (bases 1 to 2634)
  AUTHORS   Bourdon,V., Naef,F., Rao,P.H., Reuter,V., Mok,S.C., Bosl,G.J.,
            Koul,S., Murty,V.V., Kucherlapati,R.S. and Chaganti,R.S.
  TITLE     Genomic and expression analysis of the 12p11-p12 amplicon using EST
            arrays identifies two novel amplified and overexpressed genes
  JOURNAL   Cancer Res 62 (21), 6218-6223 (2002)
   PUBMED   12414650
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB239903.1, BC008368.1 and BM684866.1.
            
            On Nov 23, 2018 this sequence version replaced NM_018164.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189658.142376.1, AK001499.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000261191.12/ ENSP00000261191.7
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-13                DB239903.1         341-353
            14-2631             BC008368.1         1-2618
            2632-2634           BM684866.1         15-17               c
FEATURES             Location/Qualifiers
     source          1..2634
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12p11.23"
     gene            1..2634
                     /gene="INTS13"
                     /gene_synonym="ASUN; C12orf11; GCT1; Mat89Bb; NET48;
                     SPATA30"
                     /note="integrator complex subunit 13"
                     /db_xref="GeneID:55726"
                     /db_xref="HGNC:HGNC:20174"
                     /db_xref="MIM:615079"
     exon            1..186
                     /gene="INTS13"
                     /gene_synonym="ASUN; C12orf11; GCT1; Mat89Bb; NET48;
                     SPATA30"
                     /inference="alignment:Splign:2.1.0"
     exon            187..422
                     /gene="INTS13"
                     /gene_synonym="ASUN; C12orf11; GCT1; Mat89Bb; NET48;
                     SPATA30"
                     /inference="alignment:Splign:2.1.0"
     CDS             198..2318
                     /gene="INTS13"
                     /gene_synonym="ASUN; C12orf11; GCT1; Mat89Bb; NET48;
                     SPATA30"
                     /note="cell cycle regulator Mat89Bb homolog; sarcoma
                     antigen NY-SAR-95; protein asunder homolog;
                     spermatogenesis associated 30; asunder, spermatogenesis
                     regulator homolog (Drosphila); germ cell tumor 1"
                     /codon_start=1
                     /product="integrator complex subunit 13"
                     /protein_id="NP_060634.2"
                     /db_xref="CCDS:CCDS8708.1"
                     /db_xref="GeneID:55726"
                     /db_xref="HGNC:HGNC:20174"
                     /db_xref="MIM:615079"
                     /translation="MKIFSESHKTVFVVDHCPYMAESCRQHVEFDMLVKNRTQGIIPL
                     APISKSLWTCSVESSMEYCRIMYDIFPFKKLVNFIVSDSGAHVLNSWTQEDQNLQELM
                     AALAAVGPPNPRADPECCSILHGLVAAVETLCKITEYQHEARTLLMENAERVGNRGRI
                     ICITNAKSDSHVRMLEDCVQETIHEHNKLAANSDHLMQIQKCELVLIHTYPVGEDSLV
                     SDRSKKELSPVLTSEVHSVRAGRHLATKLNILVQQHFDLASTTITNIPMKEEQHANTS
                     ANYDVELLHHKDAHVDFLKSGDSHLGGGSREGSFKETITLKWCTPRTNNIELHYCTGA
                     YRISPVDVNSRPSSCLTNFLLNGRSVLLEQPRKSGSKVISHMLSSHGGEIFLHVLSSS
                     RSILEDPPSISEGCGGRVTDYRITDFGEFMRENRLTPFLDPRYKIDGSLEVPLERAKD
                     QLEKHTRYWPMIISQTTIFNMQAVVPLASVIVKESLTEEDVLNCQKTIYNLVDMERKN
                     DPLPISTVGTRGKGPKRDEQYRIMWNELETLVRAHINNSEKHQRVLECLMACRSKPPE
                     EEERKKRGRKREDKEDKSEKAVKDYEQEKSWQDSERLKGILERGKEELAEAEIIKDSP
                     DSPEPPNKKPLVEMDETPQVEKSKGPVSLLSLWSNRINTANSRKHQEFAGRLNSVNNR
                     AELYQHLKEENGMETTENGKASRQ"
     exon            423..497
                     /gene="INTS13"
                     /gene_synonym="ASUN; C12orf11; GCT1; Mat89Bb; NET48;
                     SPATA30"
                     /inference="alignment:Splign:2.1.0"
     exon            498..700
                     /gene="INTS13"
                     /gene_synonym="ASUN; C12orf11; GCT1; Mat89Bb; NET48;
                     SPATA30"
                     /inference="alignment:Splign:2.1.0"
     exon            701..781
                     /gene="INTS13"
                     /gene_synonym="ASUN; C12orf11; GCT1; Mat89Bb; NET48;
                     SPATA30"
                     /inference="alignment:Splign:2.1.0"
     exon            782..872
                     /gene="INTS13"
                     /gene_synonym="ASUN; C12orf11; GCT1; Mat89Bb; NET48;
                     SPATA30"
                     /inference="alignment:Splign:2.1.0"
     exon            873..1001
                     /gene="INTS13"
                     /gene_synonym="ASUN; C12orf11; GCT1; Mat89Bb; NET48;
                     SPATA30"
                     /inference="alignment:Splign:2.1.0"
     exon            1002..1086
                     /gene="INTS13"
                     /gene_synonym="ASUN; C12orf11; GCT1; Mat89Bb; NET48;
                     SPATA30"
                     /inference="alignment:Splign:2.1.0"
     exon            1087..1176
                     /gene="INTS13"
                     /gene_synonym="ASUN; C12orf11; GCT1; Mat89Bb; NET48;
                     SPATA30"
                     /inference="alignment:Splign:2.1.0"
     exon            1177..1266
                     /gene="INTS13"
                     /gene_synonym="ASUN; C12orf11; GCT1; Mat89Bb; NET48;
                     SPATA30"
                     /inference="alignment:Splign:2.1.0"
     exon            1267..1445
                     /gene="INTS13"
                     /gene_synonym="ASUN; C12orf11; GCT1; Mat89Bb; NET48;
                     SPATA30"
                     /inference="alignment:Splign:2.1.0"
     exon            1446..1616
                     /gene="INTS13"
                     /gene_synonym="ASUN; C12orf11; GCT1; Mat89Bb; NET48;
                     SPATA30"
                     /inference="alignment:Splign:2.1.0"
     exon            1617..1771
                     /gene="INTS13"
                     /gene_synonym="ASUN; C12orf11; GCT1; Mat89Bb; NET48;
                     SPATA30"
                     /inference="alignment:Splign:2.1.0"
     exon            1772..2002
                     /gene="INTS13"
                     /gene_synonym="ASUN; C12orf11; GCT1; Mat89Bb; NET48;
                     SPATA30"
                     /inference="alignment:Splign:2.1.0"
     exon            2003..2142
                     /gene="INTS13"
                     /gene_synonym="ASUN; C12orf11; GCT1; Mat89Bb; NET48;
                     SPATA30"
                     /inference="alignment:Splign:2.1.0"
     exon            2143..2278
                     /gene="INTS13"
                     /gene_synonym="ASUN; C12orf11; GCT1; Mat89Bb; NET48;
                     SPATA30"
                     /inference="alignment:Splign:2.1.0"
     exon            2279..2634
                     /gene="INTS13"
                     /gene_synonym="ASUN; C12orf11; GCT1; Mat89Bb; NET48;
                     SPATA30"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2612..2617
                     /regulatory_class="polyA_signal_sequence"
                     /gene="INTS13"
                     /gene_synonym="ASUN; C12orf11; GCT1; Mat89Bb; NET48;
                     SPATA30"
                     /note="hexamer: ATTAAA"
     polyA_site      2634
                     /gene="INTS13"
                     /gene_synonym="ASUN; C12orf11; GCT1; Mat89Bb; NET48;
                     SPATA30"
                     /note="major polyA site"
ORIGIN      
        1 cctgctctta ggaagcctgg gaaggaccgg tgtgctagga gatgatcggg gaaagcatag
       61 tcccctgtct gtggcaccag acactcccga ctgtgcgctg actctccccg cccagccagc
      121 agccttttcc agagaggctg tggtccatag cctctgttcg ttttcactgc aggaccaggc
      181 acgaaagtta aaacaaaatg aagatttttt ctgaatctca taaaacagtg tttgttgtgg
      241 atcactgccc ttatatggca gaatcttgca ggcagcatgt cgagtttgat atgctggtga
      301 agaatagaac ccaaggaatc attcctttgg cccccatatc taaatcattg tggacttgct
      361 cagtagaatc ttccatggaa tattgtagaa taatgtatga tatatttcct ttcaaaaagc
      421 tggtgaattt tattgtgagt gactctggag cacatgtttt aaattcttgg actcaagaag
      481 accaaaattt acaggagcta atggcagcat tagccgctgt tgggcctcct aatcctcggg
      541 cagatccaga gtgctgcagt attctgcatg gccttgttgc agcagtggaa actctctgca
      601 aaattactga ataccaacat gaggctcgta ctctactcat ggagaatgca gaacgtgttg
      661 gaaatagagg acgaataatc tgtattacta atgcaaaaag tgatagtcat gtgcgaatgc
      721 ttgaagactg tgtccaggaa acgattcatg aacataacaa gcttgctgca aattcagatc
      781 atctcatgca gattcaaaaa tgtgagttgg tcttgatcca cacctaccca gttggtgaag
      841 acagccttgt atctgatcgt tctaaaaaag agttgtcccc ggttttaacc agtgaagttc
      901 atagtgttcg tgcaggacgg catcttgcta ccaaattgaa tattttagta cagcaacatt
      961 ttgacttggc ttcaactact attacaaata ttccaatgaa ggaagaacag catgctaaca
     1021 catctgccaa ttatgatgtg gagctacttc atcacaaaga tgcacatgta gatttcctga
     1081 aaagtggtga ttcgcatcta ggtggcggca gtcgagaagg ctcgtttaaa gaaacaataa
     1141 cattaaagtg gtgtacacca aggacaaata acattgaatt acactattgt actggagctt
     1201 atcggatttc acctgtagat gtaaatagta gaccttcctc ctgccttact aattttcttc
     1261 taaatggtcg ttctgtttta ttggaacaac cacgaaagtc aggttctaaa gtcattagtc
     1321 atatgcttag tagccatgga ggagagattt ttttgcacgt ccttagcagt tctcgatcca
     1381 ttctagaaga tccaccttca attagtgaag gatgtggagg aagagttaca gactaccgga
     1441 ttacagattt tggtgaattt atgagggaaa acagattaac tccttttcta gaccccagat
     1501 ataaaatcga tggaagtctt gaggtccctt tggaacgagc aaaagatcag ttagaaaaac
     1561 atacccgtta ctggcctatg atcatttcac aaaccaccat ttttaacatg caagcggtag
     1621 ttccattagc cagtgttatt gtgaaagaat ctctgacaga agaagatgtg ttaaactgtc
     1681 aaaaaacaat atacaactta gttgatatgg aaagaaaaaa tgatcctcta cctatttcca
     1741 cagttggtac aagaggaaag ggccctaaaa gagatgaaca ataccgtatc atgtggaatg
     1801 aattagaaac ccttgtcaga gcccatatca acaactcaga gaaacatcaa agagtcttgg
     1861 aatgtctgat ggcatgcagg agcaaacccc cagaagagga agaacgaaag aaacgaggaa
     1921 gaaagaggga agacaaagag gacaagtcag agaaagcagt gaaagattat gaacaggaaa
     1981 agtcttggca agactcagag agattaaaag gaatcttaga gcgtggaaaa gaagaattgg
     2041 ctgaagctga gattataaaa gattcgcctg attccccaga acctccaaac aaaaaacccc
     2101 ttgttgaaat ggatgaaact ccacaagtgg aaaaatcaaa agggccagtg tcgttattat
     2161 ccttgtggag taatagaatc aatactgcca attccagaaa acatcaggaa tttgctggac
     2221 gtttgaactc tgttaataac agagctgaac tatatcaaca tcttaaagag gaaaatggga
     2281 tggagacaac agaaaatgga aaagccagcc ggcagtgaag agtgacttga agaactaaat
     2341 ttagcatatt gcaaaaatat tttgtgcgga attcgatata agtactttta cagcaagatg
     2401 gtatagttat gttgcctgga ctggttttta catttttaaa atatttcagc tgtcattttt
     2461 gtactaatta taaaattggc acataattca aaaatataca tttgagatga tttgtcctcc
     2521 caaattatac aagtttattt tatggtataa agtgttctct ctggaaatgt ttttaaaaaa
     2581 attcttaggc ttctctttgc gaaataaaac tattaaaata tttgaaatgc aaaa
//
