LOCUS       NM_017871               2114 bp    mRNA    linear   PRI 18-NOV-2024
DEFINITION  Homo sapiens integrator complex subunit 11 (INTS11), transcript
            variant 2, mRNA.
ACCESSION   NM_017871
VERSION     NM_017871.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2114)
  AUTHORS   Lin,M.H., Jensen,M.K., Elrod,N.D., Chu,H.F., Haseley,M., Beam,A.C.,
            Huang,K.L., Chiang,W., Russell,W.K., Williams,K., Proschel,C.,
            Wagner,E.J. and Tong,L.
  TITLE     Cytoplasmic binding partners of the Integrator endonuclease INTS11
            and its paralog CPSF73 are required for their nuclear function
  JOURNAL   Mol Cell 84 (15), 2900-2917 (2024)
   PUBMED   39032490
REFERENCE   2  (bases 1 to 2114)
  AUTHORS   Eaton,J.D., Board,J., Davidson,L., Estell,C. and West,S.
  TITLE     Human promoter directionality is determined by transcriptional
            initiation and the opposing activities of INTS11 and CDK9
  JOURNAL   Elife 13, 92764 (2024)
   PUBMED   38976490
  REMARK    GeneRIF: Human promoter directionality is determined by
            transcriptional initiation and the opposing activities of INTS11
            and CDK9.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2114)
  AUTHORS   Kuang,H., Li,Y., Wang,Y., Shi,M., Duan,R., Xiao,Q., She,H., Liu,Y.,
            Liang,Q., Teng,Y., Zhou,M., Liang,D., Li,Z. and Wu,L.
  TITLE     A homozygous variant in INTS11 links mitosis and neurogenesis
            defects to a severe neurodevelopmental disorder
  JOURNAL   Cell Rep 42 (12), 113445 (2023)
   PUBMED   37980560
  REMARK    GeneRIF: A homozygous variant in INTS11 links mitosis and
            neurogenesis defects to a severe neurodevelopmental disorder.
REFERENCE   4  (bases 1 to 2114)
  AUTHORS   Huang,J., Liu,X., Sun,Y., Li,Z., Lin,M.H., Hamilton,K.,
            Mandel,C.R., Sandmeir,F., Conti,E., Oyala,P.H. and Tong,L.
  TITLE     An examination of the metal ion content in the active sites of
            human endonucleases CPSF73 and INTS11
  JOURNAL   J Biol Chem 299 (4), 103047 (2023)
   PUBMED   36822327
  REMARK    GeneRIF: An examination of the metal ion content in the active
            sites of human endonucleases CPSF73 and INTS11.
REFERENCE   5  (bases 1 to 2114)
  AUTHORS   Lin,M.H., Jensen,M.K., Elrod,N.D., Huang,K.L., Welle,K.A.,
            Wagner,E.J. and Tong,L.
  TITLE     Inositol hexakisphosphate is required for Integrator function
  JOURNAL   Nat Commun 13 (1), 5742 (2022)
   PUBMED   36180473
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2114)
  AUTHORS   Bastos-Amador,P., Royo,F., Gonzalez,E., Conde-Vancells,J.,
            Palomo-Diez,L., Borras,F.E. and Falcon-Perez,J.M.
  TITLE     Proteomic analysis of microvesicles from plasma of healthy donors
            reveals high individual variability
  JOURNAL   J Proteomics 75 (12), 3574-3584 (2012)
   PUBMED   22516433
REFERENCE   7  (bases 1 to 2114)
  AUTHORS   Albrecht,T.R. and Wagner,E.J.
  TITLE     snRNA 3' end formation requires heterodimeric association of
            integrator subunits
  JOURNAL   Mol Cell Biol 32 (6), 1112-1123 (2012)
   PUBMED   22252320
  REMARK    GeneRIF: The specific heterodimeric interaction between IntS9 and
            IntS11 is mediated by a discrete domain present at the extreme C
            terminus of IntS9 and within the C terminus of IntS11, adjacent to
            the predicted active site of this endonuclease.
REFERENCE   8  (bases 1 to 2114)
  AUTHORS   Talmud,P.J., Drenos,F., Shah,S., Shah,T., Palmen,J., Verzilli,C.,
            Gaunt,T.R., Pallas,J., Lovering,R., Li,K., Casas,J.P., Sofat,R.,
            Kumari,M., Rodriguez,S., Johnson,T., Newhouse,S.J., Dominiczak,A.,
            Samani,N.J., Caulfield,M., Sever,P., Stanton,A., Shields,D.C.,
            Padmanabhan,S., Melander,O., Hastie,C., Delles,C., Ebrahim,S.,
            Marmot,M.G., Smith,G.D., Lawlor,D.A., Munroe,P.B., Day,I.N.,
            Kivimaki,M., Whittaker,J., Humphries,S.E. and Hingorani,A.D.
  CONSRTM   ASCOT investigators; NORDIL investigators; BRIGHT Consortium
  TITLE     Gene-centric association signals for lipids and apolipoproteins
            identified via the HumanCVD BeadChip
  JOURNAL   Am J Hum Genet 85 (5), 628-642 (2009)
   PUBMED   19913121
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   9  (bases 1 to 2114)
  AUTHORS   Baillat,D., Hakimi,M.A., Naar,A.M., Shilatifard,A., Cooch,N. and
            Shiekhattar,R.
  TITLE     Integrator, a multiprotein mediator of small nuclear RNA
            processing, associates with the C-terminal repeat of RNA polymerase
            II
  JOURNAL   Cell 123 (2), 265-276 (2005)
   PUBMED   16239144
REFERENCE   10 (bases 1 to 2114)
  AUTHORS   Dominski,Z., Yang,X.C., Purdy,M., Wagner,E.J. and Marzluff,W.F.
  TITLE     A CPSF-73 homologue is required for cell cycle progression but not
            cell growth and interacts with a protein having features of
            CPSF-100
  JOURNAL   Mol Cell Biol 25 (4), 1489-1500 (2005)
   PUBMED   15684398
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL136813.1, DC299993.1, AK023356.1 and AA687684.1.
            
            On Jun 3, 2019 this sequence version replaced NM_017871.5.
            
            Summary: The Integrator complex contains at least 12 subunits and
            associates with the C-terminal domain of RNA polymerase II large
            subunit (POLR2A; MIM 180660) and mediates the 3-prime end
            processing of small nuclear RNAs U1 (RNU1; MIM 180680) and U2
            (RNU2; MIM 180690). INTS11, or CPSF3L, is the catalytic subunit of
            the Integrator complex (Baillat et al., 2005 [PubMed
            16239144]).[supplied by OMIM, Mar 2008].
            
            Transcript Variant: This variant (2) lacks two alternate exons in
            the coding region which results in the use of an upstream start
            codon, compared to variant 1. The resulting protein (isoform 2) has
            a shorter and distinct N-terminus when it is compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AL136813.1, BK005728.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000435064.6/ ENSP00000413493.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-315               AL136813.1         7-321
            316-564             DC299993.1         327-575
            565-933             AL136813.1         571-939
            934-1789            AK023356.1         879-1734
            1790-2094           AL136813.1         1796-2100
            2095-2114           AA687684.1         28-47               c
FEATURES             Location/Qualifiers
     source          1..2114
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.33"
     gene            1..2114
                     /gene="INTS11"
                     /gene_synonym="CPSF3L; CPSF73L; INT11; NEDMLOB; PSF3L;
                     RC-68; RC68"
                     /note="integrator complex subunit 11"
                     /db_xref="GeneID:54973"
                     /db_xref="HGNC:HGNC:26052"
                     /db_xref="MIM:611354"
     exon            1..80
                     /gene="INTS11"
                     /gene_synonym="CPSF3L; CPSF73L; INT11; NEDMLOB; PSF3L;
                     RC-68; RC68"
                     /inference="alignment:Splign:2.1.0"
     CDS             53..1855
                     /gene="INTS11"
                     /gene_synonym="CPSF3L; CPSF73L; INT11; NEDMLOB; PSF3L;
                     RC-68; RC68"
                     /EC_number="3.1.27.-"
                     /note="isoform 2 is encoded by transcript variant 2;
                     related to CPSF subunits 68 kDa; CPSF3-like protein;
                     protein related to CPSF subunits of 68 kDa; cleavage and
                     polyadenylation-specific factor 3-like protein; cleavage
                     and polyadenylation specific factor 3-like"
                     /codon_start=1
                     /product="integrator complex subunit 11 isoform 2"
                     /protein_id="NP_060341.2"
                     /db_xref="CCDS:CCDS21.1"
                     /db_xref="GeneID:54973"
                     /db_xref="HGNC:HGNC:26052"
                     /db_xref="MIM:611354"
                     /translation="MPEIRVTPLGAGQDVGRSCILVSIAGKNVMLDCGMHMGFNDDRR
                     FPDFSYITQNGRLTDFLDCVIISHFHLDHCGALPYFSEMVGYDGPIYMTHPTQAICPI
                     LLEDYRKIAVDKKGEANFFTSQMIKDCMKKVVAVHLHQTVQVDDELEIKAYYAGHVLG
                     AAMFQIKVGSESVVYTGDYNMTPDRHLGAAWIDKCRPNLLITESTYATTIRDSKRCRE
                     RDFLKKVHETVERGGKVLIPVFALGRAQELCILLETFWERMNLKVPIYFSTGLTEKAN
                     HYYKLFIPWTNQKIRKTFVQRNMFEFKHIKAFDRAFADNPGPMVVFATPGMLHAGQSL
                     QIFRKWAGNEKNMVIMPGYCVQGTVGHKILSGQRKLEMEGRQVLEVKMQVEYMSFSAH
                     ADAKGIMQLVGQAEPESVLLVHGEAKKMEFLKQKIEQELRVNCYMPANGETVTLPTSP
                     SIPVGISLGLLKREMAQGLLPEAKKPRLLHGTLIMKDSNFRLVSSEQALKELGLAEHQ
                     LRFTCRVHLHDTRKEQETALRVYSHLKSVLKDHCVQHLPDGSVTVESVLLQAAAPSED
                     PGTKVLLVSWTYQDEELGSFLTSLLKKGLPQAPS"
     exon            81..178
                     /gene="INTS11"
                     /gene_synonym="CPSF3L; CPSF73L; INT11; NEDMLOB; PSF3L;
                     RC-68; RC68"
                     /inference="alignment:Splign:2.1.0"
     exon            179..252
                     /gene="INTS11"
                     /gene_synonym="CPSF3L; CPSF73L; INT11; NEDMLOB; PSF3L;
                     RC-68; RC68"
                     /inference="alignment:Splign:2.1.0"
     exon            253..481
                     /gene="INTS11"
                     /gene_synonym="CPSF3L; CPSF73L; INT11; NEDMLOB; PSF3L;
                     RC-68; RC68"
                     /inference="alignment:Splign:2.1.0"
     exon            482..580
                     /gene="INTS11"
                     /gene_synonym="CPSF3L; CPSF73L; INT11; NEDMLOB; PSF3L;
                     RC-68; RC68"
                     /inference="alignment:Splign:2.1.0"
     exon            581..615
                     /gene="INTS11"
                     /gene_synonym="CPSF3L; CPSF73L; INT11; NEDMLOB; PSF3L;
                     RC-68; RC68"
                     /inference="alignment:Splign:2.1.0"
     exon            616..754
                     /gene="INTS11"
                     /gene_synonym="CPSF3L; CPSF73L; INT11; NEDMLOB; PSF3L;
                     RC-68; RC68"
                     /inference="alignment:Splign:2.1.0"
     exon            755..819
                     /gene="INTS11"
                     /gene_synonym="CPSF3L; CPSF73L; INT11; NEDMLOB; PSF3L;
                     RC-68; RC68"
                     /inference="alignment:Splign:2.1.0"
     exon            820..1009
                     /gene="INTS11"
                     /gene_synonym="CPSF3L; CPSF73L; INT11; NEDMLOB; PSF3L;
                     RC-68; RC68"
                     /inference="alignment:Splign:2.1.0"
     exon            1010..1093
                     /gene="INTS11"
                     /gene_synonym="CPSF3L; CPSF73L; INT11; NEDMLOB; PSF3L;
                     RC-68; RC68"
                     /inference="alignment:Splign:2.1.0"
     exon            1094..1183
                     /gene="INTS11"
                     /gene_synonym="CPSF3L; CPSF73L; INT11; NEDMLOB; PSF3L;
                     RC-68; RC68"
                     /inference="alignment:Splign:2.1.0"
     exon            1184..1346
                     /gene="INTS11"
                     /gene_synonym="CPSF3L; CPSF73L; INT11; NEDMLOB; PSF3L;
                     RC-68; RC68"
                     /inference="alignment:Splign:2.1.0"
     exon            1347..1454
                     /gene="INTS11"
                     /gene_synonym="CPSF3L; CPSF73L; INT11; NEDMLOB; PSF3L;
                     RC-68; RC68"
                     /inference="alignment:Splign:2.1.0"
     exon            1455..1516
                     /gene="INTS11"
                     /gene_synonym="CPSF3L; CPSF73L; INT11; NEDMLOB; PSF3L;
                     RC-68; RC68"
                     /inference="alignment:Splign:2.1.0"
     exon            1517..1659
                     /gene="INTS11"
                     /gene_synonym="CPSF3L; CPSF73L; INT11; NEDMLOB; PSF3L;
                     RC-68; RC68"
                     /inference="alignment:Splign:2.1.0"
     exon            1660..1789
                     /gene="INTS11"
                     /gene_synonym="CPSF3L; CPSF73L; INT11; NEDMLOB; PSF3L;
                     RC-68; RC68"
                     /inference="alignment:Splign:2.1.0"
     exon            1790..2114
                     /gene="INTS11"
                     /gene_synonym="CPSF3L; CPSF73L; INT11; NEDMLOB; PSF3L;
                     RC-68; RC68"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2095..2100
                     /regulatory_class="polyA_signal_sequence"
                     /gene="INTS11"
                     /gene_synonym="CPSF3L; CPSF73L; INT11; NEDMLOB; PSF3L;
                     RC-68; RC68"
                     /note="hexamer: AGTAAA"
     polyA_site      2114
                     /gene="INTS11"
                     /gene_synonym="CPSF3L; CPSF73L; INT11; NEDMLOB; PSF3L;
                     RC-68; RC68"
                     /note="major polyA site"
ORIGIN      
        1 gcagtgcatc accgcaggcg ggcctcgcgg gtccgggagc gcggcggaga cgatgcctga
       61 gatcagagtc acgcccttgg gggccggcca ggacgtgggc cgaagctgca tcctggtctc
      121 cattgcgggc aagaatgtca tgctggactg tggaatgcac atgggcttca atgacgaccg
      181 acgcttccct gacttctcct acatcaccca gaacggccgc ctaacagact tcctggactg
      241 tgtgatcatt agccacttcc acctggacca ctgcggggca ctcccctact tcagcgagat
      301 ggtgggctac gacgggccca tctacatgac tcaccccacc caggccatct gccccatctt
      361 gctggaggac taccgcaaga tcgccgtaga caagaagggc gaggccaact tcttcacctc
      421 ccagatgatc aaagactgca tgaagaaggt ggtggctgtc cacctccacc agacggtcca
      481 ggtagatgat gagctggaga tcaaggccta ctatgcaggc cacgtgctgg gggcagccat
      541 gttccagatt aaagtgggct cagagtctgt ggtctacacg ggtgattata acatgacccc
      601 agaccgacac ttaggagctg cctggattga caagtgccgc cccaacctgc tcatcacaga
      661 gtccacgtac gccacgacca tccgtgactc caagcgctgc cgggagcgag acttcctgaa
      721 gaaagtccac gagaccgtgg agcgtggtgg gaaggtgctg atacctgtgt tcgcgctggg
      781 ccgcgcccag gagctctgca tcctcctgga gaccttctgg gagcgcatga acctgaaggt
      841 gcccatctac ttctccacgg ggctgaccga gaaggccaac cactactaca agctgttcat
      901 cccctggacc aaccagaaga tccgcaagac tttcgtgcag aggaacatgt ttgagttcaa
      961 gcacatcaag gccttcgacc gggcttttgc tgacaaccca ggaccgatgg ttgtgtttgc
     1021 cacgccagga atgctgcacg ctgggcagtc cctgcagatc ttccggaaat gggccggaaa
     1081 cgaaaagaac atggtcatca tgcccggcta ctgcgtgcag ggcaccgtcg gccacaagat
     1141 cctcagcggg cagcggaagc tcgagatgga ggggcggcag gtgctggagg tcaagatgca
     1201 ggtggagtac atgtcattca gcgcacacgc ggacgccaag ggcatcatgc agctggtggg
     1261 ccaggcagag ccggagagcg tgctgctggt gcatggcgag gccaagaaga tggagttcct
     1321 gaagcagaag atcgagcagg agctccgggt caactgctac atgccggcca atggcgagac
     1381 ggtgacgctg cccacaagcc ccagcatccc cgtaggcatc tcgctggggc tgctgaagcg
     1441 ggagatggcg caggggctgc tccctgaggc caagaagcct cggctcctgc acggcaccct
     1501 gatcatgaag gacagcaact tccggctggt gtcctcagag caagccctca aagagctggg
     1561 tctggctgag caccagctgc gcttcacctg ccgcgtgcac ctgcatgaca cacgcaagga
     1621 gcaggagacg gcattgcgcg tctacagcca cctcaagagc gtcctgaagg accactgtgt
     1681 gcagcacctc ccagacggct ctgtgactgt ggagtccgtc ctcctccagg ccgccgcccc
     1741 ttctgaggac ccaggcacca aggtgctgct ggtctcctgg acctaccagg acgaggagct
     1801 ggggagcttc ctcacatctc tgctgaagaa gggcctcccc caggccccca gctgaggccg
     1861 gcaactcacc cagccgccac ctctgccctc tcccagctgg acagaccctg ggcctgcact
     1921 tcaggactgt gggtgccctg ggtgaacaga ccctgcaggt cccatccctg gggacagagg
     1981 ccttgtgtca cctgcctgcc caggcagctg tttgcagctg aagaaacaaa ctggtctcca
     2041 ggctgtcttg cctttattcc tggttagggc aggtggtcct agacagcagt ttccagtaaa
     2101 agctgaacaa aaga
//
