LOCUS       NM_018142               2517 bp    mRNA    linear   PRI 18-NOV-2024
DEFINITION  Homo sapiens integrator complex subunit 10 (INTS10), transcript
            variant 7, mRNA.
ACCESSION   NM_018142
VERSION     NM_018142.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2517)
  AUTHORS   Lin,M.H., Jensen,M.K., Elrod,N.D., Chu,H.F., Haseley,M., Beam,A.C.,
            Huang,K.L., Chiang,W., Russell,W.K., Williams,K., Proschel,C.,
            Wagner,E.J. and Tong,L.
  TITLE     Cytoplasmic binding partners of the Integrator endonuclease INTS11
            and its paralog CPSF73 are required for their nuclear function
  JOURNAL   Mol Cell 84 (15), 2900-2917 (2024)
   PUBMED   39032490
REFERENCE   2  (bases 1 to 2517)
  AUTHORS   Wu,Y., Lin,Z., Luo,M., Yu,X., Chen,S. and Liu,L.
  TITLE     Effects of genetic polymorphisms in INTS10 and their interaction
            with environmental factors on progression from persistent HBV
            infection to hepatocellular carcinoma
  JOURNAL   Mol Carcinog 60 (9), 620-626 (2021)
   PUBMED   34133796
  REMARK    GeneRIF: Effects of genetic polymorphisms in INTS10 and their
            interaction with environmental factors on progression from
            persistent HBV infection to hepatocellular carcinoma.
REFERENCE   3  (bases 1 to 2517)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 2517)
  AUTHORS   Pfleiderer,M.M. and Galej,W.P.
  TITLE     Structure of the catalytic core of the Integrator complex
  JOURNAL   Mol Cell 81 (6), 1246-1259 (2021)
   PUBMED   33548203
REFERENCE   5  (bases 1 to 2517)
  AUTHORS   Beckedorff,F., Blumenthal,E., daSilva,L.F., Aoi,Y., Cingaram,P.R.,
            Yue,J., Zhang,A., Dokaneheifard,S., Valencia,M.G., Gaidosh,G.,
            Shilatifard,A. and Shiekhattar,R.
  TITLE     The Human Integrator Complex Facilitates Transcriptional Elongation
            by Endonucleolytic Cleavage of Nascent Transcripts
  JOURNAL   Cell Rep 32 (3), 107917 (2020)
   PUBMED   32697989
REFERENCE   6  (bases 1 to 2517)
  AUTHORS   Weissglas-Volkov,D., Aguilar-Salinas,C.A., Nikkola,E., Deere,K.A.,
            Cruz-Bautista,I., Arellano-Campos,O., Munoz-Hernandez,L.L.,
            Gomez-Munguia,L., Ordonez-Sanchez,M.L., Reddy,P.M., Lusis,A.J.,
            Matikainen,N., Taskinen,M.R., Riba,L., Cantor,R.M.,
            Sinsheimer,J.S., Tusie-Luna,T. and Pajukanta,P.
  TITLE     Genomic study in Mexicans identifies a new locus for triglycerides
            and refines European lipid loci
  JOURNAL   J Med Genet 50 (5), 298-308 (2013)
   PUBMED   23505323
REFERENCE   7  (bases 1 to 2517)
  AUTHORS   Ellinghaus,E., Stanulla,M., Richter,G., Ellinghaus,D., te
            Kronnie,G., Cario,G., Cazzaniga,G., Horstmann,M., Panzer
            Grumayer,R., Cave,H., Trka,J., Cinek,O., Teigler-Schlegel,A.,
            ElSharawy,A., Hasler,R., Nebel,A., Meissner,B., Bartram,T.,
            Lescai,F., Franceschi,C., Giordan,M., Nurnberg,P., Heinzow,B.,
            Zimmermann,M., Schreiber,S., Schrappe,M. and Franke,A.
  TITLE     Identification of germline susceptibility loci in
            ETV6-RUNX1-rearranged childhood acute lymphoblastic leukemia
  JOURNAL   Leukemia 26 (5), 902-909 (2012)
   PUBMED   22076464
REFERENCE   8  (bases 1 to 2517)
  AUTHORS   Kooner,J.S., Chambers,J.C., Aguilar-Salinas,C.A., Hinds,D.A.,
            Hyde,C.L., Warnes,G.R., Gomez Perez,F.J., Frazer,K.A., Elliott,P.,
            Scott,J., Milos,P.M., Cox,D.R. and Thompson,J.F.
  TITLE     Genome-wide scan identifies variation in MLXIPL associated with
            plasma triglycerides
  JOURNAL   Nat Genet 40 (2), 149-151 (2008)
   PUBMED   18193046
REFERENCE   9  (bases 1 to 2517)
  AUTHORS   Baillat,D., Hakimi,M.A., Naar,A.M., Shilatifard,A., Cooch,N. and
            Shiekhattar,R.
  TITLE     Integrator, a multiprotein mediator of small nuclear RNA
            processing, associates with the C-terminal repeat of RNA polymerase
            II
  JOURNAL   Cell 123 (2), 265-276 (2005)
   PUBMED   16239144
REFERENCE   10 (bases 1 to 2517)
  AUTHORS   Yuryev,A. and Wennogle,L.P.
  TITLE     Novel raf kinase protein-protein interactions found by an
            exhaustive yeast two-hybrid analysis
  JOURNAL   Genomics 81 (2), 112-125 (2003)
   PUBMED   12620389
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC107964.4.
            
            On Nov 22, 2018 this sequence version replaced NM_018142.3.
            
            Summary: INTS10 is a subunit of the Integrator complex, which
            associates with the C-terminal domain of RNA polymerase II large
            subunit (POLR2A; MIM 180660) and mediates 3-prime end processing of
            small nuclear RNAs U1 (RNU1; MIM 180680) and U2 (RNU2; MIM 180690)
            (Baillat et al., 2005 [PubMed 16239144]).[supplied by OMIM, Mar
            2008].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163658.285292.1,
                                           SRR1660807.148622.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000397977.8/ ENSP00000381064.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-251               AC107964.4         123888-124138       c
            252-319             AC107964.4         123212-123279       c
            320-423             AC107964.4         121878-121981       c
            424-563             AC107964.4         121036-121175       c
            564-645             AC107964.4         119034-119115       c
            646-786             AC107964.4         118113-118253       c
            787-958             AC107964.4         117510-117681       c
            959-1128            AC107964.4         116582-116751       c
            1129-1262           AC107964.4         114995-115128       c
            1263-1416           AC107964.4         110995-111148       c
            1417-1499           AC107964.4         109444-109526       c
            1500-1652           AC107964.4         108233-108385       c
            1653-1761           AC107964.4         104394-104502       c
            1762-1841           AC107964.4         98627-98706         c
            1842-2004           AC107964.4         97316-97478         c
            2005-2098           AC107964.4         95757-95850         c
            2099-2517           AC107964.4         89487-89905         c
FEATURES             Location/Qualifiers
     source          1..2517
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8p21.3"
     gene            1..2517
                     /gene="INTS10"
                     /gene_synonym="C8orf35; INT10"
                     /note="integrator complex subunit 10"
                     /db_xref="GeneID:55174"
                     /db_xref="HGNC:HGNC:25548"
                     /db_xref="MIM:611353"
     exon            1..251
                     /gene="INTS10"
                     /gene_synonym="C8orf35; INT10"
                     /inference="alignment:Splign:2.1.0"
     CDS             123..2255
                     /gene="INTS10"
                     /gene_synonym="C8orf35; INT10"
                     /note="isoform g is encoded by transcript variant 7"
                     /codon_start=1
                     /product="integrator complex subunit 10 isoform g"
                     /protein_id="NP_060612.2"
                     /db_xref="CCDS:CCDS6011.2"
                     /db_xref="GeneID:55174"
                     /db_xref="HGNC:HGNC:25548"
                     /db_xref="MIM:611353"
                     /translation="MSAQGDCEFLVQRARELVPQDLWAAKAWLITARSLYPADFNIQY
                     EMYTIERNAERTATAGRLLYDMFVNFPDQPVVWREISIITSALRNDSQDKQTQFLRSL
                     FETLPGRVQCEMLLKVTEQCFNTLERSEMLLLLLRRFPETVVQHGVGLGEALLEAETI
                     EEQESPVNCFRKLFVCDVLPLIINNHDVRLPANLLYKYLNKAAEFYINYVTRSTQIEN
                     QHQGAQDTSDLMSPSKRSSQKYIIEGLTEKSSQIVDPWERLFKILNVVGMRCEWQMDK
                     GRRSYGDILHRMKDLCRYMNNFDSEAHAKYKNQVVYSTMLVFFKNAFQYVNSIQPSLF
                     QGPNAPSQVPLVLLEDVSNVYGDVEIDRNKHIHKKRKLAEGREKTMSSDDEDCSAKGR
                     NRHIVVNKAELANSTEVLESFKLARESWELLYSLEFLDKEFTRICLAWKTDTWLWLRI
                     FLTDMIIYQGQYKKAIASLHHLAALQGSISQPQITGQGTLEHQRALIQLATCHFALGE
                     YRMTCEKVLDLMCYMVLPIQDGGKSQEEPSKVKPKFRKGSDLKLLPCTSKAIMPYCLH
                     LMLACFKLRAFTDNRDDMALGHVIVLLQQEWPRGENLFLKAVNKICQQGNFQYENFFN
                     YVTNIDMLEEFAYLRTQEGGKIHLELLPNQGMLIKHHTVTRGITKGVKEDFRLAMERQ
                     VSRCGENLMVVLHRFCINEKILLLQTLT"
     exon            252..319
                     /gene="INTS10"
                     /gene_synonym="C8orf35; INT10"
                     /inference="alignment:Splign:2.1.0"
     exon            320..423
                     /gene="INTS10"
                     /gene_synonym="C8orf35; INT10"
                     /inference="alignment:Splign:2.1.0"
     exon            424..563
                     /gene="INTS10"
                     /gene_synonym="C8orf35; INT10"
                     /inference="alignment:Splign:2.1.0"
     exon            564..645
                     /gene="INTS10"
                     /gene_synonym="C8orf35; INT10"
                     /inference="alignment:Splign:2.1.0"
     exon            646..786
                     /gene="INTS10"
                     /gene_synonym="C8orf35; INT10"
                     /inference="alignment:Splign:2.1.0"
     exon            787..958
                     /gene="INTS10"
                     /gene_synonym="C8orf35; INT10"
                     /inference="alignment:Splign:2.1.0"
     exon            959..1128
                     /gene="INTS10"
                     /gene_synonym="C8orf35; INT10"
                     /inference="alignment:Splign:2.1.0"
     exon            1129..1262
                     /gene="INTS10"
                     /gene_synonym="C8orf35; INT10"
                     /inference="alignment:Splign:2.1.0"
     exon            1263..1416
                     /gene="INTS10"
                     /gene_synonym="C8orf35; INT10"
                     /inference="alignment:Splign:2.1.0"
     exon            1417..1499
                     /gene="INTS10"
                     /gene_synonym="C8orf35; INT10"
                     /inference="alignment:Splign:2.1.0"
     exon            1500..1652
                     /gene="INTS10"
                     /gene_synonym="C8orf35; INT10"
                     /inference="alignment:Splign:2.1.0"
     exon            1653..1761
                     /gene="INTS10"
                     /gene_synonym="C8orf35; INT10"
                     /inference="alignment:Splign:2.1.0"
     exon            1762..1841
                     /gene="INTS10"
                     /gene_synonym="C8orf35; INT10"
                     /inference="alignment:Splign:2.1.0"
     exon            1842..2004
                     /gene="INTS10"
                     /gene_synonym="C8orf35; INT10"
                     /inference="alignment:Splign:2.1.0"
     exon            2005..2098
                     /gene="INTS10"
                     /gene_synonym="C8orf35; INT10"
                     /inference="alignment:Splign:2.1.0"
     exon            2099..2517
                     /gene="INTS10"
                     /gene_synonym="C8orf35; INT10"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2493..2498
                     /regulatory_class="polyA_signal_sequence"
                     /gene="INTS10"
                     /gene_synonym="C8orf35; INT10"
                     /note="hexamer: AATAAA"
     polyA_site      2517
                     /gene="INTS10"
                     /gene_synonym="C8orf35; INT10"
                     /note="major polyA site"
ORIGIN      
        1 agacatgcgc agtagcctcc cccgcggtgg cggcggcggc ggcggtggct gccgtggcgg
       61 ctgagagtcc agagccggac gttccggccg cttcgggctg gcggctggag agcgctcggg
      121 tcatgtctgc ccagggggac tgcgagttcc tggtgcagcg agcccgggag ttggtgccgc
      181 aagacctgtg ggcagccaag gcgtggctga tcacggcccg cagcctctac ccggcagact
      241 ttaacatcca gtatgagatg tacaccatcg agcggaatgc agagcggacc gccaccgccg
      301 ggaggctgct gtacgacatg tttgtgaatt tcccagacca gccggtggtg tggagagaaa
      361 tcagcattat tacatcagca ttaaggaacg attcacagga caaacaaacc caatttttaa
      421 gaagtttatt tgaaactctt cctggtcggg tccagtgtga aatgttacta aaggtcacgg
      481 aacaatgctt caacacgtta gaacgatcag aaatgttgct tctacttttg aggcgcttcc
      541 ctgaaacggt ggtgcagcat ggggttggcc ttggggaggc actattagag gctgaaacta
      601 ttgaagaaca agaatctcca gtgaactgct ttagaaaatt atttgtttgt gatgtccttc
      661 ctctaataat taacaaccat gatgttcgat tacctgccaa tttattgtat aagtacttga
      721 acaaagcagc tgaattttat atcaattatg tcactaggtc tactcaaata gaaaatcagc
      781 atcaaggcgc ccaggataca tctgatttaa tgtcacctag caaacgtagc tctcagaagt
      841 acataataga agggctgacg gaaaaatcat cccagatcgt ggacccttgg gagaggttgt
      901 ttaagatttt gaatgttgtt ggaatgagat gtgaatggca gatggataaa ggaagacgaa
      961 gctatggaga tattttgcat agaatgaagg atctctgcag atacatgaac aactttgata
     1021 gtgaagcaca tgcaaaatat aaaaaccaag tggtgtattc caccatgctg gtcttcttta
     1081 agaatgcatt ccagtatgtc aacagcatac agccatctct cttccaaggt cctaatgccc
     1141 cgagccaagt tccactggtt cttcttgaag atgtatcgaa tgtgtatggt gatgtagaaa
     1201 ttgatcgtaa taaacacatc cataaaaaga ggaaactagc tgaaggaaga gaaaaaacca
     1261 tgagttcaga cgatgaagac tgttcggcga aaggaagaaa tcgtcacatt gtagtcaata
     1321 aagccgaact tgctaactcc actgaagtgt tagaaagctt taaattggcc agggagagct
     1381 gggagttgct ctattcccta gaattccttg acaaagaatt tacaaggatt tgcttggcct
     1441 ggaagacgga tacttggctt tggttaagaa tcttcctcac tgatatgatc atctatcagg
     1501 gtcaatataa aaaggcgata gccagcctgc atcacttagc agctctccag ggatccattt
     1561 ctcagccaca gatcacaggg caggggaccc tggagcatca gagggcgctc atccagctgg
     1621 cgacgtgcca ctttgcgcta ggggagtaca gaatgacatg tgaaaaagtc cttgatttga
     1681 tgtgctacat ggtactcccc attcaagatg gaggcaaatc ccaggaggaa ccctcgaaag
     1741 taaagcccaa atttagaaaa ggttcggatc tgaagctcct gccttgtacc agcaaggcta
     1801 tcatgccata ctgcctccat ttaatgttag cctgttttaa gcttagagct ttcacagaca
     1861 acagagacga catggcattg gggcatgtga ttgtgttgct tcagcaagag tggccacggg
     1921 gcgagaatct tttcctgaaa gctgtcaata aaatttgcca acaaggaaat ttccaatatg
     1981 agaatttttt caattacgtt acaaatattg atatgctgga ggaatttgcc tacttgagaa
     2041 ctcaggaagg tgggaaaatt catctggaat tactacccaa tcaaggaatg ctgatcaagc
     2101 accacactgt aactcgaggc atcaccaaag gcgtgaagga ggactttcgc ctggccatgg
     2161 agcgccaggt ctcccgctgt ggagagaatc tgatggtggt tctgcacagg ttctgcatta
     2221 atgagaagat cttgctcctt cagactctga cctgagtgga gacctttcca ccagacacag
     2281 ctcgggcctg tgtaattgta ggagaagaca ctcagcagtg attgccatgg cacagagccg
     2341 tggtcattgt tgctgttaca aagaagaaaa ccatctgagt tctaactcct tggttgctta
     2401 aaagtagttc ccaagagtct gagaagctat ttctattttt aagagtcatt ttttgtaatt
     2461 tttgtaaaac aaaagtacca atctgttttg taaataaaaa tcatcctaaa atttgaa
//
