LOCUS       NM_001039762            4836 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens inhibitory synaptic factor 2A (INSYN2A), mRNA.
ACCESSION   NM_001039762 XM_927178 XM_942166
VERSION     NM_001039762.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4836)
  AUTHORS   Cherik,F., Lepage,M., Remerand,G., Francannet,C., Delabaere,A.,
            Salaun,G., Pebrel-Richard,C., Gouas,L., Vago,P., Tchirkov,A. and
            Goumy,C.
  TITLE     Further refining the critical region of 10q26 microdeletion
            syndrome: A possible involvement of INSYN2 and NPS in the cognitive
            phenotype
  JOURNAL   Eur J Med Genet 64 (9), 104287 (2021)
   PUBMED   34252586
  REMARK    GeneRIF: Further refining the critical region of 10q26
            microdeletion syndrome: A possible involvement of INSYN2 and NPS in
            the cognitive phenotype.
REFERENCE   2  (bases 1 to 4836)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 4836)
  AUTHORS   Uezu,A., Kanak,D.J., Bradshaw,T.W., Soderblom,E.J., Catavero,C.M.,
            Burette,A.C., Weinberg,R.J. and Soderling,S.H.
  TITLE     Identification of an elaborate complex mediating postsynaptic
            inhibition
  JOURNAL   Science 353 (6304), 1123-1129 (2016)
   PUBMED   27609886
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL390920.22, AK127465.1 and BC137112.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001039762.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK127465.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1968540,
                                           SAMEA1968832 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000522781.6/ ENSP00000429763.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-433               AL390920.22        85899-86331         c
            434-467             AK127465.1         1-34
            468-468             AL390920.22        85864-85864         c
            469-868             AK127465.1         36-435
            869-869             AL390920.22        66732-66732         c
            870-1027            BC137112.1         19-176
            1028-1028           AL390920.22        66097-66097         c
            1029-3786           BC137112.1         178-2935
            3787-4704           AL390920.22        25302-26219         c
            4705-4836           AK127465.1         4273-4404
FEATURES             Location/Qualifiers
     source          1..4836
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q26.2"
     gene            1..4836
                     /gene="INSYN2A"
                     /gene_synonym="C10orf141; FAM196A; INSYN2"
                     /note="inhibitory synaptic factor 2A"
                     /db_xref="GeneID:642938"
                     /db_xref="HGNC:HGNC:33859"
                     /db_xref="MIM:617129"
     exon            1..595
                     /gene="INSYN2A"
                     /gene_synonym="C10orf141; FAM196A; INSYN2"
                     /inference="alignment:Splign:2.1.0"
     exon            596..721
                     /gene="INSYN2A"
                     /gene_synonym="C10orf141; FAM196A; INSYN2"
                     /inference="alignment:Splign:2.1.0"
     exon            722..984
                     /gene="INSYN2A"
                     /gene_synonym="C10orf141; FAM196A; INSYN2"
                     /inference="alignment:Splign:2.1.0"
     exon            985..2173
                     /gene="INSYN2A"
                     /gene_synonym="C10orf141; FAM196A; INSYN2"
                     /inference="alignment:Splign:2.1.0"
     CDS             990..2429
                     /gene="INSYN2A"
                     /gene_synonym="C10orf141; FAM196A; INSYN2"
                     /note="protein FAM196A; inhibitory synaptic protein 2;
                     family with sequence similarity 196 member A"
                     /codon_start=1
                     /product="inhibitory synaptic factor 2A"
                     /protein_id="NP_001034851.1"
                     /db_xref="CCDS:CCDS31312.1"
                     /db_xref="GeneID:642938"
                     /db_xref="HGNC:HGNC:33859"
                     /db_xref="MIM:617129"
                     /translation="MVSKDTGKCILTTSESEVEPAACLALEMKYALDPNRQIKKRNKA
                     LQVRFKDICEAQNEQRDTQLSSGQLGEKREAKPVSCRAAYRKYMTVPARRSIPNVTKS
                     TGVQTSPDLKKCYQTFPLDRKKGNLKSLPAADPFKSQNNGFLTDAKEKNEAGPMEEAR
                     PCGAGRVHKTTALVFHSNQHMNTVDQPLGVNCTEPCKSPEPLSYGEAALQNSTRPPSE
                     EPDYQLLGRAKQDRGRPNSEEPAPPALRRVFKTEVATVYAPALSARAPEPGLSDSAAA
                     SQWSLCPADDERRRATHLNGLQAPSETALACSPPMQCLSPECSEQPSQTHTPPGLGNQ
                     PSPTAVAAGEECQRIVPHTEVVDLKAQLQMMENLISSSQETIKVLLGVIQELEKGEAH
                     REGLSYRTGQDTANCDTCRNSACIIYSVELDFKQQEDKLQPVLRKLHPIEETQVIPSP
                     YSQETYSSTPKQKSKTESKKHGRWKLWFL"
     exon            2174..2245
                     /gene="INSYN2A"
                     /gene_synonym="C10orf141; FAM196A; INSYN2"
                     /inference="alignment:Splign:2.1.0"
     exon            2246..4836
                     /gene="INSYN2A"
                     /gene_synonym="C10orf141; FAM196A; INSYN2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2581..2586
                     /regulatory_class="polyA_signal_sequence"
                     /gene="INSYN2A"
                     /gene_synonym="C10orf141; FAM196A; INSYN2"
                     /note="hexamer: AATAGA"
     polyA_site      2598
                     /gene="INSYN2A"
                     /gene_synonym="C10orf141; FAM196A; INSYN2"
                     /note="major polyA site"
     regulatory      4818..4823
                     /regulatory_class="polyA_signal_sequence"
                     /gene="INSYN2A"
                     /gene_synonym="C10orf141; FAM196A; INSYN2"
                     /note="hexamer: AATAAA"
     polyA_site      4836
                     /gene="INSYN2A"
                     /gene_synonym="C10orf141; FAM196A; INSYN2"
                     /note="major polyA site"
ORIGIN      
        1 ggggctccgc ccgcctcggt gccagccggg cgcacaggcg gcaggcgcgc ggcttggggc
       61 gccctcgcct ctggccgccc ggctccgcgg agtagctggg acctggagca gcggaaagga
      121 cttccctcct gctccctcct ctgccccgcc cccgcctcct ggccctggct ctgagatctc
      181 gccgaagaca attgcagtaa atgaggacat cggaggagcg cgaagccggg tggctgtggc
      241 tggctccgcc gcgtcgcgag caagcgagcg cgcgggcgtc cccggagctg gcccagccgc
      301 tgcctccccg cgcgcgtcgc taagcggggc cggagggacg cgagcgacgc gagctgcggc
      361 gcgggggccg gccgggccag cagggccggg ccggcagcgg tggagggggc gggcagcagg
      421 cgcgcagcgg gccaagtccc cggagccgag gcttcctccg cgtgagcgcg gcgagtctgg
      481 ccgcggatgc cctgtccgga gtgctccgtg ccgccccagg cttgccaggg tccgcagcga
      541 gacatgcccg agccaggcgc tgcatcgacc tcgacttatc tgtaagcagc ggaagatcct
      601 gaaggcacta actaaggtat ctccaggcaa ccaaggatct tacctctcac attgagaaaa
      661 accataactt cagagacatt tcctggctcc aaattcaagt cctttcagag acccctctac
      721 taattatttt ccagtaccac tctccatgga ataaaaggag ttgcaaacat ggcctttgta
      781 gatgcaggga aacccacgtt ccttttagag ctgatgttaa cccatgagaa gcgaccaccc
      841 ctcgacgact tctccttcac ggttcccacc caggagcacg gccaactctc ccccggaatc
      901 cataacggct cacgcaaata gatttctttc cgttcctcct cggagggctc tccacattta
      961 tctgctcgag acgtggcagc tccagaacca tggtcagtaa ggacaccggc aaatgcatac
     1021 tcacaacgtc ggagagtgaa gtggaacccg ccgcctgcct ggccctggag atgaaatacg
     1081 ccctggaccc caaccggcag attaaaaaac ggaacaaagc cctgcaggtg cggtttaagg
     1141 atatctgcga ggcacagaat gagcagaggg acacacagct gtcctcgggc cagctggggg
     1201 agaagcggga ggccaagccc gtgtcctgca gagcagccta ccgcaaatac atgacagtgc
     1261 ccgcacgcag gtccatcccc aacgtcacca agagcacagg cgtgcagacc tcgcccgacc
     1321 ttaagaagtg ttaccagacg ttccctctgg accgcaaaaa ggggaacctc aaaagcctcc
     1381 cagctgcaga tccctttaaa agccaaaaca atgggtttct aacagatgcg aaagagaaga
     1441 acgaggctgg acccatggag gaggcccggc catgtggcgc ggggcgggtg cacaagacca
     1501 cagccttggt tttccattcc aaccaacaca tgaacacagt ggaccagcct ttgggggtca
     1561 actgcacaga gccctgtaaa agcccggagc cgctcagcta tggagaagct gcgctccaaa
     1621 actccactcg gcctccatcc gaagagcccg attaccagct gctcgggagg gccaagcagg
     1681 accgggggag gccaaactcc gaggagcccg ctccacctgc cctcaggagg gtgtttaaaa
     1741 cggaggttgc caccgtttac gcacctgccc tcagtgccag ggcccccgag cctggtttgt
     1801 cagactctgc agccgccagc cagtggtcac tctgcccggc agatgacgag cggaggagag
     1861 ccacacatct caacgggctc caggcgccct cggaaactgc cctggcctgc tcacccccga
     1921 tgcagtgcct gtcccccgaa tgtagtgagc agccgtcgca gactcacacc ccgccggggc
     1981 tggggaacca gcctagtccc acagcggttg ctgcaggtga agaatgccaa cgaatcgtgc
     2041 ctcatacgga agtggtcgac ctcaaagcac aacttcagat gatggagaac ttgatcagtt
     2101 caagccaaga aaccatcaaa gtgctcttgg gggtcattca ggagttggaa aaaggagagg
     2161 cccatcggga agggctttca tatcggacgg ggcaagacac agctaattgt gacacatgca
     2221 ggaacagtgc atgtattatc tatagtgtgg agctggattt taagcagcaa gaagacaaac
     2281 tccagccggt tctaagaaaa ctccacccta ttgaggaaac tcaggtcata ccttcgcctt
     2341 actctcagga gacttactcc tcaactccca agcaaaaatc caaaactgaa tctaaaaagc
     2401 acggaagatg gaaactctgg ttcctttaac actcacggtg tctggagtct cgaggccgtc
     2461 tttagaaccc actggagttt aagtcaatac ttttccaaaa tgaataggat cgagggaact
     2521 gtggtgccca ttcaggcacc tcccacttct cgccctgcgt accaaaaagg cctttgtacc
     2581 aatagataat taacagaagc aaggtattct gtgtcactcc ttgccagctg ttctttgcag
     2641 ttcactgatg tgggatgtaa aatctgaaat gaaacttacg tagtcaaaga tgataagtaa
     2701 aaattttccc ccacccccga tctgcaagta atacattatc aacctgcgag atggcaggct
     2761 gtcaccctgt acacagctat aactcataat tattttcaag ccttgatttt ttttttaaat
     2821 aatgagaaga aaaagcaagc cttatgtttg cgaaggactt catttttatg tttcattttg
     2881 caaataagca gggggcgagt gcaattttca gcacatcaaa ttccggagaa agcacaattt
     2941 tttcaagtgg tcggagacca tgaataatct ctaaaatgtg actatatgta tatttgcctt
     3001 catgtgctat agcgctaagc caagtgacca catctcagtg tcacaacgac acctcaaatt
     3061 tagcatcctc ttcatctcca gacttacgac atgtttactg ctcattttcc aaatggccag
     3121 cagccaggag tcccccaaag tcaggatatg cctttaatca ctgcaagtag acagggtcag
     3181 agctattgga cactaagttt tcttagatct catttttaat cttttggtac ccaaaggcca
     3241 aataatacat tctggcaaga atctgagaac atacatagag atacacgatg gataatccac
     3301 ccaccaataa atcacaggca ttctgtgcca tggcagacag tgtttttgtg gatcgatcct
     3361 ccgagacact gttagccatg gtaagtgcag ccagacgtta tgtacaattc gttatgcttt
     3421 gtattaatgg tggaagccct gaccatctca aagagaaaca gtgcgtttag tttagctgct
     3481 accaagggac aatgtcgcct acatttaacc tattagtaag ttgtactaaa caacatactt
     3541 aggggaaagc tgtgaatcaa atgtttttag gtatttttta aatcaacagt aacacttaga
     3601 gttctctctt gattacacat tgcaatgtaa atcttagttc ctttattttt tcactcattt
     3661 ctttgcacct ttgcaagtat ctttttatag aaatcaaatc ccctagtcta ttaatgactt
     3721 tgtctatcaa ttttttgatt ttcacaatag gaagtaggga tcttactttg cctttttttt
     3781 tttttttgta caacttaaat tttgaatagt ttgtgagcat acaggaaaac ctagtcttga
     3841 agtttctgtc cagcagtttc acatctagtg gagtgctgac atgcacacct cattgactag
     3901 atgccaaaca cacagtggct aaccttggta aaaggatctc acctgctttt gtcagattgg
     3961 agctgcttct tgccatgtat tttcctcctg actcaacagc aaatctgttt tagttctaag
     4021 tgttttgatt ctacaaggac ctagtgatca gtaaccagat cgggccttga aaaaaaaatg
     4081 aagagtatgt cgtgtaaaca ttcttcgggg gccaaacaac actgcagttg tatgctttaa
     4141 tttaaaacac acatgtgcac acacacatcc tctgcggaaa cactatatga agttcgaatc
     4201 cctgaatatc aataaaagga actgagaaat attttggtgc aagaacaatg aggaagttga
     4261 tcctgtaaca tgaaggaagt gtaactgttt cacgtagact aaatatttaa aaatgggttt
     4321 catgtttttt atactgtttt taactaaagt tataaaaatg tttccaacaa gttctctctc
     4381 cttatgtttt aagaatccca actatctcag taaattgaaa taagggtatt agcagttttc
     4441 taattagtaa cacaaatctg tctaaacaag aggacatcct agtacacaaa ataatgtcac
     4501 tgtttcacac cagtctagac caaaaaaaaa taaaattaaa atgttcagag tcaaaaagga
     4561 acttctgaag ataaattaat tcatccctaa aaattaaagt gtgttcaaaa tagaaaaact
     4621 attgtcaaaa tcatttcata gtttaattgc aacacgtcac taacagatgg tgattcttct
     4681 cttggaaaga ttcaagtaaa aacgctgata caaaagcaag gtaaaacgca cagggttccc
     4741 ttatgtagat gtacacatgg cattgcatat agagattaaa ttattatact tgtcgttaag
     4801 ttctttatta atttttaaat aaaaaaatca aagatg
//
