LOCUS       NM_014215               5200 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens insulin receptor related receptor (INSRR), mRNA.
ACCESSION   NM_014215
VERSION     NM_014215.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5200)
  AUTHORS   Zhang,H., Bao,M., Liao,D., Zhang,Z., Tian,Z., Yang,E., Luo,P. and
            Jiang,X.
  TITLE     Identification of INSRR as an immune-related gene in the tumor
            microenvironment of glioblastoma by integrated bioinformatics
            analysis
  JOURNAL   Med Oncol 40 (6), 161 (2023)
   PUBMED   37099121
  REMARK    GeneRIF: Identification of INSRR as an immune-related gene in the
            tumor microenvironment of glioblastoma by integrated bioinformatics
            analysis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5200)
  AUTHORS   Salokas,K., Liu,X., Ohman,T., Chowdhury,I., Gawriyski,L.,
            Keskitalo,S. and Varjosalo,M.
  TITLE     Physical and functional interactome atlas of human receptor
            tyrosine kinases
  JOURNAL   EMBO Rep 23 (6), e54041 (2022)
   PUBMED   35384245
REFERENCE   3  (bases 1 to 5200)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 5200)
  AUTHORS   Goryashchenko,A.S., Mozhaev,A.A., Serova,O.V., Erokhina,T.N.,
            Orsa,A.N., Deyev,I.E. and Petrenko,A.G.
  TITLE     Probing Structure and Function of Alkali Sensor IRR with Monoclonal
            Antibodies
  JOURNAL   Biomolecules 10 (7), 1060 (2020)
   PUBMED   32708676
  REMARK    GeneRIF: Probing Structure and Function of Alkali Sensor IRR with
            Monoclonal Antibodies.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5200)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 5200)
  AUTHORS   Mathi,S.K., Chan,J. and Watt,V.M.
  TITLE     Insulin receptor-related receptor messenger ribonucleic acid:
            quantitative distribution and localization to subpopulations of
            epithelial cells in stomach and kidney
  JOURNAL   Endocrinology 136 (9), 4125-4132 (1995)
   PUBMED   7649121
REFERENCE   7  (bases 1 to 5200)
  AUTHORS   Kovacina,K.S. and Roth,R.A.
  TITLE     Characterization of the endogenous insulin receptor-related
            receptor in neuroblastomas
  JOURNAL   J Biol Chem 270 (4), 1881-1887 (1995)
   PUBMED   7829525
REFERENCE   8  (bases 1 to 5200)
  AUTHORS   Zhang,B. and Roth,R.A.
  TITLE     The insulin receptor-related receptor. Tissue expression, ligand
            binding specificity, and signaling capabilities
  JOURNAL   J Biol Chem 267 (26), 18320-18328 (1992)
   PUBMED   1326521
REFERENCE   9  (bases 1 to 5200)
  AUTHORS   Shier,P., Willard,H.F. and Watt,V.M.
  TITLE     Localization of the insulin receptor-related receptor gene to human
            chromosome 1
  JOURNAL   Cytogenet Cell Genet 54 (1-2), 80-81 (1990)
   PUBMED   2249481
REFERENCE   10 (bases 1 to 5200)
  AUTHORS   Shier,P. and Watt,V.M.
  TITLE     Primary structure of a putative receptor for a ligand of the
            insulin family
  JOURNAL   J Biol Chem 264 (25), 14605-14608 (1989)
   PUBMED   2768234
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL158169.17, AK310760.1 and J05046.1.
            
            On Nov 23, 2018 this sequence version replaced NM_014215.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000368195.4/ ENSP00000357178.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-197               AL158169.17        48949-49145         c
            198-698             AK310760.1         2-502
            699-4390            J05046.1           118-3809
            4391-5200           AL158169.17        30091-30900         c
FEATURES             Location/Qualifiers
     source          1..5200
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q23.1"
     gene            1..5200
                     /gene="INSRR"
                     /gene_synonym="IRR"
                     /note="insulin receptor related receptor"
                     /db_xref="GeneID:3645"
                     /db_xref="HGNC:HGNC:6093"
                     /db_xref="MIM:147671"
     exon            1..581
                     /gene="INSRR"
                     /gene_synonym="IRR"
                     /inference="alignment:Splign:2.1.0"
     CDS             497..4390
                     /gene="INSRR"
                     /gene_synonym="IRR"
                     /EC_number="2.7.10.1"
                     /note="IR-related receptor; insulin receptor-related
                     protein"
                     /codon_start=1
                     /product="insulin receptor-related protein precursor"
                     /protein_id="NP_055030.1"
                     /db_xref="CCDS:CCDS1160.1"
                     /db_xref="GeneID:3645"
                     /db_xref="HGNC:HGNC:6093"
                     /db_xref="MIM:147671"
                     /translation="MAVPSLWPWGACLPVIFLSLGFGLDTVEVCPSLDIRSEVAELRQ
                     LENCSVVEGHLQILLMFTATGEDFRGLSFPRLTQVTDYLLLFRVYGLESLRDLFPNLA
                     VIRGTRLFLGYALVIFEMPHLRDVALPALGAVLRGAVRVEKNQELCHLSTIDWGLLQP
                     APGANHIVGNKLGEECADVCPGVLGAAGEPCAKTTFSGHTDYRCWTSSHCQRVCPCPH
                     GMACTARGECCHTECLGGCSQPEDPRACVACRHLYFQGACLWACPPGTYQYESWRCVT
                     AERCASLHSVPGRASTFGIHQGSCLAQCPSGFTRNSSSIFCHKCEGLCPKECKVGTKT
                     IDSIQAAQDLVGCTHVEGSLILNLRQGYNLEPQLQHSLGLVETITGFLKIKHSFALVS
                     LGFFKNLKLIRGDAMVDGNYTLYVLDNQNLQQLGSWVAAGLTIPVGKIYFAFNPRLCL
                     EHIYRLEEVTGTRGRQNKAEINPRTNGDRAACQTRTLRFVSNVTEADRILLRWERYEP
                     LEARDLLSFIVYYKESPFQNATEHVGPDACGTQSWNLLDVELPLSRTQEPGVTLASLK
                     PWTQYAVFVRAITLTTEEDSPHQGAQSPIVYLRTLPAAPTVPQDVISTSNSSSHLLVR
                     WKPPTQRNGNLTYYLVLWQRLAEDGDLYLNDYCHRGLRLPTSNNDPRFDGEDGDPEAE
                     MESDCCPCQHPPPGQVLPPLEAQEASFQKKFENFLHNAITIPISPWKVTSINKSPQRD
                     SGRHRRAAGPLRLGGNSSDFEIQEDKVPRERAVLSGLRHFTEYRIDIHACNHAAHTVG
                     CSAATFVFARTMPHREADGIPGKVAWEASSKNSVLLRWLEPPDPNGLILKYEIKYRRL
                     GEEATVLCVSRLRYAKFGGVHLALLPPGNYSARVRATSLAGNGSWTDSVAFYILGPEE
                     EDAGGLHVLLTATPVGLTLLIVLAALGFFYGKKRNRTLYASVNPEYFSASDMYVPDEW
                     EVPREQISIIRELGQGSFGMVYEGLARGLEAGEESTPVALKTVNELASPRECIEFLKE
                     ASVMKAFKCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSHLRSLRPEAENNPGLPQPA
                     LGEMIQMAGEIADGMAYLAANKFVHRDLAARNCMVSQDFTVKIGDFGMTRDVYETDYY
                     RKGGKGLLPVRWMAPESLKDGIFTTHSDVWSFGVVLWEIVTLAEQPYQGLSNEQVLKF
                     VMDGGVLEELEGCPLQLQELMSRCWQPNPRLRPSFTHILDSIQEELRPSFRLLSFYYS
                     PECRGARGSLPTTDAEPDSSPTPRDCSPQNGGPGH"
     exon            582..1133
                     /gene="INSRR"
                     /gene_synonym="IRR"
                     /inference="alignment:Splign:2.1.0"
     exon            1134..1437
                     /gene="INSRR"
                     /gene_synonym="IRR"
                     /inference="alignment:Splign:2.1.0"
     exon            1438..1580
                     /gene="INSRR"
                     /gene_synonym="IRR"
                     /inference="alignment:Splign:2.1.0"
     exon            1581..1725
                     /gene="INSRR"
                     /gene_synonym="IRR"
                     /inference="alignment:Splign:2.1.0"
     exon            1726..1940
                     /gene="INSRR"
                     /gene_synonym="IRR"
                     /inference="alignment:Splign:2.1.0"
     exon            1941..2067
                     /gene="INSRR"
                     /gene_synonym="IRR"
                     /inference="alignment:Splign:2.1.0"
     exon            2068..2306
                     /gene="INSRR"
                     /gene_synonym="IRR"
                     /inference="alignment:Splign:2.1.0"
     exon            2307..2474
                     /gene="INSRR"
                     /gene_synonym="IRR"
                     /inference="alignment:Splign:2.1.0"
     exon            2475..2670
                     /gene="INSRR"
                     /gene_synonym="IRR"
                     /inference="alignment:Splign:2.1.0"
     exon            2671..2712
                     /gene="INSRR"
                     /gene_synonym="IRR"
                     /inference="alignment:Splign:2.1.0"
     exon            2713..2933
                     /gene="INSRR"
                     /gene_synonym="IRR"
                     /inference="alignment:Splign:2.1.0"
     exon            2934..3070
                     /gene="INSRR"
                     /gene_synonym="IRR"
                     /inference="alignment:Splign:2.1.0"
     exon            3071..3233
                     /gene="INSRR"
                     /gene_synonym="IRR"
                     /inference="alignment:Splign:2.1.0"
     exon            3234..3339
                     /gene="INSRR"
                     /gene_synonym="IRR"
                     /inference="alignment:Splign:2.1.0"
     exon            3340..3392
                     /gene="INSRR"
                     /gene_synonym="IRR"
                     /inference="alignment:Splign:2.1.0"
     exon            3393..3622
                     /gene="INSRR"
                     /gene_synonym="IRR"
                     /inference="alignment:Splign:2.1.0"
     exon            3623..3733
                     /gene="INSRR"
                     /gene_synonym="IRR"
                     /inference="alignment:Splign:2.1.0"
     exon            3734..3893
                     /gene="INSRR"
                     /gene_synonym="IRR"
                     /inference="alignment:Splign:2.1.0"
     exon            3894..4023
                     /gene="INSRR"
                     /gene_synonym="IRR"
                     /inference="alignment:Splign:2.1.0"
     exon            4024..4158
                     /gene="INSRR"
                     /gene_synonym="IRR"
                     /inference="alignment:Splign:2.1.0"
     exon            4159..5200
                     /gene="INSRR"
                     /gene_synonym="IRR"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5177..5182
                     /regulatory_class="polyA_signal_sequence"
                     /gene="INSRR"
                     /gene_synonym="IRR"
                     /note="hexamer: AATAAA"
     polyA_site      5200
                     /gene="INSRR"
                     /gene_synonym="IRR"
                     /note="major polyA site"
ORIGIN      
        1 gggaaggacc gcagccagca ctgtcagctg gcgctggggg gccgcgcgcc cggagggatc
       61 cagggagact ctccctgcgg agtcccacgc gccccgggac ccccgctgcc ctccttggga
      121 gcggtcccca gcctgctgct ccgccctcag ggttggctgg cctctcggcc tgccttttgc
      181 tcagaaccct gtgtcatttt ctccctctgg aggcccgaga ctctccctgt cactgtctgc
      241 atctctgtcc ccatctctca atctcatgct gagtctctct gtctccaact gcctgtcact
      301 gtctttgtgt ctctgtgact ctcatttctt tttttctgtc tcctgctgtc tctgtgtggg
      361 attccttgtc tctctgcccc tgccctccct ctcctatctg aaccctggtc tctgtgtccc
      421 ttagggctta tcacaccgtt ctccccagag tcaccgggag gagagccggg actggacaca
      481 agccagggct gggacaatgg cagtgcctag tctgtggccc tggggagcat gcctgcctgt
      541 gatcttcctc tccttgggat ttggcctgga tacagtagag gtgtgcccca gcctggatat
      601 tcgctcagag gtggcagagc ttcgtcagct ggagaactgc agcgtggtgg agggccacct
      661 gcagatcctg ctcatgttca cagccaccgg ggaggacttc cgcggcctca gcttccctcg
      721 cctcacccag gtcaccgact acctgctgct cttccgtgtc tacggactgg agagcctgcg
      781 cgacctcttc cccaacctag cagtcatccg cgggacgcgc ctcttcctgg gctatgcact
      841 ggtcatcttt gagatgccac atctgcgtga cgtggcactg cctgcacttg gggccgtgct
      901 gcgtggggct gtgcgtgtgg agaagaacca ggagctctgc cacctctcca ccattgactg
      961 gggactgctg cagccagcac ctggcgccaa ccacatcgtg ggcaacaagc tgggcgagga
     1021 gtgtgctgac gtgtgccctg gtgtgctggg tgctgctggt gagccctgtg ccaagaccac
     1081 cttcagcggg cacactgact acagatgctg gacctccagc cactgccaga gagtgtgccc
     1141 ctgcccccat gggatggctt gcacagcgag gggcgagtgc tgccacaccg aatgcctggg
     1201 gggctgcagc cagccagaag accctcgtgc ctgtgtagct tgccgccacc tctacttcca
     1261 gggtgcctgc ctgtgggcct gcccgccagg cacctaccag tatgagtcct ggcgctgtgt
     1321 cacagctgag cgctgtgcca gcctgcactc tgtgcccggc cgtgcctcca ccttcggcat
     1381 acaccagggc agttgcctgg cccagtgccc ttctggcttc acccgtaata gcagcagcat
     1441 attctgccac aagtgcgagg ggctgtgccc taaagagtgc aaggtaggca ccaagaccat
     1501 cgactccatc caggcggcac aggatcttgt gggctgcacg catgtggagg gaagcctcat
     1561 cctcaacctt cgccagggct acaacctgga gccacagctg cagcacagcc tggggctggt
     1621 agaaaccatt actggcttcc tcaaaatcaa gcactccttt gccctcgtgt ccctgggctt
     1681 tttcaagaac ctcaaactaa tccggggaga cgccatggtg gatgggaact acactctcta
     1741 cgtgctggac aaccagaacc tacaacagct agggtcctgg gtggccgcgg ggctcaccat
     1801 tcccgtgggc aagatctact tcgccttcaa cccgcgcctc tgcttggaac acatctaccg
     1861 actggaggag gtgacaggca cgcgaggtcg gcagaacaag gctgagatca acccccgcac
     1921 caacggagac cgcgccgcct gccagactcg caccctgcgc ttcgtgtcca acgtgacgga
     1981 ggcagaccgc atcctgctac gctgggagcg ctatgagcca ctggaggccc gcgacctgct
     2041 cagcttcatc gtgtactaca aggagtcccc attccagaac gccacagagc acgtgggtcc
     2101 agatgcttgt ggaacccaga gctggaacct gctggatgtg gagctgcccc taagccgcac
     2161 ccaggagcca ggggtgaccc tagcctccct caagccttgg acacagtacg cagtgtttgt
     2221 gcgggccatc acgctaacca ctgaggagga cagccctcat caaggagccc agagtcccat
     2281 cgtctacctc cgaacgctgc ctgcagctcc cacggtgccc caagacgtca tctccacgtc
     2341 caactcctcc tcccacctcc tggtgcgctg gaagccaccg acccagcgca atgggaacct
     2401 cacctactac ctggtgctgt ggcagcggct ggcagaggac ggcgacctct acctcaatga
     2461 ctactgccac cgcggcttgc ggctgcccac cagcaacaac gatccgcgct tcgacggcga
     2521 agacggggat cctgaggccg agatggagtc cgactgctgc ccttgccagc acccacctcc
     2581 tggtcaggtt ctgcccccgc tggaggcgca agaggcctcg ttccagaaga agtttgaaaa
     2641 ctttctacac aacgcgatca ccatccccat atccccttgg aaggtgacgt ccatcaacaa
     2701 gagcccccaa agggactcag ggcggcaccg ccgggcagct gggcccctcc ggctgggggg
     2761 caacagctcg gatttcgaga tccaggagga caaggtgccc cgtgagcgag cggtgctgag
     2821 cggcctgcgc cacttcacgg aataccggat cgacatccat gcctgcaacc acgcggcgca
     2881 caccgtgggc tgcagcgccg ccaccttcgt ctttgcgcgc accatgcccc acagagaggc
     2941 tgatggtatt ccaggaaagg tggcctggga ggcctccagc aagaacagtg tccttctgcg
     3001 ctggctcgag ccaccagacc ccaacggact catcctcaag tacgaaatca agtaccgccg
     3061 cttgggagag gaggccacag tgctgtgtgt gtcccgtctt cgatatgcga agtttggggg
     3121 agtccacctg gccctgctgc cccctggaaa ctactctgcc agggttaggg caacctcact
     3181 ggctggcaat ggctcttgga cagacagtgt tgccttctac atccttggcc cagaggagga
     3241 ggatgctggg gggctgcatg tcctcctcac tgccacccct gtggggctca cgctgctcat
     3301 cgttcttgct gcccttggtt tcttctacgg caagaagaga aacagaaccc tgtatgcttc
     3361 tgtgaatcca gagtacttca gcgcctctga tatgtatgtc cctgatgaat gggaggtgcc
     3421 tcgggagcag atctcgataa tccgggaact gggccagggc tcttttggga tggtatatga
     3481 ggggctggca cgaggacttg aggctggaga ggagtccaca cccgtggccc tgaagacggt
     3541 gaatgagctg gccagcccac gggaatgcat tgagttcctc aaggaagctt ctgtcatgaa
     3601 agccttcaag tgtcaccatg tggtgcgtct cctgggtgtg gtatctcagg gccagccaac
     3661 tctggtcatc atggagttaa tgacccgtgg ggacctcaag agccatcttc gatctttgcg
     3721 gcctgaggca gagaacaacc ctgggctccc acagccagca ttgggggaaa tgatccaaat
     3781 ggctggtgag attgcagacg gcatggccta ccttgctgcc aacaagtttg tgcaccgaga
     3841 tctagcagcc cgcaactgca tggtgtccca ggacttcacc gtcaagatcg gggacttcgg
     3901 gatgactcgg gacgtgtatg agacagacta ttaccgcaag ggtgggaagg ggctgctgcc
     3961 cgtgcgctgg atggcccccg agtccctcaa agatgggatc ttcaccaccc actcggatgt
     4021 ctggtccttt ggcgtggtac tctgggagat tgtgaccctg gcagaacaac cctaccaggg
     4081 cctgtccaat gagcaggtgc tgaagttcgt catggatggc ggggtcctgg aggagctgga
     4141 gggctgtccc cttcagctgc aggagctgat gagccgctgc tggcagccga acccacgcct
     4201 gcgcccatct ttcacacaca ttctggacag catacaggag gagctgcggc cctccttccg
     4261 cctcctctcc ttctactaca gcccggaatg ccggggggcc cggggctccc tgcctaccac
     4321 cgatgcagag cctgactcct cacccactcc aagagactgc agccctcaaa atgggggtcc
     4381 agggcactga ggggcacctc attccctggc tggcctccca tggggagaca ggaagggacc
     4441 cgacctctgt ggctgagacg cctgaatgtt cacccccacc ccaactcagg gcaagggatg
     4501 gccgagggtg gggcagagaa caggagcagg gaaggctgtg ggggtgggca gaggggtctc
     4561 accataggag tttctcagac tctgagtccc tcgggggaga gcaagcaggg tcaaagccag
     4621 aggagtagag atcaggtcag ggagagatgt cctgccctca gaggtaggga ccccactcag
     4681 actaggaaga gggggcccgc ccaccctaga ggccctgccc ctcagtttgg ggtctcctct
     4741 ggacaggtag ggccagcgac atgtttgaaa tcagatgagc aatcagaagc aggcctgggg
     4801 cgctctccat gcatgtatgg gaggggggtg gggctccaca tgactgcctt gcttgccact
     4861 ggtttcacct cctcccctca gctccactga ccaggtggca tggggagaac ccaggggcct
     4921 ggggagtggt tcccagcctg cccgccctca cctcctcctc tccttttgcc ctgcccaggg
     4981 ctccccaagc ttggtgctcc ttcctccttt tctccagggg catcccttgg agtacagtca
     5041 ccctttcttc agtccctccc ctcaatgatt agccctggat gcttaaggct ttcagagcct
     5101 catcttcctc cctcccctca ccctcaccca gccccgcccc cacccctgcc tctcatggga
     5161 agactggaga aggcacaata aatgctgagg cctgtttgta
//
