LOCUS       NM_000208               9463 bp    mRNA    linear   PRI 17-NOV-2024
DEFINITION  Homo sapiens insulin receptor (INSR), transcript variant 1, mRNA.
ACCESSION   NM_000208
VERSION     NM_000208.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 9463)
  AUTHORS   Rasheed,R.A., Rasheed,P.H. and Ali,A.M.
  TITLE     Metabolic and hormonal profiling in polycystic ovarian syndrome:
            insights into INSR gene variations
  JOURNAL   Mol Biol Rep 51 (1), 989 (2024)
   PUBMED   39287700
  REMARK    GeneRIF: Metabolic and hormonal profiling in polycystic ovarian
            syndrome: insights into INSR gene variations.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 9463)
  AUTHORS   Ciulei,G., Orasan,O.H., Cozma,A., Negrean,V., Para,I.,
            Ciumarnean,L., Leach,N., Lucaciu,R.L., Hangan,A.C. and
            Procopciuc,L.M.
  TITLE     Role of Vitamin D Receptor (BsmI-VDR) and Insulin Receptor
            (NsiI-A/G) Gene Polymorphisms in Colorectal Adenoma Susceptibility
  JOURNAL   Int J Mol Sci 25 (16), 8965 (2024)
   PUBMED   39201651
  REMARK    GeneRIF: Role of Vitamin D Receptor (BsmI-VDR) and Insulin Receptor
            (NsiI-A/G) Gene Polymorphisms in Colorectal Adenoma Susceptibility.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 9463)
  AUTHORS   Schwartz,L., Simoni,A., Yan,P., Salamon,K., Turkoglu,A., Vasquez
            Martinez,G., Zepeda-Orozco,D., Eichler,T., Wang,X. and Spencer,J.D.
  TITLE     Insulin receptor orchestrates kidney antibacterial defenses
  JOURNAL   Proc Natl Acad Sci U S A 121 (29), e2400666121 (2024)
   PUBMED   38976738
  REMARK    GeneRIF: Insulin receptor orchestrates kidney antibacterial
            defenses.
REFERENCE   4  (bases 1 to 9463)
  AUTHORS   Hubbard,S.R.
  TITLE     The insulin receptor: both a prototypical and atypical receptor
            tyrosine kinase
  JOURNAL   Cold Spring Harb Perspect Biol 5 (3), a008946 (2013)
   PUBMED   23457259
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 9463)
  AUTHORS   Mesika,A., Klar,A. and Falik Zaccai,T.C.
  TITLE     INSR-Related Severe Insulin Resistance Syndrome
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   29369573
REFERENCE   6  (bases 1 to 9463)
  AUTHORS   Gillis,D.
  TITLE     Nonsyndromic Genetic Hyperinsulinism Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301549
REFERENCE   7  (bases 1 to 9463)
  AUTHORS   Shekels,L.L., Smith,A.J., Van Etten,R.L. and Bernlohr,D.A.
  TITLE     Identification of the adipocyte acid phosphatase as a PAO-sensitive
            tyrosyl phosphatase
  JOURNAL   Protein Sci 1 (6), 710-721 (1992)
   PUBMED   1304913
REFERENCE   8  (bases 1 to 9463)
  AUTHORS   Cama,A., Quon,M.J., de la Luz Sierra,M. and Taylor,S.I.
  TITLE     Substitution of isoleucine for methionine at position 1153 in the
            beta-subunit of the human insulin receptor. A mutation that impairs
            receptor tyrosine kinase activity, receptor endocytosis, and
            insulin action
  JOURNAL   J Biol Chem 267 (12), 8383-8389 (1992)
   PUBMED   1314826
REFERENCE   9  (bases 1 to 9463)
  AUTHORS   Ullrich,A., Bell,J.R., Chen,E.Y., Herrera,R., Petruzzelli,L.M.,
            Dull,T.J., Gray,A., Coussens,L., Liao,Y.C., Tsubokawa,M. et al.
  TITLE     Human insulin receptor and its relationship to the tyrosine kinase
            family of oncogenes
  JOURNAL   Nature 313 (6005), 756-761 (1985)
   PUBMED   2983222
REFERENCE   10 (bases 1 to 9463)
  AUTHORS   Pedersen,O. and Beck-Nielsen,H.
  TITLE     A study of insulin receptors in human mononuclear leucocytes
  JOURNAL   Acta Endocrinol (Copenh) 83 (3), 556-564 (1976)
   PUBMED   185872
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC125387.2, HY015976.1,
            BC117172.1, M10051.1, X02160.1, AC010606.7, AK025527.1 and
            BU684722.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_000208.3.
            
            Summary: This gene encodes a member of the receptor tyrosine kinase
            family of proteins. The encoded preproprotein is proteolytically
            processed to generate alpha and beta subunits that form a
            heterotetrameric receptor. Binding of insulin or other ligands to
            this receptor activates the insulin signaling pathway, which
            regulates glucose uptake and release, as well as the synthesis and
            storage of carbohydrates, lipids and protein. Mutations in this
            gene underlie the inherited severe insulin resistance syndromes
            including type A insulin resistance syndrome, Donohue syndrome and
            Rabson-Mendenhall syndrome. Alternative splicing results in
            multiple transcript variants. [provided by RefSeq, Oct 2015].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (Long).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M10051.1, SRR14038194.2414418.1
                                           [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000302850.10/ ENSP00000303830.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-112               AC125387.2         90977-91088         c
            113-527             HY015976.1         2-416
            528-528             AC125387.2         90561-90561         c
            529-2754            BC117172.1         39-2264
            2755-4775           M10051.1           2370-4390
            4776-5337           X02160.1           4265-4826
            5338-5885           AC010606.7         8770-9317
            5886-7036           AK025527.1         83-1233
            7037-9108           AC010606.7         10469-12540
            9109-9463           BU684722.1         25-379              c
FEATURES             Location/Qualifiers
     source          1..9463
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.2"
     gene            1..9463
                     /gene="INSR"
                     /gene_synonym="CD220; HHF5"
                     /note="insulin receptor"
                     /db_xref="GeneID:3643"
                     /db_xref="HGNC:HGNC:6091"
                     /db_xref="MIM:147670"
     exon            1..623
                     /gene="INSR"
                     /gene_synonym="CD220; HHF5"
                     /inference="alignment:Splign:2.1.0"
     exon            624..1175
                     /gene="INSR"
                     /gene_synonym="CD220; HHF5"
                     /inference="alignment:Splign:2.1.0"
     exon            1176..1497
                     /gene="INSR"
                     /gene_synonym="CD220; HHF5"
                     /inference="alignment:Splign:2.1.0"
     exon            1498..1646
                     /gene="INSR"
                     /gene_synonym="CD220; HHF5"
                     /inference="alignment:Splign:2.1.0"
     exon            1647..1791
                     /gene="INSR"
                     /gene_synonym="CD220; HHF5"
                     /inference="alignment:Splign:2.1.0"
     exon            1792..2006
                     /gene="INSR"
                     /gene_synonym="CD220; HHF5"
                     /inference="alignment:Splign:2.1.0"
     exon            2007..2133
                     /gene="INSR"
                     /gene_synonym="CD220; HHF5"
                     /inference="alignment:Splign:2.1.0"
     exon            2134..2384
                     /gene="INSR"
                     /gene_synonym="CD220; HHF5"
                     /inference="alignment:Splign:2.1.0"
     exon            2385..2552
                     /gene="INSR"
                     /gene_synonym="CD220; HHF5"
                     /inference="alignment:Splign:2.1.0"
     exon            2553..2754
                     /gene="INSR"
                     /gene_synonym="CD220; HHF5"
                     /inference="alignment:Splign:2.1.0"
     exon            2755..2790
                     /gene="INSR"
                     /gene_synonym="CD220; HHF5"
                     /inference="alignment:Splign:2.1.0"
     exon            2791..3065
                     /gene="INSR"
                     /gene_synonym="CD220; HHF5"
                     /inference="alignment:Splign:2.1.0"
     exon            3066..3205
                     /gene="INSR"
                     /gene_synonym="CD220; HHF5"
                     /inference="alignment:Splign:2.1.0"
     exon            3206..3365
                     /gene="INSR"
                     /gene_synonym="CD220; HHF5"
                     /inference="alignment:Splign:2.1.0"
     exon            3366..3468
                     /gene="INSR"
                     /gene_synonym="CD220; HHF5"
                     /inference="alignment:Splign:2.1.0"
     exon            3469..3536
                     /gene="INSR"
                     /gene_synonym="CD220; HHF5"
                     /inference="alignment:Splign:2.1.0"
     exon            3537..3781
                     /gene="INSR"
                     /gene_synonym="CD220; HHF5"
                     /inference="alignment:Splign:2.1.0"
     exon            3782..3892
                     /gene="INSR"
                     /gene_synonym="CD220; HHF5"
                     /inference="alignment:Splign:2.1.0"
     exon            3893..4052
                     /gene="INSR"
                     /gene_synonym="CD220; HHF5"
                     /inference="alignment:Splign:2.1.0"
     exon            4053..4182
                     /gene="INSR"
                     /gene_synonym="CD220; HHF5"
                     /inference="alignment:Splign:2.1.0"
     exon            4183..4317
                     /gene="INSR"
                     /gene_synonym="CD220; HHF5"
                     /inference="alignment:Splign:2.1.0"
     exon            4318..9463
                     /gene="INSR"
                     /gene_synonym="CD220; HHF5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      9443..9448
                     /regulatory_class="polyA_signal_sequence"
                     /gene="INSR"
                     /gene_synonym="CD220; HHF5"
                     /note="hexamer: ATTAAA"
     polyA_site      9463
                     /gene="INSR"
                     /gene_synonym="CD220; HHF5"
                     /note="major polyA site"
ORIGIN      
        1 agatccgcgc cgccttttcc cgcggcccgc acggggccca gctgacgggc cgcgttgttt
       61 acgggcccga gcagccctct ctcccgccgc ccgcccgcca cccgccagcc caggtgcccg
      121 cccgccagtc agctagtccg tcggtccgcg cgtccctctg tcccggagcc cgcagatcgc
      181 gacccagagc gcgcggggcc gagagccgag agacagtccc gggcgcagcg cggagctccg
      241 ggccccgaga tcctgggacg gggcccgggc cgcagcggcc ggggggtcgg ggccaccacc
      301 gcaagggcct ccgctcagta tttgtagctg gcgaagccgc gcgcgccctt cccggggctg
      361 cctctgggcc ctccccggca ggggggctgc ggcccgcggg tcgcgggcgt ggaagagaag
      421 gacgcgcggc ccccagcgcc tcttgggtgg ccgcctcgga gcatgacccc cgcgggccag
      481 cgccgcgcgc tctgatccga ggagaccccg cgctcccgca gccatggcca ccgggggccg
      541 gcggggggcg gcggccgcgc cgctgctggt ggcggtggcc gcgctgctac tgggcgccgc
      601 gggccacctg taccccggag aggtgtgtcc cggcatggat atccggaaca acctcactag
      661 gttgcatgag ctggagaatt gctctgtcat cgaaggacac ttgcagatac tcttgatgtt
      721 caaaacgagg cccgaagatt tccgagacct cagtttcccc aaactcatca tgatcactga
      781 ttacttgctg ctcttccggg tctatgggct cgagagcctg aaggacctgt tccccaacct
      841 cacggtcatc cggggatcac gactgttctt taactacgcg ctggtcatct tcgagatggt
      901 tcacctcaag gaactcggcc tctacaacct gatgaacatc acccggggtt ctgtccgcat
      961 cgagaagaac aatgagctct gttacttggc cactatcgac tggtcccgta tcctggattc
     1021 cgtggaggat aattacatcg tgttgaacaa agatgacaac gaggagtgtg gagacatctg
     1081 tccgggtacc gcgaagggca agaccaactg ccccgccacc gtcatcaacg ggcagtttgt
     1141 cgaacgatgt tggactcata gtcactgcca gaaagtttgc ccgaccatct gtaagtcaca
     1201 cggctgcacc gccgaaggcc tctgttgcca cagcgagtgc ctgggcaact gttctcagcc
     1261 cgacgacccc accaagtgcg tggcctgccg caacttctac ctggacggca ggtgtgtgga
     1321 gacctgcccg cccccgtact accacttcca ggactggcgc tgtgtgaact tcagcttctg
     1381 ccaggacctg caccacaaat gcaagaactc gcggaggcag ggctgccacc agtacgtcat
     1441 tcacaacaac aagtgcatcc ctgagtgtcc ctccgggtac acgatgaatt ccagcaactt
     1501 gctgtgcacc ccatgcctgg gtccctgtcc caaggtgtgc cacctcctag aaggcgagaa
     1561 gaccatcgac tcggtgacgt ctgcccagga gctccgagga tgcaccgtca tcaacgggag
     1621 tctgatcatc aacattcgag gaggcaacaa tctggcagct gagctagaag ccaacctcgg
     1681 cctcattgaa gaaatttcag ggtatctaaa aatccgccga tcctacgctc tggtgtcact
     1741 ttccttcttc cggaagttac gtctgattcg aggagagacc ttggaaattg ggaactactc
     1801 cttctatgcc ttggacaacc agaacctaag gcagctctgg gactggagca aacacaacct
     1861 caccatcact caggggaaac tcttcttcca ctataacccc aaactctgct tgtcagaaat
     1921 ccacaagatg gaagaagttt caggaaccaa ggggcgccag gagagaaacg acattgccct
     1981 gaagaccaat ggggaccagg catcctgtga aaatgagtta cttaaatttt cttacattcg
     2041 gacatctttt gacaagatct tgctgagatg ggagccgtac tggccccccg acttccgaga
     2101 cctcttgggg ttcatgctgt tctacaaaga ggccccttat cagaatgtga cggagttcga
     2161 cgggcaggat gcgtgtggtt ccaacagttg gacggtggta gacattgacc cacccctgag
     2221 gtccaacgac cccaaatcac agaaccaccc agggtggctg atgcggggtc tcaagccctg
     2281 gacccagtat gccatctttg tgaagaccct ggtcaccttt tcggatgaac gccggaccta
     2341 tggggccaag agtgacatca tttatgtcca gacagatgcc accaacccct ctgtgcccct
     2401 ggatccaatc tcagtgtcta actcatcatc ccagattatt ctgaagtgga aaccaccctc
     2461 cgaccccaat ggcaacatca cccactacct ggttttctgg gagaggcagg cggaagacag
     2521 tgagctgttc gagctggatt attgcctcaa agggctgaag ctgccctcga ggacctggtc
     2581 tccaccattc gagtctgaag attctcagaa gcacaaccag agtgagtatg aggattcggc
     2641 cggcgaatgc tgctcctgtc caaagacaga ctctcagatc ctgaaggagc tggaggagtc
     2701 ctcgtttagg aagacgtttg aggattacct gcacaacgtg gttttcgtcc ccagaaaaac
     2761 ctcttcaggc actggtgccg aggaccctag gccatctcgg aaacgcaggt cccttggcga
     2821 tgttgggaat gtgacggtgg ccgtgcccac ggtggcagct ttccccaaca cttcctcgac
     2881 cagcgtgccc acgagtccgg aggagcacag gccttttgag aaggtggtga acaaggagtc
     2941 gctggtcatc tccggcttgc gacacttcac gggctatcgc atcgagctgc aggcttgcaa
     3001 ccaggacacc cctgaggaac ggtgcagtgt ggcagcctac gtcagtgcga ggaccatgcc
     3061 tgaagccaag gctgatgaca ttgttggccc tgtgacgcat gaaatctttg agaacaacgt
     3121 cgtccacttg atgtggcagg agccgaagga gcccaatggt ctgatcgtgc tgtatgaagt
     3181 gagttatcgg cgatatggtg atgaggagct gcatctctgc gtctcccgca agcacttcgc
     3241 tctggaacgg ggctgcaggc tgcgtgggct gtcaccgggg aactacagcg tgcgaatccg
     3301 ggccacctcc cttgcgggca acggctcttg gacggaaccc acctatttct acgtgacaga
     3361 ctatttagac gtcccgtcaa atattgcaaa aattatcatc ggccccctca tctttgtctt
     3421 tctcttcagt gttgtgattg gaagtattta tctattcctg agaaagaggc agccagatgg
     3481 gccgctggga ccgctttacg cttcttcaaa ccctgagtat ctcagtgcca gtgatgtgtt
     3541 tccatgctct gtgtacgtgc cggacgagtg ggaggtgtct cgagagaaga tcaccctcct
     3601 tcgagagctg gggcagggct ccttcggcat ggtgtatgag ggcaatgcca gggacatcat
     3661 caagggtgag gcagagaccc gcgtggcggt gaagacggtc aacgagtcag ccagtctccg
     3721 agagcggatt gagttcctca atgaggcctc ggtcatgaag ggcttcacct gccatcacgt
     3781 ggtgcgcctc ctgggagtgg tgtccaaggg ccagcccacg ctggtggtga tggagctgat
     3841 ggctcacgga gacctgaaga gctacctccg ttctctgcgg ccagaggctg agaataatcc
     3901 tggccgccct ccccctaccc ttcaagagat gattcagatg gcggcagaga ttgctgacgg
     3961 gatggcctac ctgaacgcca agaagtttgt gcatcgggac ctggcagcga gaaactgcat
     4021 ggtcgcccat gattttactg tcaaaattgg agactttgga atgaccagag acatctatga
     4081 aacggattac taccggaaag ggggcaaggg tctgctccct gtacggtgga tggcaccgga
     4141 gtccctgaag gatggggtct tcaccacttc ttctgacatg tggtcctttg gcgtggtcct
     4201 ttgggaaatc accagcttgg cagaacagcc ttaccaaggc ctgtctaatg aacaggtgtt
     4261 gaaatttgtc atggatggag ggtatctgga tcaacccgac aactgtccag agagagtcac
     4321 tgacctcatg cgcatgtgct ggcaattcaa ccccaagatg aggccaacct tcctggagat
     4381 tgtcaacctg ctcaaggacg acctgcaccc cagctttcca gaggtgtcgt tcttccacag
     4441 cgaggagaac aaggctcccg agagtgagga gctggagatg gagtttgagg acatggagaa
     4501 tgtgcccctg gaccgttcct cgcactgtca gagggaggag gcggggggcc gggatggagg
     4561 gtcctcgctg ggtttcaagc ggagctacga ggaacacatc ccttacacac acatgaacgg
     4621 aggcaagaaa aacgggcgga ttctgacctt gcctcggtcc aatccttcct aacagtgcct
     4681 accgtggcgg gggcgggcag gggttcccat tttcgctttc ctctggtttg aaagcctctg
     4741 gaaaactcag gattctcacg actctaccat gtccaatgga gttcagagat cgttcctata
     4801 catttctgtt catcttaagg tggactcgtt tggttaccaa tttaactagt cctgcagagg
     4861 atttaactgt gaacctggag ggcaaggggt ttccacagtt gctgctcctt tggggcaacg
     4921 acggtttcaa accaggattt tgtgtttttt cgttcccccc acccgccccc agcagatgga
     4981 aagaaagcac ctgtttttac aaattctttt tttttttttt tttttttgct ggtgtctgag
     5041 cttcagtata aaagacaaaa cttcctgttt gtggaacaaa agttcgaaag aaaaaacaaa
     5101 acaaaaacac ccagccctgt tccaggagaa tttcaagttt tacaggttga gcttcaagat
     5161 ggtttttttg gttttttttt tttctctcat ccaggctgaa ggattttttt tttctttaca
     5221 aaatgagttc ctcaaattga ccaatagctg ctgctttcat attttggata agggtctgtg
     5281 gtcccggcgt gtgctcacgt gtgtatgcac gtgtgtgtgt ccattagaca cggctgatgt
     5341 gtgtgcaaag tatccatgcg gagttgatgc tttgggaatt ggctcatgaa ggttcttctc
     5401 aagggtgcga gctcatcccc ctctctcctt ccttcttatt gactgggaga ctgtgctctc
     5461 gacagattct tcttgtgtca gaagtctagc ctcaggtttc taccctccct tcacattggt
     5521 ggccaaggga ggagcatttc atttggagtg attatgaatc ttttcaagac caaaccaagc
     5581 taggacatta aaaaaaaaaa aagaaaaaga aagaaaaaac aaaatggaaa aaggaaaaaa
     5641 aaaaagaact gagatgacag agttttgaga atatatttgt accatattta atttttaaag
     5701 tctctggtat tagcctcata agttattgac tattccccgg ggttggcggg gagtggggac
     5761 atgagttggt ctgcctgttg tggggccggg aaggggaggg agtcaggcac aagtggcctc
     5821 tttgtttggt cttaaaggca tccatttctg ggaatgaagc catgttcgct gctaacactt
     5881 ttggatgttg tgaggccacg tggagtgtgt gagagactag gttttatgga tggtctggtt
     5941 caggtaccag gtctgctgga aggttcctgt tcggataagc tggtagctac ctagctctga
     6001 gcctgccttc aagaacacct gtgttcatcc tctgattctc tgtgtgtacc tcttgtggcg
     6061 tttcctctcc cgggtgtgaa catcctaacc gttattgtgc aaacccaaga acgtcagatc
     6121 ccaaagcaca acaacctgga tggactttgg gaacatctaa gcaatgtaag agagaggtgc
     6181 actgagagta cgtcttggtc ccctccaccc tgagagcatc tgacggtcct cagtactgaa
     6241 ctcccggaag ctgctctgag cccggtgacc tcatctgggc caggtgtggt gcctgagctg
     6301 aatgctcagg tgcttacagt gttgcaatcc ctaagagagt agagtctgga ggagaaaccg
     6361 tgaaaaagac cttacacacc accaagaact tccgaatggg cgtgaatcca ccgtttcttc
     6421 tctttgcaaa aagaaccacc acagctgctc aaagaacaca gtgaactcat cactttggtt
     6481 catcaaaaaa tcatcgccca tgcgttattc ctgagtgcat tttcttacaa ctttttgact
     6541 gcttcctttt cttcttctct taagagttgt gggcttaaga atgggataga gtcataatgg
     6601 caacctccaa gccctctcaa ttcttgatta agaacacagg tagacatgaa tcccaattgt
     6661 ctattgctat cttatttata tgattcggga aaatacagca tgtaaaaata ttgctgagga
     6721 gcctcagtga ttgggtacaa gaagcaagag tacagaaatt atttttgcca aatttatttt
     6781 gtaaatatga gggtctgtac ctaaatttaa aaaaaaaaca cgtagaacta ggtattttgt
     6841 tctcttctta gtaaatttgt agtggttgta tactacacta gctgcaattt tcacattttt
     6901 ctaattcaga aaggtttttc ttatattagg ggaaaaagta tttattttaa tatataaaat
     6961 cactctgaaa atcactctca taaaaaatgg agcgcatgta aatttttatc aaagaaaaat
     7021 aaacaggtga atgggggata gtgattttct tttttcagca cagtctacct cagtgtattg
     7081 ttaagatgtg attcaatcat ggacatcttt gagatttcag aattctacct ggaaccggtc
     7141 tgaatcaggg aacgtgtgta tcagctgatt cgaatgccag ggaccagtaa gaattttgag
     7201 ggagggagtt gggatggaga aggtatggcc tttatgcgag catagatcct tttcttcctg
     7261 gctggtaata ttcttctctg aatttaatct tcctttaaaa aaaaatcctc catctattgt
     7321 cactatgttc cccaaacata aactaagttc caggctgtca tgatgtatct gatatatggg
     7381 gtaacccagc aaggtgtacc ttcctttggt gagagatggc tgccggggca aagacgggct
     7441 ttgattcaga gcaagcattc ccacctgttc catggaatcc ccctgaagtg agcacaaagg
     7501 tgccctgggc tccctgatgg tttatgccca ctcctttcag gctggtgatg caccttacac
     7561 acaaacacct aatgcaatgt ctttttaaat tctccaagtg ggatgggagc atgtgaggga
     7621 aattccaatc caaaacccat taatgtgctg aacgcttttt tttttttttt tttttttttt
     7681 gcaacaacac cttggacctc tgtgttgggg tttgactgac ctcaagctga tattattgga
     7741 ccttgtgcag ctttgataac ccatgtgaga gtctaggcag gaccagtggg gcccaaatct
     7801 tgctgctctt gtacttttag gcactgccct tgcagactca cctttctcca cctgccctgg
     7861 agaaaggtag ggtgtgctgg gcctgcccct tgcaaatggg attcaccagt ttcatttatt
     7921 tgactctact gccacagtga aaagagcaaa cagctattgg gttgcaaacc tcctttgaca
     7981 ttaggaaatg ttgactttgt aacaataaaa ctttggtcct agaaagacac ggttgtcctg
     8041 ggagtttgta gtgttaagtt gcaacaacaa caacaaaaag caacaaaacc agcttaggat
     8101 aacacttttt gttgcttgtt cttaaagatg tctcactatg attaaaaccc ttttcattaa
     8161 tgtagtgaaa gccacacagg agttccttct tccaggagga gaataccaag cacatcactt
     8221 tctctctgca tcagtgatgt caaatacgca tcagaaaatg ttcaggtttt aggagctgtc
     8281 ctaggtgctg tttcatcatt ggaagcagtg agaaagagaa gcactgctgc ttgtctggat
     8341 ataggctgag gatgattgag agaagctgtg ggaactgaca caagggtctg cataggtcat
     8401 cctgtgaccc tggggactat gttaccaact gacagacaga tctttcactg tatcctagca
     8461 gggcaggtag tccaccaaga aatgtgctta ttggattggg aggtgtttat ttgtagtctg
     8521 ctgtaacacg tgtgaaagag caggagcgtc atcagcatat gacttgcgct ggtcatccgg
     8581 taaatggatg tgctgtagtc ccagtgctaa tcatttctct ccttcacagt gggtggaagt
     8641 ttagggttaa atgtcctttg aatgtcacct ggtgagtcct tgacacctta ggctcttcag
     8701 aaacaatggt tttgttgagg atggggaaca gggaatgccg attttatata catggtacac
     8761 agagaggggt gtcacttcag aaaatcttcc agcatgttct tcagaatatt aatttatatg
     8821 cgaggtgagg ttgggaatga aaagaacagg tcagcacttt tttttttcct agaacataca
     8881 aaagaacatg gtggactttc agggagtgca atggaaggtg aatatttcct taagggtccc
     8941 cgagaaatgg gagtgagggg aggggacaca atggcttttt gagcttactt ttaccttctg
     9001 atactagtca aggtccagaa ccagccacca gccaaatttc tatctgggtg cgggccactg
     9061 aaaatccttg ttaaaaacca gatcacaaat ctggggctct tggtcccatt ggagaaggaa
     9121 ggaagagcct caaaataagt gtgcacccat gcacatattc aggaacagct tgtttagtct
     9181 ttacactttg cctgaaagtt gcttctcctc gtccctttgt gtgcctgggt ggcctcggcc
     9241 ctgtgcgttg gcaacgcagg atcaaatgtg ctgcagcttt tgcagaaaac aactcagaaa
     9301 cacaaaaccc cccaacagct caattattat tttttcaatg ttttcctaca agagccaagt
     9361 agcaccatgt acagaagacg cctttttttt tggaatattg aaatcgttct gcatgtaaaa
     9421 tatgggataa tgacctgttt atattaaaat tctgattaaa tta
//
