LOCUS       NM_032594               2891 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens INSM transcriptional repressor 2 (INSM2), mRNA.
ACCESSION   NM_032594
VERSION     NM_032594.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2891)
  AUTHORS   Cai,T., Chen,X., Wang,R., Xu,H., You,Y., Zhang,T., Lan,M.S. and
            Notkins,A.L.
  TITLE     Expression of insulinoma-associated 2 (INSM2) in pancreatic islet
            cells is regulated by the transcription factors Ngn3 and NeuroD1
  JOURNAL   Endocrinology 152 (5), 1961-1969 (2011)
   PUBMED   21343251
  REMARK    GeneRIF: Data show that INSM2 is the expressed n fetal pancreas.
REFERENCE   2  (bases 1 to 2891)
  AUTHORS   De Grijse,J., Asanghanwa,M., Nouthe,B., Albrecher,N., Goubert,P.,
            Vermeulen,I., Van Der Meeren,S., Decochez,K., Weets,I.,
            Keymeulen,B., Lampasona,V., Wenzlau,J., Hutton,J.C., Pipeleers,D.
            and Gorus,F.K.
  CONSRTM   Belgian Diabetes Registry
  TITLE     Predictive power of screening for antibodies against
            insulinoma-associated protein 2 beta (IA-2beta) and zinc
            transporter-8 to select first-degree relatives of type 1 diabetic
            patients with risk of rapid progression to clinical onset of the
            disease: implications for prevention trials
  JOURNAL   Diabetologia 53 (3), 517-524 (2010)
   PUBMED   20091020
  REMARK    GeneRIF: insulinoma-associated protein 2 beta (IA-2beta) and zinc
            transporter-8 may have a role in rapid progression of type 1
            diabetes
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AF260323.1, BC130377.1 and AL160231.4.
            
            On Nov 22, 2018 this sequence version replaced NM_032594.3.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AK096639.1, AB037912.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000307169.4/ ENSP00000306523.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-458               AF260323.1         123-580
            459-705             BC130377.1         462-708
            706-706             AL160231.4         91762-91762
            707-1824            BC130377.1         710-1827
            1825-2891           AF260323.1         1950-3016
FEATURES             Location/Qualifiers
     source          1..2891
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q13.2"
     gene            1..2891
                     /gene="INSM2"
                     /gene_synonym="IA-6; IA6; mlt1"
                     /note="INSM transcriptional repressor 2"
                     /db_xref="GeneID:84684"
                     /db_xref="HGNC:HGNC:17539"
                     /db_xref="MIM:614027"
     exon            1..2891
                     /gene="INSM2"
                     /gene_synonym="IA-6; IA6; mlt1"
                     /inference="alignment:Splign:2.1.0"
     CDS             90..1790
                     /gene="INSM2"
                     /gene_synonym="IA-6; IA6; mlt1"
                     /note="insulinoma-associated protein IA-6; zinc finger
                     protein IA-6; insulinoma-associated 2"
                     /codon_start=1
                     /product="insulinoma-associated protein 2"
                     /protein_id="NP_115983.3"
                     /db_xref="CCDS:CCDS9657.1"
                     /db_xref="GeneID:84684"
                     /db_xref="HGNC:HGNC:17539"
                     /db_xref="MIM:614027"
                     /translation="MPRGFLVKRTKRTGGLYRVRLAERVFPLLGPQGAPPFLEEAPSA
                     SLPGAERATPPTREEPGKGLTAEAAREQSGSPCRAAGVSPGTGGREGAEWRAGGREGP
                     GPSPSPSPSPAKPAGAELRRAFLERCLSSPVSAESFPGGAAAVAAFSCSVAPAAAPTP
                     GEQFLLPLRAPFPEPALQPDPAPLSAALQSLKRAAGGERRGKAPTDCASGPAAAGIKK
                     PKAMRKLSFADEVTTSPVLGLKIKEEEPGAPSRGLGGSRTPLGEFICQLCKEQYADPF
                     ALAQHRCSRIVRVEYRCPECDKVFSCPANLASHRRWHKPRPAAANAATVSSADGKPPS
                     SSSSSSRDSGAIASFLAEGKENSRIERTADQHPQARDSSGADQHPDSAPRQGLQVLTH
                     PEPPLPQGPYTEGVLGRRVPVPGSTSGGRGSEIFVCPYCHKKFRRQAYLRKHLSTHEA
                     GSARALAPGFGSERGAPLAFACPLCGAHFPTADIREKHRLWHAVREELLLPALAGAPP
                     ETSGPSGPSDGSAQQIFSCKHCPSTFFSSPGLTRHINKCHPSESRQVLLLQMPLRPGC
                     "
     regulatory      2871..2876
                     /regulatory_class="polyA_signal_sequence"
                     /gene="INSM2"
                     /gene_synonym="IA-6; IA6; mlt1"
                     /note="hexamer: AATAAA"
     polyA_site      2891
                     /gene="INSM2"
                     /gene_synonym="IA-6; IA6; mlt1"
                     /note="major polyA site"
ORIGIN      
        1 ggcgaagctc ttctagttca tctgctggcc ggctctcagt ccccgtggcg ccccctttcc
       61 tcttgtccca gagcgctctc gactccacca tgccaagggg attcctggtg aagcgaacta
      121 aacggacagg cggcttgtac cgagttcgcc ttgcggagcg tgtcttccct ctgctggggc
      181 cccagggggc gccgcccttc ttggaggagg ctcccagcgc ctccttgccc ggcgcggagc
      241 gggcgacacc ccccacccga gaggaaccag gaaaggggtt gacggcggag gcggcccggg
      301 aacagtcggg gtcgccatgt cgggcggctg gggtgagccc ggggacgggc gggcgggaag
      361 gcgcggagtg gcgggcgggt ggcagggaag gtcccgggcc cagccccagc cccagcccca
      421 gtccagcgaa gccggcaggc gcagagctgc gtcgggcgtt cctggagcgc tgcctcagct
      481 cgcccgtctc cgccgagtct ttccccgggg gcgccgccgc cgtggccgct ttctcctgct
      541 ccgtggcgcc agcagccgca ccgaccccgg gggagcagtt tctgctgccg cttcgggcgc
      601 cgttcccaga gcccgcgctt cagccggacc ctgcgcccct ctcggccgcc cttcagagtc
      661 tgaagcgggc ggccggcggc gagcgccgcg gcaaggcacc cacggactgc gcgtctggac
      721 ccgcggccgc gggaatcaag aagccaaagg ccatgaggaa gttgagcttt gccgatgagg
      781 tgaccacatc ccctgtcctg ggcctgaaga tcaaggagga ggagcccgga gcgccgtccc
      841 ggggcttggg gggcagccgc acgccactgg gggagttcat ctgccagctg tgcaaggagc
      901 agtacgcaga ccccttcgcg ctggcccagc accgctgctc ccgcatcgtg cgcgtagagt
      961 accgctgccc tgagtgcgac aaggtgttca gctgtcctgc gaacctggcc tcccatcgcc
     1021 gctggcataa gccgcgtcct gcggctgcaa acgccgccac agtctcctcc gccgacggga
     1081 agccgccttc ttcgtcgtct tcgtcctccc gggactccgg ggccattgca tcttttctgg
     1141 cggagggaaa ggagaacagc cgaatagagc ggactgcgga tcagcacccg caggccaggg
     1201 acagctccgg ggcggatcag cacccggaca gcgccccgag gcagggcctc caggtgctga
     1261 cgcatccaga gccaccgctg cctcagggcc cctacacgga gggggtgttg gggcgccggg
     1321 tacctgtgcc gggcagtacc agtggtggca ggggatccga gattttcgtg tgcccatatt
     1381 gccacaaaaa gtttcgtcgc caagcctatc tgcgcaagca cctgagcact cacgaggcgg
     1441 gctcggcccg tgcgctagcg ccgggctttg gctccgaacg cggtgcccca cttgccttcg
     1501 cttgcccatt gtgcggagcg cacttcccta cagcagatat cagggagaag caccggctgt
     1561 ggcatgctgt ccgcgaggag ctgctcctgc ccgctctggc gggggctcct cccgaaacgt
     1621 cgggccctag cgggccatct gacgggagtg cccagcaaat tttctcgtgc aagcactgcc
     1681 cgtccacttt ttttagctct ccagggctga cccggcacat caataagtgc cacccctcag
     1741 aaagccggca agtgctgctg ctgcagatgc cactgcggcc tggctgctga gggacgagag
     1801 accaggatga tttcgaggtt ggccttagag gaaacagatc atgggaattt ctgtggggct
     1861 ttcttcaact tgcaagttta ctttcattcc ttcctatgtt ttaatcccct aaaattctcc
     1921 ctgtagtcaa tgttccacca gaggagcgga cagtgaaatg taatatccct ctctagagca
     1981 ggtatgtata tggtataaac cttgagatca aagactgtca gctttaaatc cttctcactt
     2041 tccccactaa aataggattt ttccccttaa aactctggag accctaacga atcctatatg
     2101 atttgtaatt cctatggaaa gtcgcggtga atgcgtgcat gtctcaatgt ccacaaagga
     2161 ttctggctac cctttggtag ccaatgtttt ttttgtcttg tcatcacagg cgcctataca
     2221 gcttctgtct caatagggtc agatattttg cactgtatat tctgtgaatt aaaagttatg
     2281 tgattggtgt caaacttaag gagattcaag acctggcaga aaatgtaaga ggatttttgc
     2341 tgcttttggg gtgcatgggg atctcccctg taaactttcc tttgcccaat tatatgtaca
     2401 tgtccattct taagttggtg tttggaggtg gggaggatgc tactttactg gagttgagac
     2461 accccctaaa attctcaccc tcagctattt tgtgggcagt attcaggaag agctacttca
     2521 aacctttctt taaatggctt tttggaaata cagaagtcgt ttcctcaagt ttgactgttt
     2581 taatggggtt tcacccaaat tgtttaatgc ttctgctgta aatgtcatac tgtgtattca
     2641 ttatgaaaat atgtacagct taaggaagat gttaacacct gtaatccact aaggaactga
     2701 atggcaattt gctcaatatt cagtattttc ttttcagcgg caacttgttt ttgatttttt
     2761 taaaaaacca tttcagtgta cattgtgtac taattcccta ctagccagtt tgggacattg
     2821 gctgagcact gcctgacaga aagcccgtat ttgtaagatg cttaccacca aataaatgta
     2881 catagactgt g
//
