LOCUS       NP_115983                566 aa            linear   PRI 27-APR-2025
DEFINITION  insulinoma-associated protein 2 [Homo sapiens].
ACCESSION   NP_115983
VERSION     NP_115983.3
DBSOURCE    REFSEQ: accession NM_032594.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 566)
  AUTHORS   Cai,T., Chen,X., Wang,R., Xu,H., You,Y., Zhang,T., Lan,M.S. and
            Notkins,A.L.
  TITLE     Expression of insulinoma-associated 2 (INSM2) in pancreatic islet
            cells is regulated by the transcription factors Ngn3 and NeuroD1
  JOURNAL   Endocrinology 152 (5), 1961-1969 (2011)
   PUBMED   21343251
  REMARK    GeneRIF: Data show that INSM2 is the expressed n fetal pancreas.
REFERENCE   2  (residues 1 to 566)
  AUTHORS   De Grijse,J., Asanghanwa,M., Nouthe,B., Albrecher,N., Goubert,P.,
            Vermeulen,I., Van Der Meeren,S., Decochez,K., Weets,I.,
            Keymeulen,B., Lampasona,V., Wenzlau,J., Hutton,J.C., Pipeleers,D.
            and Gorus,F.K.
  CONSRTM   Belgian Diabetes Registry
  TITLE     Predictive power of screening for antibodies against
            insulinoma-associated protein 2 beta (IA-2beta) and zinc
            transporter-8 to select first-degree relatives of type 1 diabetic
            patients with risk of rapid progression to clinical onset of the
            disease: implications for prevention trials
  JOURNAL   Diabetologia 53 (3), 517-524 (2010)
   PUBMED   20091020
  REMARK    GeneRIF: insulinoma-associated protein 2 beta (IA-2beta) and zinc
            transporter-8 may have a role in rapid progression of type 1
            diabetes
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AF260323.1, BC130377.1 and AL160231.4.
            
            On Apr 17, 2007 this sequence version replaced NP_115983.2.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AK096639.1, AB037912.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000307169.4/ ENSP00000306523.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..566
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q13.2"
     Protein         1..566
                     /product="insulinoma-associated protein 2"
                     /note="insulinoma-associated protein IA-6; zinc finger
                     protein IA-6; insulinoma-associated 2"
                     /calculated_mol_wt=59361
     Region          1..20
                     /region_name="SNAG domain. /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (Q96T92.3)"
     Region          <22..>223
                     /region_name="PRK07003"
                     /note="DNA polymerase III subunit gamma/tau"
                     /db_xref="CDD:235906"
     Region          32..117
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q96T92.3)"
     Region          265..285
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          291..313
                     /region_name="zf-C2H2"
                     /note="Zinc finger, C2H2 type; pfam00096"
                     /db_xref="CDD:395048"
     Region          293..313
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          310..418
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q96T92.3)"
     Region          426..448
                     /region_name="zf-C2H2"
                     /note="Zinc finger, C2H2 type; pfam00096"
                     /db_xref="CDD:395048"
     Region          428..448
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(433,435,437,439..440,443..444,447,477,479,483..484,
                     487..488,491,532,534,536,538..539,542..543,547)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          472..492
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          527..548
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     CDS             1..566
                     /gene="INSM2"
                     /gene_synonym="IA-6; IA6; mlt1"
                     /coded_by="NM_032594.4:90..1790"
                     /db_xref="CCDS:CCDS9657.1"
                     /db_xref="GeneID:84684"
                     /db_xref="HGNC:HGNC:17539"
                     /db_xref="MIM:614027"
ORIGIN      
        1 mprgflvkrt krtgglyrvr laervfpllg pqgappflee apsaslpgae ratpptreep
       61 gkgltaeaar eqsgspcraa gvspgtggre gaewraggre gpgpspspsp spakpagael
      121 rraflercls spvsaesfpg gaaavaafsc svapaaaptp geqfllplra pfpepalqpd
      181 paplsaalqs lkraaggerr gkaptdcasg paaagikkpk amrklsfade vttspvlglk
      241 ikeeepgaps rglggsrtpl geficqlcke qyadpfalaq hrcsrivrve yrcpecdkvf
      301 scpanlashr rwhkprpaaa naatvssadg kppsssssss rdsgaiasfl aegkensrie
      361 rtadqhpqar dssgadqhpd saprqglqvl thpepplpqg pytegvlgrr vpvpgstsgg
      421 rgseifvcpy chkkfrrqay lrkhlsthea gsaralapgf gsergaplaf acplcgahfp
      481 tadirekhrl whavreelll palagappet sgpsgpsdgs aqqifsckhc pstffsspgl
      541 trhinkchps esrqvlllqm plrpgc
//
