LOCUS       NM_007179                724 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens insulin like 6 (INSL6), mRNA.
ACCESSION   NM_007179 NM_016421
VERSION     NM_007179.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 724)
  AUTHORS   Zheng,Y., Gao,W., Wang,S., Qi,B., Qi,Z., Hu,X., Zhang,Q., Lang,Y.,
            Ning,M., Luo,Z. and Li,T.
  TITLE     Myocardial Infarction-Induced INSL6 Decrease Contributes to Breast
            Cancer Progression
  JOURNAL   Dis Markers 2023, 8702914 (2023)
   PUBMED   36798786
  REMARK    GeneRIF: Myocardial Infarction-Induced INSL6 Decrease Contributes
            to Breast Cancer Progression.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 724)
  AUTHORS   Asano,K., Matsushita,T., Umeno,J., Hosono,N., Takahashi,A.,
            Kawaguchi,T., Matsumoto,T., Matsui,T., Kakuta,Y., Kinouchi,Y.,
            Shimosegawa,T., Hosokawa,M., Arimura,Y., Shinomura,Y., Kiyohara,Y.,
            Tsunoda,T., Kamatani,N., Iida,M., Nakamura,Y. and Kubo,M.
  TITLE     A genome-wide association study identifies three new susceptibility
            loci for ulcerative colitis in the Japanese population
  JOURNAL   Nat Genet 41 (12), 1325-1329 (2009)
   PUBMED   19915573
REFERENCE   3  (bases 1 to 724)
  AUTHORS   Humphray,S.J., Oliver,K., Hunt,A.R., Plumb,R.W., Loveland,J.E.,
            Howe,K.L., Andrews,T.D., Searle,S., Hunt,S.E., Scott,C.E.,
            Jones,M.C., Ainscough,R., Almeida,J.P., Ambrose,K.D., Ashwell,R.I.,
            Babbage,A.K., Babbage,S., Bagguley,C.L., Bailey,J., Banerjee,R.,
            Barker,D.J., Barlow,K.F., Bates,K., Beasley,H., Beasley,O.,
            Bird,C.P., Bray-Allen,S., Brown,A.J., Brown,J.Y., Burford,D.,
            Burrill,W., Burton,J., Carder,C., Carter,N.P., Chapman,J.C.,
            Chen,Y., Clarke,G., Clark,S.Y., Clee,C.M., Clegg,S., Collier,R.E.,
            Corby,N., Crosier,M., Cummings,A.T., Davies,J., Dhami,P., Dunn,M.,
            Dutta,I., Dyer,L.W., Earthrowl,M.E., Faulkner,L., Fleming,C.J.,
            Frankish,A., Frankland,J.A., French,L., Fricker,D.G., Garner,P.,
            Garnett,J., Ghori,J., Gilbert,J.G., Glison,C., Grafham,D.V.,
            Gribble,S., Griffiths,C., Griffiths-Jones,S., Grocock,R., Guy,J.,
            Hall,R.E., Hammond,S., Harley,J.L., Harrison,E.S., Hart,E.A.,
            Heath,P.D., Henderson,C.D., Hopkins,B.L., Howard,P.J., Howden,P.J.,
            Huckle,E., Johnson,C., Johnson,D., Joy,A.A., Kay,M., Keenan,S.,
            Kershaw,J.K., Kimberley,A.M., King,A., Knights,A., Laird,G.K.,
            Langford,C., Lawlor,S., Leongamornlert,D.A., Leversha,M., Lloyd,C.,
            Lloyd,D.M., Lovell,J., Martin,S., Mashreghi-Mohammadi,M.,
            Matthews,L., McLaren,S., McLay,K.E., McMurray,A., Milne,S.,
            Nickerson,T., Nisbett,J., Nordsiek,G., Pearce,A.V., Peck,A.I.,
            Porter,K.M., Pandian,R., Pelan,S., Phillimore,B., Povey,S.,
            Ramsey,Y., Rand,V., Scharfe,M., Sehra,H.K., Shownkeen,R.,
            Sims,S.K., Skuce,C.D., Smith,M., Steward,C.A., Swarbreck,D.,
            Sycamore,N., Tester,J., Thorpe,A., Tracey,A., Tromans,A.,
            Thomas,D.W., Wall,M., Wallis,J.M., West,A.P., Whitehead,S.L.,
            Willey,D.L., Williams,S.A., Wilming,L., Wray,P.W., Young,L.,
            Ashurst,J.L., Coulson,A., Blocker,H., Durbin,R., Sulston,J.E.,
            Hubbard,T., Jackson,M.J., Bentley,D.R., Beck,S., Rogers,J. and
            Dunham,I.
  TITLE     DNA sequence and analysis of human chromosome 9
  JOURNAL   Nature 429 (6990), 369-374 (2004)
   PUBMED   15164053
REFERENCE   4  (bases 1 to 724)
  AUTHORS   Lok,S., Johnston,D.S., Conklin,D., Lofton-Day,C.E., Adams,R.L.,
            Jelmberg,A.C., Whitmore,T.E., Schrader,S., Griswold,M.D. and
            Jaspers,S.R.
  TITLE     Identification of INSL6, a new member of the insulin family that is
            expressed in the testis of the human and rat
  JOURNAL   Biol Reprod 62 (6), 1593-1599 (2000)
   PUBMED   10819760
REFERENCE   5  (bases 1 to 724)
  AUTHORS   Hsu,S.Y.
  TITLE     Cloning of two novel mammalian paralogs of relaxin/insulin family
            proteins and their expression in testis and kidney
  JOURNAL   Mol Endocrinol 13 (12), 2163-2174 (1999)
   PUBMED   10598589
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL161450.14, AF156094.1 and
            AW117587.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_007179.2.
            
            Summary: The protein encoded by this gene contains a classical
            signature of the insulin superfamily and is significantly similar
            to relaxin and relaxin-like factor. This gene is preferentially
            expressed in testis. Its expression in testis is restricted to
            interstitial cells surrounding seminiferous tubules, which suggests
            a role in sperm development and fertilization. [provided by RefSeq,
            Jul 2008].
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF156094.1, SRR5189667.284877.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2161674 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000381641.4/ ENSP00000371054.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-21                AL161450.14        166910-166930       c
            22-472              AF156094.1         1-451
            473-724             AW117587.1         9-260               c
FEATURES             Location/Qualifiers
     source          1..724
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9p24.1"
     gene            1..724
                     /gene="INSL6"
                     /gene_synonym="RIF1"
                     /note="insulin like 6"
                     /db_xref="GeneID:11172"
                     /db_xref="HGNC:HGNC:6089"
                     /db_xref="MIM:606414"
     exon            1..326
                     /gene="INSL6"
                     /gene_synonym="RIF1"
                     /inference="alignment:Splign:2.1.0"
     CDS             38..679
                     /gene="INSL6"
                     /gene_synonym="RIF1"
                     /note="insulin-like peptide 5; insulin-like peptide INSL6;
                     relaxin/insulin-like factor 1; insulin-like peptide 6"
                     /codon_start=1
                     /product="insulin-like peptide INSL6 precursor"
                     /protein_id="NP_009110.2"
                     /db_xref="CCDS:CCDS6458.1"
                     /db_xref="GeneID:11172"
                     /db_xref="HGNC:HGNC:6089"
                     /db_xref="MIM:606414"
                     /translation="MPRLLRLSLLWLGLLLVRFSRELSDISSARKLCGRYLVKEIEKL
                     CGHANWSQFRFEEETPFSRLIAQASEKVEAYSPYQFESPQTASPARGRGTNPVSTSWE
                     EAVNSWEMQSLPEYKDKKGYSPLGKTREFSSSHNINVYIHENAKFQKKRRNKIKTLSN
                     LFWGHHPQRKRRGYSEKCCLTGCTKEELSIACLPYIDFKRLKEKRSSLVTKIY"
     exon            327..724
                     /gene="INSL6"
                     /gene_synonym="RIF1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      704..709
                     /regulatory_class="polyA_signal_sequence"
                     /gene="INSL6"
                     /gene_synonym="RIF1"
                     /note="hexamer: AATAAA"
     polyA_site      724
                     /gene="INSL6"
                     /gene_synonym="RIF1"
                     /note="major polyA site"
ORIGIN      
        1 attgcacaac gcggaggact agcctggggt cacagggatg ccgcggctcc tccgcttgtc
       61 cctgctgtgg cttggactcc tgctggttcg gttttctcgt gaactgagcg acatcagcag
      121 tgccaggaag ctgtgcggca ggtacttggt gaaagaaata gaaaaactct gcggccatgc
      181 caactggagc cagttccgtt tcgaggagga aacccctttc tcacggttga ttgcacaggc
      241 ctcggagaag gtcgaagcct acagcccata ccagttcgaa agcccgcaaa ccgcttcccc
      301 ggcccgggga agaggcacaa acccagtgtc tacttcttgg gaagaagcag taaacagttg
      361 ggaaatgcag tcactacctg agtataagga taaaaaggga tattcacccc ttggtaagac
      421 aagagaattt tcttcatcac ataatatcaa tgtatatatt catgagaatg caaaatttca
      481 gaagaaacgt agaaacaaaa ttaaaacctt aagcaatttg ttttgggggc atcatcccca
      541 aagaaaacgc agaggatatt cagaaaagtg ttgtcttaca ggatgtacaa aagaagaact
      601 tagcattgca tgtcttccat atattgattt taaaaggcta aaggaaaaaa gatcatcact
      661 tgtaactaag atatactaac catcttagaa ttttttctaa cctaataaaa gcttaataca
      721 ttta
//
