LOCUS       NM_005478                736 bp    mRNA    linear   PRI 09-JUN-2024
DEFINITION  Homo sapiens insulin like 5 (INSL5), mRNA.
ACCESSION   NM_005478
VERSION     NM_005478.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 736)
  AUTHORS   Chen,Y., Chen,J., Li,Y., Wu,Y., Wu,X., Zhang,H. and Zhang,Z.
  TITLE     Insulin-like peptide 5 is associated with insulin resistance in
            women with polycystic ovary syndrome
  JOURNAL   J Diabetes Complications 37 (7), 108493 (2023)
   PUBMED   37207506
  REMARK    GeneRIF: Insulin-like peptide 5 is associated with insulin
            resistance in women with polycystic ovary syndrome.
REFERENCE   2  (bases 1 to 736)
  AUTHORS   Chen,Y., Deng,M., Chen,Z., Han,S., Chen,J., Zhang,H., Wang,Q.,
            Jin,X., Liu,W. and Zhang,Z.
  TITLE     Insulin-like peptide 5 (INSL5) positively correlates with
            anti-Mullerian hormone (AMH) in women with the polycystic ovary
            syndrome: a case-control study
  JOURNAL   J Ovarian Res 15 (1), 118 (2022)
   PUBMED   36303231
  REMARK    GeneRIF: Insulin-like peptide 5 (INSL5) positively correlates with
            anti-Mullerian hormone (AMH) in women with the polycystic ovary
            syndrome: a case-control study.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 736)
  AUTHORS   Skok,D.J., Hauptman,N., Jerala,M. and Zidar,N.
  TITLE     Expression of Cytokine-Coding Genes BMP8B, LEFTY1 and INSL5 Could
            Distinguish between Ulcerative Colitis and Crohn's Disease
  JOURNAL   Genes (Basel) 12 (10), 1477 (2021)
   PUBMED   34680872
  REMARK    GeneRIF: Expression of Cytokine-Coding Genes BMP8B, LEFTY1 and
            INSL5 Could Distinguish between Ulcerative Colitis and Crohn's
            Disease.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 736)
  AUTHORS   Li,S.B., Liu,Y.Y., Yuan,L., Ji,M.F., Zhang,A., Li,H.Y., Tang,L.Q.,
            Fang,S.G., Zhang,H., Xing,S., Li,M.Z., Zhong,Q., Lin,S.J.,
            Liu,W.L., Huang,P., Zeng,Y.X., Zheng,Y.M., Ling,Z.Q., Sui,J.H. and
            Zeng,M.S.
  TITLE     Autocrine INSL5 promotes tumor progression and glycolysis via
            activation of STAT5 signaling
  JOURNAL   EMBO Mol Med 12 (9), e12050 (2020)
   PUBMED   32657028
  REMARK    GeneRIF: Autocrine INSL5 promotes tumor progression and glycolysis
            via activation of STAT5 signaling.
REFERENCE   5  (bases 1 to 736)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 736)
  AUTHORS   Zhang,Z. and Henzel,W.J.
  TITLE     Signal peptide prediction based on analysis of experimentally
            verified cleavage sites
  JOURNAL   Protein Sci 13 (10), 2819-2824 (2004)
   PUBMED   15340161
REFERENCE   7  (bases 1 to 736)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
REFERENCE   8  (bases 1 to 736)
  AUTHORS   Conklin,D., Lofton-Day,C.E., Haldeman,B.A., Ching,A.,
            Whitmore,T.E., Lok,S. and Jaspers,S.
  TITLE     Identification of INSL5, a new member of the insulin superfamily
  JOURNAL   Genomics 60 (1), 50-56 (1999)
   PUBMED   10458910
REFERENCE   9  (bases 1 to 736)
  AUTHORS   Koman,A., Cazaubon,S., Couraud,P.O., Ullrich,A. and Strosberg,A.D.
  TITLE     Molecular characterization and in vitro biological activity of
            placentin, a new member of the insulin gene family
  JOURNAL   J Biol Chem 271 (34), 20238-20241 (1996)
   PUBMED   8702754
REFERENCE   10 (bases 1 to 736)
  AUTHORS   Itoh,H., Toyama,R., Kozasa,T., Tsukamoto,T., Matsuoka,M. and
            Kaziro,Y.
  TITLE     Presence of three distinct molecular species of Gi protein alpha
            subunit. Structure of rat cDNAs and human genomic DNAs
  JOURNAL   J Biol Chem 263 (14), 6656-6664 (1988)
   PUBMED   2834384
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL354978.20.
            
            On Jan 1, 2020 this sequence version replaced NM_005478.5.
            
            Summary: The protein encoded by this gene contains a classical
            signature of the insulin superfamily and is highly similar to
            relaxin 3 (RLN3/INSL7). [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY359030.1, AF133816.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142348 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000304526.3/ ENSP00000302724.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-230               AL354978.20        84950-85179         c
            231-736             AL354978.20        81643-82148         c
FEATURES             Location/Qualifiers
     source          1..736
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p31.3"
     gene            1..736
                     /gene="INSL5"
                     /gene_synonym="PRO182; UNQ156"
                     /note="insulin like 5"
                     /db_xref="GeneID:10022"
                     /db_xref="HGNC:HGNC:6088"
                     /db_xref="MIM:606413"
     exon            1..230
                     /gene="INSL5"
                     /gene_synonym="PRO182; UNQ156"
                     /inference="alignment:Splign:2.1.0"
     CDS             56..463
                     /gene="INSL5"
                     /gene_synonym="PRO182; UNQ156"
                     /note="insulin-like peptide 5; insulin-like peptide INSL5;
                     prepro-INSL5"
                     /codon_start=1
                     /product="insulin-like peptide INSL5 precursor"
                     /protein_id="NP_005469.2"
                     /db_xref="CCDS:CCDS634.1"
                     /db_xref="GeneID:10022"
                     /db_xref="HGNC:HGNC:6088"
                     /db_xref="MIM:606413"
                     /translation="MKGSIFTLFLFSVLFAISEVRSKESVRLCGLEYIRTVIYICASS
                     RWRRHQEGIPQAQQAETGNSFQLPHKREFSEENPAQNLPKVDASGEDRLWGGQMPTEE
                     LWKSKKHSVMSRQDLQTLCCTDGCSMTDLSALC"
     exon            231..736
                     /gene="INSL5"
                     /gene_synonym="PRO182; UNQ156"
                     /inference="alignment:Splign:2.1.0"
     regulatory      716..721
                     /regulatory_class="polyA_signal_sequence"
                     /gene="INSL5"
                     /gene_synonym="PRO182; UNQ156"
                     /note="hexamer: AATAAA"
     polyA_site      736
                     /gene="INSL5"
                     /gene_synonym="PRO182; UNQ156"
                     /note="major polyA site"
ORIGIN      
        1 agaatttgat ttgactatat ttaccatatc agattcacat tcagtcctca gcaaaatgaa
       61 gggctccatt ttcactctgt ttttattctc tgtcctattt gccatctcag aagtgcggag
      121 caaggagtct gtgagactct gtgggctaga atacatacgg acagtcatct atatctgtgc
      181 tagctccagg tggagaaggc atcaggaggg gatccctcaa gctcagcaag ctgagacagg
      241 aaactccttc cagctcccac ataaacgtga gttttctgag gaaaatccag cgcaaaacct
      301 tccgaaggtg gatgcctcag gggaagaccg tctttggggt ggacagatgc ccactgaaga
      361 gctttggaag tcaaagaagc attcagtgat gtcaagacaa gatttacaaa ctttgtgttg
      421 cactgatggc tgttccatga ctgatttgag tgctctttgc taagacaaga gcaaataccc
      481 aatgggtggc agagctttat cacatgttta attacagtgt tttactgcct ggtagaacac
      541 taatattgtg ttattaaaat gatggctttt gggtaggcaa aacttctttt ctaaaaggta
      601 tagctgagcg gttgaaacca cagtgatctc tattttctcc ctttgccaag gttaatgaac
      661 tgttcttttc aaattctact aatgctttga aatttcaaat gctgcgcaaa attgcaataa
      721 aaatgctata aaccaa
//
