LOCUS       NM_002195               1952 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens insulin like 4 (INSL4), mRNA.
ACCESSION   NM_002195
VERSION     NM_002195.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1952)
  AUTHORS   Yang,R., Li,S.W., Chen,Z., Zhou,X., Ni,W., Fu,D.A., Lu,J.,
            Kaye,F.J. and Wu,L.
  TITLE     Role of INSL4 Signaling in Sustaining the Growth and Viability of
            LKB1-Inactivated Lung Cancer
  JOURNAL   J Natl Cancer Inst 111 (7), 664-674 (2019)
   PUBMED   30423141
  REMARK    GeneRIF: LKB1 deficiency induces an autocrine INSL4 signaling that
            critically supports the growth and survival of lung cancer cells.
            Therefore, aberrant INSL4 signaling is a promising therapeutic
            target for LKB1-deficient lung cancers.
REFERENCE   2  (bases 1 to 1952)
  AUTHORS   Goh,W., Yamamoto,S.Y., Thompson,K.S. and Bryant-Greenwood,G.D.
  TITLE     Relaxin, its receptor (RXFP1), and insulin-like peptide 4
            expression through gestation and in placenta accreta
  JOURNAL   Reprod Sci 20 (8), 968-980 (2013)
   PUBMED   23302396
  REMARK    GeneRIF: Report decreased INSL4 gene expression in both the
            invasive and the noninvasive areas of villous trophoblast in
            patients with placenta accreta.
REFERENCE   3  (bases 1 to 1952)
  AUTHORS   Asano,K., Matsushita,T., Umeno,J., Hosono,N., Takahashi,A.,
            Kawaguchi,T., Matsumoto,T., Matsui,T., Kakuta,Y., Kinouchi,Y.,
            Shimosegawa,T., Hosokawa,M., Arimura,Y., Shinomura,Y., Kiyohara,Y.,
            Tsunoda,T., Kamatani,N., Iida,M., Nakamura,Y. and Kubo,M.
  TITLE     A genome-wide association study identifies three new susceptibility
            loci for ulcerative colitis in the Japanese population
  JOURNAL   Nat Genet 41 (12), 1325-1329 (2009)
   PUBMED   19915573
REFERENCE   4  (bases 1 to 1952)
  AUTHORS   Millar,L., Streiner,N., Webster,L., Yamamoto,S., Okabe,R.,
            Kawamata,T., Shimoda,J., Bullesbach,E., Schwabe,C. and
            Bryant-Greenwood,G.
  TITLE     Early placental insulin-like protein (INSL4 or EPIL) in placental
            and fetal membrane growth
  JOURNAL   Biol Reprod 73 (4), 695-702 (2005)
   PUBMED   15958731
  REMARK    GeneRIF: Expression of the INSL4 gene was doubled in the placenta
            of the growth-restricted twin compared to the normally grown
            sibling, suggesting that it may be linked to a higher level of
            apoptosis and loss of cell viability
REFERENCE   5  (bases 1 to 1952)
  AUTHORS   Burger,H., Kemming,D., Helms,M., Feldmann,U., Matuschek,A.,
            Bocker,W. and Brandt,B.
  TITLE     [Expression of early placenta insulin-like growth factor (EPIL) in
            breast cancer cells provides an autocrine loop with enhancement of
            predominantly HER-2-related invasivity]
  JOURNAL   Verh Dtsch Ges Pathol 89, 201-206 (2005)
   PUBMED   18035692
  REMARK    GeneRIF: A tight interaction between HER-2 gene and EPIL in
            invasive breast cancer cells is probable.
REFERENCE   6  (bases 1 to 1952)
  AUTHORS   Laurent,A., Rouillac,C., Delezoide,A.L., Giovangrandi,Y.,
            Vekemans,M., Bellet,D., Abitbol,M. and Vidaud,M.
  TITLE     Insulin-like 4 (INSL4) gene expression in human embryonic and
            trophoblastic tissues
  JOURNAL   Mol Reprod Dev 51 (2), 123-129 (1998)
   PUBMED   9740319
REFERENCE   7  (bases 1 to 1952)
  AUTHORS   Veitia,R., Laurent,A., Quintana-Murci,L., Ottolenghi,C.,
            Fellous,M., Vidaud,M. and McElreavey,K.
  TITLE     The INSL4 gene maps close to WI-5527 at 9p24.1-->p23.3 clustered
            with two relaxin genes and outside the critical region for the
            monosomy 9p syndrome
  JOURNAL   Cytogenet Cell Genet 81 (3-4), 275-277 (1998)
   PUBMED   9730618
REFERENCE   8  (bases 1 to 1952)
  AUTHORS   Bellet,D., Lavaissiere,L., Mock,P., Laurent,A., Sabourin,J.C.,
            Bedossa,P., Le Bouteiller,P., Frydman,R., Troalen,F. and
            Bidart,J.M.
  TITLE     Identification of pro-EPIL and EPIL peptides translated from
            insulin-like 4 (INSL4) mRNA in human placenta
  JOURNAL   J Clin Endocrinol Metab 82 (9), 3169-3172 (1997)
   PUBMED   9284764
REFERENCE   9  (bases 1 to 1952)
  AUTHORS   Koman,A., Cazaubon,S., Couraud,P.O., Ullrich,A. and Strosberg,A.D.
  TITLE     Molecular characterization and in vitro biological activity of
            placentin, a new member of the insulin gene family
  JOURNAL   J Biol Chem 271 (34), 20238-20241 (1996)
   PUBMED   8702754
REFERENCE   10 (bases 1 to 1952)
  AUTHORS   Chassin,D., Laurent,A., Janneau,J.L., Berger,R. and Bellet,D.
  TITLE     Cloning of a new member of the insulin gene superfamily (INSL4)
            expressed in human placenta
  JOURNAL   Genomics 29 (2), 465-470 (1995)
   PUBMED   8666396
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from L34838.1 and AL133547.16.
            
            On May 17, 2019 this sequence version replaced NM_002195.1.
            
            Summary: INSL4 encodes the insulin-like 4 protein, a member of the
            insulin superfamily. INSL4 encodes a precursor that undergoes
            post-translational cleavage to produce 3 polypeptide chains, A-C,
            that form tertiary structures composed of either all three chains,
            or just the A and B chains. Expression of INSL4 products occurs
            within the early placental cytotrophoblast and syncytiotrophoblast.
            [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AU136752.2, AK291543.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142853, SAMEA2146236
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000239316.4/ ENSP00000239316.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-615               L34838.1           1-615
            616-1952            AL133547.16        44213-45549
FEATURES             Location/Qualifiers
     source          1..1952
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9p24.1"
     gene            1..1952
                     /gene="INSL4"
                     /gene_synonym="EPIL; PLACENTIN"
                     /note="insulin like 4"
                     /db_xref="GeneID:3641"
                     /db_xref="HGNC:HGNC:6087"
                     /db_xref="MIM:600910"
     exon            1..301
                     /gene="INSL4"
                     /gene_synonym="EPIL; PLACENTIN"
                     /inference="alignment:Splign:2.1.0"
     CDS             106..525
                     /gene="INSL4"
                     /gene_synonym="EPIL; PLACENTIN"
                     /note="early placenta insulin-like peptide (EPIL);
                     insulin-like peptide 4; insulin-like 4 (placenta)"
                     /codon_start=1
                     /product="early placenta insulin-like peptide precursor"
                     /protein_id="NP_002186.1"
                     /db_xref="CCDS:CCDS6459.1"
                     /db_xref="GeneID:3641"
                     /db_xref="HGNC:HGNC:6087"
                     /db_xref="MIM:600910"
                     /translation="MASLFRSYLPAIWLLLSQLLRESLAAELRGCGPRFGKHLLSYCP
                     MPEKTFTTTPGGWLLESGRPKEMVSTSNNKDGQALGTTSEFIPNLSPELKKPLSEGQP
                     SLKKIILSRKKRSGRHRFDPFCCEVICDDGTSVKLCT"
     exon            302..1952
                     /gene="INSL4"
                     /gene_synonym="EPIL; PLACENTIN"
                     /inference="alignment:Splign:2.1.0"
     regulatory      597..602
                     /regulatory_class="polyA_signal_sequence"
                     /gene="INSL4"
                     /gene_synonym="EPIL; PLACENTIN"
                     /note="hexamer: ATTAAA"
     polyA_site      621
                     /gene="INSL4"
                     /gene_synonym="EPIL; PLACENTIN"
                     /note="major polyA site"
     regulatory      946..951
                     /regulatory_class="polyA_signal_sequence"
                     /gene="INSL4"
                     /gene_synonym="EPIL; PLACENTIN"
                     /note="hexamer: AATAAA"
     regulatory      970..975
                     /regulatory_class="polyA_signal_sequence"
                     /gene="INSL4"
                     /gene_synonym="EPIL; PLACENTIN"
                     /note="hexamer: CATAAA"
     polyA_site      975
                     /gene="INSL4"
                     /gene_synonym="EPIL; PLACENTIN"
     polyA_site      997
                     /gene="INSL4"
                     /gene_synonym="EPIL; PLACENTIN"
ORIGIN      
        1 agtctggagc ccagaaggga cacaccagca cagtctggta ggctacagca gcaagtctct
       61 aaagaaaggc tgagaacacc cagaacagga gagttcaggt ccaggatggc cagcctgttc
      121 cggtcctatc tgccagcaat ctggctgctg ctgagccaac tccttagaga aagcctagca
      181 gcagagctga ggggatgtgg tccccgattt ggaaaacact tgctgtcata ttgccccatg
      241 cctgagaaga cattcaccac caccccagga gggtggctgc tggaatctgg acgtcccaaa
      301 gaaatggtgt caacctccaa caacaaagat ggacaagcct taggtacgac atcagaattc
      361 attcctaatt tgtcaccaga gctgaagaaa ccactgtctg aagggcagcc atcattgaag
      421 aaaataatac tttcccgcaa aaagagaagt ggacgtcaca gatttgatcc attctgttgt
      481 gaagtaattt gtgacgatgg aacttcagtt aaattatgta catagtagag taatcatgga
      541 ctggacatct catccattct catatgtatt ctcaatgaca aattcactga tgcccaatta
      601 aatgattgct gtttattaga acatgagaat cattattagt attcacatgt ttcacttgct
      661 ctgtactaat atagtctctc caaatggagg aagttagata gatggaataa gttctagtag
      721 ttgatagtac aatggggaaa ttatacttaa caataattca ctgtatattc caaaatagct
      781 agaagagaat tgtaatgatt ccaacacaaa aaagatgaat gttagtttgg atgcatatcc
      841 caattaccct gatttgatca ttacacatta tatacacgta tcaaaatatc acatgtacta
      901 caaaaatgtg tataactgta atatgtgaac tacaaactta ctggaaataa atttttaaag
      961 ttttacacac ataaacacat acgttcacac acactcactc aagtctcttc atttttcctc
     1021 ttttcacact agaagaaatg taagagataa aggatctaac catctctaac atcagctcat
     1081 agtacggagg aaaagcagtg aaggaatgaa ctggtgggag aggtattagg catgttcacc
     1141 ctagggtaaa cccagagacc tccctagaac tttgcccaat gcatatcctc cacctgcctc
     1201 tcagcacgct gcctttagac cttcaatcat tctataaact cctcttttgt ccctggcatt
     1261 actccacatc ccctcatcaa agtggtgaat tggcacaaat actggcattc ctctggctac
     1321 acatacctcc tccctatgtg tctctaaatc ctaaatcaaa gagtacattt tatactctgt
     1381 cagtgaggtt ctactagttg tgtttgtttg tttgcaggct aactgaagct gctactacct
     1441 cattatcagg tcctataaac ttaattcaag tggcatgatt tgagtagccc cctgtgcctg
     1501 cccataaagt gctctgaatc tagtgtggga catggagaag caaaggataa taagtgcaat
     1561 gatacttgta ggtcatcata gagactgtaa tgatccacag gaatcagggt cgtgtttaat
     1621 gccaacatgt gaaagaataa atatacaggg aacagtgtag gtaagaggag agagcaaaat
     1681 ttccctaagg aaactgatgg ctgatctgca tcttgaaaga catctaagca gaagagagtg
     1741 caaaaaggga caagtagaag cccaggaaaa tgcacaaagg cctggaagca tagcatgtgt
     1801 ggaaacagcc agagtcagca gggcaggagg tggtgtggag aaaaggaatt gtcaagatct
     1861 ggttggaatg gagacaggag agaggatctc aaacgattcc acacaatgca gctatggggt
     1921 ttaggctgca tcctggagta aggaagaact gc
//
