LOCUS       NM_001567               4789 bp    mRNA    linear   PRI 03-SEP-2024
DEFINITION  Homo sapiens inositol polyphosphate phosphatase like 1 (INPPL1),
            mRNA.
ACCESSION   NM_001567
VERSION     NM_001567.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4789)
  AUTHORS   Ji,X., Wu,Q., Cao,X., Liu,S., Zhang,J., Chen,S., Shan,J., Zhang,Y.,
            Li,B. and Zhao,H.
  TITLE     Helicobacter pylori East Asian type CagA hijacks more SHIP2 by its
            EPIYA-D motif to potentiate the oncogenicity
  JOURNAL   Virulence 15 (1), 2375549 (2024)
   PUBMED   38982595
  REMARK    GeneRIF: Helicobacter pylori East Asian type CagA hijacks more
            SHIP2 by its EPIYA-D motif to potentiate the oncogenicity.
REFERENCE   2  (bases 1 to 4789)
  AUTHORS   Ando,K., Kucukali,F., Doeraene,E., Nagaraj,S., Antonelli,E.M.,
            Thazin Htut,M., Yilmaz,Z., Kosa,A.C., Lopez-Guitierrez,L.,
            Quintanilla-Sanchez,C., Aydin,E., Ramos,A.R., Mansour,S.,
            Turbant,S., Schurmans,S., Sleegers,K., Erneux,C., Brion,J.P. and
            Leroy,K.
  CONSRTM   Brain Bank NeuroCEB Neuropathology Network
  TITLE     Alteration of gene expression and protein solubility of the PI
            5-phosphatase SHIP2 are correlated with Alzheimer's disease
            pathology progression
  JOURNAL   Acta Neuropathol 147 (1), 94 (2024)
   PUBMED   38833073
  REMARK    GeneRIF: Alteration of gene expression and protein solubility of
            the PI 5-phosphatase SHIP2 are correlated with Alzheimer's disease
            pathology progression.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4789)
  AUTHORS   Bradshaw,W.J., Kennedy,E.C., Moreira,T., Smith,L.A., Chalk,R.,
            Katis,V.L., Benesch,J.L.P., Brennan,P.E., Murphy,E.J. and
            Gileadi,O.
  TITLE     Regulation of inositol 5-phosphatase activity by the C2 domain of
            SHIP1 and SHIP2
  JOURNAL   Structure 32 (4), 453-466 (2024)
   PUBMED   38309262
  REMARK    GeneRIF: Regulation of inositol 5-phosphatase activity by the C2
            domain of SHIP1 and SHIP2.
REFERENCE   4  (bases 1 to 4789)
  AUTHORS   Xu,L., Xiang,W., Yang,J., Gao,J., Wang,X., Meng,L., Ye,K.,
            Zhao,X.H., Zhang,X.D., Jin,L. and Ye,Y.
  TITLE     PHB2 promotes SHIP2 ubiquitination via the E3 ligase NEDD4 to
            regulate AKT signaling in gastric cancer
  JOURNAL   J Exp Clin Cancer Res 43 (1), 17 (2024)
   PUBMED   38200519
  REMARK    GeneRIF: PHB2 promotes SHIP2 ubiquitination via the E3 ligase NEDD4
            to regulate AKT signaling in gastric cancer.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4789)
  AUTHORS   Ren,L., Chen,S., Yao,D. and Yan,H.
  TITLE     OxLDL-stimulated macrophage exosomes promote proatherogenic
            vascular smooth muscle cell viability and invasion via delivering
            miR-186-5p then inactivating SHIP2 mediated PI3K/AKT/mTOR pathway
  JOURNAL   Mol Immunol 146, 27-37 (2022)
   PUBMED   35421738
  REMARK    GeneRIF: OxLDL-stimulated macrophage exosomes promote
            proatherogenic vascular smooth muscle cell viability and invasion
            via delivering miR-186-5p then inactivating SHIP2 mediated
            PI3K/AKT/mTOR pathway.
REFERENCE   6  (bases 1 to 4789)
  AUTHORS   Habib,T., Hejna,J.A., Moses,R.E. and Decker,S.J.
  TITLE     Growth factors and insulin stimulate tyrosine phosphorylation of
            the 51C/SHIP2 protein
  JOURNAL   J Biol Chem 273 (29), 18605-18609 (1998)
   PUBMED   9660833
REFERENCE   7  (bases 1 to 4789)
  AUTHORS   Le Drean,E., Vely,F., Olcese,L., Cambiaggi,A., Guia,S., Krystal,G.,
            Gervois,N., Moretta,A., Jotereau,F. and Vivier,E.
  TITLE     Inhibition of antigen-induced T cell response and antibody-induced
            NK cell cytotoxicity by NKG2A: association of NKG2A with SHP-1 and
            SHP-2 protein-tyrosine phosphatases
  JOURNAL   Eur J Immunol 28 (1), 264-276 (1998)
   PUBMED   9485206
  REMARK    Erratum:[Eur J Immunol 1998 Mar;28(3):1122]
REFERENCE   8  (bases 1 to 4789)
  AUTHORS   Pesesse,X., Deleu,S., De Smedt,F., Drayer,L. and Erneux,C.
  TITLE     Identification of a second SH2-domain-containing protein closely
            related to the phosphatidylinositol polyphosphate 5-phosphatase
            SHIP
  JOURNAL   Biochem Biophys Res Commun 239 (3), 697-700 (1997)
   PUBMED   9367831
REFERENCE   9  (bases 1 to 4789)
  AUTHORS   Hejna,J.A., Saito,H., Merkens,L.S., Tittle,T.V., Jakobs,P.M.,
            Whitney,M.A., Grompe,M., Friedberg,A.S. and Moses,R.E.
  TITLE     Cloning and characterization of a human cDNA (INPPL1) sharing
            homology with inositol polyphosphate phosphatases
  JOURNAL   Genomics 29 (1), 285-287 (1995)
   PUBMED   8530088
REFERENCE   10 (bases 1 to 4789)
  AUTHORS   Slama,V. and Dudek,J.
  TITLE     [Stability of diluted solutions of peracetic acid]
  JOURNAL   Cesk Farm 17 (1), 40-41 (1968)
   PUBMED   5668240
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AP000593.4, BC140853.1,
            Y14385.1 and BG236320.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_001567.3.
            
            Summary: The protein encoded by this gene is an SH2-containing
            5'-inositol phosphatase that is involved in the regulation of
            insulin function. The encoded protein also plays a role in the
            regulation of epidermal growth factor receptor turnover and actin
            remodelling. Additionally, this gene supports metastatic growth in
            breast cancer and is a valuable biomarker for breast cancer.
            [provided by RefSeq, Jan 2009].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: Y14385.1, BC140853.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000298229.7/ ENSP00000298229.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-71                AP000593.4         13627-13697
            72-4042             BC140853.1         1-3971
            4043-4747           Y14385.1           4036-4740
            4748-4789           BG236320.1         9-50                c
FEATURES             Location/Qualifiers
     source          1..4789
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q13.4"
     gene            1..4789
                     /gene="INPPL1"
                     /gene_synonym="OPSMD; SHIP2"
                     /note="inositol polyphosphate phosphatase like 1"
                     /db_xref="GeneID:3636"
                     /db_xref="HGNC:HGNC:6080"
                     /db_xref="MIM:600829"
     exon            1..400
                     /gene="INPPL1"
                     /gene_synonym="OPSMD; SHIP2"
                     /inference="alignment:Splign:2.1.0"
     CDS             219..3995
                     /gene="INPPL1"
                     /gene_synonym="OPSMD; SHIP2"
                     /EC_number="3.1.3.86"
                     /note="SH2 domain-containing inositol-5'-phosphatase 2;
                     51C protein; SHIP-2; INPPL-1; protein 51C"
                     /codon_start=1
                     /product="phosphatidylinositol 3,4,5-trisphosphate
                     5-phosphatase 2"
                     /protein_id="NP_001558.3"
                     /db_xref="CCDS:CCDS8213.1"
                     /db_xref="GeneID:3636"
                     /db_xref="HGNC:HGNC:6080"
                     /db_xref="MIM:600829"
                     /translation="MASACGAPGPGGALGSQAPSWYHRDLSRAAAEELLARAGRDGSF
                     LVRDSESVAGAFALCVLYQKHVHTYRILPDGEDFLAVQTSQGVPVRRFQTLGELIGLY
                     AQPNQGLVCALLLPVEGEREPDPPDDRDASDGEDEKPPLPPRSGSTSISAPTGPSSPL
                     PAPETPTAPAAESAPNGLSTVSHDYLKGSYGLDLEAVRGGASHLPHLTRTLATSCRRL
                     HSEVDKVLSGLEILSKVFDQQSSPMVTRLLQQQNLPQTGEQELESLVLKLSVLKDFLS
                     GIQKKALKALQDMSSTAPPAPQPSTRKAKTIPVQAFEVKLDVTLGDLTKIGKSQKFTL
                     SVDVEGGRLVLLRRQRDSQEDWTTFTHDRIRQLIKSQRVQNKLGVVFEKEKDRTQRKD
                     FIFVSARKREAFCQLLQLMKNKHSKQDEPDMISVFIGTWNMGSVPPPKNVTSWFTSKG
                     LGKTLDEVTVTIPHDIYVFGTQENSVGDREWLDLLRGGLKELTDLDYRPIAMQSLWNI
                     KVAVLVKPEHENRISHVSTSSVKTGIANTLGNKGAVGVSFMFNGTSFGFVNCHLTSGN
                     EKTARRNQNYLDILRLLSLGDRQLNAFDISLRFTHLFWFGDLNYRLDMDIQEILNYIS
                     RKEFEPLLRVDQLNLEREKHKVFLRFSEEEISFPPTYRYERGSRDTYAWHKQKPTGVR
                     TNVPSWCDRILWKSYPETHIICNSYGCTDDIVTSDHSPVFGTFEVGVTSQFISKKGLS
                     KTSDQAYIEFESIEAIVKTASRTKFFIEFYSTCLEEYKKSFENDAQSSDNINFLKVQW
                     SSRQLPTLKPILADIEYLQDQHLLLTVKSMDGYESYGECVVALKSMIGSTAQQFLTFL
                     SHRGEETGNIRGSMKVRVPTERLGTRERLYEWISIDKDEAGAKSKAPSVSRGSQEPRS
                     GSRKPAFTEASCPLSRLFEEPEKPPPTGRPPAPPRAAPREEPLTPRLKPEGAPEPEGV
                     AAPPPKNSFNNPAYYVLEGVPHQLLPPEPPSPARAPVPSATKNKVAITVPAPQLGHHR
                     HPRVGEGSSSDEESGGTLPPPDFPPPPLPDSAIFLPPSLDPLPGPVVRGRGGAEARGP
                     PPPKAHPRPPLPPGPSPASTFLGEVASGDDRSCSVLQMAKTLSEVDYAPAGPARSALL
                     PGPLELQPPRGLPSDYGRPLSFPPPRIRESIQEDLAEEAPCLQGGRASGLGEAGMSAW
                     LRAIGLERYEEGLVHNGWDDLEFLSDITEEDLEEAGVQDPAHKRLLLDTLQLSK"
     exon            401..464
                     /gene="INPPL1"
                     /gene_synonym="OPSMD; SHIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            465..615
                     /gene="INPPL1"
                     /gene_synonym="OPSMD; SHIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            616..736
                     /gene="INPPL1"
                     /gene_synonym="OPSMD; SHIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            737..877
                     /gene="INPPL1"
                     /gene_synonym="OPSMD; SHIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            878..971
                     /gene="INPPL1"
                     /gene_synonym="OPSMD; SHIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            972..1061
                     /gene="INPPL1"
                     /gene_synonym="OPSMD; SHIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1062..1157
                     /gene="INPPL1"
                     /gene_synonym="OPSMD; SHIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1158..1308
                     /gene="INPPL1"
                     /gene_synonym="OPSMD; SHIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1309..1415
                     /gene="INPPL1"
                     /gene_synonym="OPSMD; SHIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1416..1518
                     /gene="INPPL1"
                     /gene_synonym="OPSMD; SHIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1519..1715
                     /gene="INPPL1"
                     /gene_synonym="OPSMD; SHIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1716..1833
                     /gene="INPPL1"
                     /gene_synonym="OPSMD; SHIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1834..1930
                     /gene="INPPL1"
                     /gene_synonym="OPSMD; SHIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1931..2069
                     /gene="INPPL1"
                     /gene_synonym="OPSMD; SHIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2070..2169
                     /gene="INPPL1"
                     /gene_synonym="OPSMD; SHIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2170..2258
                     /gene="INPPL1"
                     /gene_synonym="OPSMD; SHIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2259..2340
                     /gene="INPPL1"
                     /gene_synonym="OPSMD; SHIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2341..2430
                     /gene="INPPL1"
                     /gene_synonym="OPSMD; SHIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2431..2544
                     /gene="INPPL1"
                     /gene_synonym="OPSMD; SHIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2545..2633
                     /gene="INPPL1"
                     /gene_synonym="OPSMD; SHIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2634..2721
                     /gene="INPPL1"
                     /gene_synonym="OPSMD; SHIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2722..2877
                     /gene="INPPL1"
                     /gene_synonym="OPSMD; SHIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2878..2956
                     /gene="INPPL1"
                     /gene_synonym="OPSMD; SHIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2957..3097
                     /gene="INPPL1"
                     /gene_synonym="OPSMD; SHIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            3098..3770
                     /gene="INPPL1"
                     /gene_synonym="OPSMD; SHIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            3771..3904
                     /gene="INPPL1"
                     /gene_synonym="OPSMD; SHIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            3905..4789
                     /gene="INPPL1"
                     /gene_synonym="OPSMD; SHIP2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4726..4731
                     /regulatory_class="polyA_signal_sequence"
                     /gene="INPPL1"
                     /gene_synonym="OPSMD; SHIP2"
                     /note="hexamer: AATAAA"
     polyA_site      4747
                     /gene="INPPL1"
                     /gene_synonym="OPSMD; SHIP2"
                     /note="major polyA site"
     regulatory      4767..4772
                     /regulatory_class="polyA_signal_sequence"
                     /gene="INPPL1"
                     /gene_synonym="OPSMD; SHIP2"
                     /note="hexamer: ATTACA"
     polyA_site      4789
                     /gene="INPPL1"
                     /gene_synonym="OPSMD; SHIP2"
ORIGIN      
        1 ctttctcttc aagttgaggc cggcgctgca ggcagcggcg gctgcgcggt gaacgaggcg
       61 gcctgcgcgg cggagtgctg agtcccgatc cccggctctg tccggcccac ggatcctcaa
      121 gcccgggccc cgggcccggc cccagcctca gccctgagcg tctcggggcg gatggcgcgg
      181 ggcggcgggg gcgggcggtg ctgagccctg cgcgggccat ggcctcggcc tgcggggcgc
      241 cgggcccggg gggcgccctg ggcagccagg ccccctcctg gtaccaccgc gacctgagcc
      301 gggcggccgc ggaggagctg ctggcccggg cgggccgcga tggcagcttc ctggtccgag
      361 acagcgagag cgtggcgggg gccttcgcgc tctgcgtcct gtatcagaag catgtgcaca
      421 cgtatcgcat tctgcctgat ggagaagatt tcttggctgt gcagacctcg cagggtgtgc
      481 ctgtgcgccg cttccagacc ctgggtgagc tcatcggcct gtacgcccag cccaaccagg
      541 gccttgtgtg cgccctgctt cttcctgtag agggtgagcg agagccggac ccaccggatg
      601 accgggatgc ctcagatggg gaggatgaga agcccccgct gcccccgcgc tctggctcca
      661 ccagcatttc tgcccccact gggcccagca gtcccctgcc agctcctgag actcccacag
      721 ctccagctgc tgagagtgct cccaatgggc tgagcaccgt ctcgcacgac tacctgaaag
      781 gcagctatgg gctggacctg gaagctgtga ggggtggagc cagccacctg ccccacctca
      841 cccgtaccct cgctacctca tgccggaggc tgcacagtga ggtggacaag gtcctgtcag
      901 gcctggagat cctgtccaag gtgtttgacc agcagagctc gcccatggtg acccgccttt
      961 tgcagcagca gaacctgcca cagacagggg agcaggaact agagagcctg gtgctgaagc
     1021 tgtcagtgct aaaggacttc ctgtcaggca tccagaagaa ggccctgaag gccctacagg
     1081 acatgagctc cacagcaccc ccagctccgc agccatccac acgtaaggcc aagaccatcc
     1141 ccgtgcaggc ctttgaggtg aagctagatg tgaccctggg tgacctgacc aagattggga
     1201 agtcacagaa gttcacgctg agcgtggatg tggagggtgg gcggctggtg ctgctgcgga
     1261 gacagcggga ctcccaggag gactggacca ccttcacgca cgaccgcatc cgccagctca
     1321 ttaagtccca gcgtgtccag aacaagctgg gtgttgtgtt tgagaaggag aaggaccgga
     1381 ctcagcgcaa ggacttcatc tttgtcagtg cccggaagcg ggaggccttc tgccagctgt
     1441 tgcagctcat gaagaacaag cactccaagc aggacgagcc cgacatgatc tcagtcttca
     1501 taggcacctg gaacatggga agtgtaccac ctccaaaaaa cgtgacatcc tggttcacat
     1561 cgaagggtct ggggaagacc ctggacgagg tcacagtgac cataccccat gacatctatg
     1621 tctttgggac ccaggagaac tcagtgggcg accgcgagtg gctggaccta ctgcgcgggg
     1681 gcctcaagga gcttacggat ctggattacc gcccgattgc catgcaatca ctgtggaata
     1741 tcaaggtggc agtgctggtc aagccagagc acgagaaccg tatcagccat gtcagtacgt
     1801 ccagtgtgaa gactggcatc gccaacaccc tggggaacaa gggggctgtg ggcgtctcct
     1861 tcatgtttaa tggcacctca tttggctttg tgaattgtca cctcacctcg ggaaatgaga
     1921 agacggctcg gaggaaccaa aactacttgg acatcctgcg gctgctctcg ctgggcgacc
     1981 ggcagctcaa tgcctttgac atctctctgc gtttcacaca cctcttctgg tttggggacc
     2041 tcaactaccg cctggacatg gatatccagg agatcctgaa ctacatcagc aggaaagagt
     2101 ttgagcccct cctcagggtg gaccagctca acctggagcg ggagaagcac aaggtcttcc
     2161 ttcgattcag tgaggaggag atctccttcc cacccaccta ccgctatgag cggggttccc
     2221 gggacacata tgcctggcac aagcagaagc caactggggt ccggaccaat gtgccctcat
     2281 ggtgtgaccg gattctgtgg aaatcctacc ctgaaactca catcatctgc aattcttatg
     2341 gttgcactga tgacatcgtc accagcgacc attcccccgt gtttgggaca tttgaggttg
     2401 gagttacctc ccagttcatc tccaagaaag ggctctcaaa gacttcagac caggcctaca
     2461 ttgagtttga gagcatcgag gccattgtga agacagccag ccgcaccaag ttcttcatcg
     2521 agttctactc tacctgcctg gaggaataca agaagagctt tgagaatgat gcccagagca
     2581 gtgacaacat caacttcctc aaagtgcagt ggtcttcacg ccagctgccc acgctcaaac
     2641 caattctggc tgatatcgag tacctgcagg accagcacct cctgctcaca gtcaagtcca
     2701 tggatggcta tgaatcctat ggggagtgtg tggttgcact caaatccatg atcggcagca
     2761 cggcccaaca gttcctgacc ttcctatccc accgtggcga ggagacaggc aatatcagag
     2821 gctccatgaa ggtgcgggtg cccacggagc gcctgggcac ccgtgagcgg ctctacgagt
     2881 ggatcagcat tgataaggat gaggcaggag caaagagcaa agccccctct gtgtcccgag
     2941 ggagccagga gcccaggtca gggagccgca agccagcctt cacagaggcc tcctgcccgc
     3001 tctccaggtt atttgaagaa ccagagaaac cgccaccaac ggggaggccc ccagccccac
     3061 cccgagcagc tccccgggag gagcccttga cccccaggtt gaagccagag ggagctcctg
     3121 aaccagaagg ggtggcggcc cccccaccca agaacagctt caataaccct gcctactacg
     3181 tccttgaagg ggtcccgcac cagctgctgc ccccggagcc accctcgcct gccagggccc
     3241 ctgtcccatc tgccaccaag aacaaagtgg ccattacagt gcctgctcca cagcttgggc
     3301 accaccggca ccctcgtgtg ggagagggga gttcttcaga tgaggagtct ggaggcacac
     3361 tgccccctcc agactttcca cctccaccac tgccggactc agccatcttc ctgcccccca
     3421 gcctggatcc tttaccaggg ccagtggtcc ggggccgtgg tggggctgag gcccgtggcc
     3481 caccacctcc caaggcccat ccaaggcctc cactgccccc aggcccctca ccagccagca
     3541 ctttcctggg ggaagtggcc agtggggatg accggtcctg ctcggtgctg cagatggcca
     3601 agacgctgag cgaggtggac tatgcccctg ctgggcctgc acgctcagcg ctcctcccag
     3661 gccccctgga gctgcagccc ccccggggac tgccctcgga ctatggccgg cccctcagct
     3721 tccctccacc ccgcatccgg gagagcatcc aggaagacct ggcagaggag gctccgtgcc
     3781 tgcagggcgg gcgggccagc gggctgggcg aggcaggcat gagtgcctgg ctgcgggcca
     3841 tcggcttgga gcgctatgag gagggcctgg tgcataatgg ctgggacgac ctggagtttc
     3901 tcagtgacat caccgaggag gacttggagg aggctggggt gcaggacccg gctcacaagc
     3961 gcctccttct ggacaccctg cagctcagca agtgatagcg gaggcaccac gaagctgtga
     4021 actcagagcc cctccctgct accaaggccc agctatggcc ccagggttga aaagttatga
     4081 gggtcagggc agtatctctc tgcctattta ttggggtgcc tatttattgg ggatctgcat
     4141 tccccgctgc ccaatcattt gcaatgccct aattagggca tcctgcccct cgccttttag
     4201 gctcaggacg gaaggtcagt tgccatggtt accgaggacc ctggttactc tggtgctgtc
     4261 ctgttttact ggaccccgcc tcccagcccc aggggtgcct gtgggggtcc atttgggtac
     4321 gtctgggccc ccactttcac cagtttctgc ggccttccac cgggcctgaa ccacagcgga
     4381 ggagctccgc taagacctcc ccacccccgc tgggggtggg ggcgggtgtc cgtccggaaa
     4441 tgaaggaata gcccgaggac cgggctgggg tttatttaaa ctgttctgtg tgggtctggg
     4501 gagggagagc accttaatat tattggggtt ggttggggtg gggcaggatc tcagccataa
     4561 agtgccagtt tgcttagttc tcactgtctc ctggtctgtg ctgccctgct ctggggatgc
     4621 acggcggcag ggtgggggag ggaggttcct cgcaggtctc agcccgggac agggtcttgc
     4681 aagcagcctc ctgggcagtc gtaagggttg cggcgtgatg tcttcaataa attaagtttt
     4741 atttggattg agtaaaactt caataaatta caagtttttc aaagaaaaa
//
