LOCUS       NM_001284285            3348 bp    mRNA    linear   PRI 26-JUL-2023
DEFINITION  Homo sapiens inositol polyphosphate-5-phosphatase J (INPP5J),
            transcript variant 1, mRNA.
ACCESSION   NM_001284285 XM_005261562
VERSION     NM_001284285.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3348)
  AUTHORS   Luck K, Kim DK, Lambourne L, Spirohn K, Begg BE, Bian W, Brignall
            R, Cafarelli T, Campos-Laborie FJ, Charloteaux B, Choi D, Cote AG,
            Daley M, Deimling S, Desbuleux A, Dricot A, Gebbia M, Hardy MF,
            Kishore N, Knapp JJ, Kovacs IA, Lemmens I, Mee MW, Mellor JC,
            Pollis C, Pons C, Richardson AD, Schlabach S, Teeking B, Yadav A,
            Babor M, Balcha D, Basha O, Bowman-Colin C, Chin SF, Choi SG,
            Colabella C, Coppin G, D'Amata C, De Ridder D, De Rouck S,
            Duran-Frigola M, Ennajdaoui H, Goebels F, Goehring L, Gopal A,
            Haddad G, Hatchi E, Helmy M, Jacob Y, Kassa Y, Landini S, Li R, van
            Lieshout N, MacWilliams A, Markey D, Paulson JN, Rangarajan S,
            Rasla J, Rayhan A, Rolland T, San-Miguel A, Shen Y, Sheykhkarimli
            D, Sheynkman GM, Simonovsky E, Tasan M, Tejeda A, Tropepe V,
            Twizere JC, Wang Y, Weatheritt RJ, Weile J, Xia Y, Yang X,
            Yeger-Lotem E, Zhong Q, Aloy P, Bader GD, De Las Rivas J, Gaudet S,
            Hao T, Rak J, Tavernier J, Hill DE, Vidal M, Roth FP and Calderwood
            MA.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 3348)
  AUTHORS   Dong R, Zhu T, Benedetti L, Gowrishankar S, Deng H, Cai Y, Wang X,
            Shen K and De Camilli P.
  TITLE     The inositol 5-phosphatase INPP5K participates in the fine control
            of ER organization
  JOURNAL   J Cell Biol 217 (10), 3577-3592 (2018)
   PUBMED   30087126
REFERENCE   3  (bases 1 to 3348)
  AUTHORS   Zhu T, Yuan J, Wang Y, Gong C, Xie Y and Li H.
  TITLE     MiR-661 contributed to cell proliferation of human ovarian cancer
            cells by repressing INPP5J expression
  JOURNAL   Biomed Pharmacother 75, 123-128 (2015)
   PUBMED   26282217
  REMARK    GeneRIF: Suggest miR-661 functions as a tumor promoter by targeting
            the INPP5J gene, and then promoting cell proliferation of ovarian
            cancer cells.
REFERENCE   4  (bases 1 to 3348)
  AUTHORS   Ooms LM, Binge LC, Davies EM, Rahman P, Conway JR, Gurung R,
            Ferguson DT, Papa A, Fedele CG, Vieusseux JL, Chai RC, Koentgen F,
            Price JT, Tiganis T, Timpson P, McLean CA and Mitchell CA.
  TITLE     The Inositol Polyphosphate 5-Phosphatase PIPP Regulates
            AKT1-Dependent Breast Cancer Growth and Metastasis
  JOURNAL   Cancer Cell 28 (2), 155-169 (2015)
   PUBMED   26267533
  REMARK    GeneRIF: Findings indicate inositol polyphosphate 5-phosphatase
            PIPP (INPP5J) as a suppressor of oncogenic phosphoinositide
            3-kinase (PI3K)/AKT signaling in breast cancer.
REFERENCE   5  (bases 1 to 3348)
  AUTHORS   Lin C, Liu A, Zhu J, Zhang X, Wu G, Ren P, Wu J, Li M, Li J and
            Song L.
  TITLE     miR-508 sustains phosphoinositide signalling and promotes
            aggressive phenotype of oesophageal squamous cell carcinoma
  JOURNAL   Nat Commun 5, 4620 (2014)
   PUBMED   25099196
  REMARK    GeneRIF: miR-508 has a role in sustaining phosphoinositide
            signalling and promotes aggressive phenotype of oesophageal
            squamous cell carcinoma by suppressing INPP5J
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3348)
  AUTHORS   Ye Y, Jin L, Wilmott JS, Hu WL, Yosufi B, Thorne RF, Liu T, Rizos
            H, Yan XG, Dong L, Tay KH, Tseng HY, Guo ST, de Bock CE, Jiang CC,
            Wang CY, Wu M, Zhang LJ, Hersey P, Scolyer RA and Zhang XD.
  TITLE     PI(4,5)P2 5-phosphatase A regulates PI3K/Akt signalling and has a
            tumour suppressive role in human melanoma
  JOURNAL   Nat Commun 4, 1508 (2013)
   PUBMED   23443536
  REMARK    GeneRIF: these results establish the tumour suppressive role of
            phosphatidylinositol 4,5-bisphosphate 5-phosphatase and reveal
            mechanisms involved in its downregulation in melanoma.
REFERENCE   7  (bases 1 to 3348)
  AUTHORS   Gurung R, Tan A, Ooms LM, McGrath MJ, Huysmans RD, Munday AD,
            Prescott M, Whisstock JC and Mitchell CA.
  TITLE     Identification of a novel domain in two mammalian
            inositol-polyphosphate 5-phosphatases that mediates membrane ruffle
            localization. The inositol 5-phosphatase skip localizes to the
            endoplasmic reticulum and translocates to membrane ruffles
            following epidermal growth factor stimulation
  JOURNAL   J Biol Chem 278 (13), 11376-11385 (2003)
   PUBMED   12536145
REFERENCE   8  (bases 1 to 3348)
  AUTHORS   Mochizuki Y and Takenawa T.
  TITLE     Novel inositol polyphosphate 5-phosphatase localizes at membrane
            ruffles
  JOURNAL   J Biol Chem 274 (51), 36790-36795 (1999)
   PUBMED   10593988
  REMARK    Erratum:[J Biol Chem 2000 Jul 7;275(27):20956]
REFERENCE   9  (bases 1 to 3348)
  AUTHORS   Kramer J, Aguirre-Arteta AM, Thiel C, Gross CM, Dietz R, Cardoso MC
            and Leonhardt H.
  TITLE     A novel isoform of the smooth muscle cell differentiation marker
            smoothelin
  JOURNAL   J Mol Med (Berl) 77 (2), 294-298 (1999)
   PUBMED   10023782
  REMARK    Erratum:[J Mol Med 1999 Apr;77(4):399]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK092859.1, AC005005.1, AK293992.1 and AW014134.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001284285.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK092859.1, SRR7346977.1488136.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968832
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000331075.10/ ENSP00000333262.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-845               AK092859.1         1-845
            846-846             AC005005.1         52573-52573         c
            847-1173            AK092859.1         846-1172
            1174-1294           AC005005.1         52125-52245         c
            1295-2451           AK092859.1         1294-2450
            2452-2452           AC005005.1         44632-44632         c
            2453-2769           AK092859.1         2452-2768
            2770-3090           AK293992.1         2892-3212
            3091-3348           AW014134.1         17-274              c
FEATURES             Location/Qualifiers
     source          1..3348
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q12.2"
     gene            1..3348
                     /gene="INPP5J"
                     /gene_synonym="INPP5; PIB5PA; PIPP"
                     /note="inositol polyphosphate-5-phosphatase J"
                     /db_xref="GeneID:27124"
                     /db_xref="HGNC:HGNC:8956"
                     /db_xref="MIM:606481"
     exon            1..154
                     /gene="INPP5J"
                     /gene_synonym="INPP5; PIB5PA; PIPP"
                     /inference="alignment:Splign:2.1.0"
     CDS             50..3070
                     /gene="INPP5J"
                     /gene_synonym="INPP5; PIB5PA; PIPP"
                     /EC_number="3.1.3.56"
                     /EC_number="3.1.3.36"
                     /note="isoform a is encoded by transcript variant 1;
                     phosphatidylinositol 4,5-bisphosphate 5-phosphatase A;
                     phosphatidylinositol 1,4,5-trisphosphate 5-phosphatase;
                     phosphatidylinositol 1,3,4,5-tetrakisphosphate
                     5-phosphatase"
                     /codon_start=1
                     /product="phosphatidylinositol 4,5-bisphosphate
                     5-phosphatase A isoform a"
                     /protein_id="NP_001271214.1"
                     /db_xref="CCDS:CCDS63453.1"
                     /db_xref="GeneID:27124"
                     /db_xref="HGNC:HGNC:8956"
                     /db_xref="MIM:606481"
                     /translation="MEGQSSRGSRRPGTRAGLGSLPMPQGVAQTGAPSKVDSSFQLPA
                     KKNAALGPSEPRLALAPVGPRAAMSASSEGPRLALASPRPILAPLCTPEGQKTATAHR
                     SSSLAPTSVGQLVMSASAGPKPPPATTGSVLAPTSLGLVMPASAGPRSPPVTLGPNLA
                     PTSRDQKQEPPASVGPKPTLAASGLSLALASEEQPPELPSTPSPVPSPVLSPTQEQAL
                     APASTASGAASVGQTSARKRDAPAPRPLPASEGHLQPPAQTSGPTGSPPCIQTSPDPR
                     LSPSFRARPEALHSSPEDPVLPRPPQTLPLDVGQGPSEPGTHSPGLLSPTFRPGAPSG
                     QTVPPPLPKPPRSPSRSPSHSPNRSPCVPPAPDMALPRLGTQSTGPGRCLSPNLQAQE
                     APAPVTTSSSTSTLSSSPWSAQPTWKSDPGFRITVVTWNVGTAMPPDDVTSLLHLGGG
                     DDSDGADMIAIGLQEVNSMLNKRLKDALFTDQWSELFMDALGPFNFVLVSSVRMQGVI
                     LLLFAKYYHLPFLRDVQTDCTRTGLGGYWGNKGGVSVRLAAFGHMLCFLNCHLPAHMD
                     KAEQRKDNFQTILSLQQFQGPGAQGILDHDLVFWFGDLNFRIESYDLHFVKFAIDSDQ
                     LHQLWEKDQLNMAKNTWPILKGFQEGPLNFAPTFKFDVGTNKYDTSAKKRKPAWTDRI
                     LWKVKAPGGGPSPSGRKSHRLQVTQHSYRSHMEYTVSDHKPVAAQFLLQFAFRDDMPL
                     VRLEVADEWVRPEQAVVRYRMETVFARSSWDWIGLYRVGFRHCKDYVAYVWAKHEDVD
                     GNTYQVTFSEESLPKGHGDFILGYYSHNHSILIGITEPFQISLPSSELASSSTDSSGT
                     SSEGEDDSTLELLAPKSRSPSPGKSKRHRSRSPGLARFPGLALRPSSRERRGASRSPS
                     PQSRRLSRVAPDRSSNGSSRGSSEEGPSGLPGPWAFPPAVPRSLGLLPALRLETVDPG
                     GGGSWGPDREALAPNSLSPSPQGHRGLEEGGLGP"
     exon            155..1320
                     /gene="INPP5J"
                     /gene_synonym="INPP5; PIB5PA; PIPP"
                     /inference="alignment:Splign:2.1.0"
     exon            1321..1434
                     /gene="INPP5J"
                     /gene_synonym="INPP5; PIB5PA; PIPP"
                     /inference="alignment:Splign:2.1.0"
     exon            1435..1543
                     /gene="INPP5J"
                     /gene_synonym="INPP5; PIB5PA; PIPP"
                     /inference="alignment:Splign:2.1.0"
     exon            1544..1660
                     /gene="INPP5J"
                     /gene_synonym="INPP5; PIB5PA; PIPP"
                     /inference="alignment:Splign:2.1.0"
     exon            1661..1836
                     /gene="INPP5J"
                     /gene_synonym="INPP5; PIB5PA; PIPP"
                     /inference="alignment:Splign:2.1.0"
     exon            1837..1948
                     /gene="INPP5J"
                     /gene_synonym="INPP5; PIB5PA; PIPP"
                     /inference="alignment:Splign:2.1.0"
     exon            1949..2058
                     /gene="INPP5J"
                     /gene_synonym="INPP5; PIB5PA; PIPP"
                     /inference="alignment:Splign:2.1.0"
     exon            2059..2242
                     /gene="INPP5J"
                     /gene_synonym="INPP5; PIB5PA; PIPP"
                     /inference="alignment:Splign:2.1.0"
     exon            2243..2380
                     /gene="INPP5J"
                     /gene_synonym="INPP5; PIB5PA; PIPP"
                     /inference="alignment:Splign:2.1.0"
     exon            2381..2458
                     /gene="INPP5J"
                     /gene_synonym="INPP5; PIB5PA; PIPP"
                     /inference="alignment:Splign:2.1.0"
     exon            2459..2563
                     /gene="INPP5J"
                     /gene_synonym="INPP5; PIB5PA; PIPP"
                     /inference="alignment:Splign:2.1.0"
     exon            2564..3348
                     /gene="INPP5J"
                     /gene_synonym="INPP5; PIB5PA; PIPP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3330..3335
                     /regulatory_class="polyA_signal_sequence"
                     /gene="INPP5J"
                     /gene_synonym="INPP5; PIB5PA; PIPP"
                     /note="hexamer: ATTAAA"
     polyA_site      3348
                     /gene="INPP5J"
                     /gene_synonym="INPP5; PIB5PA; PIPP"
                     /note="major polyA site"
ORIGIN      
        1 agagctggag ccggagccaa gggagtccag gctgccgggg gctgcagaca tggagggcca
       61 gagcagcagg ggcagcagga ggccagggac ccgggctggc ctgggttccc tgcccatgcc
      121 ccagggtgtt gcccaaactg gggcaccctc caaggtggac tcaagttttc agctcccagc
      181 aaagaagaac gcagccctag gaccctcgga accaaggttg gctctggcac ctgtagggcc
      241 acgggcagct atgtcagctt cctcggaagg accgaggctg gctctggcat ctccccgacc
      301 aatcctggct ccactgtgta cccctgaagg gcagaaaaca gctactgccc accgcagctc
      361 cagcctggcc ccaacatctg tgggccagct ggtgatgtct gcctcagctg gaccaaagcc
      421 tcccccagcg accacaggct cagttctggc tccgacgtcc ctggggctgg tgatgcctgc
      481 ctcagcaggg ccaagatctc ccccagtcac cctggggccc aatctggccc caacctccag
      541 agaccagaag caggagccac ctgcctccgt gggacccaag ccaacactgg cagcctctgg
      601 cctgagcctg gccctggctt ctgaggagca gcccccagaa ctcccctcca ccccttcccc
      661 ggtgcccagt ccagttctgt ctccaactca ggaacaggcc ctggctccag catccacggc
      721 atcaggcgca gcctctgtgg gacagacatc agctagaaag agggatgccc cagcccctag
      781 acctctccct gcttctgagg ggcatctcca gcctccagct cagacatctg gtcctacagg
      841 ctccccaccc tgcatccaaa cctccccaga ccctcggctc tccccctcct tccgagcccg
      901 gcctgaggcc ctccacagca gccctgagga tcctgttttg ccacggccac cccagacctt
      961 gcccttggat gtgggccagg gtccttcaga gcctggcact cactcccctg gacttctgtc
     1021 ccccaccttc cggcctgggg ccccctcagg ccagactgtg cccccacctc tgcccaagcc
     1081 accccgatca cccagccgtt ccccaagcca ctccccgaat cgctctccct gtgttccccc
     1141 agcccctgac atggccctcc caaggcttgg cacacagagt acagggcctg gcaggtgcct
     1201 gagccccaac cttcaggccc aagaagcccc agccccagtc accacctcct cttctacatc
     1261 caccctgtca tcctcccctt ggtcagctca gcctacctgg aagagcgacc ccggcttccg
     1321 gatcactgtg gtcacatgga acgtgggcac tgccatgccc ccagacgatg tcacatccct
     1381 cctccacctg ggcggtggtg acgacagcga cggcgcagac atgatcgcca tagggttgca
     1441 ggaagtgaac tccatgctca acaagcgact caaggacgcc ctcttcacgg accagtggag
     1501 tgagctgttc atggatgcgc tagggccctt caacttcgtg ctggtgagtt cggtgaggat
     1561 gcagggtgtc atcctgctgc tgttcgccaa gtactaccac ctgcccttcc tgcgagacgt
     1621 gcagaccgac tgcacgcgca ctggcctggg cggctactgg ggtaacaagg gtggcgtgag
     1681 cgtgcgcctg gcggccttcg ggcacatgct ctgcttcctg aactgccact tgcctgcgca
     1741 tatggacaag gcggagcagc gcaaagacaa cttccagacc atcctcagcc tccagcagtt
     1801 ccaagggccg ggcgcacagg gcatcctgga tcatgacctc gtgttctggt tcggggacct
     1861 gaacttccgc attgagagct atgacctgca ctttgtcaag tttgccatcg acagtgacca
     1921 gctccatcag ctctgggaga aggaccagct caacatggcc aagaacacct ggcccattct
     1981 gaagggcttt caggaggggc ccctcaactt cgctcccacc ttcaagtttg atgtgggtac
     2041 caacaaatac gataccagtg ccaagaaacg gaagccagct tggacagacc gtatcctatg
     2101 gaaggtcaag gctccaggtg ggggtcccag cccctcagga cggaagagcc accgactcca
     2161 ggtgacgcag cacagctacc gcagccacat ggaatacaca gtcagcgacc acaagcctgt
     2221 ggctgcccag ttcctcctgc agtttgcctt cagggacgac atgccactgg tgcggctgga
     2281 ggtggcagat gagtgggtgc ggcccgagca ggcggtggtg aggtaccgca tggaaacagt
     2341 gttcgcccgc agctcctggg actggatcgg cttataccgg gtgggtttcc gccattgcaa
     2401 ggactatgtg gcttatgtct gggccaaaca tgaagatgtg gatgggaata cctaccaggt
     2461 aacattcagt gaggaatcac tgcccaaggg ccatggagac ttcatcctgg gctactatag
     2521 tcacaaccac agcatcctca tcggcatcac tgaacccttc cagatctcgc tgccttcctc
     2581 ggagttggcc agcagcagca cagacagctc aggcaccagc tcagagggag aggatgacag
     2641 cacactggag ctccttgcac ccaagtcccg cagccccagt cctggcaagt ccaagcgaca
     2701 ccgcagccgc agcccgggac tggccaggtt ccctgggctt gccctacggc cctcatcccg
     2761 tgaacgccgt ggtgccagcc gtagcccctc accccagagc cgccgcctgt cccgagtggc
     2821 tcctgacagg agcagtaatg gcagcagccg gggcagtagt gaagaggggc cctctgggtt
     2881 gcctggcccc tgggccttcc caccagctgt gcctcgaagc ctgggcctgt tgcccgcctt
     2941 gcgcctagag actgtagacc ctggtggtgg tggctcctgg ggacctgatc gggaggccct
     3001 ggcgcccaac agcctgtctc ctagtcccca gggccatcgg gggctggagg aagggggcct
     3061 ggggccctga gggtggggta ggcagatggg ccaaggtgac caccattctg cctcaatctt
     3121 ttgcaagccc acctgcctct ctcctgctgc tcctccagct gtatctgcac ctgcctctct
     3181 gtcctggcca ggggtggaca actggggtcc cccaaaactc agtcctggca cctcaactgt
     3241 gacaatcagc aaagccccac ccaggccccc atctgggatg atgggagagc tctggcagat
     3301 gtcccaatcc tggaggtcat ccattaggaa ttaaattctc cagcctca
//
