LOCUS       NM_014937               4979 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens inositol polyphosphate-5-phosphatase F (INPP5F),
            transcript variant 1, mRNA.
ACCESSION   NM_014937
VERSION     NM_014937.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4979)
  AUTHORS   Xue,F., Gao,L., Chen,T., Chen,H., Zhang,H., Wang,T., Han,Z.,
            Gao,S., Wang,L., Hu,Y., Tang,J., Huang,L., Liu,G. and Zhang,Y.
  TITLE     Parkinson's Disease rs117896735 Variant Regulates INPP5F Expression
            in Brain Tissues and Increases Risk of Alzheimer's Disease
  JOURNAL   J Alzheimers Dis 89 (1), 67-77 (2022)
   PUBMED   35848021
  REMARK    GeneRIF: Parkinson's Disease rs117896735 Variant Regulates INPP5F
            Expression in Brain Tissues and Increases Risk of Alzheimer's
            Disease.
REFERENCE   2  (bases 1 to 4979)
  AUTHORS   Zhao,X., Chang,S., Liu,X., Wang,S., Zhang,Y., Lu,X., Zhang,T.,
            Zhang,H. and Wang,L.
  TITLE     Imprinting aberrations of SNRPN, ZAC1 and INPP5F genes involved in
            the pathogenesis of congenital heart disease with extracardiac
            malformations
  JOURNAL   J Cell Mol Med 24 (17), 9898-9907 (2020)
   PUBMED   32693431
  REMARK    GeneRIF: Imprinting aberrations of SNRPN, ZAC1 and INPP5F genes
            involved in the pathogenesis of congenital heart disease with
            extracardiac malformations.
REFERENCE   3  (bases 1 to 4979)
  AUTHORS   Palermo,G., Maisel,D., Barrett,M., Smith,H., Duchateau-Nguyen,G.,
            Nguyen,T., Yeh,R.F., Dufour,A., Robak,T., Dornan,D. and Weisser,M.
  CONSRTM   REACH investigators
  TITLE     Gene expression of INPP5F as an independent prognostic marker in
            fludarabine-based therapy of chronic lymphocytic leukemia
  JOURNAL   Blood Cancer J 5 (10), e353 (2015)
   PUBMED   26430724
  REMARK    GeneRIF: we identified inositol polyphosphate-5-phosphatase F
            (INPP5F) as a prognostic factor for progression-free survival in
            Chronic lymphocytic leukemia
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4979)
  AUTHORS   Hsu,F., Hu,F. and Mao,Y.
  TITLE     Spatiotemporal control of phosphatidylinositol 4-phosphate by Sac2
            regulates endocytic recycling
  JOURNAL   J Cell Biol 209 (1), 97-110 (2015)
   PUBMED   25869669
  REMARK    GeneRIF: Sac2 colocalizes with early endosomal markers and is
            recruited to transferrin-containing vesicles during endocytic
            recycling.
REFERENCE   5  (bases 1 to 4979)
  AUTHORS   Nakatsu,F., Messa,M., Nandez,R., Czapla,H., Zou,Y.,
            Strittmatter,S.M. and De Camilli,P.
  TITLE     Sac2/INPP5F is an inositol 4-phosphatase that functions in the
            endocytic pathway
  JOURNAL   J Cell Biol 209 (1), 85-95 (2015)
   PUBMED   25869668
REFERENCE   6  (bases 1 to 4979)
  AUTHORS   Zhu,W., Trivedi,C.M., Zhou,D., Yuan,L., Lu,M.M. and Epstein,J.A.
  TITLE     Inpp5f is a polyphosphoinositide phosphatase that regulates cardiac
            hypertrophic responsiveness
  JOURNAL   Circ Res 105 (12), 1240-1247 (2009)
   PUBMED   19875726
  REMARK    GeneRIF: Inpp5f is a polyphosphoinositide phosphatase that
            regulates cardiac hypertrophic responsiveness.
REFERENCE   7  (bases 1 to 4979)
  AUTHORS   Thole,J.M., Vermeer,J.E., Zhang,Y., Gadella,T.W. Jr. and Nielsen,E.
  TITLE     Root hair defective4 encodes a phosphatidylinositol-4-phosphate
            phosphatase required for proper root hair development in
            Arabidopsis thaliana
  JOURNAL   Plant Cell 20 (2), 381-395 (2008)
   PUBMED   18281508
REFERENCE   8  (bases 1 to 4979)
  AUTHORS   Grupe,A., Li,Y., Rowland,C., Nowotny,P., Hinrichs,A.L., Smemo,S.,
            Kauwe,J.S., Maxwell,T.J., Cherny,S., Doil,L., Tacey,K., van
            Luchene,R., Myers,A., Wavrant-De Vrieze,F., Kaleem,M.,
            Hollingworth,P., Jehu,L., Foy,C., Archer,N., Hamilton,G.,
            Holmans,P., Morris,C.M., Catanese,J., Sninsky,J., White,T.J.,
            Powell,J., Hardy,J., O'Donovan,M., Lovestone,S., Jones,L.,
            Morris,J.C., Thal,L., Owen,M., Williams,J. and Goate,A.
  TITLE     A scan of chromosome 10 identifies a novel locus showing strong
            association with late-onset Alzheimer disease
  JOURNAL   Am J Hum Genet 78 (1), 78-88 (2006)
   PUBMED   16385451
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   9  (bases 1 to 4979)
  AUTHORS   Zhong,R. and Ye,Z.H.
  TITLE     The SAC domain-containing protein gene family in Arabidopsis
  JOURNAL   Plant Physiol 132 (2), 544-555 (2003)
   PUBMED   12805586
REFERENCE   10 (bases 1 to 4979)
  AUTHORS   Minagawa,T., Ijuin,T., Mochizuki,Y. and Takenawa,T.
  TITLE     Identification and characterization of a sac domain-containing
            phosphoinositide 5-phosphatase
  JOURNAL   J Biol Chem 276 (25), 22011-22015 (2001)
   PUBMED   11274189
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL158014.20, AB023183.1 and
            AC027672.12.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_014937.3.
            
            Summary: The protein encoded by this gene is an inositol
            1,4,5-trisphosphate (InsP3) 5-phosphatase and contains a Sac
            domain. The activity of this protein is specific for
            phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol
            3,4,5-trisphosphate. Alternatively spliced transcript variants
            encoding multiple isoforms have been observed for this gene.
            [provided by RefSeq, Aug 2011].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC111493.1, SRR1803614.56583.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000650623.2/ ENSP00000497527.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-47                AL158014.20        42078-42124
            48-4357             AB023183.1         1-4310
            4358-4979           AC027672.12        186408-187029       c
FEATURES             Location/Qualifiers
     source          1..4979
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q26.11"
     gene            1..4979
                     /gene="INPP5F"
                     /gene_synonym="hSAC2; MSTP007; MSTPO47; SAC2"
                     /note="inositol polyphosphate-5-phosphatase F"
                     /db_xref="GeneID:22876"
                     /db_xref="HGNC:HGNC:17054"
                     /db_xref="MIM:609389"
     exon            1..310
                     /gene="INPP5F"
                     /gene_synonym="hSAC2; MSTP007; MSTPO47; SAC2"
                     /inference="alignment:Splign:2.1.0"
     CDS             214..3612
                     /gene="INPP5F"
                     /gene_synonym="hSAC2; MSTP007; MSTPO47; SAC2"
                     /EC_number="3.1.3.25"
                     /note="isoform 1 is encoded by transcript variant 1; Sac
                     domain-containing inositol phosphatase 2;
                     phosphatidylinositide phosphatase SAC2; sac
                     domain-containing phosphoinositide 5-phosphatase 2; sac
                     domain-containing phosphoinositide 4-phosphatase 2"
                     /codon_start=1
                     /product="phosphatidylinositide phosphatase SAC2 isoform
                     1"
                     /protein_id="NP_055752.1"
                     /db_xref="CCDS:CCDS7616.1"
                     /db_xref="GeneID:22876"
                     /db_xref="HGNC:HGNC:17054"
                     /db_xref="MIM:609389"
                     /translation="MELFQAKDHYILQQGERALWCSRRDGGLQLRPATDLLLAWNPIC
                     LGLVEGVIGKIQLHSDLPWWLILIRQKALVGKLPGDHEVCKVTKIAVLSLSEMEPQDL
                     ELELCKKHHFGINKPEKIIPSPDDSKFLLKTFTHIKSNVSAPNKKKVKESKEKEKLER
                     RLLEELLKMFMDSESFYYSLTYDLTNSVQRQSTGERDGRPLWQKVDDRFFWNKYMIQD
                     LTEIGTPDVDFWIIPMIQGFVQIEELVVNYTESSDDEKSSPETPPQESTCVDDIHPRF
                     LVALISRRSRHRAGMRYKRRGVDKNGNVANYVETEQLIHVHNHTLSFVQTRGSVPVFW
                     SQVGYRYNPRPRLDRSEKETVAYFCAHFEEQLNIYKKQVIINLVDQAGREKIIGDAYL
                     KQVLLFNNSHLTYVSFDFHEHCRGMKFENVQTLTDAIYDIILDMKWCWVDEAGVICKQ
                     EGIFRVNCMDCLDRTNVVQAAIARVVMEQQLKKLGVMPPEQPLPVKCNRIYQIMWANN
                     GDSISRQYAGTAALKGDFTRTGERKLAGVMKDGVNSANRYYLNRFKDAYRQAVIDLMQ
                     GIPVTEDLYSIFTKEKEHEALHKENQRSHQELISQLLQSYMKLLLPDDEKFHGGWALI
                     DCDPSLIDATHRDVDVLLLLSNSAYYVAYYDDEVDKVNQYQRLSLENLEKIEIGPEPT
                     LFGKPKFSCMRLHYRYKEASGYFHTLRAVMRNPEEDGKDTLQCIAEMLQITKQAMGSD
                     LPIIEKKLERKSSKPHEDIIGIRSQNQGSLAQGKNFLMSKFSSLNQKVKQTKSNVNIG
                     NLRKLGNFTKPEMKVNFLKPNLKVNLWKSDSSLETMENTGVMDKVQAESDGDMSSDND
                     SYHSDEFLTNSKSDEDRQLANSLESVGPIDYVLPSCGIIASAPRLGSRSQSLSSTDSS
                     VHAPSEITVAHGSGLGKGQESPLKKSPSAGDVHILTGFAKPMDIYCHRFVQDAQNKVT
                     HLSETRSVSQQASQERNQMTNQVSNETQSESTEQTPSRPSQLDVSLSATGPQFLSVEP
                     AHSVASQKTPTSASSMLELETGLHVTPSPSESSSSRAVSPFAKIRSSMVQVASITQAG
                     LTHGINFAVSKVQKSPPEPEIINQVQQNELKKMFIQCQTRIIQI"
     exon            311..391
                     /gene="INPP5F"
                     /gene_synonym="hSAC2; MSTP007; MSTPO47; SAC2"
                     /inference="alignment:Splign:2.1.0"
     exon            392..528
                     /gene="INPP5F"
                     /gene_synonym="hSAC2; MSTP007; MSTPO47; SAC2"
                     /inference="alignment:Splign:2.1.0"
     exon            529..657
                     /gene="INPP5F"
                     /gene_synonym="hSAC2; MSTP007; MSTPO47; SAC2"
                     /inference="alignment:Splign:2.1.0"
     exon            658..825
                     /gene="INPP5F"
                     /gene_synonym="hSAC2; MSTP007; MSTPO47; SAC2"
                     /inference="alignment:Splign:2.1.0"
     exon            826..882
                     /gene="INPP5F"
                     /gene_synonym="hSAC2; MSTP007; MSTPO47; SAC2"
                     /inference="alignment:Splign:2.1.0"
     exon            883..1081
                     /gene="INPP5F"
                     /gene_synonym="hSAC2; MSTP007; MSTPO47; SAC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1082..1261
                     /gene="INPP5F"
                     /gene_synonym="hSAC2; MSTP007; MSTPO47; SAC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1262..1329
                     /gene="INPP5F"
                     /gene_synonym="hSAC2; MSTP007; MSTPO47; SAC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1330..1454
                     /gene="INPP5F"
                     /gene_synonym="hSAC2; MSTP007; MSTPO47; SAC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1455..1532
                     /gene="INPP5F"
                     /gene_synonym="hSAC2; MSTP007; MSTPO47; SAC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1533..1653
                     /gene="INPP5F"
                     /gene_synonym="hSAC2; MSTP007; MSTPO47; SAC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1654..1782
                     /gene="INPP5F"
                     /gene_synonym="hSAC2; MSTP007; MSTPO47; SAC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1783..1900
                     /gene="INPP5F"
                     /gene_synonym="hSAC2; MSTP007; MSTPO47; SAC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1901..2099
                     /gene="INPP5F"
                     /gene_synonym="hSAC2; MSTP007; MSTPO47; SAC2"
                     /inference="alignment:Splign:2.1.0"
     exon            2100..2171
                     /gene="INPP5F"
                     /gene_synonym="hSAC2; MSTP007; MSTPO47; SAC2"
                     /inference="alignment:Splign:2.1.0"
     exon            2172..2245
                     /gene="INPP5F"
                     /gene_synonym="hSAC2; MSTP007; MSTPO47; SAC2"
                     /inference="alignment:Splign:2.1.0"
     exon            2246..2374
                     /gene="INPP5F"
                     /gene_synonym="hSAC2; MSTP007; MSTPO47; SAC2"
                     /inference="alignment:Splign:2.1.0"
     exon            2375..2462
                     /gene="INPP5F"
                     /gene_synonym="hSAC2; MSTP007; MSTPO47; SAC2"
                     /inference="alignment:Splign:2.1.0"
     exon            2463..4979
                     /gene="INPP5F"
                     /gene_synonym="hSAC2; MSTP007; MSTPO47; SAC2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4952..4957
                     /regulatory_class="polyA_signal_sequence"
                     /gene="INPP5F"
                     /gene_synonym="hSAC2; MSTP007; MSTPO47; SAC2"
                     /note="hexamer: AATAAA"
     polyA_site      4979
                     /gene="INPP5F"
                     /gene_synonym="hSAC2; MSTP007; MSTPO47; SAC2"
                     /note="major polyA site"
ORIGIN      
        1 gagaggcctc tacggccgcc gctgccgccg ccgctgccgg ggcgcgttct cctcctaccg
       61 gtcgggtgcc ccggggcgtt ccctctgccg ctgcttctcg gcgcggttcc tacccggccg
      121 ctccccgagg cgcgggctct ggcggcctcg accgactagg acgccccgtg cgccgcccgc
      181 gggccgccgc ctccctgggc gcgcggggcc agcatggagc tcttccaagc caaggaccac
      241 tacatcctgc agcagggcga gcgcgcgctg tggtgcagcc gccgcgacgg cggcctccag
      301 ctccgacccg ctactgatct acttcttgcc tggaatccca tttgtttggg gttggtagaa
      361 ggtgttattg ggaaaattca acttcattca gatcttccat ggtggcttat tctaattcgg
      421 cagaaagcat tggtgggcaa actcccagga gaccatgagg tctgtaaagt taccaaaatt
      481 gctgtgctct cactttctga aatggaacct caggatcttg agctagagct ctgtaagaag
      541 catcattttg gtattaacaa accagagaag atcataccat ctcctgatga ctcaaagttt
      601 ctactgaaga cctttacgca tattaaatcc aatgtgtctg ctcctaataa aaagaaagtt
      661 aaggaaagta aagagaagga gaagttggag aggagattac ttgaagagtt gctgaagatg
      721 ttcatggact cagaatcctt ttattatagc ttgacctatg acctgaccaa ttccgtgcag
      781 aggcagagca ctggggagag ggacggtcgg cccctctggc agaaggttga tgaccgattt
      841 ttttggaata aatacatgat acaagatctt actgagattg gtactccaga tgtggacttt
      901 tggattatcc ccatgatcca aggttttgtg cagattgaag aacttgtggt taattatacc
      961 gaatcatctg atgatgagaa aagcagccca gagacccccc ctcaggagtc cacctgtgta
     1021 gatgatattc acccacgatt tctagtggct ctcatttcac gccgaagtag gcacagagca
     1081 ggaatgcgct ataaacgaag aggagtggat aaaaatggaa atgttgccaa ttatgtggag
     1141 actgagcagt tgattcatgt tcataatcat accctgtcat ttgttcaaac acgaggctct
     1201 gtgcctgtct tttggagcca ggttgggtat cgatataacc caagaccgcg gctggacaga
     1261 agtgaaaagg aaactgttgc ctatttctgt gcccatttcg aagaacaact gaacatttac
     1321 aaaaaacagg ttattattaa cttggtagac caggcaggaa gagagaagat tattggcgat
     1381 gcttacctga agcaagtgtt gcttttcaac aactcacacc tcacttacgt ttcgtttgac
     1441 ttccatgagc actgccgagg aatgaagttt gagaatgttc agacactaac agatgccatt
     1501 tatgacatta ttcttgatat gaagtggtgt tgggttgatg aagctggggt aatatgtaag
     1561 caggaaggga tttttcgtgt taattgtatg gactgcctgg atcgcaccaa cgtggtccaa
     1621 gctgccatcg cgagagtggt catggaacag cagctgaaaa aattaggtgt gatgcccccg
     1681 gaacagccat tacctgtgaa atgtaatcgc atctaccaga taatgtgggc caataatggt
     1741 gactccatta gcagacagta tgctgggaca gctgctctga agggtgactt tacaaggaca
     1801 ggagaaagga agttagcagg agttatgaaa gatggagtga actcagcaaa cagatattac
     1861 ctcaaccgat ttaaggatgc ttataggcaa gctgttatag atttgatgca aggcattcca
     1921 gtgacagaag atctttattc catatttacc aaggagaaag aacatgaagc tttgcataag
     1981 gaaaatcaga gaagccacca ggaactaatt agccagctct tacaaagtta catgaagtta
     2041 ctactgcctg atgatgagaa gttccatggg ggctgggccc tcattgactg tgaccctagc
     2101 ctcattgatg ctactcacag agacgtggat gtgctgttac tgctttctaa ctctgcctac
     2161 tacgtggcct attatgatga tgaagttgat aaagtaaacc agtatcaacg actaagtcta
     2221 gaaaacctgg aaaaaattga aataggccct gaacccactc tttttggtaa gccaaagttc
     2281 tcctgcatgc gactgcacta cagatacaaa gaagcgagtg gctatttcca cacattgcga
     2341 gctgtaatgc gtaatcctga agaggatgga aaagataccc ttcagtgcat tgcagagatg
     2401 ctgcagatca ccaagcaagc catgggatcg gatttaccca taattgagaa gaaacttgag
     2461 aggaagagca gtaaacctca cgaagacatc attggtatca ggtctcaaaa ccaaggttct
     2521 ttggcccagg gaaagaattt tttaatgagc aaattttcat ctctaaatca aaaagtgaag
     2581 cagaccaaat ccaatgtaaa tattggcaac ctccgaaagc taggaaactt taccaaacct
     2641 gaaatgaaag ttaactttct aaaaccaaac ttaaaagtaa atctttggaa atcagatagt
     2701 agtcttgaaa ctatggaaaa cacaggagtg atggataagg ttcaggcaga gtctgatggg
     2761 gacatgtctt cagataatga ctcataccac tctgatgaat tccttacaaa ttctaagtct
     2821 gatgaagaca ggcagctagc taactcatta gagagtgtag ggccaataga ttacgttctt
     2881 cctagttgtg gtattattgc ctcagcgcct cgattgggca gtcggtccca gtctcttagc
     2941 agcacagata gtagcgttca tgctccttca gagattactg ttgctcatgg gagtgggctt
     3001 ggaaaaggcc aggagtctcc tttgaagaaa agtccttctg ctggcgacgt acacatattg
     3061 actggctttg ccaagcctat ggatatttac tgccacagat ttgtgcaaga tgcacagaac
     3121 aaagtgaccc acctatcaga gaccagatct gtgtctcagc aggctagtca ggaaagaaat
     3181 caaatgacca atcaagtttc aaatgaaacc caatcagaat caacagaaca gacaccttct
     3241 cggccatcgc aattagatgt ctctctttct gcaacaggcc cacagttttt gtcagttgag
     3301 ccagcgcatt cagttgcatc tcaaaaaacc cccacctccg cttccagcat gcttgaactt
     3361 gagacagggc ttcatgtaac tccttctcct tcagagagca gtagcagcag agcagtctct
     3421 ccctttgcca agattcgaag ttccatggtc caggttgcta gtattaccca agctggatta
     3481 acccatggga taaactttgc agtgtcaaaa gttcagaaga gtcctccaga acctgaaatc
     3541 attaatcaag tccagcaaaa tgaacttaaa aagatgttta tacaatgcca gacacggata
     3601 attcagattt agcttttagc cataagaatc cttccatggc ttttatttaa aaatatgaaa
     3661 ttttcacctc ttggggtatt ttaattgtac tgtctgaacc cagggatcac aaattctgtt
     3721 cattggaaag ggttttaaac ggagtcggaa cctgagtaga tttccaaatt ttacagccag
     3781 gactacagaa gtgcatcatt ctagaatgtg tagacctgag tagcttatac actacagagc
     3841 actttgctta tttgaaagta attcagcaac aggtcacttt gggatataac ctgaaccttt
     3901 ttttggagtg gggtgggtag actacagtag acacaagggc tggacatgca gatgcttagg
     3961 ggattagcgt ttttcataat ttgttctgtt tgtcagttca ttcctgtgtg ttcttacctc
     4021 tacaaagtaa attacacatt tagtttttag tgactttaac atgttactga agcatttgaa
     4081 tataaagcta ttttagtttt gatggcttaa ctgttccctg aggagttgag ggttattgac
     4141 actagagaaa tgaattctca tttgatccta attttccccg tattctactt gaacacatta
     4201 aaaatactct gctgcctata caatgtaaac ctaggagcat taagacttgt cacacagtaa
     4261 acctgataca tcagaggtga ataccagcac ctattaggtt tcattttgct gttttcagga
     4321 atgtaagaac acccatattg gctactggaa attctagaag tcagtcaggt tttaatttat
     4381 tccaggaggg gcatcctcga catcttatgt agatgatcca caacttcaaa atttagtctg
     4441 ggcctagtgc agtggctcac acctataatc ccaacacttt gggaggccag gagttttgag
     4501 accagcctgg gaaacatctg tctctacaaa aaaatacaaa aattagctgg gcatagtggt
     4561 gcatgcctgt gtttctagct acgcaggagg attgcttgag cccatgagat tgaggctgca
     4621 gtgagctgtg atcgtgccac tgacctccag cctgggggac agagcaagac cgtgtctcaa
     4681 aaacaattta gtctgaaaca caattgtgct gaatctgtct gactataact ctgaccacac
     4741 agaaccaggg ctgcccctgt aatccccaca gtaagaaagt tgtatggcat attccaacaa
     4801 gtattggttc gtctggtgtc tttagagctt tactctgttg aagtgactga ttctcaactg
     4861 aacattatgt cgttactttg ataagcattc cacttttgtt atttattagt gctatctttt
     4921 ttttttacgt gttaaatctt gtgattatta aaataaagta ccattgtaat ttaaagtga
//
