LOCUS       NM_001017915            4902 bp    mRNA    linear   PRI 08-OCT-2024
DEFINITION  Homo sapiens inositol polyphosphate-5-phosphatase D (INPP5D),
            transcript variant 1, mRNA.
ACCESSION   NM_001017915
VERSION     NM_001017915.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4902)
  AUTHORS   Lu,G., Liu,H., Wang,H., Tang,X., Luo,S., Du,M., Christiani,D.C. and
            Wei,Q.
  TITLE     Potentially functional variants of INPP5D and EXOSC3 in immunity B
            cell-related genes are associated with non-small cell lung cancer
            survival
  JOURNAL   Front Immunol 15, 1440454 (2024)
   PUBMED   39176091
  REMARK    GeneRIF: Potentially functional variants of INPP5D and EXOSC3 in
            immunity B cell-related genes are associated with non-small cell
            lung cancer survival.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4902)
  AUTHORS   Ramakrishnan,G.S., Berry,W.L., Pacherille,A., Kerr,W.G.,
            Chisholm,J.D., Pedicone,C. and Humphrey,M.B.
  TITLE     SHIP inhibition mediates select TREM2-induced microglial functions
  JOURNAL   Mol Immunol 170, 35-45 (2024)
   PUBMED   38613944
  REMARK    GeneRIF: SHIP inhibition mediates select TREM2-induced microglial
            functions.
REFERENCE   3  (bases 1 to 4902)
  AUTHORS   Bradshaw,W.J., Kennedy,E.C., Moreira,T., Smith,L.A., Chalk,R.,
            Katis,V.L., Benesch,J.L.P., Brennan,P.E., Murphy,E.J. and
            Gileadi,O.
  TITLE     Regulation of inositol 5-phosphatase activity by the C2 domain of
            SHIP1 and SHIP2
  JOURNAL   Structure 32 (4), 453-466 (2024)
   PUBMED   38309262
  REMARK    GeneRIF: Regulation of inositol 5-phosphatase activity by the C2
            domain of SHIP1 and SHIP2.
REFERENCE   4  (bases 1 to 4902)
  AUTHORS   Nalaskowski,M.M., Metzner,A., Brehm,M.A., Labiadh,S., Brauer,H.,
            Grabinski,N., Mayr,G.W. and Jucker,M.
  TITLE     The inositol 5-phosphatase SHIP1 is a nucleo-cytoplasmic shuttling
            protein and enzymatically active in cell nuclei
  JOURNAL   Cell Signal 24 (3), 621-628 (2012)
   PUBMED   21864674
  REMARK    GeneRIF: The identification of SHIP1 as a nuclear inositol 5
            phosphatase adds another member of the phosphoinositide and
            inositol modulating molecules to the emerging network of inositide
            signaling in the nucleus.
REFERENCE   5  (bases 1 to 4902)
  AUTHORS   Kerr,W.G.
  TITLE     Inhibitor and activator: dual functions for SHIP in immunity and
            cancer
  JOURNAL   Ann N Y Acad Sci 1217, 1-17 (2011)
   PUBMED   21155837
  REMARK    GeneRIF: This review summarizes how SHIP participates in normal
            immune physiology or the pathologies that result when SHIP is
            mutated. SHIP can have either inhibitory or activating roles in
            cell signaling.
            Review article
REFERENCE   6  (bases 1 to 4902)
  AUTHORS   Ware,M.D., Rosten,P., Damen,J.E., Liu,L., Humphries,R.K. and
            Krystal,G.
  TITLE     Cloning and characterization of human SHIP, the 145-kD inositol
            5-phosphatase that associates with SHC after cytokine stimulation
  JOURNAL   Blood 88 (8), 2833-2840 (1996)
   PUBMED   8874179
REFERENCE   7  (bases 1 to 4902)
  AUTHORS   Drayer,A.L., Pesesse,X., De Smedt,F., Woscholski,R., Parker,P. and
            Erneux,C.
  TITLE     Cloning and expression of a human placenta inositol
            1,3,4,5-tetrakisphosphate and phosphatidylinositol
            3,4,5-trisphosphate 5-phosphatase
  JOURNAL   Biochem Biophys Res Commun 225 (1), 243-249 (1996)
   PUBMED   8769125
REFERENCE   8  (bases 1 to 4902)
  AUTHORS   Lioubin,M.N., Algate,P.A., Tsai,S., Carlberg,K., Aebersold,A. and
            Rohrschneider,L.R.
  TITLE     p150Ship, a signal transduction molecule with inositol
            polyphosphate-5-phosphatase activity
  JOURNAL   Genes Dev 10 (9), 1084-1095 (1996)
   PUBMED   8654924
REFERENCE   9  (bases 1 to 4902)
  AUTHORS   Kavanaugh,W.M., Pot,D.A., Chin,S.M., Deuter-Reinhard,M.,
            Jefferson,A.B., Norris,F.A., Masiarz,F.R., Cousens,L.S.,
            Majerus,P.W. and Williams,L.T.
  TITLE     Multiple forms of an inositol polyphosphate 5-phosphatase form
            signaling complexes with Shc and Grb2
  JOURNAL   Curr Biol 6 (4), 438-445 (1996)
   PUBMED   8723348
REFERENCE   10 (bases 1 to 4902)
  AUTHORS   Damen,J.E., Liu,L., Rosten,P., Humphries,R.K., Jefferson,A.B.,
            Majerus,P.W. and Krystal,G.
  TITLE     The 145-kDa protein induced to associate with Shc by multiple
            cytokines is an inositol tetraphosphate and phosphatidylinositol
            3,4,5-triphosphate 5-phosphatase
  JOURNAL   Proc Natl Acad Sci U S A 93 (4), 1689-1693 (1996)
   PUBMED   8643691
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AW503130.1, U53470.1 and
            BC099920.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 24, 2018 this sequence version replaced NM_001017915.2.
            
            Summary: This gene is a member of the inositol
            polyphosphate-5-phosphatase (INPP5) family and encodes a protein
            with an N-terminal SH2 domain, an inositol phosphatase domain, and
            two C-terminal protein interaction domains. Expression of this
            protein is restricted to hematopoietic cells where its movement
            from the cytosol to the plasma membrane is mediated by tyrosine
            phosphorylation. At the plasma membrane, the protein hydrolyzes the
            5' phosphate from phosphatidylinositol (3,4,5)-trisphosphate and
            inositol-1,3,4,5-tetrakisphosphate, thereby affecting multiple
            signaling pathways. The protein is also partly localized to the
            nucleus, where it may be involved in nuclear inositol phosphate
            signaling processes. Overall, the protein functions as a negative
            regulator of myeloid cell proliferation and survival. Mutations in
            this gene are associated with defects and cancers of the immune
            system. Deficiencies in the encoded protein, SHIP1, have been
            associated with Inflammatory Bowel Disease types such as Crohn's
            Disease and Ulcerative Colitis. Alternative splicing of this gene
            results in multiple transcript variants. [provided by RefSeq, Jul
            2020].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803616.38964.1, U84400.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000445964.6/ ENSP00000405338.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-118               AW503130.1         266-383
            119-1177            U53470.1           112-1170
            1178-4902           BC099920.1         1161-4885
FEATURES             Location/Qualifiers
     source          1..4902
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q37.1"
     gene            1..4902
                     /gene="INPP5D"
                     /gene_synonym="hp51CN; p150Ship; SHIP; SHIP-1; SHIP1;
                     SIP-145"
                     /note="inositol polyphosphate-5-phosphatase D"
                     /db_xref="GeneID:3635"
                     /db_xref="HGNC:HGNC:6079"
                     /db_xref="MIM:601582"
     exon            1..271
                     /gene="INPP5D"
                     /gene_synonym="hp51CN; p150Ship; SHIP; SHIP-1; SHIP1;
                     SIP-145"
                     /inference="alignment:Splign:2.1.0"
     CDS             138..3707
                     /gene="INPP5D"
                     /gene_synonym="hp51CN; p150Ship; SHIP; SHIP-1; SHIP1;
                     SIP-145"
                     /EC_number="3.1.3.56"
                     /EC_number="3.1.3.36"
                     /EC_number="3.1.3.86"
                     /note="isoform a is encoded by transcript variant 1;
                     signaling inositol polyphosphate 5 phosphatase SIP-145;
                     inositol polyphosphate-5-phosphatase, 145kDa; SH2
                     domain-containing inositol 5'-phosphatase 1;
                     phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1;
                     signaling inositol polyphosphate phosphatase SHIP II;
                     phosphatidylinositol 4,5-bisphosphate 5-phosphatase"
                     /codon_start=1
                     /product="phosphatidylinositol 3,4,5-trisphosphate
                     5-phosphatase 1 isoform a"
                     /protein_id="NP_001017915.1"
                     /db_xref="CCDS:CCDS74672.1"
                     /db_xref="GeneID:3635"
                     /db_xref="HGNC:HGNC:6079"
                     /db_xref="MIM:601582"
                     /translation="MVPCWNHGNITRSKAEELLSRTGKDGSFLVRASESISRAYALCV
                     LYRNCVYTYRILPNEDDKFTVQASEGVSMRFFTKLDQLIEFYKKENMGLVTHLQYPVP
                     LEEEDTGDDPEEDTVESVVSPPELPPRNIPLTASSCEAKEVPFSNENPRATETSRPSL
                     SETLFQRLQSMDTSGLPEEHLKAIQDYLSTQLAQDSEFVKTGSSSLPHLKKLTTLLCK
                     ELYGEVIRTLPSLESLQRLFDQQLSPGLRPRPQVPGEANPINMVSKLSQLTSLLSSIE
                     DKVKALLHEGPESPHRPSLIPPVTFEVKAESLGIPQKMQLKVDVESGKLIIKKSKDGS
                     EDKFYSHKKILQLIKSQKFLNKLVILVETEKEKILRKEYVFADSKKREGFCQLLQQMK
                     NKHSEQPEPDMITIFIGTWNMGNAPPPKKITSWFLSKGQGKTRDDSADYIPHDIYVIG
                     TQEDPLSEKEWLEILKHSLQEITSVTFKTVAIHTLWNIRIVVLAKPEHENRISHICTD
                     NVKTGIANTLGNKGAVGVSFMFNGTSLGFVNSHLTSGSEKKLRRNQNYMNILRFLALG
                     DKKLSPFNITHRFTHLFWFGDLNYRVDLPTWEAETIIQKIKQQQYADLLSHDQLLTER
                     REQKVFLHFEEEEITFAPTYRFERLTRDKYAYTKQKATGMKYNLPSWCDRVLWKSYPL
                     VHVVCQSYGSTSDIMTSDHSPVFATFEAGVTSQFVSKNGPGTVDSQGQIEFLRCYATL
                     KTKSQTKFYLEFHSSCLESFVKSQEGENEEGSEGELVVKFGETLPKLKPIISDPEYLL
                     DQHILISIKSSDSDESYGEGCIALRLEATETQLPIYTPLTHHGELTGHFQGEIKLQTS
                     QGKTREKLYDFVKTERDESSGPKTLKSLTSHDPMKQWEVTSRAPPCSGSSITEIINPN
                     YMGVGPFGPPMPLHVKQTLSPDQQPTAWSYDQPPKDSPLGPCRGESPPTPPGQPPISP
                     KKFLPSTANRGLPPRTQESRPSDLGKNAGDTLPQEDLPLTKPEMFENPLYGSLSSFPK
                     PAPRKDQESPKMPRKEPPPCPEPGILSPSIVLTKAQEADRGEGPGKQVPAPRLRSFTC
                     SSSAEGRAAGGDKSQGKPKTPVSSQAPVPAKRPIKPSRSEINQQTPPTPTPRPPLPVK
                     SPAVLHLQHSKGRDYRDNTELPHHGKHRPEEGPPGPLGRTAMQ"
     exon            272..335
                     /gene="INPP5D"
                     /gene_synonym="hp51CN; p150Ship; SHIP; SHIP-1; SHIP1;
                     SIP-145"
                     /inference="alignment:Splign:2.1.0"
     exon            336..486
                     /gene="INPP5D"
                     /gene_synonym="hp51CN; p150Ship; SHIP; SHIP-1; SHIP1;
                     SIP-145"
                     /inference="alignment:Splign:2.1.0"
     exon            487..661
                     /gene="INPP5D"
                     /gene_synonym="hp51CN; p150Ship; SHIP; SHIP-1; SHIP1;
                     SIP-145"
                     /inference="alignment:Splign:2.1.0"
     exon            662..802
                     /gene="INPP5D"
                     /gene_synonym="hp51CN; p150Ship; SHIP; SHIP-1; SHIP1;
                     SIP-145"
                     /inference="alignment:Splign:2.1.0"
     exon            803..890
                     /gene="INPP5D"
                     /gene_synonym="hp51CN; p150Ship; SHIP; SHIP-1; SHIP1;
                     SIP-145"
                     /inference="alignment:Splign:2.1.0"
     exon            891..971
                     /gene="INPP5D"
                     /gene_synonym="hp51CN; p150Ship; SHIP; SHIP-1; SHIP1;
                     SIP-145"
                     /inference="alignment:Splign:2.1.0"
     exon            972..1043
                     /gene="INPP5D"
                     /gene_synonym="hp51CN; p150Ship; SHIP; SHIP-1; SHIP1;
                     SIP-145"
                     /inference="alignment:Splign:2.1.0"
     exon            1044..1167
                     /gene="INPP5D"
                     /gene_synonym="hp51CN; p150Ship; SHIP; SHIP-1; SHIP1;
                     SIP-145"
                     /inference="alignment:Splign:2.1.0"
     exon            1168..1274
                     /gene="INPP5D"
                     /gene_synonym="hp51CN; p150Ship; SHIP; SHIP-1; SHIP1;
                     SIP-145"
                     /inference="alignment:Splign:2.1.0"
     exon            1275..1377
                     /gene="INPP5D"
                     /gene_synonym="hp51CN; p150Ship; SHIP; SHIP-1; SHIP1;
                     SIP-145"
                     /inference="alignment:Splign:2.1.0"
     exon            1378..1574
                     /gene="INPP5D"
                     /gene_synonym="hp51CN; p150Ship; SHIP; SHIP-1; SHIP1;
                     SIP-145"
                     /inference="alignment:Splign:2.1.0"
     exon            1575..1692
                     /gene="INPP5D"
                     /gene_synonym="hp51CN; p150Ship; SHIP; SHIP-1; SHIP1;
                     SIP-145"
                     /inference="alignment:Splign:2.1.0"
     exon            1693..1789
                     /gene="INPP5D"
                     /gene_synonym="hp51CN; p150Ship; SHIP; SHIP-1; SHIP1;
                     SIP-145"
                     /inference="alignment:Splign:2.1.0"
     exon            1790..1928
                     /gene="INPP5D"
                     /gene_synonym="hp51CN; p150Ship; SHIP; SHIP-1; SHIP1;
                     SIP-145"
                     /inference="alignment:Splign:2.1.0"
     exon            1929..2037
                     /gene="INPP5D"
                     /gene_synonym="hp51CN; p150Ship; SHIP; SHIP-1; SHIP1;
                     SIP-145"
                     /inference="alignment:Splign:2.1.0"
     exon            2038..2126
                     /gene="INPP5D"
                     /gene_synonym="hp51CN; p150Ship; SHIP; SHIP-1; SHIP1;
                     SIP-145"
                     /inference="alignment:Splign:2.1.0"
     exon            2127..2208
                     /gene="INPP5D"
                     /gene_synonym="hp51CN; p150Ship; SHIP; SHIP-1; SHIP1;
                     SIP-145"
                     /inference="alignment:Splign:2.1.0"
     exon            2209..2298
                     /gene="INPP5D"
                     /gene_synonym="hp51CN; p150Ship; SHIP; SHIP-1; SHIP1;
                     SIP-145"
                     /inference="alignment:Splign:2.1.0"
     exon            2299..2412
                     /gene="INPP5D"
                     /gene_synonym="hp51CN; p150Ship; SHIP; SHIP-1; SHIP1;
                     SIP-145"
                     /inference="alignment:Splign:2.1.0"
     exon            2413..2495
                     /gene="INPP5D"
                     /gene_synonym="hp51CN; p150Ship; SHIP; SHIP-1; SHIP1;
                     SIP-145"
                     /inference="alignment:Splign:2.1.0"
     exon            2496..2583
                     /gene="INPP5D"
                     /gene_synonym="hp51CN; p150Ship; SHIP; SHIP-1; SHIP1;
                     SIP-145"
                     /inference="alignment:Splign:2.1.0"
     exon            2584..2733
                     /gene="INPP5D"
                     /gene_synonym="hp51CN; p150Ship; SHIP; SHIP-1; SHIP1;
                     SIP-145"
                     /inference="alignment:Splign:2.1.0"
     exon            2734..2830
                     /gene="INPP5D"
                     /gene_synonym="hp51CN; p150Ship; SHIP; SHIP-1; SHIP1;
                     SIP-145"
                     /inference="alignment:Splign:2.1.0"
     exon            2831..3112
                     /gene="INPP5D"
                     /gene_synonym="hp51CN; p150Ship; SHIP; SHIP-1; SHIP1;
                     SIP-145"
                     /inference="alignment:Splign:2.1.0"
     exon            3113..3704
                     /gene="INPP5D"
                     /gene_synonym="hp51CN; p150Ship; SHIP; SHIP-1; SHIP1;
                     SIP-145"
                     /inference="alignment:Splign:2.1.0"
     exon            3705..4902
                     /gene="INPP5D"
                     /gene_synonym="hp51CN; p150Ship; SHIP; SHIP-1; SHIP1;
                     SIP-145"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4879..4884
                     /regulatory_class="polyA_signal_sequence"
                     /gene="INPP5D"
                     /gene_synonym="hp51CN; p150Ship; SHIP; SHIP-1; SHIP1;
                     SIP-145"
                     /note="hexamer: AATAAA"
     polyA_site      4902
                     /gene="INPP5D"
                     /gene_synonym="hp51CN; p150Ship; SHIP; SHIP-1; SHIP1;
                     SIP-145"
                     /note="major polyA site"
ORIGIN      
        1 agttaagctg gtggcagcag ccgaggccac caagaggcaa cgggcggcag gttgcagtgg
       61 aggggcctcc gctcccctcg gtggtgtgtg ggtcctgggg gtgcctgccg gcccggccga
      121 ggaggcccac gcccaccatg gtcccctgct ggaaccatgg caacatcacc cgctccaagg
      181 cggaggagct gctttccagg acaggcaagg acgggagctt cctcgtgcgt gccagcgagt
      241 ccatctcccg ggcatacgcg ctctgcgtgc tgtatcggaa ttgcgtttac acttacagaa
      301 ttctgcccaa tgaagatgat aaattcactg ttcaggcatc cgaaggcgtc tccatgaggt
      361 tcttcaccaa gctggaccag ctcatcgagt tttacaagaa ggaaaacatg gggctggtga
      421 cccatctgca ataccctgtg ccgctggagg aagaggacac aggcgacgac cctgaggagg
      481 acacagtaga aagtgtcgtg tctccacccg agctgccccc aagaaacatc ccgctgactg
      541 ccagctcctg tgaggccaag gaggttcctt tttcaaacga gaatccccga gcgaccgaga
      601 ccagccggcc gagcctctcc gagacattgt tccagcgact gcaaagcatg gacaccagtg
      661 ggcttccaga agagcatctt aaggccatcc aagattattt aagcactcag ctcgcccagg
      721 actctgaatt tgtgaagaca gggtccagca gtcttcctca cctgaagaaa ctgaccacac
      781 tgctctgcaa ggagctctat ggagaagtca tccggaccct cccatccctg gagtctctgc
      841 agaggttatt tgaccagcag ctctccccgg gcctccgtcc acgtcctcag gttcctggtg
      901 aggccaatcc catcaacatg gtgtccaagc tcagccaact gacaagcctg ttgtcgtcca
      961 ttgaagacaa ggtcaaggcc ttgctgcacg agggtcctga gtctccgcac cggccctccc
     1021 ttatccctcc agtcaccttt gaggtgaagg cagagtctct ggggattcct cagaaaatgc
     1081 agctcaaagt cgacgttgag tctgggaaac tgatcattaa gaagtccaag gatggttctg
     1141 aggacaagtt ctacagccac aagaaaatcc tgcagctcat taagtcacag aaatttctga
     1201 ataagttggt gatcttggtg gaaacagaga aggagaagat cctgcggaag gaatatgttt
     1261 ttgctgactc caaaaagaga gaaggcttct gccagctcct gcagcagatg aagaacaagc
     1321 actcagagca gccggagccc gacatgatca ccatcttcat cggcacctgg aacatgggta
     1381 acgccccccc tcccaagaag atcacgtcct ggtttctctc caaggggcag ggaaagacgc
     1441 gggacgactc tgcggactac atcccccatg acatttacgt gatcggcacc caagaggacc
     1501 ccctgagtga gaaggagtgg ctggagatcc tcaaacactc cctgcaagaa atcaccagtg
     1561 tgacttttaa aacagtcgcc atccacacgc tctggaacat ccgcatcgtg gtgctggcca
     1621 agcctgagca cgagaaccgg atcagccaca tctgtactga caacgtgaag acaggcattg
     1681 caaacacact ggggaacaag ggagccgtgg gggtgtcgtt catgttcaat ggaacctcct
     1741 tagggttcgt caacagccac ttgacttcag gaagtgaaaa gaaactcagg cgaaaccaaa
     1801 actatatgaa cattctccgg ttcctggccc tgggcgacaa gaagctgagt ccctttaaca
     1861 tcactcaccg cttcacgcac ctcttctggt ttggggatct taactaccgt gtggatctgc
     1921 ctacctggga ggcagaaacc atcatccaga aaatcaagca gcagcagtac gcagacctcc
     1981 tgtcccacga ccagctgctc acagagagga gggagcagaa ggtcttccta cacttcgagg
     2041 aggaagaaat cacgtttgcc ccaacctacc gttttgagag actgactcgg gacaaatacg
     2101 cctacaccaa gcagaaagcg acagggatga agtacaactt gccttcctgg tgtgaccgag
     2161 tcctctggaa gtcttatccc ctggtgcacg tggtgtgtca gtcttatggc agtaccagcg
     2221 acatcatgac gagtgaccac agccctgtct ttgccacatt tgaggcagga gtcacttccc
     2281 agtttgtctc caagaacggt cccgggactg ttgacagcca aggacagatt gagtttctca
     2341 ggtgctatgc cacattgaag accaagtccc agaccaaatt ctacctggag ttccactcga
     2401 gctgcttgga gagttttgtc aagagtcagg aaggagaaaa tgaagaagga agtgaggggg
     2461 agctggtggt gaagtttggt gagactcttc caaagctgaa gcccattatc tctgaccctg
     2521 agtacctgct agaccagcac atcctcatca gcatcaagtc ctctgacagc gacgaatcct
     2581 atggcgaggg ctgcattgcc cttcggttag aggccacaga aacgcagctg cccatctaca
     2641 cgcctctcac ccaccatggg gagttgacag gccacttcca gggggagatc aagctgcaga
     2701 cctctcaggg caagacgagg gagaagctct atgactttgt gaagacggag cgtgatgaat
     2761 ccagtgggcc aaagaccctg aagagcctca ccagccacga ccccatgaag cagtgggaag
     2821 tcactagcag ggcccctccg tgcagtggct ccagcatcac tgaaatcatc aaccccaact
     2881 acatgggagt ggggcccttt gggccaccaa tgcccctgca cgtgaagcag accttgtccc
     2941 ctgaccagca gcccacagcc tggagctacg accagccgcc caaggactcc ccgctggggc
     3001 cctgcagggg agaaagtcct ccgacacctc ccggccagcc gcccatatca cccaagaagt
     3061 ttttaccctc aacagcaaac cggggtctcc ctcccaggac acaggagtca aggcccagtg
     3121 acctggggaa gaacgcaggg gacacgctgc ctcaggagga cctgccgctg acgaagcccg
     3181 agatgtttga gaaccccctg tatgggtccc tgagttcctt ccctaagcct gctcccagga
     3241 aggaccagga atcccccaaa atgccgcgga aggaaccccc gccctgcccg gaacccggca
     3301 tcttgtcgcc cagcatcgtg ctcaccaaag cccaggaggc tgatcgcggc gaggggcccg
     3361 gcaagcaggt gcccgcgccc cggctgcgct ccttcacgtg ctcatcctct gccgagggca
     3421 gggcggccgg cggggacaag agccaaggga agcccaagac cccggtcagc tcccaggccc
     3481 cggtgccggc caagaggccc atcaagcctt ccagatcgga aatcaaccag cagaccccgc
     3541 ccaccccgac gccgcggccg ccgctgccag tcaagagccc ggcggtgctg cacctccagc
     3601 actccaaggg ccgcgactac cgcgacaaca ccgagctccc gcatcacggc aagcaccggc
     3661 cggaggaggg gccaccaggg cctctaggca ggactgccat gcagtgaagc cctcagtgag
     3721 ctgccactga gtcgggagcc cagaggaacg gcgtgaagcc actggaccct ctcccgggac
     3781 ctcctgctgg ctcctcctgc ccagcttcct atgcaaggct ttgtgttttc aggaaagggc
     3841 ctagcttctg tgtggcccac agagttcact gcctgtgaga cttagcacca agtgctgagg
     3901 ctggaagaaa aacgcacacc agacgggcaa caaacagtct gggtccccag ctcgctcttg
     3961 gtacttggga ccccagtgcc tcgttgaggg cgccattctg aagaaaggaa ctgcagcgcc
     4021 gatttgaggg tggagatata gataataata atattaataa taataatggc cacatggatc
     4081 gaacactcat gatgtgccaa gtgctgtgct aagtgcttta cgaacattcg tcatatcagg
     4141 atgacctcga gagctgaggc tctagccacc taaaaccacg tgcccaaacc caccagttta
     4201 aaacggtgtg tgttcggagg ggtgaaagca ttaagaagcc cagtgccctc ctggagtgag
     4261 acaagggctc ggccttaagg agctgaagag tctgggtagc ttgtttaggg tacaagaagc
     4321 ctgttctgtc cagcttcagt gacacaagct gctttagcta aagtcccgcg ggttccggca
     4381 tggctaggct gagagcaggg atctacctgg cttctcagtt ctttggttgg aaggagcagg
     4441 aaatcagctc ctattctcca gtggagagat ctggcctcag cttgggctag agatgccaag
     4501 gcctgtgcca ggttccctgt gccctcctcg aggtgggcag ccatcaccag ccacagttaa
     4561 gccaagcccc ccaacatgta ttccatcgtg ctggtagaag agtctttgct gttgctcccg
     4621 aaagccgtgc tctccagcct ggctgccagg gagggtgggc ctcttggttc caggctcttg
     4681 aaatagtgca gccttttctt cctatctctg tggctttcag ctctgcttcc ttggttatta
     4741 ggagaataga tgggtgatgt ctttccttat gttgcttttt caacatagca gaattaatgt
     4801 agggagctaa atccagtggt gtgtgtgaat gcagaaggga atgcacccca cattcccatg
     4861 atggaagtct gcgtaaccaa taaattgtgc ctttctcact ca
//
