LOCUS       NM_005540               4450 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens inositol polyphosphate-5-phosphatase B (INPP5B),
            transcript variant 1, mRNA.
ACCESSION   NM_005540 XM_375718
VERSION     NM_005540.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4450)
  AUTHORS   Droubi,A., Wallis,C., Anderson,K.E., Rahman,S., de Sa,A.,
            Rahman,T., Stephens,L.R., Hawkins,P.T. and Lowe,M.
  TITLE     The inositol 5-phosphatase INPP5B regulates B cell receptor
            clustering and signaling
  JOURNAL   J Cell Biol 221 (9) (2022)
   PUBMED   35878408
  REMARK    GeneRIF: The inositol 5-phosphatase INPP5B regulates B cell
            receptor clustering and signaling.
REFERENCE   2  (bases 1 to 4450)
  AUTHORS   Nakatsu,F., Messa,M., Nandez,R., Czapla,H., Zou,Y.,
            Strittmatter,S.M. and De Camilli,P.
  TITLE     Sac2/INPP5F is an inositol 4-phosphatase that functions in the
            endocytic pathway
  JOURNAL   J Cell Biol 209 (1), 85-95 (2015)
   PUBMED   25869668
REFERENCE   3  (bases 1 to 4450)
  AUTHORS   Montjean,R., Aoidi,R., Desbois,P., Rucci,J., Trichet,M.,
            Salomon,R., Rendu,J., Faure,J., Lunardi,J., Gacon,G., Billuart,P.
            and Dorseuil,O.
  TITLE     OCRL-mutated fibroblasts from patients with Dent-2 disease exhibit
            INPP5B-independent phenotypic variability relatively to Lowe
            syndrome cells
  JOURNAL   Hum Mol Genet 24 (4), 994-1006 (2015)
   PUBMED   25305077
  REMARK    GeneRIF: OCRL-mutated fibroblasts from patients with Dent-2 disease
            exhibit INPP5B-independent phenotypic variability relatively to
            Lowe syndrome cells
REFERENCE   4  (bases 1 to 4450)
  AUTHORS   Pirruccello,M., Nandez,R., Idevall-Hagren,O., Alcazar-Roman,A.,
            Abriola,L., Berwick,S.A., Lucast,L., Morel,D. and De Camilli,P.
  TITLE     Identification of inhibitors of inositol 5-phosphatases through
            multiple screening strategies
  JOURNAL   ACS Chem Biol 9 (6), 1359-1368 (2014)
   PUBMED   24742366
REFERENCE   5  (bases 1 to 4450)
  AUTHORS   Tresaugues,L., Silvander,C., Flodin,S., Welin,M., Nyman,T.,
            Graslund,S., Hammarstrom,M., Berglund,H. and Nordlund,P.
  TITLE     Structural basis for phosphoinositide substrate recognition,
            catalysis, and membrane interactions in human inositol
            polyphosphate 5-phosphatases
  JOURNAL   Structure 22 (5), 744-755 (2014)
   PUBMED   24704254
  REMARK    GeneRIF: The crystal structures of human INPP5B in complex with
            phosphoinositide substrate analogs revealed a membrane interaction
            patch likely to assist in sequestering substrates from the lipid
            bilayer.
REFERENCE   6  (bases 1 to 4450)
  AUTHORS   Speed,C.J., Matzaris,M., Bird,P.I. and Mitchell,C.A.
  TITLE     Tissue distribution and intracellular localisation of the 75-kDa
            inositol polyphosphate 5-phosphatase
  JOURNAL   Eur J Biochem 234 (1), 216-224 (1995)
   PUBMED   8529643
REFERENCE   7  (bases 1 to 4450)
  AUTHORS   Jefferson,A.B. and Majerus,P.W.
  TITLE     Properties of type II inositol polyphosphate 5-phosphatase
  JOURNAL   J Biol Chem 270 (16), 9370-9377 (1995)
   PUBMED   7721860
REFERENCE   8  (bases 1 to 4450)
  AUTHORS   Janne,P.A., Dutra,A.S., Dracopoli,N.C., Charnas,L.R., Puck,J.M. and
            Nussbaum,R.L.
  TITLE     Localization of the 75-kDa inositol polyphosphate-5-phosphatase
            (INPP5B) to human chromosome band 1p34
  JOURNAL   Cytogenet Cell Genet 66 (3), 164-166 (1994)
   PUBMED   8125013
REFERENCE   9  (bases 1 to 4450)
  AUTHORS   Ross,T.S., Jefferson,A.B., Mitchell,C.A. and Majerus,P.W.
  TITLE     Cloning and expression of human 75-kDa inositol
            polyphosphate-5-phosphatase
  JOURNAL   J Biol Chem 266 (30), 20283-20289 (1991)
   PUBMED   1718960
REFERENCE   10 (bases 1 to 4450)
  AUTHORS   Mitchell,C.A., Connolly,T.M. and Majerus,P.W.
  TITLE     Identification and isolation of a 75-kDa inositol
            polyphosphate-5-phosphatase from human platelets
  JOURNAL   J Biol Chem 264 (15), 8873-8877 (1989)
   PUBMED   2542294
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA125087.1, M74161.1,
            AL603790.41, AL929472.21 and BC042529.2.
            
            On Nov 22, 2018 this sequence version replaced NM_005540.2.
            
            Summary: This gene encodes a member of a family of inositol
            polyphosphate-5-phosphatases. These enzymes function in the
            regulation of calcium signaling by inactivating inositol
            phosphates. The encoded protein is localized to the cytosol and
            mitochondria, and associates with membranes through an isoprenyl
            modification near the C-terminus. Alternatively spliced transcript
            variants of this gene have been described. [provided by RefSeq, Jul
            2014].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1). Variants 1 and 5 both encode the same isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803615.214807.1,
                                           SRR1803611.270451.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            MANE Ensembl match                 :: ENST00000373024.8/
                                                  ENSP00000362115.3
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2                 DA125087.1         6-7
            3-224               M74161.1           1-222
            225-225             AL603790.41        17892-17892         c
            226-1493            M74161.1           224-1491
            1494-1494           AL929472.21        111560-111560       c
            1495-2083           M74161.1           1493-2081
            2084-2084           AL929472.21        101849-101849       c
            2085-2836           M74161.1           2083-2834
            2837-4176           AL929472.21        89697-91036         c
            4177-4450           BC042529.2         3556-3829
FEATURES             Location/Qualifiers
     source          1..4450
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p34.3"
     gene            1..4450
                     /gene="INPP5B"
                     /gene_synonym="5PTase"
                     /note="inositol polyphosphate-5-phosphatase B"
                     /db_xref="GeneID:3633"
                     /db_xref="HGNC:HGNC:6077"
                     /db_xref="MIM:147264"
     exon            1..64
                     /gene="INPP5B"
                     /gene_synonym="5PTase"
                     /inference="alignment:Splign:2.1.0"
     exon            65..147
                     /gene="INPP5B"
                     /gene_synonym="5PTase"
                     /inference="alignment:Splign:2.1.0"
     CDS             91..2832
                     /gene="INPP5B"
                     /gene_synonym="5PTase"
                     /EC_number="3.1.3.36"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; phosphoinositide 5-phosphatase; type II
                     inositol 1,4,5-trisphosphate 5-phosphatase; inositol
                     polyphosphate-5-phosphatase, 75kDa"
                     /codon_start=1
                     /product="type II inositol 1,4,5-trisphosphate
                     5-phosphatase isoform 1 precursor"
                     /protein_id="NP_005531.2"
                     /db_xref="CCDS:CCDS41306.1"
                     /db_xref="GeneID:3633"
                     /db_xref="HGNC:HGNC:6077"
                     /db_xref="MIM:147264"
                     /translation="MDQSVAIQETLAEGEYCVIAVQGVLCEGDSRQSRLLGLVRYRLE
                     HGGQEHALFLYTHRRMAITGDDVSLDQIVPVSRDFTLEEVSPDGELYILGSDVTVQLD
                     TAELSLVFQLPFGSQTRMFLHEVARACPGFDSATRDPEFLWLSRYRCAELELEMPTPR
                     GCNSALVTWPGYATIGGGGSNFDGLRPNGKGVPMDQSSRGQDKPESLQPRQNKSKSEI
                     TDMVRSSTITVSDKAHILSMQKFGLRDTIVKSHLLQKEEDYTYIQNFRFFAGTYNVNG
                     QSPKECLRLWLSNGIQAPDVYCVGFQELDLSKEAFFFHDTPKEEEWFKAVSEGLHPDA
                     KYAKVKLIRLVGIMLLLYVKQEHAAYISEVEAETVGTGIMGRMGNKGGVAIRFQFHNT
                     SICVVNSHLAAHIEEYERRNQDYKDICSRMQFCQPDPSLPPLTISNHDVILWLGDLNY
                     RIEELDVEKVKKLIEEKDFQMLYAYDQLKIQVAAKTVFEGFTEGELTFQPTYKYDTGS
                     DDWDTSEKCRAPAWCDRILWKGKNITQLSYQSHMALKTSDHKPVSSVFDIGVRVVNDE
                     LYRKTLEEIVRSLDKMENANIPSVSLSKREFCFQNVKYMQLKVESFTIHNGQVPCHFE
                     FINKPDEESYCKQWLNANPSRGFLLPDSDVEIDLELFVNKMTATKLNSGEDKIEDILV
                     LHLDRGKDYFLSVSGNYLPSCFGSPIHTLCYMREPILDLPLETISELTLMPVWTGDDG
                     SQLDSPMEIPKELWMMVDYLYRNAVQQEDLFQQPGLRSEFEHIRDCLDTGMIDNLSAS
                     NHSVAEALLLFLESLPEPVICYSTYHNCLECSGNYTASKQVISTLPIFHKNVFHYLMA
                     FLRELLKNSAKNHLDENILASIFGSLLLRNPAGHQKLDMTEKKKAQEFIHQFLCNPL"
     exon            148..242
                     /gene="INPP5B"
                     /gene_synonym="5PTase"
                     /inference="alignment:Splign:2.1.0"
     exon            243..340
                     /gene="INPP5B"
                     /gene_synonym="5PTase"
                     /inference="alignment:Splign:2.1.0"
     exon            341..370
                     /gene="INPP5B"
                     /gene_synonym="5PTase"
                     /inference="alignment:Splign:2.1.0"
     exon            371..481
                     /gene="INPP5B"
                     /gene_synonym="5PTase"
                     /inference="alignment:Splign:2.1.0"
     exon            482..622
                     /gene="INPP5B"
                     /gene_synonym="5PTase"
                     /inference="alignment:Splign:2.1.0"
     exon            623..719
                     /gene="INPP5B"
                     /gene_synonym="5PTase"
                     /inference="alignment:Splign:2.1.0"
     exon            720..887
                     /gene="INPP5B"
                     /gene_synonym="5PTase"
                     /inference="alignment:Splign:2.1.0"
     exon            888..989
                     /gene="INPP5B"
                     /gene_synonym="5PTase"
                     /inference="alignment:Splign:2.1.0"
     exon            990..1104
                     /gene="INPP5B"
                     /gene_synonym="5PTase"
                     /inference="alignment:Splign:2.1.0"
     exon            1105..1221
                     /gene="INPP5B"
                     /gene_synonym="5PTase"
                     /inference="alignment:Splign:2.1.0"
     exon            1222..1409
                     /gene="INPP5B"
                     /gene_synonym="5PTase"
                     /inference="alignment:Splign:2.1.0"
     exon            1410..1521
                     /gene="INPP5B"
                     /gene_synonym="5PTase"
                     /inference="alignment:Splign:2.1.0"
     exon            1522..1631
                     /gene="INPP5B"
                     /gene_synonym="5PTase"
                     /inference="alignment:Splign:2.1.0"
     exon            1632..1767
                     /gene="INPP5B"
                     /gene_synonym="5PTase"
                     /inference="alignment:Splign:2.1.0"
     exon            1768..1878
                     /gene="INPP5B"
                     /gene_synonym="5PTase"
                     /inference="alignment:Splign:2.1.0"
     exon            1879..2041
                     /gene="INPP5B"
                     /gene_synonym="5PTase"
                     /inference="alignment:Splign:2.1.0"
     exon            2042..2277
                     /gene="INPP5B"
                     /gene_synonym="5PTase"
                     /inference="alignment:Splign:2.1.0"
     exon            2278..2391
                     /gene="INPP5B"
                     /gene_synonym="5PTase"
                     /inference="alignment:Splign:2.1.0"
     exon            2392..2476
                     /gene="INPP5B"
                     /gene_synonym="5PTase"
                     /inference="alignment:Splign:2.1.0"
     exon            2477..2604
                     /gene="INPP5B"
                     /gene_synonym="5PTase"
                     /inference="alignment:Splign:2.1.0"
     exon            2605..2716
                     /gene="INPP5B"
                     /gene_synonym="5PTase"
                     /inference="alignment:Splign:2.1.0"
     exon            2717..4450
                     /gene="INPP5B"
                     /gene_synonym="5PTase"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4429..4434
                     /regulatory_class="polyA_signal_sequence"
                     /gene="INPP5B"
                     /gene_synonym="5PTase"
                     /note="hexamer: GATAAA"
     polyA_site      4450
                     /gene="INPP5B"
                     /gene_synonym="5PTase"
                     /note="major polyA site"
ORIGIN      
        1 gtagtcactg tcccggaacc tggggcagcg gagtcccgtg cgccctgtgg tgacagctca
       61 ggagggtgtg tgcgctcagc aggggccagc atggaccagt ctgtggcaat ccaggagacg
      121 ctggctgagg gggaatactg cgtcatcgcg gtgcaaggtg tgctgtgtga gggggacagc
      181 cggcagagcc gcctcctggg actcgtgcgc taccgcctgg agcacggcgg ccaggaacac
      241 gctctcttcc tctatacgca ccggaggatg gccattaccg gggacgatgt ctctctggac
      301 cagatagtgc cagtctcgcg ggattttacg ctggaagaag tgtccccaga tggtgaactc
      361 tacatccttg gctcagatgt gaccgtccag ctggacacag cagagcttag cctcgtattc
      421 caactgccct ttggttcaca aaccaggatg ttcctccacg aagttgccag ggcctgtcca
      481 ggcttcgatt ctgcgacccg ggatcctgaa ttcctgtggc tgtctcggta taggtgcgca
      541 gagctggagc tggagatgcc aacgccgcgc ggttgtaact cggccctagt tacctggcca
      601 gggtacgcga caattggcgg aggtggttct aactttgatg gtttgagacc aaatgggaag
      661 ggagtgccta tggaccaaag ctccaggggt caagataaac cagaaagctt gcaaccaaga
      721 cagaataaat ccaagtccga aattactgac atggttcgct cctccactat cacagtgtcg
      781 gacaaggctc atattttatc catgcagaag tttggactgc gagatacaat tgtgaaatca
      841 catctactac agaaagaaga ggattacacc tatatccaga acttcaggtt ttttgcggga
      901 acatacaatg taaatgggca gtcccccaaa gaatgcctcc ggctgtggct gagcaatggt
      961 atccaggccc cagatgtcta ttgtgtaggg ttccaggagc ttgatctgag taaggaagct
     1021 tttttctttc acgatacccc aaaggaggaa gagtggttca aagctgtgtc agagggtctt
     1081 catccagatg ccaaatatgc aaaggtgaag cttatccgac tggttgggat tatgctgctg
     1141 ttatatgtca aacaggagca tgcagcttat atctcagaag tggaagccga gactgtgggg
     1201 acaggaatca tggggaggat gggcaacaag ggaggcgtgg cgatcaggtt ccagttccac
     1261 aacaccagca tctgcgttgt gaattctcac ttggcagccc acattgaaga gtatgagagg
     1321 aggaaccagg actataagga catttgttct cgaatgcagt tttgtcagcc tgacccaagc
     1381 cttccccctc tcaccatcag caaccatgat gtgatcttgt ggctggggga cctcaactac
     1441 aggatagaag agctggatgt ggaaaaagtg aaaaagctca tcgaagagaa ggactttcaa
     1501 atgctgtatg catatgatca gctgaaaatt caggtggccg caaagactgt ctttgaaggc
     1561 ttcacagagg gtgagctcac attccagcct acttacaagt atgatacggg ctctgacgac
     1621 tgggatacca gtgagaagtg ccgtgctcct gcctggtgtg atcggattct ctggaaaggg
     1681 aagaacatca ctcagctgag ttaccagagc cacatggccc tgaagaccag tgaccacaag
     1741 cctgtcagct cagtgtttga catcggggtg agggtcgtaa atgacgagct ttaccggaag
     1801 acactggagg aaattgttcg ctccctggat aagatggaaa atgccaacat tccttctgtg
     1861 tccctgtcca agcgagagtt ctgttttcag aatgtgaagt acatgcaatt gaaagtagaa
     1921 tcctttacaa ttcataatgg acaagtaccc tgtcattttg aattcatcaa caagcctgat
     1981 gaagagtctt actgtaagca gtggctgaat gccaacccca gcagaggctt cctcctgcca
     2041 gattctgatg ttgagattga cttggagctc ttcgtaaata agatgacagc tacaaagctc
     2101 aactcgggtg aagacaaaat tgaggacatt ctggttctgc acttggacag gggaaaggat
     2161 tactttttgt ctgtgtctgg gaactacctg cccagctgtt ttgggtctcc cattcataca
     2221 ctgtgttaca tgagagagcc aatcttggac ctaccacttg aaaccattag tgagctgact
     2281 ctgatgccag tatggactgg agatgatggg agccagttgg atagccccat ggaaatcccc
     2341 aaagagctct ggatgatggt tgattacctg taccgaaatg ctgtccagca ggaagatctg
     2401 tttcagcaac caggcctgag gtcagaattt gaacatatca gggactgctt ggatactgga
     2461 atgattgata acctctctgc cagcaatcat tctgtagccg aagccctgct gcttttcctg
     2521 gagagccttc cagagcctgt catctgttac agcacctacc ataactgctt ggagtgttct
     2581 ggcaactaca cagcaagcaa acaggtcatt tctactctcc ccatattcca caaaaatgtc
     2641 ttccactact tgatggcgtt tttgcgagaa ctgctgaaaa attcagcaaa aaatcatttg
     2701 gatgagaata ttctagctag catatttggc agcttattgc ttcgaaaccc agctggtcac
     2761 caaaagcttg atatgacaga gaagaagaag gctcaagaat ttattcacca gttcctctgc
     2821 aacccactct gagcctctct ctcctcctat tttacttgag gctgccaatt accagcccca
     2881 cctgtttcag ctcaagagat gccttaagat aattatgtga ggccacttgg tagcaagaat
     2941 ggcagctatt tcctgagcct agtaccccaa ttaagcccac cattggttag cacactcagc
     3001 gctgtgagtc gtgaagacac gggagaaaat ccaccataat aaaactgaca ttcaattttc
     3061 aactttagtt atttaacaca gattttttta ttttttattt ttttttattt tgagacggag
     3121 ttttgctctg tcgcgcaggg tggagtgcgg tggcacgatc tcggctcact gcaacctctg
     3181 cctcctgggt gcaagcaatt atcctgcctc agcctcccga gtagctggga ctgcaggcac
     3241 acactgccac gcccagctaa ttttttgcat tttagtagag acggggtttc accgtgttgc
     3301 ccaggctgtt ctaaaactcc tgaactcagg taatctgcct gcctcggcct ccccaagtgc
     3361 taggattaca gatgtgagcc accacgcccg gccttttttt tttttttttc ttttttgaga
     3421 tggagtttca ctcttgttgc ccaggctgga gtgcgttggc gtggtcttgg ctcactgcaa
     3481 cctctgcctc cttggttcaa gcaattctcc tgcctcagcc tctcgagtag ctgggattat
     3541 aggcgtccgc caccatgcct ggctaatttt tttgtgtgtt tttagtatag acacggtttc
     3601 accatgttgg ccaggctggt ctcgaatgcc tggcctcagg tgatccacct gccttggcct
     3661 cccaaagtgc tgggattaca ggcatgaacc accacgcctg gcctaaaatg tttttaaata
     3721 actgtacttg tactcactca ccctacctcc agggcatagt cagtctgggc tgagatcccc
     3781 atgatcagat atttgatgga aagtcctgaa aggccaatga gttggatggc aagaatgcag
     3841 gcagaagctg ctggataaaa taggctacag ccacctcaga tgctttcagt gctctgtctg
     3901 aggatgtgta tatgcatatg caaactcgac ccccgttcct gcccagataa tggctcaata
     3961 actctgaggc tggttgctca gcctctgagg gcaatacagg catttaaaaa attaaaatga
     4021 ccaggcacag tggctcacgc ctgtaatctc ggcactttgg gagactgagg tgggagcatc
     4081 acttgagacc aggagtttgg gaccaggctg ggcaacacag ggagaccccc tctctacaaa
     4141 aacattttta aaaaattagc tgggtgtggt gatgcatgcc tgtggtccca gttacttggg
     4201 aggctgacgt gggtggctca cttgagcaca ggagtttgag gctgcagtga cctatgacca
     4261 catcactgta cgccagcccg ggtgagagag ggagaccccg tctctaaaaa taaaatgtaa
     4321 aatcactgaa aaaatgagtg ttcggtgaaa caagtgggat tttctgggcc agcaagtctt
     4381 ccaaactgta tatgatgcat cctgtctcca tgtgtaatat attttaatga taaatgtatt
     4441 tttaacagtg
//
