LOCUS       NM_001365825            4356 bp    mRNA    linear   PRI 03-APR-2024
DEFINITION  Homo sapiens inositol polyphosphate-5-phosphatase B (INPP5B),
            transcript variant 10, mRNA.
ACCESSION   NM_001365825
VERSION     NM_001365825.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4356)
  AUTHORS   Droubi,A., Wallis,C., Anderson,K.E., Rahman,S., de Sa,A.,
            Rahman,T., Stephens,L.R., Hawkins,P.T. and Lowe,M.
  TITLE     The inositol 5-phosphatase INPP5B regulates B cell receptor
            clustering and signaling
  JOURNAL   J Cell Biol 221 (9) (2022)
   PUBMED   35878408
  REMARK    GeneRIF: The inositol 5-phosphatase INPP5B regulates B cell
            receptor clustering and signaling.
REFERENCE   2  (bases 1 to 4356)
  AUTHORS   Nakatsu,F., Messa,M., Nandez,R., Czapla,H., Zou,Y.,
            Strittmatter,S.M. and De Camilli,P.
  TITLE     Sac2/INPP5F is an inositol 4-phosphatase that functions in the
            endocytic pathway
  JOURNAL   J Cell Biol 209 (1), 85-95 (2015)
   PUBMED   25869668
REFERENCE   3  (bases 1 to 4356)
  AUTHORS   Montjean,R., Aoidi,R., Desbois,P., Rucci,J., Trichet,M.,
            Salomon,R., Rendu,J., Faure,J., Lunardi,J., Gacon,G., Billuart,P.
            and Dorseuil,O.
  TITLE     OCRL-mutated fibroblasts from patients with Dent-2 disease exhibit
            INPP5B-independent phenotypic variability relatively to Lowe
            syndrome cells
  JOURNAL   Hum Mol Genet 24 (4), 994-1006 (2015)
   PUBMED   25305077
  REMARK    GeneRIF: OCRL-mutated fibroblasts from patients with Dent-2 disease
            exhibit INPP5B-independent phenotypic variability relatively to
            Lowe syndrome cells
REFERENCE   4  (bases 1 to 4356)
  AUTHORS   Pirruccello,M., Nandez,R., Idevall-Hagren,O., Alcazar-Roman,A.,
            Abriola,L., Berwick,S.A., Lucast,L., Morel,D. and De Camilli,P.
  TITLE     Identification of inhibitors of inositol 5-phosphatases through
            multiple screening strategies
  JOURNAL   ACS Chem Biol 9 (6), 1359-1368 (2014)
   PUBMED   24742366
REFERENCE   5  (bases 1 to 4356)
  AUTHORS   Tresaugues,L., Silvander,C., Flodin,S., Welin,M., Nyman,T.,
            Graslund,S., Hammarstrom,M., Berglund,H. and Nordlund,P.
  TITLE     Structural basis for phosphoinositide substrate recognition,
            catalysis, and membrane interactions in human inositol
            polyphosphate 5-phosphatases
  JOURNAL   Structure 22 (5), 744-755 (2014)
   PUBMED   24704254
  REMARK    GeneRIF: The crystal structures of human INPP5B in complex with
            phosphoinositide substrate analogs revealed a membrane interaction
            patch likely to assist in sequestering substrates from the lipid
            bilayer.
REFERENCE   6  (bases 1 to 4356)
  AUTHORS   Speed,C.J., Matzaris,M., Bird,P.I. and Mitchell,C.A.
  TITLE     Tissue distribution and intracellular localisation of the 75-kDa
            inositol polyphosphate 5-phosphatase
  JOURNAL   Eur J Biochem 234 (1), 216-224 (1995)
   PUBMED   8529643
REFERENCE   7  (bases 1 to 4356)
  AUTHORS   Jefferson,A.B. and Majerus,P.W.
  TITLE     Properties of type II inositol polyphosphate 5-phosphatase
  JOURNAL   J Biol Chem 270 (16), 9370-9377 (1995)
   PUBMED   7721860
REFERENCE   8  (bases 1 to 4356)
  AUTHORS   Janne,P.A., Dutra,A.S., Dracopoli,N.C., Charnas,L.R., Puck,J.M. and
            Nussbaum,R.L.
  TITLE     Localization of the 75-kDa inositol polyphosphate-5-phosphatase
            (INPP5B) to human chromosome band 1p34
  JOURNAL   Cytogenet Cell Genet 66 (3), 164-166 (1994)
   PUBMED   8125013
REFERENCE   9  (bases 1 to 4356)
  AUTHORS   Ross,T.S., Jefferson,A.B., Mitchell,C.A. and Majerus,P.W.
  TITLE     Cloning and expression of human 75-kDa inositol
            polyphosphate-5-phosphatase
  JOURNAL   J Biol Chem 266 (30), 20283-20289 (1991)
   PUBMED   1718960
REFERENCE   10 (bases 1 to 4356)
  AUTHORS   Mitchell,C.A., Connolly,T.M. and Majerus,P.W.
  TITLE     Identification and isolation of a 75-kDa inositol
            polyphosphate-5-phosphatase from human platelets
  JOURNAL   J Biol Chem 264 (15), 8873-8877 (1989)
   PUBMED   2542294
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL603790.41 and AL929472.21.
            
            Summary: This gene encodes a member of a family of inositol
            polyphosphate-5-phosphatases. These enzymes function in the
            regulation of calcium signaling by inactivating inositol
            phosphates. The encoded protein is localized to the cytosol and
            mitochondria, and associates with membranes through an isoprenyl
            modification near the C-terminus. Alternatively spliced transcript
            variants of this gene have been described. [provided by RefSeq, Jul
            2014].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA1965299, SAMEA1966682
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-68                AL603790.41        19109-19176         c
            69-151              AL603790.41        18371-18453         c
            152-246             AL603790.41        17875-17969         c
            247-276             AL603790.41        15759-15788         c
            277-387             AL603790.41        12807-12917         c
            388-528             AL603790.41        4032-4172           c
            529-625             AL929472.21        120084-120180       c
            626-793             AL929472.21        118283-118450       c
            794-895             AL929472.21        116969-117070       c
            896-1010            AL929472.21        116077-116191       c
            1011-1127           AL929472.21        115614-115730       c
            1128-1315           AL929472.21        114364-114551       c
            1316-1427           AL929472.21        111533-111644       c
            1428-1537           AL929472.21        108811-108920       c
            1538-1673           AL929472.21        106914-107049       c
            1674-1784           AL929472.21        104332-104442       c
            1785-1947           AL929472.21        102719-102881       c
            1948-2183           AL929472.21        101656-101891       c
            2184-2297           AL929472.21        97227-97340         c
            2298-2382           AL929472.21        95185-95269         c
            2383-2510           AL929472.21        94487-94614         c
            2511-2622           AL929472.21        93038-93149         c
            2623-4356           AL929472.21        89423-91156         c
FEATURES             Location/Qualifiers
     source          1..4356
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p34.3"
     gene            1..4356
                     /gene="INPP5B"
                     /gene_synonym="5PTase"
                     /note="inositol polyphosphate-5-phosphatase B"
                     /db_xref="GeneID:3633"
                     /db_xref="HGNC:HGNC:6077"
                     /db_xref="MIM:147264"
     exon            1..68
                     /gene="INPP5B"
                     /gene_synonym="5PTase"
                     /inference="alignment:Splign:2.1.0"
     exon            69..151
                     /gene="INPP5B"
                     /gene_synonym="5PTase"
                     /inference="alignment:Splign:2.1.0"
     exon            152..246
                     /gene="INPP5B"
                     /gene_synonym="5PTase"
                     /inference="alignment:Splign:2.1.0"
     exon            247..276
                     /gene="INPP5B"
                     /gene_synonym="5PTase"
                     /inference="alignment:Splign:2.1.0"
     exon            277..387
                     /gene="INPP5B"
                     /gene_synonym="5PTase"
                     /inference="alignment:Splign:2.1.0"
     CDS             354..2738
                     /gene="INPP5B"
                     /gene_synonym="5PTase"
                     /EC_number="3.1.3.36"
                     /note="isoform 7 is encoded by transcript variant 10;
                     phosphoinositide 5-phosphatase; type II inositol
                     1,4,5-trisphosphate 5-phosphatase; inositol
                     polyphosphate-5-phosphatase, 75kDa"
                     /codon_start=1
                     /product="type II inositol 1,4,5-trisphosphate
                     5-phosphatase isoform 7"
                     /protein_id="NP_001352754.1"
                     /db_xref="GeneID:3633"
                     /db_xref="HGNC:HGNC:6077"
                     /db_xref="MIM:147264"
                     /translation="MFLHEVARACPGFDSATRDPEFLWLSRYRCAELELEMPTPRGCN
                     SALVTWPGYATIGGGGSNFDGLRPNGKGVPMDQSSRGQDKPESLQPRQNKSKSEITDM
                     VRSSTITVSDKAHILSMQKFGLRDTIVKSHLLQKEEDYTYIQNFRFFAGTYNVNGQSP
                     KECLRLWLSNGIQAPDVYCVGFQELDLSKEAFFFHDTPKEEEWFKAVSEGLHPDAKYA
                     KVKLIRLVGIMLLLYVKQEHAAYISEVEAETVGTGIMGRMGNKGGVAIRFQFHNTSIC
                     VVNSHLAAHIEEYERRNQDYKDICSRMQFCQPDPSLPPLTISNHDVILWLGDLNYRIE
                     ELDVEKVKKLIEEKDFQMLYAYDQLKIQVAAKTVFEGFTEGELTFQPTYKYDTGSDDW
                     DTSEKCRAPAWCDRILWKGKNITQLSYQSHMALKTSDHKPVSSVFDIGVRVVNDELYR
                     KTLEEIVRSLDKMENANIPSVSLSKREFCFQNVKYMQLKVESFTIHNGQVPCHFEFIN
                     KPDEESYCKQWLNANPSRGFLLPDSDVEIDLELFVNKMTATKLNSGEDKIEDILVLHL
                     DRGKDYFLSVSGNYLPSCFGSPIHTLCYMREPILDLPLETISELTLMPVWTGDDGSQL
                     DSPMEIPKELWMMVDYLYRNAVQQEDLFQQPGLRSEFEHIRDCLDTGMIDNLSASNHS
                     VAEALLLFLESLPEPVICYSTYHNCLECSGNYTASKQVISTLPIFHKNVFHYLMAFLR
                     ELLKNSAKNHLDENILASIFGSLLLRNPAGHQKLDMTEKKKAQEFIHQFLCNPL"
     exon            388..528
                     /gene="INPP5B"
                     /gene_synonym="5PTase"
                     /inference="alignment:Splign:2.1.0"
     exon            529..625
                     /gene="INPP5B"
                     /gene_synonym="5PTase"
                     /inference="alignment:Splign:2.1.0"
     exon            626..793
                     /gene="INPP5B"
                     /gene_synonym="5PTase"
                     /inference="alignment:Splign:2.1.0"
     exon            794..895
                     /gene="INPP5B"
                     /gene_synonym="5PTase"
                     /inference="alignment:Splign:2.1.0"
     exon            896..1010
                     /gene="INPP5B"
                     /gene_synonym="5PTase"
                     /inference="alignment:Splign:2.1.0"
     exon            1011..1127
                     /gene="INPP5B"
                     /gene_synonym="5PTase"
                     /inference="alignment:Splign:2.1.0"
     exon            1128..1315
                     /gene="INPP5B"
                     /gene_synonym="5PTase"
                     /inference="alignment:Splign:2.1.0"
     exon            1316..1427
                     /gene="INPP5B"
                     /gene_synonym="5PTase"
                     /inference="alignment:Splign:2.1.0"
     exon            1428..1537
                     /gene="INPP5B"
                     /gene_synonym="5PTase"
                     /inference="alignment:Splign:2.1.0"
     exon            1538..1673
                     /gene="INPP5B"
                     /gene_synonym="5PTase"
                     /inference="alignment:Splign:2.1.0"
     exon            1674..1784
                     /gene="INPP5B"
                     /gene_synonym="5PTase"
                     /inference="alignment:Splign:2.1.0"
     exon            1785..1947
                     /gene="INPP5B"
                     /gene_synonym="5PTase"
                     /inference="alignment:Splign:2.1.0"
     exon            1948..2183
                     /gene="INPP5B"
                     /gene_synonym="5PTase"
                     /inference="alignment:Splign:2.1.0"
     exon            2184..2297
                     /gene="INPP5B"
                     /gene_synonym="5PTase"
                     /inference="alignment:Splign:2.1.0"
     exon            2298..2382
                     /gene="INPP5B"
                     /gene_synonym="5PTase"
                     /inference="alignment:Splign:2.1.0"
     exon            2383..2510
                     /gene="INPP5B"
                     /gene_synonym="5PTase"
                     /inference="alignment:Splign:2.1.0"
     exon            2511..2622
                     /gene="INPP5B"
                     /gene_synonym="5PTase"
                     /inference="alignment:Splign:2.1.0"
     exon            2623..4356
                     /gene="INPP5B"
                     /gene_synonym="5PTase"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4335..4340
                     /regulatory_class="polyA_signal_sequence"
                     /gene="INPP5B"
                     /gene_synonym="5PTase"
                     /note="hexamer: GATAAA"
     polyA_site      4356
                     /gene="INPP5B"
                     /gene_synonym="5PTase"
                     /note="major polyA site"
ORIGIN      
        1 aaatgtagtc actgtcccgg aacctggggc agcggagtcc cgtgcgccct gtggtgacag
       61 ctcaggaggg tgtgtgcgct cagcaggggc cagcatggac cagtctgtgg caatccagga
      121 gacgctggct gagggggaat actgcgtcat cgcggtgcaa ggtgtgctgt gtgaggggga
      181 cagccggcag agccgcctcc tgggactcgt gcgctaccgc ctggagcacg gcggccagga
      241 acacgctgtc cccagatggt gaactctaca tccttggctc agatgtgacc gtccagctgg
      301 acacagcaga gcttagcctc gtattccaac tgccctttgg ttcacaaacc aggatgttcc
      361 tccacgaagt tgccagggcc tgtccaggct tcgattctgc gacccgggat cctgaattcc
      421 tgtggctgtc tcggtatagg tgcgcagagc tggagctgga gatgccaacg ccgcgcggtt
      481 gtaactcggc cctagttacc tggccagggt acgcgacaat tggcggaggt ggttctaact
      541 ttgatggttt gagaccaaat gggaagggag tgcctatgga ccaaagctcc aggggtcaag
      601 ataaaccaga aagcttgcaa ccaagacaga ataaatccaa gtccgaaatt actgacatgg
      661 ttcgctcctc cactatcaca gtgtcggaca aggctcatat tttatccatg cagaagtttg
      721 gactgcgaga tacaattgtg aaatcacatc tactacagaa agaagaggat tacacctata
      781 tccagaactt caggtttttt gcgggaacat acaatgtaaa tgggcagtcc cccaaagaat
      841 gcctccggct gtggctgagc aatggtatcc aggccccaga tgtctattgt gtagggttcc
      901 aggagcttga tctgagtaag gaagcttttt tctttcacga taccccaaag gaggaagagt
      961 ggttcaaagc tgtgtcagag ggtcttcatc cagatgccaa atatgcaaag gtgaagctta
     1021 tccgactggt tgggattatg ctgctgttat atgtcaaaca ggagcatgca gcttatatct
     1081 cagaagtgga agccgagact gtggggacag gaatcatggg gaggatgggc aacaagggag
     1141 gcgtggcgat caggttccag ttccacaaca ccagcatctg cgttgtgaat tctcacttgg
     1201 cagcccacat tgaagagtat gagaggagga accaggacta taaggacatt tgttctcgaa
     1261 tgcagttttg tcagcctgac ccaagccttc cccctctcac catcagcaac catgatgtga
     1321 tcttgtggct gggggacctc aactacagga tagaagagct ggatgtggaa aaagtgaaaa
     1381 agctcatcga agagaaggac tttcaaatgc tgtatgcata tgatcagctg aaaattcagg
     1441 tggccgcaaa gactgtcttt gaaggcttca cagagggtga gctcacattc cagcctactt
     1501 acaagtatga tacgggctct gacgactggg ataccagtga gaagtgccgt gctcctgcct
     1561 ggtgtgatcg gattctctgg aaagggaaga acatcactca gctgagttac cagagccaca
     1621 tggccctgaa gaccagtgac cacaagcctg tcagctcagt gtttgacatc ggggtgaggg
     1681 tcgtaaatga cgagctttac cggaagacac tggaggaaat tgttcgctcc ctggataaga
     1741 tggaaaatgc caacattcct tctgtgtccc tgtccaagcg agagttctgt tttcagaatg
     1801 tgaagtacat gcaattgaaa gtagaatcct ttacaattca taatggacaa gtaccctgtc
     1861 attttgaatt catcaacaag cctgatgaag agtcttactg taagcagtgg ctgaatgcca
     1921 accccagcag aggcttcctc ctgccagatt ctgatgttga gattgacttg gagctcttcg
     1981 taaataagat gacagctaca aagctcaact cgggtgaaga caaaattgag gacattctgg
     2041 ttctgcactt ggacagggga aaggattact ttttgtctgt gtctgggaac tacctgccca
     2101 gctgttttgg gtctcccatt catacactgt gttacatgag agagccaatc ttggacctac
     2161 cacttgaaac cattagtgag ctgactctga tgccagtatg gactggagat gatgggagcc
     2221 agttggatag ccccatggaa atccccaaag agctctggat gatggttgat tacctgtacc
     2281 gaaatgctgt ccagcaggaa gatctgtttc agcaaccagg cctgaggtca gaatttgaac
     2341 atatcaggga ctgcttggat actggaatga ttgataacct ctctgccagc aatcattctg
     2401 tagccgaagc cctgctgctt ttcctggaga gccttccaga gcctgtcatc tgttacagca
     2461 cctaccataa ctgcttggag tgttctggca actacacagc aagcaaacag gtcatttcta
     2521 ctctccccat attccacaaa aatgtcttcc actacttgat ggcgtttttg cgagaactgc
     2581 tgaaaaattc agcaaaaaat catttggatg agaatattct agctagcata tttggcagct
     2641 tattgcttcg aaacccagct ggtcaccaaa agcttgatat gacagagaag aagaaggctc
     2701 aagaatttat tcaccagttc ctctgcaacc cactctgagc ctctctctcc tcctatttta
     2761 cttgaggctg ccaattacca gccccacctg tttcagctca agagatgcct taagataatt
     2821 atgtgaggcc acttggtagc aagaatggca gctatttcct gagcctagta ccccaattaa
     2881 gcccaccatt ggttagcaca ctcagcgctg tgagtcgtga agacacggga gaaaatccac
     2941 cataataaaa ctgacattca attttcaact ttagttattt aacacagatt tttttatttt
     3001 ttattttttt ttattttgag acggagtttt gctctgtcgc gcagggtgga gtgcggtggc
     3061 acgatctcgg ctcactgcaa cctctgcctc ctgggtgcaa gcaattatcc tgcctcagcc
     3121 tcccgagtag ctgggactgc aggcacacac tgccacgccc agctaatttt ttgcatttta
     3181 gtagagacgg ggtttcaccg tgttgcccag gctgttctaa aactcctgaa ctcaggtaat
     3241 ctgcctgcct cggcctcccc aagtgctagg attacagatg tgagccacca cgcccggcct
     3301 tttttttttt tttttctttt ttgagatgga gtttcactct tgttgcccag gctggagtgc
     3361 gttggcgtgg tcttggctca ctgcaacctc tgcctccttg gttcaagcaa ttctcctgcc
     3421 tcagcctctc gagtagctgg gattataggc gtccgccacc atgcctggct aatttttttg
     3481 tgtgttttta gtatagacac ggtttcacca tgttggccag gctggtctcg aatgcctggc
     3541 ctcaggtgat ccacctgcct tggcctccca aagtgctggg attacaggca tgaaccacca
     3601 cgcctggcct aaaatgtttt taaataactg tacttgtact cactcaccct acctccaggg
     3661 catagtcagt ctgggctgag atccccatga tcagatattt gatggaaagt cctgaaaggc
     3721 caatgagttg gatggcaaga atgcaggcag aagctgctgg ataaaatagg ctacagccac
     3781 ctcagatgct ttcagtgctc tgtctgagga tgtgtatatg catatgcaaa ctcgaccccc
     3841 gttcctgccc agataatggc tcaataactc tgaggctggt tgctcagcct ctgagggcaa
     3901 tacaggcatt taaaaaatta aaatgaccag gcacagtggc tcacgcctgt aatctcggca
     3961 ctttgggaga ctgaggtggg agcatcactt gagaccagga gtttgggacc aggctgggca
     4021 acacagggag accccctctc tacaaaaaca tttttaaaaa attagctggg tgtggtgatg
     4081 catgcctgtg gtcccagtta cttgggaggc tgacgtgggt ggctcacttg agcacaggag
     4141 tttgaggctg cagtgaccta tgaccacatc actgtacgcc agcccgggtg agagagggag
     4201 accccgtctc taaaaataaa atgtaaaatc actgaaaaaa tgagtgttcg gtgaaacaag
     4261 tgggattttc tgggccagca agtcttccaa actgtatatg atgcatcctg tctccatgtg
     4321 taatatattt taatgataaa tgtattttta acagtg
//
