LOCUS       NM_001365822            4384 bp    mRNA    linear   PRI 03-APR-2024
DEFINITION  Homo sapiens inositol polyphosphate-5-phosphatase B (INPP5B),
            transcript variant 7, mRNA.
ACCESSION   NM_001365822 XM_017001207
VERSION     NM_001365822.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4384)
  AUTHORS   Droubi,A., Wallis,C., Anderson,K.E., Rahman,S., de Sa,A.,
            Rahman,T., Stephens,L.R., Hawkins,P.T. and Lowe,M.
  TITLE     The inositol 5-phosphatase INPP5B regulates B cell receptor
            clustering and signaling
  JOURNAL   J Cell Biol 221 (9) (2022)
   PUBMED   35878408
  REMARK    GeneRIF: The inositol 5-phosphatase INPP5B regulates B cell
            receptor clustering and signaling.
REFERENCE   2  (bases 1 to 4384)
  AUTHORS   Nakatsu,F., Messa,M., Nandez,R., Czapla,H., Zou,Y.,
            Strittmatter,S.M. and De Camilli,P.
  TITLE     Sac2/INPP5F is an inositol 4-phosphatase that functions in the
            endocytic pathway
  JOURNAL   J Cell Biol 209 (1), 85-95 (2015)
   PUBMED   25869668
REFERENCE   3  (bases 1 to 4384)
  AUTHORS   Montjean,R., Aoidi,R., Desbois,P., Rucci,J., Trichet,M.,
            Salomon,R., Rendu,J., Faure,J., Lunardi,J., Gacon,G., Billuart,P.
            and Dorseuil,O.
  TITLE     OCRL-mutated fibroblasts from patients with Dent-2 disease exhibit
            INPP5B-independent phenotypic variability relatively to Lowe
            syndrome cells
  JOURNAL   Hum Mol Genet 24 (4), 994-1006 (2015)
   PUBMED   25305077
  REMARK    GeneRIF: OCRL-mutated fibroblasts from patients with Dent-2 disease
            exhibit INPP5B-independent phenotypic variability relatively to
            Lowe syndrome cells
REFERENCE   4  (bases 1 to 4384)
  AUTHORS   Pirruccello,M., Nandez,R., Idevall-Hagren,O., Alcazar-Roman,A.,
            Abriola,L., Berwick,S.A., Lucast,L., Morel,D. and De Camilli,P.
  TITLE     Identification of inhibitors of inositol 5-phosphatases through
            multiple screening strategies
  JOURNAL   ACS Chem Biol 9 (6), 1359-1368 (2014)
   PUBMED   24742366
REFERENCE   5  (bases 1 to 4384)
  AUTHORS   Tresaugues,L., Silvander,C., Flodin,S., Welin,M., Nyman,T.,
            Graslund,S., Hammarstrom,M., Berglund,H. and Nordlund,P.
  TITLE     Structural basis for phosphoinositide substrate recognition,
            catalysis, and membrane interactions in human inositol
            polyphosphate 5-phosphatases
  JOURNAL   Structure 22 (5), 744-755 (2014)
   PUBMED   24704254
  REMARK    GeneRIF: The crystal structures of human INPP5B in complex with
            phosphoinositide substrate analogs revealed a membrane interaction
            patch likely to assist in sequestering substrates from the lipid
            bilayer.
REFERENCE   6  (bases 1 to 4384)
  AUTHORS   Speed,C.J., Matzaris,M., Bird,P.I. and Mitchell,C.A.
  TITLE     Tissue distribution and intracellular localisation of the 75-kDa
            inositol polyphosphate 5-phosphatase
  JOURNAL   Eur J Biochem 234 (1), 216-224 (1995)
   PUBMED   8529643
REFERENCE   7  (bases 1 to 4384)
  AUTHORS   Jefferson,A.B. and Majerus,P.W.
  TITLE     Properties of type II inositol polyphosphate 5-phosphatase
  JOURNAL   J Biol Chem 270 (16), 9370-9377 (1995)
   PUBMED   7721860
REFERENCE   8  (bases 1 to 4384)
  AUTHORS   Janne,P.A., Dutra,A.S., Dracopoli,N.C., Charnas,L.R., Puck,J.M. and
            Nussbaum,R.L.
  TITLE     Localization of the 75-kDa inositol polyphosphate-5-phosphatase
            (INPP5B) to human chromosome band 1p34
  JOURNAL   Cytogenet Cell Genet 66 (3), 164-166 (1994)
   PUBMED   8125013
REFERENCE   9  (bases 1 to 4384)
  AUTHORS   Ross,T.S., Jefferson,A.B., Mitchell,C.A. and Majerus,P.W.
  TITLE     Cloning and expression of human 75-kDa inositol
            polyphosphate-5-phosphatase
  JOURNAL   J Biol Chem 266 (30), 20283-20289 (1991)
   PUBMED   1718960
REFERENCE   10 (bases 1 to 4384)
  AUTHORS   Mitchell,C.A., Connolly,T.M. and Majerus,P.W.
  TITLE     Identification and isolation of a 75-kDa inositol
            polyphosphate-5-phosphatase from human platelets
  JOURNAL   J Biol Chem 264 (15), 8873-8877 (1989)
   PUBMED   2542294
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL603790.41 and AL929472.21.
            
            On Sep 13, 2018 this sequence version replaced XM_017001207.2.
            
            Summary: This gene encodes a member of a family of inositol
            polyphosphate-5-phosphatases. These enzymes function in the
            regulation of calcium signaling by inactivating inositol
            phosphates. The encoded protein is localized to the cytosol and
            mitochondria, and associates with membranes through an isoprenyl
            modification near the C-terminus. Alternatively spliced transcript
            variants of this gene have been described. [provided by RefSeq, Jul
            2014].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA1965299, SAMEA1966682
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-96                AL603790.41        18893-18988         c
            97-179              AL603790.41        18371-18453         c
            180-274             AL603790.41        17875-17969         c
            275-304             AL603790.41        15759-15788         c
            305-415             AL603790.41        12807-12917         c
            416-556             AL603790.41        4032-4172           c
            557-653             AL929472.21        120084-120180       c
            654-821             AL929472.21        118283-118450       c
            822-923             AL929472.21        116969-117070       c
            924-1038            AL929472.21        116077-116191       c
            1039-1155           AL929472.21        115614-115730       c
            1156-1343           AL929472.21        114364-114551       c
            1344-1455           AL929472.21        111533-111644       c
            1456-1565           AL929472.21        108811-108920       c
            1566-1701           AL929472.21        106914-107049       c
            1702-1812           AL929472.21        104332-104442       c
            1813-1975           AL929472.21        102719-102881       c
            1976-2211           AL929472.21        101656-101891       c
            2212-2325           AL929472.21        97227-97340         c
            2326-2410           AL929472.21        95185-95269         c
            2411-2538           AL929472.21        94487-94614         c
            2539-2650           AL929472.21        93038-93149         c
            2651-4384           AL929472.21        89423-91156         c
FEATURES             Location/Qualifiers
     source          1..4384
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p34.3"
     gene            1..4384
                     /gene="INPP5B"
                     /gene_synonym="5PTase"
                     /note="inositol polyphosphate-5-phosphatase B"
                     /db_xref="GeneID:3633"
                     /db_xref="HGNC:HGNC:6077"
                     /db_xref="MIM:147264"
     exon            1..96
                     /gene="INPP5B"
                     /gene_synonym="5PTase"
                     /inference="alignment:Splign:2.1.0"
     CDS             91..2766
                     /gene="INPP5B"
                     /gene_synonym="5PTase"
                     /EC_number="3.1.3.36"
                     /note="isoform 5 is encoded by transcript variant 7;
                     phosphoinositide 5-phosphatase; type II inositol
                     1,4,5-trisphosphate 5-phosphatase; inositol
                     polyphosphate-5-phosphatase, 75kDa"
                     /codon_start=1
                     /product="type II inositol 1,4,5-trisphosphate
                     5-phosphatase isoform 5"
                     /protein_id="NP_001352751.1"
                     /db_xref="GeneID:3633"
                     /db_xref="HGNC:HGNC:6077"
                     /db_xref="MIM:147264"
                     /translation="MTGVCAQQGPAWTSLWQSRRRWLRGNTASSRCKVCCVRGTAGRA
                     ASWDSCATAWSTAARNTLSPDGELYILGSDVTVQLDTAELSLVFQLPFGSQTRMFLHE
                     VARACPGFDSATRDPEFLWLSRYRCAELELEMPTPRGCNSALVTWPGYATIGGGGSNF
                     DGLRPNGKGVPMDQSSRGQDKPESLQPRQNKSKSEITDMVRSSTITVSDKAHILSMQK
                     FGLRDTIVKSHLLQKEEDYTYIQNFRFFAGTYNVNGQSPKECLRLWLSNGIQAPDVYC
                     VGFQELDLSKEAFFFHDTPKEEEWFKAVSEGLHPDAKYAKVKLIRLVGIMLLLYVKQE
                     HAAYISEVEAETVGTGIMGRMGNKGGVAIRFQFHNTSICVVNSHLAAHIEEYERRNQD
                     YKDICSRMQFCQPDPSLPPLTISNHDVILWLGDLNYRIEELDVEKVKKLIEEKDFQML
                     YAYDQLKIQVAAKTVFEGFTEGELTFQPTYKYDTGSDDWDTSEKCRAPAWCDRILWKG
                     KNITQLSYQSHMALKTSDHKPVSSVFDIGVRVVNDELYRKTLEEIVRSLDKMENANIP
                     SVSLSKREFCFQNVKYMQLKVESFTIHNGQVPCHFEFINKPDEESYCKQWLNANPSRG
                     FLLPDSDVEIDLELFVNKMTATKLNSGEDKIEDILVLHLDRGKDYFLSVSGNYLPSCF
                     GSPIHTLCYMREPILDLPLETISELTLMPVWTGDDGSQLDSPMEIPKELWMMVDYLYR
                     NAVQQEDLFQQPGLRSEFEHIRDCLDTGMIDNLSASNHSVAEALLLFLESLPEPVICY
                     STYHNCLECSGNYTASKQVISTLPIFHKNVFHYLMAFLRELLKNSAKNHLDENILASI
                     FGSLLLRNPAGHQKLDMTEKKKAQEFIHQFLCNPL"
     exon            97..179
                     /gene="INPP5B"
                     /gene_synonym="5PTase"
                     /inference="alignment:Splign:2.1.0"
     exon            180..274
                     /gene="INPP5B"
                     /gene_synonym="5PTase"
                     /inference="alignment:Splign:2.1.0"
     exon            275..304
                     /gene="INPP5B"
                     /gene_synonym="5PTase"
                     /inference="alignment:Splign:2.1.0"
     exon            305..415
                     /gene="INPP5B"
                     /gene_synonym="5PTase"
                     /inference="alignment:Splign:2.1.0"
     exon            416..556
                     /gene="INPP5B"
                     /gene_synonym="5PTase"
                     /inference="alignment:Splign:2.1.0"
     exon            557..653
                     /gene="INPP5B"
                     /gene_synonym="5PTase"
                     /inference="alignment:Splign:2.1.0"
     exon            654..821
                     /gene="INPP5B"
                     /gene_synonym="5PTase"
                     /inference="alignment:Splign:2.1.0"
     exon            822..923
                     /gene="INPP5B"
                     /gene_synonym="5PTase"
                     /inference="alignment:Splign:2.1.0"
     exon            924..1038
                     /gene="INPP5B"
                     /gene_synonym="5PTase"
                     /inference="alignment:Splign:2.1.0"
     exon            1039..1155
                     /gene="INPP5B"
                     /gene_synonym="5PTase"
                     /inference="alignment:Splign:2.1.0"
     exon            1156..1343
                     /gene="INPP5B"
                     /gene_synonym="5PTase"
                     /inference="alignment:Splign:2.1.0"
     exon            1344..1455
                     /gene="INPP5B"
                     /gene_synonym="5PTase"
                     /inference="alignment:Splign:2.1.0"
     exon            1456..1565
                     /gene="INPP5B"
                     /gene_synonym="5PTase"
                     /inference="alignment:Splign:2.1.0"
     exon            1566..1701
                     /gene="INPP5B"
                     /gene_synonym="5PTase"
                     /inference="alignment:Splign:2.1.0"
     exon            1702..1812
                     /gene="INPP5B"
                     /gene_synonym="5PTase"
                     /inference="alignment:Splign:2.1.0"
     exon            1813..1975
                     /gene="INPP5B"
                     /gene_synonym="5PTase"
                     /inference="alignment:Splign:2.1.0"
     exon            1976..2211
                     /gene="INPP5B"
                     /gene_synonym="5PTase"
                     /inference="alignment:Splign:2.1.0"
     exon            2212..2325
                     /gene="INPP5B"
                     /gene_synonym="5PTase"
                     /inference="alignment:Splign:2.1.0"
     exon            2326..2410
                     /gene="INPP5B"
                     /gene_synonym="5PTase"
                     /inference="alignment:Splign:2.1.0"
     exon            2411..2538
                     /gene="INPP5B"
                     /gene_synonym="5PTase"
                     /inference="alignment:Splign:2.1.0"
     exon            2539..2650
                     /gene="INPP5B"
                     /gene_synonym="5PTase"
                     /inference="alignment:Splign:2.1.0"
     exon            2651..4384
                     /gene="INPP5B"
                     /gene_synonym="5PTase"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4363..4368
                     /regulatory_class="polyA_signal_sequence"
                     /gene="INPP5B"
                     /gene_synonym="5PTase"
                     /note="hexamer: GATAAA"
     polyA_site      4384
                     /gene="INPP5B"
                     /gene_synonym="5PTase"
                     /note="major polyA site"
ORIGIN      
        1 gatgcaatgg gcctgctggg gcgggggtga agggcaagca gcaatgggac acttcctgtc
       61 tccaaggaaa gaggaatggg accctcctga atgacaggtg tgtgcgctca gcaggggcca
      121 gcatggacca gtctgtggca atccaggaga cgctggctga gggggaatac tgcgtcatcg
      181 cggtgcaagg tgtgctgtgt gagggggaca gccggcagag ccgcctcctg ggactcgtgc
      241 gctaccgcct ggagcacggc ggccaggaac acgctgtccc cagatggtga actctacatc
      301 cttggctcag atgtgaccgt ccagctggac acagcagagc ttagcctcgt attccaactg
      361 ccctttggtt cacaaaccag gatgttcctc cacgaagttg ccagggcctg tccaggcttc
      421 gattctgcga cccgggatcc tgaattcctg tggctgtctc ggtataggtg cgcagagctg
      481 gagctggaga tgccaacgcc gcgcggttgt aactcggccc tagttacctg gccagggtac
      541 gcgacaattg gcggaggtgg ttctaacttt gatggtttga gaccaaatgg gaagggagtg
      601 cctatggacc aaagctccag gggtcaagat aaaccagaaa gcttgcaacc aagacagaat
      661 aaatccaagt ccgaaattac tgacatggtt cgctcctcca ctatcacagt gtcggacaag
      721 gctcatattt tatccatgca gaagtttgga ctgcgagata caattgtgaa atcacatcta
      781 ctacagaaag aagaggatta cacctatatc cagaacttca ggttttttgc gggaacatac
      841 aatgtaaatg ggcagtcccc caaagaatgc ctccggctgt ggctgagcaa tggtatccag
      901 gccccagatg tctattgtgt agggttccag gagcttgatc tgagtaagga agcttttttc
      961 tttcacgata ccccaaagga ggaagagtgg ttcaaagctg tgtcagaggg tcttcatcca
     1021 gatgccaaat atgcaaaggt gaagcttatc cgactggttg ggattatgct gctgttatat
     1081 gtcaaacagg agcatgcagc ttatatctca gaagtggaag ccgagactgt ggggacagga
     1141 atcatgggga ggatgggcaa caagggaggc gtggcgatca ggttccagtt ccacaacacc
     1201 agcatctgcg ttgtgaattc tcacttggca gcccacattg aagagtatga gaggaggaac
     1261 caggactata aggacatttg ttctcgaatg cagttttgtc agcctgaccc aagccttccc
     1321 cctctcacca tcagcaacca tgatgtgatc ttgtggctgg gggacctcaa ctacaggata
     1381 gaagagctgg atgtggaaaa agtgaaaaag ctcatcgaag agaaggactt tcaaatgctg
     1441 tatgcatatg atcagctgaa aattcaggtg gccgcaaaga ctgtctttga aggcttcaca
     1501 gagggtgagc tcacattcca gcctacttac aagtatgata cgggctctga cgactgggat
     1561 accagtgaga agtgccgtgc tcctgcctgg tgtgatcgga ttctctggaa agggaagaac
     1621 atcactcagc tgagttacca gagccacatg gccctgaaga ccagtgacca caagcctgtc
     1681 agctcagtgt ttgacatcgg ggtgagggtc gtaaatgacg agctttaccg gaagacactg
     1741 gaggaaattg ttcgctccct ggataagatg gaaaatgcca acattccttc tgtgtccctg
     1801 tccaagcgag agttctgttt tcagaatgtg aagtacatgc aattgaaagt agaatccttt
     1861 acaattcata atggacaagt accctgtcat tttgaattca tcaacaagcc tgatgaagag
     1921 tcttactgta agcagtggct gaatgccaac cccagcagag gcttcctcct gccagattct
     1981 gatgttgaga ttgacttgga gctcttcgta aataagatga cagctacaaa gctcaactcg
     2041 ggtgaagaca aaattgagga cattctggtt ctgcacttgg acaggggaaa ggattacttt
     2101 ttgtctgtgt ctgggaacta cctgcccagc tgttttgggt ctcccattca tacactgtgt
     2161 tacatgagag agccaatctt ggacctacca cttgaaacca ttagtgagct gactctgatg
     2221 ccagtatgga ctggagatga tgggagccag ttggatagcc ccatggaaat ccccaaagag
     2281 ctctggatga tggttgatta cctgtaccga aatgctgtcc agcaggaaga tctgtttcag
     2341 caaccaggcc tgaggtcaga atttgaacat atcagggact gcttggatac tggaatgatt
     2401 gataacctct ctgccagcaa tcattctgta gccgaagccc tgctgctttt cctggagagc
     2461 cttccagagc ctgtcatctg ttacagcacc taccataact gcttggagtg ttctggcaac
     2521 tacacagcaa gcaaacaggt catttctact ctccccatat tccacaaaaa tgtcttccac
     2581 tacttgatgg cgtttttgcg agaactgctg aaaaattcag caaaaaatca tttggatgag
     2641 aatattctag ctagcatatt tggcagctta ttgcttcgaa acccagctgg tcaccaaaag
     2701 cttgatatga cagagaagaa gaaggctcaa gaatttattc accagttcct ctgcaaccca
     2761 ctctgagcct ctctctcctc ctattttact tgaggctgcc aattaccagc cccacctgtt
     2821 tcagctcaag agatgcctta agataattat gtgaggccac ttggtagcaa gaatggcagc
     2881 tatttcctga gcctagtacc ccaattaagc ccaccattgg ttagcacact cagcgctgtg
     2941 agtcgtgaag acacgggaga aaatccacca taataaaact gacattcaat tttcaacttt
     3001 agttatttaa cacagatttt tttatttttt attttttttt attttgagac ggagttttgc
     3061 tctgtcgcgc agggtggagt gcggtggcac gatctcggct cactgcaacc tctgcctcct
     3121 gggtgcaagc aattatcctg cctcagcctc ccgagtagct gggactgcag gcacacactg
     3181 ccacgcccag ctaatttttt gcattttagt agagacgggg tttcaccgtg ttgcccaggc
     3241 tgttctaaaa ctcctgaact caggtaatct gcctgcctcg gcctccccaa gtgctaggat
     3301 tacagatgtg agccaccacg cccggccttt tttttttttt tttctttttt gagatggagt
     3361 ttcactcttg ttgcccaggc tggagtgcgt tggcgtggtc ttggctcact gcaacctctg
     3421 cctccttggt tcaagcaatt ctcctgcctc agcctctcga gtagctggga ttataggcgt
     3481 ccgccaccat gcctggctaa tttttttgtg tgtttttagt atagacacgg tttcaccatg
     3541 ttggccaggc tggtctcgaa tgcctggcct caggtgatcc acctgccttg gcctcccaaa
     3601 gtgctgggat tacaggcatg aaccaccacg cctggcctaa aatgttttta aataactgta
     3661 cttgtactca ctcaccctac ctccagggca tagtcagtct gggctgagat ccccatgatc
     3721 agatatttga tggaaagtcc tgaaaggcca atgagttgga tggcaagaat gcaggcagaa
     3781 gctgctggat aaaataggct acagccacct cagatgcttt cagtgctctg tctgaggatg
     3841 tgtatatgca tatgcaaact cgacccccgt tcctgcccag ataatggctc aataactctg
     3901 aggctggttg ctcagcctct gagggcaata caggcattta aaaaattaaa atgaccaggc
     3961 acagtggctc acgcctgtaa tctcggcact ttgggagact gaggtgggag catcacttga
     4021 gaccaggagt ttgggaccag gctgggcaac acagggagac cccctctcta caaaaacatt
     4081 tttaaaaaat tagctgggtg tggtgatgca tgcctgtggt cccagttact tgggaggctg
     4141 acgtgggtgg ctcacttgag cacaggagtt tgaggctgca gtgacctatg accacatcac
     4201 tgtacgccag cccgggtgag agagggagac cccgtctcta aaaataaaat gtaaaatcac
     4261 tgaaaaaatg agtgttcggt gaaacaagtg ggattttctg ggccagcaag tcttccaaac
     4321 tgtatatgat gcatcctgtc tccatgtgta atatatttta atgataaatg tatttttaac
     4381 agtg
//
