LOCUS       NM_005539               3000 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens inositol polyphosphate-5-phosphatase A (INPP5A),
            transcript variant 1, mRNA.
ACCESSION   NM_005539 XM_936595
VERSION     NM_005539.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3000)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 3000)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 3000)
  AUTHORS   Yang,A.W., Sachs,A.J. and Nystuen,A.M.
  TITLE     Deletion of Inpp5a causes ataxia and cerebellar degeneration in
            mice
  JOURNAL   Neurogenetics 16 (4), 277-285 (2015)
   PUBMED   26051944
  REMARK    GeneRIF: The ataxic phenotype and characteristics neurodegeneration
            of the Inpp5a Gt(OST50073)Lex mouse indicate a crucial role for
            Inpp5a in purkinje cells survival.
REFERENCE   4  (bases 1 to 3000)
  AUTHORS   Xu,B., Roos,J.L., Dexheimer,P., Boone,B., Plummer,B., Levy,S.,
            Gogos,J.A. and Karayiorgou,M.
  TITLE     Exome sequencing supports a de novo mutational paradigm for
            schizophrenia
  JOURNAL   Nat Genet 43 (9), 864-868 (2011)
   PUBMED   21822266
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3000)
  AUTHORS   Sekulic,A., Kim,S.Y., Hostetter,G., Savage,S., Einspahr,J.G.,
            Prasad,A., Sagerman,P., Curiel-Lewandrowski,C., Krouse,R.,
            Bowden,G.T., Warneke,J., Alberts,D.S., Pittelkow,M.R., DiCaudo,D.,
            Nickoloff,B.J., Trent,J.M. and Bittner,M.
  TITLE     Loss of inositol polyphosphate 5-phosphatase is an early event in
            development of cutaneous squamous cell carcinoma
  JOURNAL   Cancer Prev Res (Phila) 3 (10), 1277-1283 (2010)
   PUBMED   20876729
  REMARK    GeneRIF: NPP5Amay play a role in development and progression of
            cutaneous squamous cell carcinoma tumors
REFERENCE   6  (bases 1 to 3000)
  AUTHORS   Auethavekiat,V., Abrams,C.S. and Majerus,P.W.
  TITLE     Phosphorylation of platelet pleckstrin activates inositol
            polyphosphate 5-phosphatase I
  JOURNAL   J Biol Chem 272 (3), 1786-1790 (1997)
   PUBMED   8999861
REFERENCE   7  (bases 1 to 3000)
  AUTHORS   De Smedt,F., Boom,A., Pesesse,X., Schiffmann,S.N. and Erneux,C.
  TITLE     Post-translational modification of human brain type I
            inositol-1,4,5-trisphosphate 5-phosphatase by farnesylation
  JOURNAL   J Biol Chem 271 (17), 10419-10424 (1996)
   PUBMED   8626616
REFERENCE   8  (bases 1 to 3000)
  AUTHORS   Mitchell,C.A., Speed,C.J., Nicholl,J. and Sutherland,G.R.
  TITLE     Chromosomal mapping of the gene (INPP5A) encoding the 43-kDa
            membrane-associated inositol polyphosphate 5-phosphatase to 10q26.3
            by fluorescence in situ hybridization
  JOURNAL   Genomics 31 (1), 139-140 (1996)
   PUBMED   8808294
REFERENCE   9  (bases 1 to 3000)
  AUTHORS   Laxminarayan,K.M., Chan,B.K., Tetaz,T., Bird,P.I. and Mitchell,C.A.
  TITLE     Characterization of a cDNA encoding the 43-kDa membrane-associated
            inositol-polyphosphate 5-phosphatase
  JOURNAL   J Biol Chem 269 (25), 17305-17310 (1994)
   PUBMED   8006039
REFERENCE   10 (bases 1 to 3000)
  AUTHORS   De Smedt,F., Verjans,B., Mailleux,P. and Erneux,C.
  TITLE     Cloning and expression of human brain type I inositol
            1,4,5-trisphosphate 5-phosphatase. High levels of mRNA in
            cerebellar Purkinje cells
  JOURNAL   FEBS Lett 347 (1), 69-72 (1994)
   PUBMED   8013665
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from HY025461.1, BC096280.2,
            AL392043.21, Z31695.1 and BI964266.1.
            
            On Nov 22, 2018 this sequence version replaced NM_005539.4.
            
            Summary: The protein encoded by this gene is a membrane-associated
            type I inositol 1,4,5-trisphosphate (InsP3) 5-phosphatase. InsP3
            5-phosphatases hydrolyze Ins(1,4,5)P3, which mobilizes
            intracellular calcium and acts as a second messenger mediating cell
            responses to various stimulation. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660805.117453.1, Z31695.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000368594.8/ ENSP00000357583.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-443               HY025461.1         10-452
            444-1787            BC096280.2         196-1539
            1788-1788           AL392043.21        104823-104823
            1789-2725           Z31695.1           1430-2366
            2726-3000           BI964266.1         114-388
FEATURES             Location/Qualifiers
     source          1..3000
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q26.3"
     gene            1..3000
                     /gene="INPP5A"
                     /gene_synonym="5PTASE"
                     /note="inositol polyphosphate-5-phosphatase A"
                     /db_xref="GeneID:3632"
                     /db_xref="HGNC:HGNC:6076"
                     /db_xref="MIM:600106"
     exon            1..385
                     /gene="INPP5A"
                     /gene_synonym="5PTASE"
                     /inference="alignment:Splign:2.1.0"
     CDS             311..1549
                     /gene="INPP5A"
                     /gene_synonym="5PTASE"
                     /EC_number="3.1.3.56"
                     /note="isoform a is encoded by transcript variant 1; CTCL
                     tumor antigen HD-CL-02; inositol
                     polyphosphate-5-phosphatase, 40kD; 43 kDa inositol
                     polyphosphate 5-phophatase; InsP3 5-phosphatase; inositol
                     polyphosphate-5-phosphatase, 40kDa; type I
                     inositol-1,4,5-trisphosphate 5-phophatase; inositol
                     trisphosphate-5-phosphatase, 40kD; type I inositol
                     1,4,5-trisphosphate 5-phosphatase; 43 kDa inositol
                     polyphosphate 5-phosphatase"
                     /codon_start=1
                     /product="inositol polyphosphate-5-phosphatase A isoform
                     a"
                     /protein_id="NP_005530.3"
                     /db_xref="CCDS:CCDS7669.2"
                     /db_xref="GeneID:3632"
                     /db_xref="HGNC:HGNC:6076"
                     /db_xref="MIM:600106"
                     /translation="MAGKAAAPGTAVLLVTANVGSLFDDPENLQKNWLREFYQVVHTH
                     KPHFMALHCQEFGGKNYEASMSHVDKFVKELLSSDAMKEYNRARVYLDENYKSQEHFT
                     ALGSFYFLHESLKNIYQFDFKAKKYRKVAGKEIYSDTLESTPMLEKEKFPQDYFPECK
                     WSRKGFIRTRWCIADCAFDLVNIHLFHDASNLVAWETSPSVYSGIRHKALGYVLDRII
                     DQRFEKVSYFVFGDFNFRLDSKSVVETLCTKATMQTVRAADTNEVVKLIFRESDNDRK
                     VMLQLEKKLFDYFNQEVFRDNNGTALLEFDKELSVFKDRLYELDISFPPSYPYSEDAR
                     QGEQYMNTRCPAWCDRILMSPSAKELVLRSESEEKVVTYDHIGPNVCMGDHKPVFLAF
                     RIMPGAGKPHAHVHKCCVVQ"
     exon            386..427
                     /gene="INPP5A"
                     /gene_synonym="5PTASE"
                     /inference="alignment:Splign:2.1.0"
     exon            428..528
                     /gene="INPP5A"
                     /gene_synonym="5PTASE"
                     /inference="alignment:Splign:2.1.0"
     exon            529..616
                     /gene="INPP5A"
                     /gene_synonym="5PTASE"
                     /inference="alignment:Splign:2.1.0"
     exon            617..680
                     /gene="INPP5A"
                     /gene_synonym="5PTASE"
                     /inference="alignment:Splign:2.1.0"
     exon            681..784
                     /gene="INPP5A"
                     /gene_synonym="5PTASE"
                     /inference="alignment:Splign:2.1.0"
     exon            785..837
                     /gene="INPP5A"
                     /gene_synonym="5PTASE"
                     /inference="alignment:Splign:2.1.0"
     exon            838..957
                     /gene="INPP5A"
                     /gene_synonym="5PTASE"
                     /inference="alignment:Splign:2.1.0"
     exon            958..1042
                     /gene="INPP5A"
                     /gene_synonym="5PTASE"
                     /inference="alignment:Splign:2.1.0"
     exon            1043..1138
                     /gene="INPP5A"
                     /gene_synonym="5PTASE"
                     /inference="alignment:Splign:2.1.0"
     exon            1139..1213
                     /gene="INPP5A"
                     /gene_synonym="5PTASE"
                     /inference="alignment:Splign:2.1.0"
     exon            1214..1287
                     /gene="INPP5A"
                     /gene_synonym="5PTASE"
                     /inference="alignment:Splign:2.1.0"
     exon            1288..1399
                     /gene="INPP5A"
                     /gene_synonym="5PTASE"
                     /inference="alignment:Splign:2.1.0"
     exon            1400..1468
                     /gene="INPP5A"
                     /gene_synonym="5PTASE"
                     /inference="alignment:Splign:2.1.0"
     exon            1469..1556
                     /gene="INPP5A"
                     /gene_synonym="5PTASE"
                     /inference="alignment:Splign:2.1.0"
     exon            1557..3000
                     /gene="INPP5A"
                     /gene_synonym="5PTASE"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2976..2981
                     /regulatory_class="polyA_signal_sequence"
                     /gene="INPP5A"
                     /gene_synonym="5PTASE"
                     /note="hexamer: AATAAA"
     polyA_site      3000
                     /gene="INPP5A"
                     /gene_synonym="5PTASE"
                     /note="major polyA site"
ORIGIN      
        1 acttgccctc agcctgagtc ggcggcggct gcgggaactt tcccagcgga tctaatggct
       61 gcgcgcgggc cgctgtgagg cgcggcggcg agcgacgggc gcggggccgc ggagcagcga
      121 gcgagcgagc gagcgcgagg ccggagcccc ggccaggccc ggccgacccg ccgagcccgc
      181 gatgcgcccc ggggccgccc cccggcgcag ctgacgcccc gcggccccgc gaagaccccg
      241 gccggccggt cccggaggaa gcggccgccg ccgccgccgc ccagcccagc gcccgcgccg
      301 cccgggcacc atggcgggga aggcggccgc cccgggcacc gcggtgctgc tggtcacggc
      361 caacgtgggc tcgctcttcg acgacccaga aaacctgcag aagaactggc ttcgggaatt
      421 ttaccaggtc gtgcacacac acaagccgca cttcatggcc ttgcactgtc aggagtttgg
      481 agggaagaac tacgaggcct ccatgtccca cgtggacaag ttcgtcaaag aactattgtc
      541 gagtgatgcg atgaaagaat ataacagggc tcgagtctac ctggatgaaa actacaaatc
      601 ccaggagcac ttcacggcac taggaagctt ttattttctt catgagtcct taaaaaacat
      661 ctaccagttt gactttaaag ctaagaagta tagaaaggtc gctggcaaag agatctactc
      721 ggatacctta gagagcacgc ccatgctgga gaaggagaag tttccgcagg actacttccc
      781 cgagtgcaaa tggtcaagaa aaggcttcat ccggacgagg tggtgcattg cagactgtgc
      841 ctttgacttg gtgaatatcc atcttttcca tgatgcttcc aatctggtcg cctgggaaac
      901 aagcccttcc gtgtactcgg gaatccggca caaggcactg ggctacgtgc tggacagaat
      961 cattgatcag cgattcgaga aggtttccta ctttgtattt ggtgatttca acttccggct
     1021 ggattccaag tccgtcgtgg agacgctctg cacaaaagcc accatgcaga cggtccgggc
     1081 cgccgacacc aatgaagtgg tgaagctcat atttcgtgag tcggacaacg accggaaggt
     1141 tatgctccag ttagaaaaga aactcttcga ctacttcaac caggaggttt tccgagacaa
     1201 caacggcacc gcgctcttgg agtttgacaa ggagttgtct gtctttaagg acagactgta
     1261 tgaactggac atctcgttcc ctcccagcta cccgtacagt gaggacgccc gccagggtga
     1321 gcagtacatg aacacccggt gcccagcctg gtgtgaccgc atcctcatgt ccccgtctgc
     1381 caaggagctg gtgctgcggt cggagagcga ggagaaggtt gtcacctatg accacattgg
     1441 gcccaacgtc tgcatgggag accacaagcc cgtgttcctg gccttccgaa tcatgcccgg
     1501 ggcaggtaaa cctcatgccc atgtgcacaa gtgttgtgtc gtgcagtgac gtggtgggaa
     1561 gagatgccag cgccacgaga ggacacttcg tgagcctccc tgtagccgtg gaccgaatac
     1621 gcactcttga aagctgcatc gagaacccgc ccaagcgcca cctgctagac ggccagcccc
     1681 acacttcgct tcagcctccg gaccattccg gagcagcctc acatacctca ctgtctcgtc
     1741 tgtctatgtg acattaagta gaaatattgg tttttttttt ttttttttaa ataagtcaca
     1801 gtcctgttgt caaaactcta atagacagca aagagggtct gtaccgtaga cttcacagtt
     1861 ttcagttttt aatgattgcc agtggagggg cttcttcagc acagagaccc cccactgtgt
     1921 ccagggaccc cctctgccag gtggaggtgt gtccaggggc tggggaagcc gagacgggca
     1981 ctccctctgc cggccggcag cgtggccctg agcatggcaa gggggtctgt ctctgccgat
     2041 gctccttccg cggcactgac tctgcgccgt gtcacatggt ttttgaatca cactgcagct
     2101 gctttccatt tttatatata tataaatata tataaatata tactttttaa aaataattta
     2161 taaatcttac caaaacttat gctaaatata ctttccagta tgaacgcaca ggagagtccc
     2221 atcagcaggc ggcattggag tctaggagct cagctgtgtg tccatcaaca cacaaattcg
     2281 taaaaaacac acatggcctc gccatcgtgg gtaaaatcgg ccccacagca cgtctgcacc
     2341 agcgggccgt tactcccatg ccgttcttct gtgtaatatt aagaactgaa tgtgaagttt
     2401 atagctagcc tgggtgtacc ttttaagaat tttgtaaacc gtttgtctgt cttttgttac
     2461 tgttttatgg tgccaagtat cctacgttac aacaataata tcatgggaga aatagaaata
     2521 gcctagtttg cttccaatag aaactgcttt taacatgggc tgtatataaa aatattaaag
     2581 agaaacaaaa ctgtacattt cctcattgct ccgctacaga caacccatgt cataaccttg
     2641 ttgcaaatat ttttctccta tagcagtaag tacagcatta gaaggtgatt agagagtctg
     2701 ttgatgaaac acaaatgtat gttttattga ttttacttta gaacactaca gagttcctgg
     2761 accgggtgaa ggcattagct gggtgtttgt gtgggataaa tactaccact gcaagtgact
     2821 gctgtccgct gcggaatctg ttcttggtgg aagcacaggt ccgtgtcgct gctgtggttg
     2881 ccgctgtccg cggttcaaca cggagtccgc cccgcgggtt tcagctgttg gtcgttctga
     2941 ggggcctttg gaagtgaccg gtctggttcc taagcaataa aattgaccgt ggtgaaaata
//
