LOCUS       NM_001385460            3699 bp    mRNA    linear   PRI 12-FEB-2025
DEFINITION  Homo sapiens inositol polyphosphate-4-phosphatase type II B
            (INPP4B), transcript variant 42, mRNA.
ACCESSION   NM_001385460 XM_005263323
VERSION     NM_001385460.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3699)
  AUTHORS   Saffi,G.T., To,L., Kleine,N., Melo,C.M.P., Chen,K., Genc,G.,
            Lee,K.C.D., Chow,J.T., Jang,G.H., Gallinger,S., Botelho,R.J. and
            Salmena,L.
  TITLE     INPP4B promotes PDAC aggressiveness via PIKfyve and
            TRPML-1-mediated lysosomal exocytosis
  JOURNAL   J Cell Biol 223 (11) (2024)
   PUBMED   39120584
  REMARK    GeneRIF: INPP4B promotes PDAC aggressiveness via PIKfyve and
            TRPML-1-mediated lysosomal exocytosis.
REFERENCE   2  (bases 1 to 3699)
  AUTHORS   Lai,M., Mao,Z., Tang,D., Lan,S., Yan,R., Xiang,Q., Zhao,X., Su,M.
            and Wang,Y.
  TITLE     [Preliminary Study of the Role of INPP4B in Promoting Colorectal
            Cancer Metastasis and the Mechanisms Involved]
  JOURNAL   Sichuan Da Xue Xue Bao Yi Xue Ban 55 (5), 1186-1194 (2024)
   PUBMED   39507966
  REMARK    GeneRIF: [Preliminary Study of the Role of INPP4B in Promoting
            Colorectal Cancer Metastasis and the Mechanisms Involved].
REFERENCE   3  (bases 1 to 3699)
  AUTHORS   Zhao,J., Du,X.M., Si,W., Zhao,X.H. and Zhou,Z.Q.
  TITLE     Role of INPP4B in the proliferation, migration, invasion, and
            survival of human endometrial cancer cells
  JOURNAL   Histol Histopathol 39 (9), 1197-1208 (2024)
   PUBMED   38318760
  REMARK    GeneRIF: Role of INPP4B in the proliferation, migration, invasion,
            and survival of human endometrial cancer cells.
REFERENCE   4  (bases 1 to 3699)
  AUTHORS   Gorji,M., Farsani,M.A., Kargar,M., Garavand,J. and Mohammadi,M.H.
  TITLE     Investigating the multifaceted cooperation of autophagy, PI3K/AKT
            signaling pathways, and INPP4B gene in de novo acute myeloid
            leukemia patients
  JOURNAL   Curr Res Transl Med 72 (2), 103429 (2024)
   PUBMED   38246071
  REMARK    GeneRIF: Investigating the multifaceted cooperation of autophagy,
            PI3K/AKT signaling pathways, and INPP4B gene in de novo acute
            myeloid leukemia patients.
REFERENCE   5  (bases 1 to 3699)
  AUTHORS   Xu,M., Ren,J., Jia,W., Wang,S., Liu,Y., Chen,X., Shi,J. and Wang,H.
  TITLE     Regulation of B-1 cell numbers and B cell-mediated antibody
            production by Inpp4b
  JOURNAL   Scand J Immunol 98 (4), e13309 (2023)
   PUBMED   37389566
  REMARK    GeneRIF: Regulation of B-1 cell numbers and B cell-mediated
            antibody production by Inpp4b.
REFERENCE   6  (bases 1 to 3699)
  AUTHORS   Rampersaud,E., Damcott,C.M., Fu,M., Shen,H., McArdle,P., Shi,X.,
            Shelton,J., Yin,J., Chang,Y.P., Ott,S.H., Zhang,L., Zhao,Y.,
            Mitchell,B.D., O'Connell,J. and Shuldiner,A.R.
  TITLE     Identification of novel candidate genes for type 2 diabetes from a
            genome-wide association scan in the Old Order Amish: evidence for
            replication from diabetes-related quantitative traits and from
            independent populations
  JOURNAL   Diabetes 56 (12), 3053-3062 (2007)
   PUBMED   17846126
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 3699)
  AUTHORS   Munday,A.D., Norris,F.A., Caldwell,K.K., Brown,S., Majerus,P.W. and
            Mitchell,C.A.
  TITLE     The inositol polyphosphate 4-phosphatase forms a complex with
            phosphatidylinositol 3-kinase in human platelet cytosol
  JOURNAL   Proc Natl Acad Sci U S A 96 (7), 3640-3645 (1999)
   PUBMED   10097090
REFERENCE   8  (bases 1 to 3699)
  AUTHORS   Zhang,X. and Majerus,P.W.
  TITLE     Phosphatidylinositol signalling reactions
  JOURNAL   Semin Cell Dev Biol 9 (2), 153-160 (1998)
   PUBMED   9599410
  REMARK    Review article
REFERENCE   9  (bases 1 to 3699)
  AUTHORS   Norris,F.A., Atkins,R.C. and Majerus,P.W.
  TITLE     The cDNA cloning and characterization of inositol polyphosphate
            4-phosphatase type II. Evidence for conserved alternative splicing
            in the 4-phosphatase family
  JOURNAL   J Biol Chem 272 (38), 23859-23864 (1997)
   PUBMED   9295334
REFERENCE   10 (bases 1 to 3699)
  AUTHORS   Norris,F.A., Auethavekiat,V. and Majerus,P.W.
  TITLE     The isolation and characterization of cDNA encoding human and rat
            brain inositol polyphosphate 4-phosphatase
  JOURNAL   J Biol Chem 270 (27), 16128-16133 (1995)
   PUBMED   7608176
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC093860.3 and AC108077.3.
            
            On Jul 17, 2020 this sequence version replaced XM_005263323.3.
            
            Summary: INPP4B encodes the inositol polyphosphate 4-phosphatase
            type II, one of the enzymes involved in phosphatidylinositol
            signaling pathways. This enzyme removes the phosphate group at
            position 4 of the inositol ring from inositol 3,4-bisphosphate.
            There is limited data to suggest that the human type II enzyme is
            subject to alternative splicing, as has been established for the
            type I enzyme. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660809.196490.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-133               AC093860.3         178658-178790       c
            134-213             AC093860.3         178416-178495       c
            214-325             AC093860.3         143621-143732       c
            326-398             AC093860.3         133450-133522       c
            399-546             AC093860.3         110822-110969       c
            547-677             AC093860.3         81854-81984         c
            678-782             AC093860.3         81383-81487         c
            783-891             AC093860.3         66045-66153         c
            892-1069            AC093860.3         46590-46767         c
            1070-1273           AC093860.3         33316-33519         c
            1274-1430           AC093860.3         18798-18954         c
            1431-1603           AC108077.3         102529-102701       c
            1604-1727           AC108077.3         101233-101356       c
            1728-1845           AC108077.3         100069-100186       c
            1846-1986           AC108077.3         90483-90623         c
            1987-2084           AC108077.3         86034-86131         c
            2085-2197           AC108077.3         64085-64197         c
            2198-2352           AC108077.3         59972-60126         c
            2353-3699           AC108077.3         6897-8243           c
FEATURES             Location/Qualifiers
     source          1..3699
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q31.21"
     gene            1..3699
                     /gene="INPP4B"
                     /note="inositol polyphosphate-4-phosphatase type II B"
                     /db_xref="GeneID:8821"
                     /db_xref="HGNC:HGNC:6075"
                     /db_xref="MIM:607494"
     exon            1..133
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     CDS             98..2527
                     /gene="INPP4B"
                     /EC_number="3.1.3.66"
                     /note="isoform 5 is encoded by transcript variant 42;
                     inositol polyphosphate 4-phosphatase II; 4-phosphatase II;
                     type II inositol 3,4-bisphosphate 4-phosphatase; inositol
                     polyphosphate-4-phosphatase, type II, 105kDa"
                     /codon_start=1
                     /product="inositol polyphosphate 4-phosphatase type II
                     isoform 5"
                     /protein_id="NP_001372389.1"
                     /db_xref="GeneID:8821"
                     /db_xref="HGNC:HGNC:6075"
                     /db_xref="MIM:607494"
                     /translation="MIHFHPLILPHERSFLGYASFKVGELLKSKEQLLVLSLRTSDGG
                     KVVGTIEVSVVKMGEIEDGEADHITTDVQGQKCALVCECTAPESVSGKDNLPFLNSVL
                     KNPVCKLYRFPTSDNKWMRIREQMSESILSFHIPKELISLHIKEDLCRNQEIKELGEL
                     SPHWDNLRKNVLTHCDQMVNMYQDILTELSKETGSSFKSSSSKGEKTLEFVPINLHLQ
                     RMQVHSPHLKDALYDVITVGAPAAHFQGFKNGGLRKLLHRFETERRNTGYQFIYYSPE
                     NTAKAKEVLSNINQLQPLIATHADLLLNSASQHSPDSLKNSLKMLSEKTELFVHAFKD
                     QLVRSALLALYTARPGGILKKPPSPKSSTEESSPQDQPPVMRGQDSIPHHSDYDEEEW
                     DRVWANVGKSLNCIIAMVDKLIERDGGSEGSGGNNDGEKEPSLTDAIPSHPREDWYEQ
                     LYPLILTLKDCMGEVVNRAKQSLTFVLLQELAYSLPQCLMLTLRRDIVFSQALAGLVC
                     GFIIKLQTSLYDPGFLQQLHTVGLIVQYEGLLSTYSDEIGMLEDMAVGISDLKKVAFK
                     IIEAKSNDVLPVITGRREHYVVEVKLPARMFESLPLQIKEGQLLHVYPVLFNVGINEQ
                     QTLAERFGDVSLQESINQENFELLQEYYKIFMEKMPPDYISHFQEQNDLKALLENLLQ
                     NIQSKKRKNVEIMWLAATICRKLNGIRFTCCKSAKDRTSMSVTLEQCSILRDEHQLHK
                     DFFIRALDCMRSRQTQGALNESDDPETGCLTDNKPTSRHFYPVALLLVSSHLLVVWLI
                     LSLALLLAKYQ"
     exon            134..213
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     exon            214..325
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     exon            326..398
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     exon            399..546
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     exon            547..677
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     exon            678..782
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     exon            783..891
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     exon            892..1069
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     exon            1070..1273
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     exon            1274..1430
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     exon            1431..1603
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     exon            1604..1727
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     exon            1728..1845
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     exon            1846..1986
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     exon            1987..2084
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     exon            2085..2197
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     exon            2198..2352
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     exon            2353..3699
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3681..3686
                     /regulatory_class="polyA_signal_sequence"
                     /gene="INPP4B"
                     /note="hexamer: AATAAA"
     polyA_site      3699
                     /gene="INPP4B"
                     /note="major polyA site"
ORIGIN      
        1 atatgcagag aaaattatag ttagtgaaac aactctgggt gctgtatttt acctcttgtt
       61 attttctagc ctgttggtct cttttctttt agggaaaatg atacattttc accctttaat
      121 cctaccccat gagcgaagtt tcttgggcta tgccagtttt aaagtgggag agctgctgaa
      181 gtcaaaggag caattgctgg tcctgagcct gagaacttca gatggtggca aagtggttgg
      241 caccatagaa gtcagtgtcg tgaagatggg ggagattgag gatggggaag ccgaccacat
      301 caccacagat gtacagggac aaaagtgtgc cctggtatgt gaatgtacag ccccggaaag
      361 tgtgagcgga aaagataact tacctttttt gaattcagtg ttaaagaacc cagtatgtaa
      421 attatataga tttcccacat ctgacaataa gtggatgcga attcgagagc agatgtcaga
      481 gagcattctt tcctttcata ttcctaagga attgatttcc cttcacatta aagaagattt
      541 gtgcagaaac caggagataa aagaacttgg tgagctttct ccacattggg acaatctgcg
      601 aaaaaatgtc cttactcact gtgatcaaat ggtgaatatg taccaagaca ttctgacaga
      661 acttagcaag gaaacagggt cctctttcaa atcaagcagc agcaaaggag agaaaacatt
      721 agaatttgtt ccaataaatc tacatctgca aagaatgcag gtacacagcc ctcacttgaa
      781 agatgctctc tacgatgtca tcactgtggg agccccagct gcccattttc agggatttaa
      841 gaatggtggt cttcggaagc tactccatag atttgaaaca gaaagaagaa ataccggata
      901 ccagtttatt tactattcac ctgaaaacac agccaaagca aaggaagttc tcagcaacat
      961 caatcaacta caacctctta tagcaaccca tgcagaccta ctgcttaatt ctgcaagcca
     1021 gcattctcca gacagcttga agaattcttt aaagatgctt tcagaaaaaa cagagctttt
     1081 tgtacatgcc ttcaaggatc aacttgtcag gagtgctctt ttagcactct acactgcaag
     1141 gccaggaggc attcttaaga agccaccctc tcctaagagc agcacagagg agagcagtcc
     1201 ccaagaccaa cccccagtga tgagagggca ggactccata ccacatcatt cagactatga
     1261 tgaggaagag tgggacaggg tgtgggccaa tgtggggaag agcctgaact gcattattgc
     1321 tatggtggac aaactgattg aaagagatgg tggcagtgaa ggcagtggcg gcaacaatga
     1381 tggagaaaag gaaccttcat taacagatgc cattccctct cacccaagag aggactggta
     1441 tgaacagttg tatcccctca tccttaccct gaaggactgc atgggagaag tggtgaaccg
     1501 agccaagcag tccctgacat ttgtgctcct tcaggaactt gcgtacagct tgccccagtg
     1561 tctgatgctg acgctaagaa gagacatcgt cttcagccaa gcacttgctg gattggtttg
     1621 tggttttatc atcaaattac agacaagtct gtatgaccca ggcttcctac agcagcttca
     1681 cacagtgggg ttgatagtac aatatgaagg actgctaagt acatacagcg atgaaattgg
     1741 aatgctagag gacatggccg ttggcatttc cgatttaaag aaagttgcat ttaaaataat
     1801 tgaagccaaa tccaatgatg tgttgccagt tataacagga agacgagaac attacgtggt
     1861 agaggtcaag cttccagcca gaatgtttga gtcactacct ctacagatta aagaaggaca
     1921 gttgcttcat gtgtatccag tactttttaa tgttggaatc aatgaacagc aaactctggc
     1981 tgaaaggttt ggagatgtct ctttgcaaga aagtattaat caggaaaact tcgaacttct
     2041 acaagaatat tacaagatat ttatggaaaa gatgcctcct gattatattt cacattttca
     2101 ggaacaaaat gatttaaaag cattgctaga aaatctcctt caaaatatcc aatccaaaaa
     2161 aagaaagaat gtagaaatta tgtggctggc tgcaacgatt tgccgcaaac tgaatggtat
     2221 tcgtttcacc tgttgtaaaa gtgccaaaga caggacatcg atgtcagtga cacttgaaca
     2281 atgctcaatc ttgagagatg agcaccagtt acacaaggac ttctttatcc gagcgctgga
     2341 ttgcatgaga agcagacaaa cccagggagc actgaatgaa tccgatgatc ctgaaacagg
     2401 ctgtctaact gataacaagc caacttctcg acacttctat cctgtcgcct tgctgcttgt
     2461 cagctcacac ctgctagttg tgtggcttat tttaagtctg gcgttactct tagccaaata
     2521 ccaataagtt ttatgttgta ttcctttttc ttttctacaa atgacaatga actttaaatt
     2581 atggggacaa tgctgtaata tttttacatt ttcaaattca cagaatttaa aaaatgttaa
     2641 attgtgttta gtttgttttt cctaaaatct aaaaaacaaa aagtactatg cattaggtgg
     2701 attattttgc tcttttgttc atggaaaggt gtttcccact gttaactagc tcaagaagaa
     2761 tttttaaatt actgtctttg gaataagaca aagaacagaa tcctgaaagc ttgaagttct
     2821 gaacctcctg tcctcatccc actaaattta ttaaagaaat taagactgaa atttgcacaa
     2881 acactgaaac cctgagacaa gttctagaga tgtgggaggt tgcagacttt atttccactg
     2941 tgctaatatc atagatgcca tctgctgata gaaatttttt ttaacctgtt ttacttcttt
     3001 gctgcaatta actcttttct gtcaagtaac tttatggaga gaatggctat ttatgttttg
     3061 taattaaatt acctgtttgt atctcttgtt tgggttgatt tggctttcag aggacttttc
     3121 tattcttttt aacaaggtct tgtttgtgtc ttgatgtacc attcccagca cttgtgactt
     3181 ttgtactgtc cgtggacaag cactcttcct ttataaagct gagacttggc ccaggctgtt
     3241 cagaaagcca ttttctctct tccttgcaca gctaaaataa taaaatagag atgaaatttt
     3301 tctttaaaaa tctatagggc cagacttaat aaattaaatg ccttatttct agaacctgca
     3361 tccttagggc tacatataga ttttaatgtg ttttaaagag actgagaaat taatttgtgg
     3421 aaatgttata aaaaggcaga tatatttatg aaactaaagt ggagctgtat tgtggagcaa
     3481 attatattta aagagtttat taaattttaa atgttaagag taaagagact taagtcatct
     3541 ctttcagagg gcaataatgg tattgggcct ggcctaggat ttaattttgt aagatgtatc
     3601 atcacttgtg gaaaaaaaaa atgtagagtt gaatctttgt tatttttact tggatggttg
     3661 ctgcaactct gcattaaaca aataaagcat atttattta
//
