LOCUS       NM_001385459            3634 bp    mRNA    linear   PRI 07-DEC-2024
DEFINITION  Homo sapiens inositol polyphosphate-4-phosphatase type II B
            (INPP4B), transcript variant 41, mRNA.
ACCESSION   NM_001385459 XM_005263325
VERSION     NM_001385459.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3634)
  AUTHORS   Saffi,G.T., To,L., Kleine,N., Melo,C.M.P., Chen,K., Genc,G.,
            Lee,K.C.D., Chow,J.T., Jang,G.H., Gallinger,S., Botelho,R.J. and
            Salmena,L.
  TITLE     INPP4B promotes PDAC aggressiveness via PIKfyve and
            TRPML-1-mediated lysosomal exocytosis
  JOURNAL   J Cell Biol 223 (11) (2024)
   PUBMED   39120584
  REMARK    GeneRIF: INPP4B promotes PDAC aggressiveness via PIKfyve and
            TRPML-1-mediated lysosomal exocytosis.
REFERENCE   2  (bases 1 to 3634)
  AUTHORS   Lai,M., Mao,Z., Tang,D., Lan,S., Yan,R., Xiang,Q., Zhao,X., Su,M.
            and Wang,Y.
  TITLE     [Preliminary Study of the Role of INPP4B in Promoting Colorectal
            Cancer Metastasis and the Mechanisms Involved]
  JOURNAL   Sichuan Da Xue Xue Bao Yi Xue Ban 55 (5), 1186-1194 (2024)
   PUBMED   39507966
  REMARK    GeneRIF: [Preliminary Study of the Role of INPP4B in Promoting
            Colorectal Cancer Metastasis and the Mechanisms Involved].
REFERENCE   3  (bases 1 to 3634)
  AUTHORS   Zhao,J., Du,X.M., Si,W., Zhao,X.H. and Zhou,Z.Q.
  TITLE     Role of INPP4B in the proliferation, migration, invasion, and
            survival of human endometrial cancer cells
  JOURNAL   Histol Histopathol 39 (9), 1197-1208 (2024)
   PUBMED   38318760
  REMARK    GeneRIF: Role of INPP4B in the proliferation, migration, invasion,
            and survival of human endometrial cancer cells.
REFERENCE   4  (bases 1 to 3634)
  AUTHORS   Gorji,M., Farsani,M.A., Kargar,M., Garavand,J. and Mohammadi,M.H.
  TITLE     Investigating the multifaceted cooperation of autophagy, PI3K/AKT
            signaling pathways, and INPP4B gene in de novo acute myeloid
            leukemia patients
  JOURNAL   Curr Res Transl Med 72 (2), 103429 (2024)
   PUBMED   38246071
  REMARK    GeneRIF: Investigating the multifaceted cooperation of autophagy,
            PI3K/AKT signaling pathways, and INPP4B gene in de novo acute
            myeloid leukemia patients.
REFERENCE   5  (bases 1 to 3634)
  AUTHORS   Xu,M., Ren,J., Jia,W., Wang,S., Liu,Y., Chen,X., Shi,J. and Wang,H.
  TITLE     Regulation of B-1 cell numbers and B cell-mediated antibody
            production by Inpp4b
  JOURNAL   Scand J Immunol 98 (4), e13309 (2023)
   PUBMED   37389566
  REMARK    GeneRIF: Regulation of B-1 cell numbers and B cell-mediated
            antibody production by Inpp4b.
REFERENCE   6  (bases 1 to 3634)
  AUTHORS   Rampersaud,E., Damcott,C.M., Fu,M., Shen,H., McArdle,P., Shi,X.,
            Shelton,J., Yin,J., Chang,Y.P., Ott,S.H., Zhang,L., Zhao,Y.,
            Mitchell,B.D., O'Connell,J. and Shuldiner,A.R.
  TITLE     Identification of novel candidate genes for type 2 diabetes from a
            genome-wide association scan in the Old Order Amish: evidence for
            replication from diabetes-related quantitative traits and from
            independent populations
  JOURNAL   Diabetes 56 (12), 3053-3062 (2007)
   PUBMED   17846126
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 3634)
  AUTHORS   Munday,A.D., Norris,F.A., Caldwell,K.K., Brown,S., Majerus,P.W. and
            Mitchell,C.A.
  TITLE     The inositol polyphosphate 4-phosphatase forms a complex with
            phosphatidylinositol 3-kinase in human platelet cytosol
  JOURNAL   Proc Natl Acad Sci U S A 96 (7), 3640-3645 (1999)
   PUBMED   10097090
REFERENCE   8  (bases 1 to 3634)
  AUTHORS   Zhang,X. and Majerus,P.W.
  TITLE     Phosphatidylinositol signalling reactions
  JOURNAL   Semin Cell Dev Biol 9 (2), 153-160 (1998)
   PUBMED   9599410
  REMARK    Review article
REFERENCE   9  (bases 1 to 3634)
  AUTHORS   Norris,F.A., Atkins,R.C. and Majerus,P.W.
  TITLE     The cDNA cloning and characterization of inositol polyphosphate
            4-phosphatase type II. Evidence for conserved alternative splicing
            in the 4-phosphatase family
  JOURNAL   J Biol Chem 272 (38), 23859-23864 (1997)
   PUBMED   9295334
REFERENCE   10 (bases 1 to 3634)
  AUTHORS   Norris,F.A., Auethavekiat,V. and Majerus,P.W.
  TITLE     The isolation and characterization of cDNA encoding human and rat
            brain inositol polyphosphate 4-phosphatase
  JOURNAL   J Biol Chem 270 (27), 16128-16133 (1995)
   PUBMED   7608176
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC093860.3 and AC108077.3.
            
            On Jul 17, 2020 this sequence version replaced XM_005263325.3.
            
            Summary: INPP4B encodes the inositol polyphosphate 4-phosphatase
            type II, one of the enzymes involved in phosphatidylinositol
            signaling pathways. This enzyme removes the phosphate group at
            position 4 of the inositol ring from inositol 3,4-bisphosphate.
            There is limited data to suggest that the human type II enzyme is
            subject to alternative splicing, as has been established for the
            type I enzyme. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803616.135110.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-68                AC093860.3         178835-178902       c
            69-148              AC093860.3         178416-178495       c
            149-260             AC093860.3         143621-143732       c
            261-333             AC093860.3         133450-133522       c
            334-481             AC093860.3         110822-110969       c
            482-612             AC093860.3         81854-81984         c
            613-717             AC093860.3         81383-81487         c
            718-826             AC093860.3         66045-66153         c
            827-1004            AC093860.3         46590-46767         c
            1005-1208           AC093860.3         33316-33519         c
            1209-1365           AC093860.3         18798-18954         c
            1366-1538           AC108077.3         102529-102701       c
            1539-1662           AC108077.3         101233-101356       c
            1663-1780           AC108077.3         100069-100186       c
            1781-1921           AC108077.3         90483-90623         c
            1922-2019           AC108077.3         86034-86131         c
            2020-2132           AC108077.3         64085-64197         c
            2133-2287           AC108077.3         59972-60126         c
            2288-3634           AC108077.3         6897-8243           c
FEATURES             Location/Qualifiers
     source          1..3634
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q31.21"
     gene            1..3634
                     /gene="INPP4B"
                     /note="inositol polyphosphate-4-phosphatase type II B"
                     /db_xref="GeneID:8821"
                     /db_xref="HGNC:HGNC:6075"
                     /db_xref="MIM:607494"
     exon            1..68
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     exon            69..148
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     exon            149..260
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     CDS             201..2462
                     /gene="INPP4B"
                     /EC_number="3.1.3.66"
                     /note="isoform 7 is encoded by transcript variant 41;
                     inositol polyphosphate 4-phosphatase II; 4-phosphatase II;
                     type II inositol 3,4-bisphosphate 4-phosphatase; inositol
                     polyphosphate-4-phosphatase, type II, 105kDa"
                     /codon_start=1
                     /product="inositol polyphosphate 4-phosphatase type II
                     isoform 7"
                     /protein_id="NP_001372388.1"
                     /db_xref="GeneID:8821"
                     /db_xref="HGNC:HGNC:6075"
                     /db_xref="MIM:607494"
                     /translation="MGEIEDGEADHITTDVQGQKCALVCECTAPESVSGKDNLPFLNS
                     VLKNPVCKLYRFPTSDNKWMRIREQMSESILSFHIPKELISLHIKEDLCRNQEIKELG
                     ELSPHWDNLRKNVLTHCDQMVNMYQDILTELSKETGSSFKSSSSKGEKTLEFVPINLH
                     LQRMQVHSPHLKDALYDVITVGAPAAHFQGFKNGGLRKLLHRFETERRNTGYQFIYYS
                     PENTAKAKEVLSNINQLQPLIATHADLLLNSASQHSPDSLKNSLKMLSEKTELFVHAF
                     KDQLVRSALLALYTARPGGILKKPPSPKSSTEESSPQDQPPVMRGQDSIPHHSDYDEE
                     EWDRVWANVGKSLNCIIAMVDKLIERDGGSEGSGGNNDGEKEPSLTDAIPSHPREDWY
                     EQLYPLILTLKDCMGEVVNRAKQSLTFVLLQELAYSLPQCLMLTLRRDIVFSQALAGL
                     VCGFIIKLQTSLYDPGFLQQLHTVGLIVQYEGLLSTYSDEIGMLEDMAVGISDLKKVA
                     FKIIEAKSNDVLPVITGRREHYVVEVKLPARMFESLPLQIKEGQLLHVYPVLFNVGIN
                     EQQTLAERFGDVSLQESINQENFELLQEYYKIFMEKMPPDYISHFQEQNDLKALLENL
                     LQNIQSKKRKNVEIMWLAATICRKLNGIRFTCCKSAKDRTSMSVTLEQCSILRDEHQL
                     HKDFFIRALDCMRSRQTQGALNESDDPETGCLTDNKPTSRHFYPVALLLVSSHLLVVW
                     LILSLALLLAKYQ"
     exon            261..333
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     exon            334..481
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     exon            482..612
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     exon            613..717
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     exon            718..826
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     exon            827..1004
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     exon            1005..1208
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     exon            1209..1365
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     exon            1366..1538
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     exon            1539..1662
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     exon            1663..1780
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     exon            1781..1921
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     exon            1922..2019
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     exon            2020..2132
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     exon            2133..2287
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     exon            2288..3634
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3616..3621
                     /regulatory_class="polyA_signal_sequence"
                     /gene="INPP4B"
                     /note="hexamer: AATAAA"
     polyA_site      3634
                     /gene="INPP4B"
                     /note="major polyA site"
ORIGIN      
        1 atatctggaa tacaaagttg ttgctgccag tgatttgagg aattctaata agaggaacaa
       61 cagcattgcg aagtttcttg ggctatgcca gttttaaagt gggagagctg ctgaagtcaa
      121 aggagcaatt gctggtcctg agcctgagaa cttcagatgg tggcaaagtg gttggcacca
      181 tagaagtcag tgtcgtgaag atgggggaga ttgaggatgg ggaagccgac cacatcacca
      241 cagatgtaca gggacaaaag tgtgccctgg tatgtgaatg tacagccccg gaaagtgtga
      301 gcggaaaaga taacttacct tttttgaatt cagtgttaaa gaacccagta tgtaaattat
      361 atagatttcc cacatctgac aataagtgga tgcgaattcg agagcagatg tcagagagca
      421 ttctttcctt tcatattcct aaggaattga tttcccttca cattaaagaa gatttgtgca
      481 gaaaccagga gataaaagaa cttggtgagc tttctccaca ttgggacaat ctgcgaaaaa
      541 atgtccttac tcactgtgat caaatggtga atatgtacca agacattctg acagaactta
      601 gcaaggaaac agggtcctct ttcaaatcaa gcagcagcaa aggagagaaa acattagaat
      661 ttgttccaat aaatctacat ctgcaaagaa tgcaggtaca cagccctcac ttgaaagatg
      721 ctctctacga tgtcatcact gtgggagccc cagctgccca ttttcaggga tttaagaatg
      781 gtggtcttcg gaagctactc catagatttg aaacagaaag aagaaatacc ggataccagt
      841 ttatttacta ttcacctgaa aacacagcca aagcaaagga agttctcagc aacatcaatc
      901 aactacaacc tcttatagca acccatgcag acctactgct taattctgca agccagcatt
      961 ctccagacag cttgaagaat tctttaaaga tgctttcaga aaaaacagag ctttttgtac
     1021 atgccttcaa ggatcaactt gtcaggagtg ctcttttagc actctacact gcaaggccag
     1081 gaggcattct taagaagcca ccctctccta agagcagcac agaggagagc agtccccaag
     1141 accaaccccc agtgatgaga gggcaggact ccataccaca tcattcagac tatgatgagg
     1201 aagagtggga cagggtgtgg gccaatgtgg ggaagagcct gaactgcatt attgctatgg
     1261 tggacaaact gattgaaaga gatggtggca gtgaaggcag tggcggcaac aatgatggag
     1321 aaaaggaacc ttcattaaca gatgccattc cctctcaccc aagagaggac tggtatgaac
     1381 agttgtatcc cctcatcctt accctgaagg actgcatggg agaagtggtg aaccgagcca
     1441 agcagtccct gacatttgtg ctccttcagg aacttgcgta cagcttgccc cagtgtctga
     1501 tgctgacgct aagaagagac atcgtcttca gccaagcact tgctggattg gtttgtggtt
     1561 ttatcatcaa attacagaca agtctgtatg acccaggctt cctacagcag cttcacacag
     1621 tggggttgat agtacaatat gaaggactgc taagtacata cagcgatgaa attggaatgc
     1681 tagaggacat ggccgttggc atttccgatt taaagaaagt tgcatttaaa ataattgaag
     1741 ccaaatccaa tgatgtgttg ccagttataa caggaagacg agaacattac gtggtagagg
     1801 tcaagcttcc agccagaatg tttgagtcac tacctctaca gattaaagaa ggacagttgc
     1861 ttcatgtgta tccagtactt tttaatgttg gaatcaatga acagcaaact ctggctgaaa
     1921 ggtttggaga tgtctctttg caagaaagta ttaatcagga aaacttcgaa cttctacaag
     1981 aatattacaa gatatttatg gaaaagatgc ctcctgatta tatttcacat tttcaggaac
     2041 aaaatgattt aaaagcattg ctagaaaatc tccttcaaaa tatccaatcc aaaaaaagaa
     2101 agaatgtaga aattatgtgg ctggctgcaa cgatttgccg caaactgaat ggtattcgtt
     2161 tcacctgttg taaaagtgcc aaagacagga catcgatgtc agtgacactt gaacaatgct
     2221 caatcttgag agatgagcac cagttacaca aggacttctt tatccgagcg ctggattgca
     2281 tgagaagcag acaaacccag ggagcactga atgaatccga tgatcctgaa acaggctgtc
     2341 taactgataa caagccaact tctcgacact tctatcctgt cgccttgctg cttgtcagct
     2401 cacacctgct agttgtgtgg cttattttaa gtctggcgtt actcttagcc aaataccaat
     2461 aagttttatg ttgtattcct ttttcttttc tacaaatgac aatgaacttt aaattatggg
     2521 gacaatgctg taatattttt acattttcaa attcacagaa tttaaaaaat gttaaattgt
     2581 gtttagtttg tttttcctaa aatctaaaaa acaaaaagta ctatgcatta ggtggattat
     2641 tttgctcttt tgttcatgga aaggtgtttc ccactgttaa ctagctcaag aagaattttt
     2701 aaattactgt ctttggaata agacaaagaa cagaatcctg aaagcttgaa gttctgaacc
     2761 tcctgtcctc atcccactaa atttattaaa gaaattaaga ctgaaatttg cacaaacact
     2821 gaaaccctga gacaagttct agagatgtgg gaggttgcag actttatttc cactgtgcta
     2881 atatcataga tgccatctgc tgatagaaat tttttttaac ctgttttact tctttgctgc
     2941 aattaactct tttctgtcaa gtaactttat ggagagaatg gctatttatg ttttgtaatt
     3001 aaattacctg tttgtatctc ttgtttgggt tgatttggct ttcagaggac ttttctattc
     3061 tttttaacaa ggtcttgttt gtgtcttgat gtaccattcc cagcacttgt gacttttgta
     3121 ctgtccgtgg acaagcactc ttcctttata aagctgagac ttggcccagg ctgttcagaa
     3181 agccattttc tctcttcctt gcacagctaa aataataaaa tagagatgaa atttttcttt
     3241 aaaaatctat agggccagac ttaataaatt aaatgcctta tttctagaac ctgcatcctt
     3301 agggctacat atagatttta atgtgtttta aagagactga gaaattaatt tgtggaaatg
     3361 ttataaaaag gcagatatat ttatgaaact aaagtggagc tgtattgtgg agcaaattat
     3421 atttaaagag tttattaaat tttaaatgtt aagagtaaag agacttaagt catctctttc
     3481 agagggcaat aatggtattg ggcctggcct aggatttaat tttgtaagat gtatcatcac
     3541 ttgtggaaaa aaaaaatgta gagttgaatc tttgttattt ttacttggat ggttgctgca
     3601 actctgcatt aaacaaataa agcatattta ttta
//
