LOCUS       NM_001385458            7838 bp    mRNA    linear   PRI 07-DEC-2024
DEFINITION  Homo sapiens inositol polyphosphate-4-phosphatase type II B
            (INPP4B), transcript variant 40, mRNA.
ACCESSION   NM_001385458
VERSION     NM_001385458.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7838)
  AUTHORS   Saffi,G.T., To,L., Kleine,N., Melo,C.M.P., Chen,K., Genc,G.,
            Lee,K.C.D., Chow,J.T., Jang,G.H., Gallinger,S., Botelho,R.J. and
            Salmena,L.
  TITLE     INPP4B promotes PDAC aggressiveness via PIKfyve and
            TRPML-1-mediated lysosomal exocytosis
  JOURNAL   J Cell Biol 223 (11) (2024)
   PUBMED   39120584
  REMARK    GeneRIF: INPP4B promotes PDAC aggressiveness via PIKfyve and
            TRPML-1-mediated lysosomal exocytosis.
REFERENCE   2  (bases 1 to 7838)
  AUTHORS   Lai,M., Mao,Z., Tang,D., Lan,S., Yan,R., Xiang,Q., Zhao,X., Su,M.
            and Wang,Y.
  TITLE     [Preliminary Study of the Role of INPP4B in Promoting Colorectal
            Cancer Metastasis and the Mechanisms Involved]
  JOURNAL   Sichuan Da Xue Xue Bao Yi Xue Ban 55 (5), 1186-1194 (2024)
   PUBMED   39507966
  REMARK    GeneRIF: [Preliminary Study of the Role of INPP4B in Promoting
            Colorectal Cancer Metastasis and the Mechanisms Involved].
REFERENCE   3  (bases 1 to 7838)
  AUTHORS   Zhao,J., Du,X.M., Si,W., Zhao,X.H. and Zhou,Z.Q.
  TITLE     Role of INPP4B in the proliferation, migration, invasion, and
            survival of human endometrial cancer cells
  JOURNAL   Histol Histopathol 39 (9), 1197-1208 (2024)
   PUBMED   38318760
  REMARK    GeneRIF: Role of INPP4B in the proliferation, migration, invasion,
            and survival of human endometrial cancer cells.
REFERENCE   4  (bases 1 to 7838)
  AUTHORS   Gorji,M., Farsani,M.A., Kargar,M., Garavand,J. and Mohammadi,M.H.
  TITLE     Investigating the multifaceted cooperation of autophagy, PI3K/AKT
            signaling pathways, and INPP4B gene in de novo acute myeloid
            leukemia patients
  JOURNAL   Curr Res Transl Med 72 (2), 103429 (2024)
   PUBMED   38246071
  REMARK    GeneRIF: Investigating the multifaceted cooperation of autophagy,
            PI3K/AKT signaling pathways, and INPP4B gene in de novo acute
            myeloid leukemia patients.
REFERENCE   5  (bases 1 to 7838)
  AUTHORS   Xu,M., Ren,J., Jia,W., Wang,S., Liu,Y., Chen,X., Shi,J. and Wang,H.
  TITLE     Regulation of B-1 cell numbers and B cell-mediated antibody
            production by Inpp4b
  JOURNAL   Scand J Immunol 98 (4), e13309 (2023)
   PUBMED   37389566
  REMARK    GeneRIF: Regulation of B-1 cell numbers and B cell-mediated
            antibody production by Inpp4b.
REFERENCE   6  (bases 1 to 7838)
  AUTHORS   Rampersaud,E., Damcott,C.M., Fu,M., Shen,H., McArdle,P., Shi,X.,
            Shelton,J., Yin,J., Chang,Y.P., Ott,S.H., Zhang,L., Zhao,Y.,
            Mitchell,B.D., O'Connell,J. and Shuldiner,A.R.
  TITLE     Identification of novel candidate genes for type 2 diabetes from a
            genome-wide association scan in the Old Order Amish: evidence for
            replication from diabetes-related quantitative traits and from
            independent populations
  JOURNAL   Diabetes 56 (12), 3053-3062 (2007)
   PUBMED   17846126
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 7838)
  AUTHORS   Munday,A.D., Norris,F.A., Caldwell,K.K., Brown,S., Majerus,P.W. and
            Mitchell,C.A.
  TITLE     The inositol polyphosphate 4-phosphatase forms a complex with
            phosphatidylinositol 3-kinase in human platelet cytosol
  JOURNAL   Proc Natl Acad Sci U S A 96 (7), 3640-3645 (1999)
   PUBMED   10097090
REFERENCE   8  (bases 1 to 7838)
  AUTHORS   Zhang,X. and Majerus,P.W.
  TITLE     Phosphatidylinositol signalling reactions
  JOURNAL   Semin Cell Dev Biol 9 (2), 153-160 (1998)
   PUBMED   9599410
  REMARK    Review article
REFERENCE   9  (bases 1 to 7838)
  AUTHORS   Norris,F.A., Atkins,R.C. and Majerus,P.W.
  TITLE     The cDNA cloning and characterization of inositol polyphosphate
            4-phosphatase type II. Evidence for conserved alternative splicing
            in the 4-phosphatase family
  JOURNAL   J Biol Chem 272 (38), 23859-23864 (1997)
   PUBMED   9295334
REFERENCE   10 (bases 1 to 7838)
  AUTHORS   Norris,F.A., Auethavekiat,V. and Majerus,P.W.
  TITLE     The isolation and characterization of cDNA encoding human and rat
            brain inositol polyphosphate 4-phosphatase
  JOURNAL   J Biol Chem 270 (27), 16128-16133 (1995)
   PUBMED   7608176
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC093860.3 and AC108077.3.
            
            Summary: INPP4B encodes the inositol polyphosphate 4-phosphatase
            type II, one of the enzymes involved in phosphatidylinositol
            signaling pathways. This enzyme removes the phosphate group at
            position 4 of the inositol ring from inositol 3,4-bisphosphate.
            There is limited data to suggest that the human type II enzyme is
            subject to alternative splicing, as has been established for the
            type I enzyme. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DRR138518.345259.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-68                AC093860.3         178835-178902       c
            69-148              AC093860.3         178416-178495       c
            149-260             AC093860.3         143621-143732       c
            261-333             AC093860.3         133450-133522       c
            334-481             AC093860.3         110822-110969       c
            482-612             AC093860.3         81854-81984         c
            613-717             AC093860.3         81383-81487         c
            718-826             AC093860.3         66045-66153         c
            827-1004            AC093860.3         46590-46767         c
            1005-1161           AC093860.3         18798-18954         c
            1162-1334           AC108077.3         102529-102701       c
            1335-1458           AC108077.3         101233-101356       c
            1459-1576           AC108077.3         100069-100186       c
            1577-1717           AC108077.3         90483-90623         c
            1718-1815           AC108077.3         86034-86131         c
            1816-1928           AC108077.3         64085-64197         c
            1929-2083           AC108077.3         59972-60126         c
            2084-7838           AC108077.3         1101-6855           c
FEATURES             Location/Qualifiers
     source          1..7838
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q31.21"
     gene            1..7838
                     /gene="INPP4B"
                     /note="inositol polyphosphate-4-phosphatase type II B"
                     /db_xref="GeneID:8821"
                     /db_xref="HGNC:HGNC:6075"
                     /db_xref="MIM:607494"
     exon            1..68
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     exon            69..148
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     exon            149..260
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     CDS             201..2216
                     /gene="INPP4B"
                     /EC_number="3.1.3.66"
                     /note="isoform 17 is encoded by transcript variant 40;
                     inositol polyphosphate 4-phosphatase II; 4-phosphatase II;
                     type II inositol 3,4-bisphosphate 4-phosphatase; inositol
                     polyphosphate-4-phosphatase, type II, 105kDa"
                     /codon_start=1
                     /product="inositol polyphosphate 4-phosphatase type II
                     isoform 17"
                     /protein_id="NP_001372387.1"
                     /db_xref="GeneID:8821"
                     /db_xref="HGNC:HGNC:6075"
                     /db_xref="MIM:607494"
                     /translation="MGEIEDGEADHITTDVQGQKCALVCECTAPESVSGKDNLPFLNS
                     VLKNPVCKLYRFPTSDNKWMRIREQMSESILSFHIPKELISLHIKEDLCRNQEIKELG
                     ELSPHWDNLRKNVLTHCDQMVNMYQDILTELSKETGSSFKSSSSKGEKTLEFVPINLH
                     LQRMQVHSPHLKDALYDVITVGAPAAHFQGFKNGGLRKLLHRFETERRNTGYQFIYYS
                     PENTAKAKEVLSNINQLQPLIATHADLLLNSASQHSPDSLKNSLKMLSEKDRVWANVG
                     KSLNCIIAMVDKLIERDGGSEGSGGNNDGEKEPSLTDAIPSHPREDWYEQLYPLILTL
                     KDCMGEVVNRAKQSLTFVLLQELAYSLPQCLMLTLRRDIVFSQALAGLVCGFIIKLQT
                     SLYDPGFLQQLHTVGLIVQYEGLLSTYSDEIGMLEDMAVGISDLKKVAFKIIEAKSND
                     VLPVITGRREHYVVEVKLPARMFESLPLQIKEGQLLHVYPVLFNVGINEQQTLAERFG
                     DVSLQESINQENFELLQEYYKIFMEKMPPDYISHFQEQNDLKALLENLLQNIQSKKRK
                     NVEIMWLAATICRKLNGIRFTCCKSAKDRTSMSVTLEQCSILRDEHQLHKDFFIRALD
                     CMRREGCRIENVLKNIKCRKYAFNMLQLMAFPKYYRPPEGTYGKADT"
     exon            261..333
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     exon            334..481
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     exon            482..612
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     exon            613..717
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     exon            718..826
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     exon            827..1004
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     exon            1005..1161
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     exon            1162..1334
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     exon            1335..1458
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     exon            1459..1576
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     exon            1577..1717
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     exon            1718..1815
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     exon            1816..1928
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     exon            1929..2083
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     exon            2084..7838
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2232..2237
                     /regulatory_class="polyA_signal_sequence"
                     /gene="INPP4B"
                     /note="hexamer: AATAAA"
     regulatory      2248..2253
                     /regulatory_class="polyA_signal_sequence"
                     /gene="INPP4B"
                     /note="hexamer: AATACA"
     polyA_site      2258
                     /gene="INPP4B"
     polyA_site      2273
                     /gene="INPP4B"
                     /note="major polyA site"
     regulatory      7817..7822
                     /regulatory_class="polyA_signal_sequence"
                     /gene="INPP4B"
                     /note="hexamer: AATAAA"
     polyA_site      7838
                     /gene="INPP4B"
ORIGIN      
        1 atatctggaa tacaaagttg ttgctgccag tgatttgagg aattctaata agaggaacaa
       61 cagcattgcg aagtttcttg ggctatgcca gttttaaagt gggagagctg ctgaagtcaa
      121 aggagcaatt gctggtcctg agcctgagaa cttcagatgg tggcaaagtg gttggcacca
      181 tagaagtcag tgtcgtgaag atgggggaga ttgaggatgg ggaagccgac cacatcacca
      241 cagatgtaca gggacaaaag tgtgccctgg tatgtgaatg tacagccccg gaaagtgtga
      301 gcggaaaaga taacttacct tttttgaatt cagtgttaaa gaacccagta tgtaaattat
      361 atagatttcc cacatctgac aataagtgga tgcgaattcg agagcagatg tcagagagca
      421 ttctttcctt tcatattcct aaggaattga tttcccttca cattaaagaa gatttgtgca
      481 gaaaccagga gataaaagaa cttggtgagc tttctccaca ttgggacaat ctgcgaaaaa
      541 atgtccttac tcactgtgat caaatggtga atatgtacca agacattctg acagaactta
      601 gcaaggaaac agggtcctct ttcaaatcaa gcagcagcaa aggagagaaa acattagaat
      661 ttgttccaat aaatctacat ctgcaaagaa tgcaggtaca cagccctcac ttgaaagatg
      721 ctctctacga tgtcatcact gtgggagccc cagctgccca ttttcaggga tttaagaatg
      781 gtggtcttcg gaagctactc catagatttg aaacagaaag aagaaatacc ggataccagt
      841 ttatttacta ttcacctgaa aacacagcca aagcaaagga agttctcagc aacatcaatc
      901 aactacaacc tcttatagca acccatgcag acctactgct taattctgca agccagcatt
      961 ctccagacag cttgaagaat tctttaaaga tgctttcaga aaaagacagg gtgtgggcca
     1021 atgtggggaa gagcctgaac tgcattattg ctatggtgga caaactgatt gaaagagatg
     1081 gtggcagtga aggcagtggc ggcaacaatg atggagaaaa ggaaccttca ttaacagatg
     1141 ccattccctc tcacccaaga gaggactggt atgaacagtt gtatcccctc atccttaccc
     1201 tgaaggactg catgggagaa gtggtgaacc gagccaagca gtccctgaca tttgtgctcc
     1261 ttcaggaact tgcgtacagc ttgccccagt gtctgatgct gacgctaaga agagacatcg
     1321 tcttcagcca agcacttgct ggattggttt gtggttttat catcaaatta cagacaagtc
     1381 tgtatgaccc aggcttccta cagcagcttc acacagtggg gttgatagta caatatgaag
     1441 gactgctaag tacatacagc gatgaaattg gaatgctaga ggacatggcc gttggcattt
     1501 ccgatttaaa gaaagttgca tttaaaataa ttgaagccaa atccaatgat gtgttgccag
     1561 ttataacagg aagacgagaa cattacgtgg tagaggtcaa gcttccagcc agaatgtttg
     1621 agtcactacc tctacagatt aaagaaggac agttgcttca tgtgtatcca gtacttttta
     1681 atgttggaat caatgaacag caaactctgg ctgaaaggtt tggagatgtc tctttgcaag
     1741 aaagtattaa tcaggaaaac ttcgaacttc tacaagaata ttacaagata tttatggaaa
     1801 agatgcctcc tgattatatt tcacattttc aggaacaaaa tgatttaaaa gcattgctag
     1861 aaaatctcct tcaaaatatc caatccaaaa aaagaaagaa tgtagaaatt atgtggctgg
     1921 ctgcaacgat ttgccgcaaa ctgaatggta ttcgtttcac ctgttgtaaa agtgccaaag
     1981 acaggacatc gatgtcagtg acacttgaac aatgctcaat cttgagagat gagcaccagt
     2041 tacacaagga cttctttatc cgagcgctgg attgcatgag aagagaagga tgccgcatag
     2101 agaatgtact gaagaatatc aaatgcagaa agtatgcttt caacatgcta cagctgatgg
     2161 ctttccccaa gtactacaga cctccagagg ggacttatgg aaaagctgac acctaagttt
     2221 accaacatgt taataaacag gaacacaaat acatttcagt tggataatct tcaccttggt
     2281 cttttttgtt tgtttttatt gtcatgaatt tgtggtgggg gagatgatca cagatgtttc
     2341 ccaaaatcta ggaactactt caattcatca tcagcatatt gctctgaaag aaatccattt
     2401 taaaaaatct tacatgattc agtactgtca tttctagttc taagcttcta tgtgttgagc
     2461 ctagctgatt gagattggtt cacaaagtgt aaatttcatt catgagtatt taaatgtttc
     2521 tgaggaaaca tggatcattt caataggact aggggtgatt cacagagcac cactctccaa
     2581 ccaaatggaa gagaggagag ggggaaaagg aacatatttt ttttgtgata caacttaata
     2641 gcctatgaga acacagtcaa cctgagaatc aatgtaaggg atttaaaaaa aatgtgtagc
     2701 cactcaatta ggtagagtta actcatgatc tggaatactg aggcagtttg caggtatgtt
     2761 ccacaatgat ctctatcatc cagtcaaggt gtgactcctc ccttgcaaca ggcatatgca
     2821 tggagtgagt aaagtggtca acagaccttt caaaaccatg gcatcttttc agaactctga
     2881 cttgggttgt gtgatctagc tgtgaatgta gcaatataga acgtttaata gaatgataag
     2941 caaaacactg caatgatcta aaattacaaa taaaataaaa atgaacaaca ttttgatacc
     3001 caaaatgaaa attcccatca gcctgaactt tatgttgtga agttcatgaa tgtcagtgag
     3061 gtatctctga gatgtttctt agcagtcatc ctggtgtaag catgcagtta tggcataggt
     3121 ttgtgtgtgt taataagcct ttaaaacata tgcaaccaca acaaatgata aagtaaaaca
     3181 attattttct gttgccctga atatcaaact tgcccttgcc cttactcagc aaaataacat
     3241 ttataagttt tccaaaatcc caaagtagaa gtttccttaa aaaaatcatc ttgtataata
     3301 ccagtattca aacatgggta aggttaatca cccccaatca ctcaggagat agttgcagaa
     3361 tttgaattac aatctcttct tactttccta gcctgtggct tgtcacttct ccaaattgcc
     3421 atgctaaata tgcatgaaaa ttgagggaga atgctagtta aaaagaaatt aggatttatc
     3481 actggaattg aaactaagag tacaaaagtc tgaacgaatg aaacttttct ccaaatttta
     3541 caaattcttg ttcctttctc attagaagag catgctatcc aaagcataaa tctcccttga
     3601 aaataacaga ggcttcttaa gccctctctt agctatgatc aatggatgat attatgcttc
     3661 ccatagctaa tgtgatagct ccttgcctag gattcctgtt gaaataagga ttctagcccc
     3721 atgttaagtt tttcaaatta ctacaaattt tagataagca tttggagctt tttatactag
     3781 aattatcaat tttttatttt agctaattac ctgtgggcat tatacttgag gcaggtacca
     3841 aactacttac agccttttta atgaaaatgt gctgtgtact ttgaatccat tcatagacaa
     3901 aattaccttg atgttctctt aactcattct ttattttagt gattaaatac aacctttgag
     3961 ttgttcaata tcatttgaaa atggtaggat ttgtggttat tttcattacc ctattagatt
     4021 taagataggc tgggatgaca gaggcctcct tgaatagcta tgaagcctca ttcagcatat
     4081 caaatggtag tctgagttct aagaaacctt aagtaattta tcattctgta aatactctta
     4141 taagcaataa tttttatttg tatttttgaa aacaaactac ttaaatatgg aaaaatatta
     4201 actggaaagc cagcagtagg gttttctatt tttaaaagac atttcaagga tttcctgtaa
     4261 tcccagcact ttgggagcca aggtggatag atcacctgag gtcaggaatt ggagatcagc
     4321 ctggccaaca tggtgaaacc ccatctctac taaagataca aaaattagct ggatgtggtg
     4381 gcacacacgt gtaatcccag ctacttggga ggctgaggca agagaatcgc ttgaaccccg
     4441 gaggcggagg ttgcagtgag ctgagatcat gccattgcac tccagcctgg gtgaaaagag
     4501 cgaaactcca tctttaaata agtaaataaa tgaataatat agaagtctca aattatagtg
     4561 cttactgtaa tacaaatgct tatgaatttt cattcattac catagtcatc tgcatttcct
     4621 tatagaaagc ctgtactggt gcaaacttct aaaagtggat ttcatcaaga aaatgtgttt
     4681 catagagaca acaatattgc ttttttcctg agaggcagtt cattcttaaa caaccacttc
     4741 actatttctt aagttattaa ggctaaatca aagagcaaat gttaaagtgt ttaaatctct
     4801 cttgaacaaa cacagccaca gtcatgctat tctatctata ttttcactta aaagatacac
     4861 cagcagacct attttaggag gtcatattga gccaaaaaat gaactgagca aatgacattt
     4921 ccaaactctt tttttgctca aaaataatat gttccccttt gatattaaat gcagatatca
     4981 attctggatt agctatttac tgagccctag gaaaaacata tttaaagaca aggaaaccat
     5041 tcatttacat ctcatatcat tgctttttgc ttttaaatat cgccttgagg tttgtctaca
     5101 ctctgccaaa acaatccctg aacataagtt tggtcagcct cataattcag tgagtcgagc
     5161 aaccatttgt tccaagtgat aaattgtact aaatgacaaa ctgcccaatc agggcagagc
     5221 tccatggacc cagcctccag cccttatttt ataagactaa cccctcttct gaaaaactct
     5281 gaaggcttaa aagctagcat ttggatggag gatacttcct ttttatcctt cagctatgta
     5341 tggcacttta cataaaataa gaggtaaaaa aggagagaaa ctgatgtgta taaagtaatg
     5401 cctttcttcc caagcaaatc aaacctctcc ctatgtaaaa gttgatagtg taccaagaga
     5461 cacaatacca ctggtgggct ggaactagct cgttctgatg cataaaagtt gataattaaa
     5521 gtaccagaaa ttttgtaagc tagttgttaa acattaccat tattaaatat gaaattataa
     5581 aacacagtgg aatacattaa aaaccaatgt aataatcaaa acataccact tcccaattat
     5641 tttactacct tatactattt attagtactc ttgagtctat ttaggtctat tacatcttta
     5701 cagtgaaaac aggatacaat attgtgctac tgtgggtctc ttcctgactg cagattcagt
     5761 aacatggtgt tcgtagcttg aaactgtcca cagtgggagt atttaacacc atagaaactg
     5821 gctggcaaat gctacaaact agcaatttta attcctggaa aggcaattgt tgagcattta
     5881 ccagcacaca atgaatgcca tattcttttt tttttattag gaaataaatt attggaggca
     5941 gtataaaatt atttaaaaag tatcaaatgc aatcccttat cttcagatgg ctataatttt
     6001 ggttatataa atgttttggt ttttaccttc tttaaagact cctattaggt taaaagtcat
     6061 atttgatgac tatattttat tcataattaa attattaaat caccttttct cctgataatg
     6121 ctttgccaga gaattcttag caattcaact gtagtctaag caataactca gggctaaatt
     6181 cagggaactg ttagcccaat cagatatcac taaaaatgta cttcaccatc tattttggag
     6241 tttataattt tggcatttgc taaaagtagg aaaaacagta acatattact gtgcccagat
     6301 tctaataaat atagctcaat tgaaaccaaa actgttacat taaacaaatt acactctggc
     6361 actatgctaa atcaccacag atgttttagg tgtttgattt ccaagcagga tggtatatca
     6421 tttgtttggt tcaatatatg aggcaccatt tgtagtcttt taggaaataa attagctttt
     6481 atcacagatt taggaaactt gtctaaaaaa actgtgatca tcagttacag agggaaggaa
     6541 acatattgaa cacaaggcat catagtagct ggaggcctta aaaattatgc acgaccaaaa
     6601 agaatgattt ggtgagagat gtgtagctga ttgacaattt tagtgtgaat tcatattcat
     6661 ttaacccagc agcaatctac ataagctatg ctttttccca cctgtattta tgtttcttag
     6721 cttataaagt cccaatatat tatatctttt gttgctttgg cagttttaat ttagagctct
     6781 gcgttcacag agatgccacc tatagcaaaa actatcttta agaattggaa aataaaatga
     6841 atgttttaga taaaatattg caagccatta tgtgtagagt taatgtatgg aaatttgcat
     6901 ttgtttttct gaatcatggt gtacattaat cactcattga attctatttc taagcaaata
     6961 agagaatcaa acatttctaa aaggaacata tgtcttgcta ttaataacaa ggagacagga
     7021 aaaatagtaa ggtaatataa gcaaaaaaaa aaatgtaatg aatttagcta tcctaaattg
     7081 gaatttttac agattgcatg catacttaga attttaaatt tttaaaagat ttacaattga
     7141 gtatggtacc cacagagagt gagtaccaag ggaaggaaga cctaatacaa gtgatgttgc
     7201 ctgataaatc acatcttgcc aaaaaaaata tattttagta aatacagttc tttaggaaga
     7261 aaaatgttgc cctttcacac tcacagtgta aatacattca taatattcct tcaatcatct
     7321 aaattaccgc caggtcatga aaggacgcga tcaatgatga cctattgcac tcacaggtaa
     7381 cattgactca aattttggca atattgctat attatctaga taattcttgt gatgttttta
     7441 tgtcactatc aacattaaaa atattttgtt aaacaactat gaaactttca aaagtttgca
     7501 tataactgta tgggcactct catttcactg catacataca atactttgta tacacatact
     7561 tctcgtgtgg atattttata attttattta atctaacatt taacttttag gtttttgtgg
     7621 tactcatctg aaaggttggc atttgttttc tttttatgtt atatatgtat tttagatgaa
     7681 tcaataatgt gtattcctag aaattttttc taggcataaa tagatcattt tatgttggca
     7741 tttaagagat atcatttttg ttttattgtt ctgtgtaaac catattcatt gtacactgtg
     7801 tgtatatttt tgtttaaata aatgattttt atttttta
//
