LOCUS       NM_001385457            8042 bp    mRNA    linear   PRI 07-DEC-2024
DEFINITION  Homo sapiens inositol polyphosphate-4-phosphatase type II B
            (INPP4B), transcript variant 39, mRNA.
ACCESSION   NM_001385457
VERSION     NM_001385457.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8042)
  AUTHORS   Saffi,G.T., To,L., Kleine,N., Melo,C.M.P., Chen,K., Genc,G.,
            Lee,K.C.D., Chow,J.T., Jang,G.H., Gallinger,S., Botelho,R.J. and
            Salmena,L.
  TITLE     INPP4B promotes PDAC aggressiveness via PIKfyve and
            TRPML-1-mediated lysosomal exocytosis
  JOURNAL   J Cell Biol 223 (11) (2024)
   PUBMED   39120584
  REMARK    GeneRIF: INPP4B promotes PDAC aggressiveness via PIKfyve and
            TRPML-1-mediated lysosomal exocytosis.
REFERENCE   2  (bases 1 to 8042)
  AUTHORS   Lai,M., Mao,Z., Tang,D., Lan,S., Yan,R., Xiang,Q., Zhao,X., Su,M.
            and Wang,Y.
  TITLE     [Preliminary Study of the Role of INPP4B in Promoting Colorectal
            Cancer Metastasis and the Mechanisms Involved]
  JOURNAL   Sichuan Da Xue Xue Bao Yi Xue Ban 55 (5), 1186-1194 (2024)
   PUBMED   39507966
  REMARK    GeneRIF: [Preliminary Study of the Role of INPP4B in Promoting
            Colorectal Cancer Metastasis and the Mechanisms Involved].
REFERENCE   3  (bases 1 to 8042)
  AUTHORS   Zhao,J., Du,X.M., Si,W., Zhao,X.H. and Zhou,Z.Q.
  TITLE     Role of INPP4B in the proliferation, migration, invasion, and
            survival of human endometrial cancer cells
  JOURNAL   Histol Histopathol 39 (9), 1197-1208 (2024)
   PUBMED   38318760
  REMARK    GeneRIF: Role of INPP4B in the proliferation, migration, invasion,
            and survival of human endometrial cancer cells.
REFERENCE   4  (bases 1 to 8042)
  AUTHORS   Gorji,M., Farsani,M.A., Kargar,M., Garavand,J. and Mohammadi,M.H.
  TITLE     Investigating the multifaceted cooperation of autophagy, PI3K/AKT
            signaling pathways, and INPP4B gene in de novo acute myeloid
            leukemia patients
  JOURNAL   Curr Res Transl Med 72 (2), 103429 (2024)
   PUBMED   38246071
  REMARK    GeneRIF: Investigating the multifaceted cooperation of autophagy,
            PI3K/AKT signaling pathways, and INPP4B gene in de novo acute
            myeloid leukemia patients.
REFERENCE   5  (bases 1 to 8042)
  AUTHORS   Xu,M., Ren,J., Jia,W., Wang,S., Liu,Y., Chen,X., Shi,J. and Wang,H.
  TITLE     Regulation of B-1 cell numbers and B cell-mediated antibody
            production by Inpp4b
  JOURNAL   Scand J Immunol 98 (4), e13309 (2023)
   PUBMED   37389566
  REMARK    GeneRIF: Regulation of B-1 cell numbers and B cell-mediated
            antibody production by Inpp4b.
REFERENCE   6  (bases 1 to 8042)
  AUTHORS   Rampersaud,E., Damcott,C.M., Fu,M., Shen,H., McArdle,P., Shi,X.,
            Shelton,J., Yin,J., Chang,Y.P., Ott,S.H., Zhang,L., Zhao,Y.,
            Mitchell,B.D., O'Connell,J. and Shuldiner,A.R.
  TITLE     Identification of novel candidate genes for type 2 diabetes from a
            genome-wide association scan in the Old Order Amish: evidence for
            replication from diabetes-related quantitative traits and from
            independent populations
  JOURNAL   Diabetes 56 (12), 3053-3062 (2007)
   PUBMED   17846126
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 8042)
  AUTHORS   Munday,A.D., Norris,F.A., Caldwell,K.K., Brown,S., Majerus,P.W. and
            Mitchell,C.A.
  TITLE     The inositol polyphosphate 4-phosphatase forms a complex with
            phosphatidylinositol 3-kinase in human platelet cytosol
  JOURNAL   Proc Natl Acad Sci U S A 96 (7), 3640-3645 (1999)
   PUBMED   10097090
REFERENCE   8  (bases 1 to 8042)
  AUTHORS   Zhang,X. and Majerus,P.W.
  TITLE     Phosphatidylinositol signalling reactions
  JOURNAL   Semin Cell Dev Biol 9 (2), 153-160 (1998)
   PUBMED   9599410
  REMARK    Review article
REFERENCE   9  (bases 1 to 8042)
  AUTHORS   Norris,F.A., Atkins,R.C. and Majerus,P.W.
  TITLE     The cDNA cloning and characterization of inositol polyphosphate
            4-phosphatase type II. Evidence for conserved alternative splicing
            in the 4-phosphatase family
  JOURNAL   J Biol Chem 272 (38), 23859-23864 (1997)
   PUBMED   9295334
REFERENCE   10 (bases 1 to 8042)
  AUTHORS   Norris,F.A., Auethavekiat,V. and Majerus,P.W.
  TITLE     The isolation and characterization of cDNA encoding human and rat
            brain inositol polyphosphate 4-phosphatase
  JOURNAL   J Biol Chem 270 (27), 16128-16133 (1995)
   PUBMED   7608176
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC093860.3 and AC108077.3.
            
            Summary: INPP4B encodes the inositol polyphosphate 4-phosphatase
            type II, one of the enzymes involved in phosphatidylinositol
            signaling pathways. This enzyme removes the phosphate group at
            position 4 of the inositol ring from inositol 3,4-bisphosphate.
            There is limited data to suggest that the human type II enzyme is
            subject to alternative splicing, as has been established for the
            type I enzyme. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: SRR14038194.1492633.1, SRR1803612.172946.1
                                    [ECO:0000331]
            RNAseq introns       :: mixed sample support SAMEA1965299,
                                    SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-68                AC093860.3         178835-178902       c
            69-148              AC093860.3         178416-178495       c
            149-260             AC093860.3         143621-143732       c
            261-333             AC093860.3         133450-133522       c
            334-481             AC093860.3         110822-110969       c
            482-612             AC093860.3         81854-81984         c
            613-717             AC093860.3         81383-81487         c
            718-826             AC093860.3         66045-66153         c
            827-1004            AC093860.3         46590-46767         c
            1005-1208           AC093860.3         33316-33519         c
            1209-1365           AC093860.3         18798-18954         c
            1366-1538           AC108077.3         102529-102701       c
            1539-1662           AC108077.3         101233-101356       c
            1663-1780           AC108077.3         100069-100186       c
            1781-1921           AC108077.3         90483-90623         c
            1922-2019           AC108077.3         86034-86131         c
            2020-2132           AC108077.3         64085-64197         c
            2133-2287           AC108077.3         59972-60126         c
            2288-8042           AC108077.3         1101-6855           c
FEATURES             Location/Qualifiers
     source          1..8042
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q31.21"
     gene            1..8042
                     /gene="INPP4B"
                     /note="inositol polyphosphate-4-phosphatase type II B"
                     /db_xref="GeneID:8821"
                     /db_xref="HGNC:HGNC:6075"
                     /db_xref="MIM:607494"
     exon            1..68
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     exon            69..148
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     exon            149..260
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     CDS             201..2420
                     /gene="INPP4B"
                     /EC_number="3.1.3.66"
                     /note="isoform 10 is encoded by transcript variant 39;
                     inositol polyphosphate 4-phosphatase II; 4-phosphatase II;
                     type II inositol 3,4-bisphosphate 4-phosphatase; inositol
                     polyphosphate-4-phosphatase, type II, 105kDa"
                     /codon_start=1
                     /product="inositol polyphosphate 4-phosphatase type II
                     isoform 10"
                     /protein_id="NP_001372386.1"
                     /db_xref="GeneID:8821"
                     /db_xref="HGNC:HGNC:6075"
                     /db_xref="MIM:607494"
                     /translation="MGEIEDGEADHITTDVQGQKCALVCECTAPESVSGKDNLPFLNS
                     VLKNPVCKLYRFPTSDNKWMRIREQMSESILSFHIPKELISLHIKEDLCRNQEIKELG
                     ELSPHWDNLRKNVLTHCDQMVNMYQDILTELSKETGSSFKSSSSKGEKTLEFVPINLH
                     LQRMQVHSPHLKDALYDVITVGAPAAHFQGFKNGGLRKLLHRFETERRNTGYQFIYYS
                     PENTAKAKEVLSNINQLQPLIATHADLLLNSASQHSPDSLKNSLKMLSEKTELFVHAF
                     KDQLVRSALLALYTARPGGILKKPPSPKSSTEESSPQDQPPVMRGQDSIPHHSDYDEE
                     EWDRVWANVGKSLNCIIAMVDKLIERDGGSEGSGGNNDGEKEPSLTDAIPSHPREDWY
                     EQLYPLILTLKDCMGEVVNRAKQSLTFVLLQELAYSLPQCLMLTLRRDIVFSQALAGL
                     VCGFIIKLQTSLYDPGFLQQLHTVGLIVQYEGLLSTYSDEIGMLEDMAVGISDLKKVA
                     FKIIEAKSNDVLPVITGRREHYVVEVKLPARMFESLPLQIKEGQLLHVYPVLFNVGIN
                     EQQTLAERFGDVSLQESINQENFELLQEYYKIFMEKMPPDYISHFQEQNDLKALLENL
                     LQNIQSKKRKNVEIMWLAATICRKLNGIRFTCCKSAKDRTSMSVTLEQCSILRDEHQL
                     HKDFFIRALDCMRREGCRIENVLKNIKCRKYAFNMLQLMAFPKYYRPPEGTYGKADT"
     exon            261..333
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     exon            334..481
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     exon            482..612
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     exon            613..717
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     exon            718..826
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     exon            827..1004
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     exon            1005..1208
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     exon            1209..1365
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     exon            1366..1538
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     exon            1539..1662
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     exon            1663..1780
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     exon            1781..1921
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     exon            1922..2019
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     exon            2020..2132
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     exon            2133..2287
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     exon            2288..8042
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2436..2441
                     /regulatory_class="polyA_signal_sequence"
                     /gene="INPP4B"
                     /note="hexamer: AATAAA"
     regulatory      2452..2457
                     /regulatory_class="polyA_signal_sequence"
                     /gene="INPP4B"
                     /note="hexamer: AATACA"
     polyA_site      2462
                     /gene="INPP4B"
     polyA_site      2477
                     /gene="INPP4B"
                     /note="major polyA site"
     regulatory      8021..8026
                     /regulatory_class="polyA_signal_sequence"
                     /gene="INPP4B"
                     /note="hexamer: AATAAA"
     polyA_site      8042
                     /gene="INPP4B"
ORIGIN      
        1 atatctggaa tacaaagttg ttgctgccag tgatttgagg aattctaata agaggaacaa
       61 cagcattgcg aagtttcttg ggctatgcca gttttaaagt gggagagctg ctgaagtcaa
      121 aggagcaatt gctggtcctg agcctgagaa cttcagatgg tggcaaagtg gttggcacca
      181 tagaagtcag tgtcgtgaag atgggggaga ttgaggatgg ggaagccgac cacatcacca
      241 cagatgtaca gggacaaaag tgtgccctgg tatgtgaatg tacagccccg gaaagtgtga
      301 gcggaaaaga taacttacct tttttgaatt cagtgttaaa gaacccagta tgtaaattat
      361 atagatttcc cacatctgac aataagtgga tgcgaattcg agagcagatg tcagagagca
      421 ttctttcctt tcatattcct aaggaattga tttcccttca cattaaagaa gatttgtgca
      481 gaaaccagga gataaaagaa cttggtgagc tttctccaca ttgggacaat ctgcgaaaaa
      541 atgtccttac tcactgtgat caaatggtga atatgtacca agacattctg acagaactta
      601 gcaaggaaac agggtcctct ttcaaatcaa gcagcagcaa aggagagaaa acattagaat
      661 ttgttccaat aaatctacat ctgcaaagaa tgcaggtaca cagccctcac ttgaaagatg
      721 ctctctacga tgtcatcact gtgggagccc cagctgccca ttttcaggga tttaagaatg
      781 gtggtcttcg gaagctactc catagatttg aaacagaaag aagaaatacc ggataccagt
      841 ttatttacta ttcacctgaa aacacagcca aagcaaagga agttctcagc aacatcaatc
      901 aactacaacc tcttatagca acccatgcag acctactgct taattctgca agccagcatt
      961 ctccagacag cttgaagaat tctttaaaga tgctttcaga aaaaacagag ctttttgtac
     1021 atgccttcaa ggatcaactt gtcaggagtg ctcttttagc actctacact gcaaggccag
     1081 gaggcattct taagaagcca ccctctccta agagcagcac agaggagagc agtccccaag
     1141 accaaccccc agtgatgaga gggcaggact ccataccaca tcattcagac tatgatgagg
     1201 aagagtggga cagggtgtgg gccaatgtgg ggaagagcct gaactgcatt attgctatgg
     1261 tggacaaact gattgaaaga gatggtggca gtgaaggcag tggcggcaac aatgatggag
     1321 aaaaggaacc ttcattaaca gatgccattc cctctcaccc aagagaggac tggtatgaac
     1381 agttgtatcc cctcatcctt accctgaagg actgcatggg agaagtggtg aaccgagcca
     1441 agcagtccct gacatttgtg ctccttcagg aacttgcgta cagcttgccc cagtgtctga
     1501 tgctgacgct aagaagagac atcgtcttca gccaagcact tgctggattg gtttgtggtt
     1561 ttatcatcaa attacagaca agtctgtatg acccaggctt cctacagcag cttcacacag
     1621 tggggttgat agtacaatat gaaggactgc taagtacata cagcgatgaa attggaatgc
     1681 tagaggacat ggccgttggc atttccgatt taaagaaagt tgcatttaaa ataattgaag
     1741 ccaaatccaa tgatgtgttg ccagttataa caggaagacg agaacattac gtggtagagg
     1801 tcaagcttcc agccagaatg tttgagtcac tacctctaca gattaaagaa ggacagttgc
     1861 ttcatgtgta tccagtactt tttaatgttg gaatcaatga acagcaaact ctggctgaaa
     1921 ggtttggaga tgtctctttg caagaaagta ttaatcagga aaacttcgaa cttctacaag
     1981 aatattacaa gatatttatg gaaaagatgc ctcctgatta tatttcacat tttcaggaac
     2041 aaaatgattt aaaagcattg ctagaaaatc tccttcaaaa tatccaatcc aaaaaaagaa
     2101 agaatgtaga aattatgtgg ctggctgcaa cgatttgccg caaactgaat ggtattcgtt
     2161 tcacctgttg taaaagtgcc aaagacagga catcgatgtc agtgacactt gaacaatgct
     2221 caatcttgag agatgagcac cagttacaca aggacttctt tatccgagcg ctggattgca
     2281 tgagaagaga aggatgccgc atagagaatg tactgaagaa tatcaaatgc agaaagtatg
     2341 ctttcaacat gctacagctg atggctttcc ccaagtacta cagacctcca gaggggactt
     2401 atggaaaagc tgacacctaa gtttaccaac atgttaataa acaggaacac aaatacattt
     2461 cagttggata atcttcacct tggtcttttt tgtttgtttt tattgtcatg aatttgtggt
     2521 gggggagatg atcacagatg tttcccaaaa tctaggaact acttcaattc atcatcagca
     2581 tattgctctg aaagaaatcc attttaaaaa atcttacatg attcagtact gtcatttcta
     2641 gttctaagct tctatgtgtt gagcctagct gattgagatt ggttcacaaa gtgtaaattt
     2701 cattcatgag tatttaaatg tttctgagga aacatggatc atttcaatag gactaggggt
     2761 gattcacaga gcaccactct ccaaccaaat ggaagagagg agagggggaa aaggaacata
     2821 ttttttttgt gatacaactt aatagcctat gagaacacag tcaacctgag aatcaatgta
     2881 agggatttaa aaaaaatgtg tagccactca attaggtaga gttaactcat gatctggaat
     2941 actgaggcag tttgcaggta tgttccacaa tgatctctat catccagtca aggtgtgact
     3001 cctcccttgc aacaggcata tgcatggagt gagtaaagtg gtcaacagac ctttcaaaac
     3061 catggcatct tttcagaact ctgacttggg ttgtgtgatc tagctgtgaa tgtagcaata
     3121 tagaacgttt aatagaatga taagcaaaac actgcaatga tctaaaatta caaataaaat
     3181 aaaaatgaac aacattttga tacccaaaat gaaaattccc atcagcctga actttatgtt
     3241 gtgaagttca tgaatgtcag tgaggtatct ctgagatgtt tcttagcagt catcctggtg
     3301 taagcatgca gttatggcat aggtttgtgt gtgttaataa gcctttaaaa catatgcaac
     3361 cacaacaaat gataaagtaa aacaattatt ttctgttgcc ctgaatatca aacttgccct
     3421 tgcccttact cagcaaaata acatttataa gttttccaaa atcccaaagt agaagtttcc
     3481 ttaaaaaaat catcttgtat aataccagta ttcaaacatg ggtaaggtta atcaccccca
     3541 atcactcagg agatagttgc agaatttgaa ttacaatctc ttcttacttt cctagcctgt
     3601 ggcttgtcac ttctccaaat tgccatgcta aatatgcatg aaaattgagg gagaatgcta
     3661 gttaaaaaga aattaggatt tatcactgga attgaaacta agagtacaaa agtctgaacg
     3721 aatgaaactt ttctccaaat tttacaaatt cttgttcctt tctcattaga agagcatgct
     3781 atccaaagca taaatctccc ttgaaaataa cagaggcttc ttaagccctc tcttagctat
     3841 gatcaatgga tgatattatg cttcccatag ctaatgtgat agctccttgc ctaggattcc
     3901 tgttgaaata aggattctag ccccatgtta agtttttcaa attactacaa attttagata
     3961 agcatttgga gctttttata ctagaattat caatttttta ttttagctaa ttacctgtgg
     4021 gcattatact tgaggcaggt accaaactac ttacagcctt tttaatgaaa atgtgctgtg
     4081 tactttgaat ccattcatag acaaaattac cttgatgttc tcttaactca ttctttattt
     4141 tagtgattaa atacaacctt tgagttgttc aatatcattt gaaaatggta ggatttgtgg
     4201 ttattttcat taccctatta gatttaagat aggctgggat gacagaggcc tccttgaata
     4261 gctatgaagc ctcattcagc atatcaaatg gtagtctgag ttctaagaaa ccttaagtaa
     4321 tttatcattc tgtaaatact cttataagca ataattttta tttgtatttt tgaaaacaaa
     4381 ctacttaaat atggaaaaat attaactgga aagccagcag tagggttttc tatttttaaa
     4441 agacatttca aggatttcct gtaatcccag cactttggga gccaaggtgg atagatcacc
     4501 tgaggtcagg aattggagat cagcctggcc aacatggtga aaccccatct ctactaaaga
     4561 tacaaaaatt agctggatgt ggtggcacac acgtgtaatc ccagctactt gggaggctga
     4621 ggcaagagaa tcgcttgaac cccggaggcg gaggttgcag tgagctgaga tcatgccatt
     4681 gcactccagc ctgggtgaaa agagcgaaac tccatcttta aataagtaaa taaatgaata
     4741 atatagaagt ctcaaattat agtgcttact gtaatacaaa tgcttatgaa ttttcattca
     4801 ttaccatagt catctgcatt tccttataga aagcctgtac tggtgcaaac ttctaaaagt
     4861 ggatttcatc aagaaaatgt gtttcataga gacaacaata ttgctttttt cctgagaggc
     4921 agttcattct taaacaacca cttcactatt tcttaagtta ttaaggctaa atcaaagagc
     4981 aaatgttaaa gtgtttaaat ctctcttgaa caaacacagc cacagtcatg ctattctatc
     5041 tatattttca cttaaaagat acaccagcag acctatttta ggaggtcata ttgagccaaa
     5101 aaatgaactg agcaaatgac atttccaaac tctttttttg ctcaaaaata atatgttccc
     5161 ctttgatatt aaatgcagat atcaattctg gattagctat ttactgagcc ctaggaaaaa
     5221 catatttaaa gacaaggaaa ccattcattt acatctcata tcattgcttt ttgcttttaa
     5281 atatcgcctt gaggtttgtc tacactctgc caaaacaatc cctgaacata agtttggtca
     5341 gcctcataat tcagtgagtc gagcaaccat ttgttccaag tgataaattg tactaaatga
     5401 caaactgccc aatcagggca gagctccatg gacccagcct ccagccctta ttttataaga
     5461 ctaacccctc ttctgaaaaa ctctgaaggc ttaaaagcta gcatttggat ggaggatact
     5521 tcctttttat ccttcagcta tgtatggcac tttacataaa ataagaggta aaaaaggaga
     5581 gaaactgatg tgtataaagt aatgcctttc ttcccaagca aatcaaacct ctccctatgt
     5641 aaaagttgat agtgtaccaa gagacacaat accactggtg ggctggaact agctcgttct
     5701 gatgcataaa agttgataat taaagtacca gaaattttgt aagctagttg ttaaacatta
     5761 ccattattaa atatgaaatt ataaaacaca gtggaataca ttaaaaacca atgtaataat
     5821 caaaacatac cacttcccaa ttattttact accttatact atttattagt actcttgagt
     5881 ctatttaggt ctattacatc tttacagtga aaacaggata caatattgtg ctactgtggg
     5941 tctcttcctg actgcagatt cagtaacatg gtgttcgtag cttgaaactg tccacagtgg
     6001 gagtatttaa caccatagaa actggctggc aaatgctaca aactagcaat tttaattcct
     6061 ggaaaggcaa ttgttgagca tttaccagca cacaatgaat gccatattct ttttttttta
     6121 ttaggaaata aattattgga ggcagtataa aattatttaa aaagtatcaa atgcaatccc
     6181 ttatcttcag atggctataa ttttggttat ataaatgttt tggtttttac cttctttaaa
     6241 gactcctatt aggttaaaag tcatatttga tgactatatt ttattcataa ttaaattatt
     6301 aaatcacctt ttctcctgat aatgctttgc cagagaattc ttagcaattc aactgtagtc
     6361 taagcaataa ctcagggcta aattcaggga actgttagcc caatcagata tcactaaaaa
     6421 tgtacttcac catctatttt ggagtttata attttggcat ttgctaaaag taggaaaaac
     6481 agtaacatat tactgtgccc agattctaat aaatatagct caattgaaac caaaactgtt
     6541 acattaaaca aattacactc tggcactatg ctaaatcacc acagatgttt taggtgtttg
     6601 atttccaagc aggatggtat atcatttgtt tggttcaata tatgaggcac catttgtagt
     6661 cttttaggaa ataaattagc ttttatcaca gatttaggaa acttgtctaa aaaaactgtg
     6721 atcatcagtt acagagggaa ggaaacatat tgaacacaag gcatcatagt agctggaggc
     6781 cttaaaaatt atgcacgacc aaaaagaatg atttggtgag agatgtgtag ctgattgaca
     6841 attttagtgt gaattcatat tcatttaacc cagcagcaat ctacataagc tatgcttttt
     6901 cccacctgta tttatgtttc ttagcttata aagtcccaat atattatatc ttttgttgct
     6961 ttggcagttt taatttagag ctctgcgttc acagagatgc cacctatagc aaaaactatc
     7021 tttaagaatt ggaaaataaa atgaatgttt tagataaaat attgcaagcc attatgtgta
     7081 gagttaatgt atggaaattt gcatttgttt ttctgaatca tggtgtacat taatcactca
     7141 ttgaattcta tttctaagca aataagagaa tcaaacattt ctaaaaggaa catatgtctt
     7201 gctattaata acaaggagac aggaaaaata gtaaggtaat ataagcaaaa aaaaaaatgt
     7261 aatgaattta gctatcctaa attggaattt ttacagattg catgcatact tagaatttta
     7321 aatttttaaa agatttacaa ttgagtatgg tacccacaga gagtgagtac caagggaagg
     7381 aagacctaat acaagtgatg ttgcctgata aatcacatct tgccaaaaaa aatatatttt
     7441 agtaaataca gttctttagg aagaaaaatg ttgccctttc acactcacag tgtaaataca
     7501 ttcataatat tccttcaatc atctaaatta ccgccaggtc atgaaaggac gcgatcaatg
     7561 atgacctatt gcactcacag gtaacattga ctcaaatttt ggcaatattg ctatattatc
     7621 tagataattc ttgtgatgtt tttatgtcac tatcaacatt aaaaatattt tgttaaacaa
     7681 ctatgaaact ttcaaaagtt tgcatataac tgtatgggca ctctcatttc actgcataca
     7741 tacaatactt tgtatacaca tacttctcgt gtggatattt tataatttta tttaatctaa
     7801 catttaactt ttaggttttt gtggtactca tctgaaaggt tggcatttgt tttcttttta
     7861 tgttatatat gtattttaga tgaatcaata atgtgtattc ctagaaattt tttctaggca
     7921 taaatagatc attttatgtt ggcatttaag agatatcatt tttgttttat tgttctgtgt
     7981 aaaccatatt cattgtacac tgtgtgtata tttttgttta aataaatgat ttttattttt
     8041 ta
//
