LOCUS       NM_001385455            8410 bp    mRNA    linear   PRI 07-DEC-2024
DEFINITION  Homo sapiens inositol polyphosphate-4-phosphatase type II B
            (INPP4B), transcript variant 37, mRNA.
ACCESSION   NM_001385455
VERSION     NM_001385455.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8410)
  AUTHORS   Saffi,G.T., To,L., Kleine,N., Melo,C.M.P., Chen,K., Genc,G.,
            Lee,K.C.D., Chow,J.T., Jang,G.H., Gallinger,S., Botelho,R.J. and
            Salmena,L.
  TITLE     INPP4B promotes PDAC aggressiveness via PIKfyve and
            TRPML-1-mediated lysosomal exocytosis
  JOURNAL   J Cell Biol 223 (11) (2024)
   PUBMED   39120584
  REMARK    GeneRIF: INPP4B promotes PDAC aggressiveness via PIKfyve and
            TRPML-1-mediated lysosomal exocytosis.
REFERENCE   2  (bases 1 to 8410)
  AUTHORS   Lai,M., Mao,Z., Tang,D., Lan,S., Yan,R., Xiang,Q., Zhao,X., Su,M.
            and Wang,Y.
  TITLE     [Preliminary Study of the Role of INPP4B in Promoting Colorectal
            Cancer Metastasis and the Mechanisms Involved]
  JOURNAL   Sichuan Da Xue Xue Bao Yi Xue Ban 55 (5), 1186-1194 (2024)
   PUBMED   39507966
  REMARK    GeneRIF: [Preliminary Study of the Role of INPP4B in Promoting
            Colorectal Cancer Metastasis and the Mechanisms Involved].
REFERENCE   3  (bases 1 to 8410)
  AUTHORS   Zhao,J., Du,X.M., Si,W., Zhao,X.H. and Zhou,Z.Q.
  TITLE     Role of INPP4B in the proliferation, migration, invasion, and
            survival of human endometrial cancer cells
  JOURNAL   Histol Histopathol 39 (9), 1197-1208 (2024)
   PUBMED   38318760
  REMARK    GeneRIF: Role of INPP4B in the proliferation, migration, invasion,
            and survival of human endometrial cancer cells.
REFERENCE   4  (bases 1 to 8410)
  AUTHORS   Gorji,M., Farsani,M.A., Kargar,M., Garavand,J. and Mohammadi,M.H.
  TITLE     Investigating the multifaceted cooperation of autophagy, PI3K/AKT
            signaling pathways, and INPP4B gene in de novo acute myeloid
            leukemia patients
  JOURNAL   Curr Res Transl Med 72 (2), 103429 (2024)
   PUBMED   38246071
  REMARK    GeneRIF: Investigating the multifaceted cooperation of autophagy,
            PI3K/AKT signaling pathways, and INPP4B gene in de novo acute
            myeloid leukemia patients.
REFERENCE   5  (bases 1 to 8410)
  AUTHORS   Xu,M., Ren,J., Jia,W., Wang,S., Liu,Y., Chen,X., Shi,J. and Wang,H.
  TITLE     Regulation of B-1 cell numbers and B cell-mediated antibody
            production by Inpp4b
  JOURNAL   Scand J Immunol 98 (4), e13309 (2023)
   PUBMED   37389566
  REMARK    GeneRIF: Regulation of B-1 cell numbers and B cell-mediated
            antibody production by Inpp4b.
REFERENCE   6  (bases 1 to 8410)
  AUTHORS   Rampersaud,E., Damcott,C.M., Fu,M., Shen,H., McArdle,P., Shi,X.,
            Shelton,J., Yin,J., Chang,Y.P., Ott,S.H., Zhang,L., Zhao,Y.,
            Mitchell,B.D., O'Connell,J. and Shuldiner,A.R.
  TITLE     Identification of novel candidate genes for type 2 diabetes from a
            genome-wide association scan in the Old Order Amish: evidence for
            replication from diabetes-related quantitative traits and from
            independent populations
  JOURNAL   Diabetes 56 (12), 3053-3062 (2007)
   PUBMED   17846126
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 8410)
  AUTHORS   Munday,A.D., Norris,F.A., Caldwell,K.K., Brown,S., Majerus,P.W. and
            Mitchell,C.A.
  TITLE     The inositol polyphosphate 4-phosphatase forms a complex with
            phosphatidylinositol 3-kinase in human platelet cytosol
  JOURNAL   Proc Natl Acad Sci U S A 96 (7), 3640-3645 (1999)
   PUBMED   10097090
REFERENCE   8  (bases 1 to 8410)
  AUTHORS   Zhang,X. and Majerus,P.W.
  TITLE     Phosphatidylinositol signalling reactions
  JOURNAL   Semin Cell Dev Biol 9 (2), 153-160 (1998)
   PUBMED   9599410
  REMARK    Review article
REFERENCE   9  (bases 1 to 8410)
  AUTHORS   Norris,F.A., Atkins,R.C. and Majerus,P.W.
  TITLE     The cDNA cloning and characterization of inositol polyphosphate
            4-phosphatase type II. Evidence for conserved alternative splicing
            in the 4-phosphatase family
  JOURNAL   J Biol Chem 272 (38), 23859-23864 (1997)
   PUBMED   9295334
REFERENCE   10 (bases 1 to 8410)
  AUTHORS   Norris,F.A., Auethavekiat,V. and Majerus,P.W.
  TITLE     The isolation and characterization of cDNA encoding human and rat
            brain inositol polyphosphate 4-phosphatase
  JOURNAL   J Biol Chem 270 (27), 16128-16133 (1995)
   PUBMED   7608176
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC108060.3, AC093860.3 and
            AC108077.3.
            
            Summary: INPP4B encodes the inositol polyphosphate 4-phosphatase
            type II, one of the enzymes involved in phosphatidylinositol
            signaling pathways. This enzyme removes the phosphate group at
            position 4 of the inositol ring from inositol 3,4-bisphosphate.
            There is limited data to suggest that the human type II enzyme is
            subject to alternative splicing, as has been established for the
            type I enzyme. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038193.3374809.1,
                                           SRR14038192.611822.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-241               AC108060.3         86724-86964         c
            242-358             AC108060.3         84456-84572         c
            359-409             AC093860.3         187670-187720       c
            410-489             AC093860.3         178416-178495       c
            490-601             AC093860.3         143621-143732       c
            602-674             AC093860.3         133450-133522       c
            675-822             AC093860.3         110822-110969       c
            823-953             AC093860.3         81854-81984         c
            954-1058            AC093860.3         81383-81487         c
            1059-1085           AC093860.3         75698-75724         c
            1086-1194           AC093860.3         66045-66153         c
            1195-1372           AC093860.3         46590-46767         c
            1373-1576           AC093860.3         33316-33519         c
            1577-1733           AC093860.3         18798-18954         c
            1734-1906           AC108077.3         102529-102701       c
            1907-2030           AC108077.3         101233-101356       c
            2031-2148           AC108077.3         100069-100186       c
            2149-2289           AC108077.3         90483-90623         c
            2290-2387           AC108077.3         86034-86131         c
            2388-2500           AC108077.3         64085-64197         c
            2501-2655           AC108077.3         59972-60126         c
            2656-8410           AC108077.3         1101-6855           c
FEATURES             Location/Qualifiers
     source          1..8410
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q31.21"
     gene            1..8410
                     /gene="INPP4B"
                     /note="inositol polyphosphate-4-phosphatase type II B"
                     /db_xref="GeneID:8821"
                     /db_xref="HGNC:HGNC:6075"
                     /db_xref="MIM:607494"
     exon            1..241
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     exon            242..358
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     exon            359..409
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     exon            410..489
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     exon            490..601
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     CDS             542..2788
                     /gene="INPP4B"
                     /EC_number="3.1.3.66"
                     /note="isoform 8 is encoded by transcript variant 37;
                     inositol polyphosphate 4-phosphatase II; 4-phosphatase II;
                     type II inositol 3,4-bisphosphate 4-phosphatase; inositol
                     polyphosphate-4-phosphatase, type II, 105kDa"
                     /codon_start=1
                     /product="inositol polyphosphate 4-phosphatase type II
                     isoform 8"
                     /protein_id="NP_001372384.1"
                     /db_xref="GeneID:8821"
                     /db_xref="HGNC:HGNC:6075"
                     /db_xref="MIM:607494"
                     /translation="MGEIEDGEADHITTDVQGQKCALVCECTAPESVSGKDNLPFLNS
                     VLKNPVCKLYRFPTSDNKWMRIREQMSESILSFHIPKELISLHIKEDLCRNQEIKELG
                     ELSPHWDNLRKNVLTHCDQMVNMYQDILTELSKETGSSFKSSSSKGEKTLEFVPINLH
                     LQRMQVHSPHLKDISSGIPQIDALYDVITVGAPAAHFQGFKNGGLRKLLHRFETERRN
                     TGYQFIYYSPENTAKAKEVLSNINQLQPLIATHADLLLNSASQHSPDSLKNSLKMLSE
                     KTELFVHAFKDQLVRSALLALYTARPGGILKKPPSPKSSTEESSPQDQPPVMRGQDSI
                     PHHSDYDEEEWDRVWANVGKSLNCIIAMVDKLIERDGGSEGSGGNNDGEKEPSLTDAI
                     PSHPREDWYEQLYPLILTLKDCMGEVVNRAKQSLTFVLLQELAYSLPQCLMLTLRRDI
                     VFSQALAGLVCGFIIKLQTSLYDPGFLQQLHTVGLIVQYEGLLSTYSDEIGMLEDMAV
                     GISDLKKVAFKIIEAKSNDVLPVITGRREHYVVEVKLPARMFESLPLQIKEGQLLHVY
                     PVLFNVGINEQQTLAERFGDVSLQESINQENFELLQEYYKIFMEKMPPDYISHFQEQN
                     DLKALLENLLQNIQSKKRKNVEIMWLAATICRKLNGIRFTCCKSAKDRTSMSVTLEQC
                     SILRDEHQLHKDFFIRALDCMRREGCRIENVLKNIKCRKYAFNMLQLMAFPKYYRPPE
                     GTYGKADT"
     exon            602..674
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     exon            675..822
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     exon            823..953
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     exon            954..1058
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     exon            1059..1085
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     exon            1086..1194
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     exon            1195..1372
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     exon            1373..1576
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     exon            1577..1733
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     exon            1734..1906
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     exon            1907..2030
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     exon            2031..2148
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     exon            2149..2289
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     exon            2290..2387
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     exon            2388..2500
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     exon            2501..2655
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     exon            2656..8410
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2804..2809
                     /regulatory_class="polyA_signal_sequence"
                     /gene="INPP4B"
                     /note="hexamer: AATAAA"
     regulatory      2820..2825
                     /regulatory_class="polyA_signal_sequence"
                     /gene="INPP4B"
                     /note="hexamer: AATACA"
     polyA_site      2830
                     /gene="INPP4B"
     polyA_site      2845
                     /gene="INPP4B"
                     /note="major polyA site"
     regulatory      8389..8394
                     /regulatory_class="polyA_signal_sequence"
                     /gene="INPP4B"
                     /note="hexamer: AATAAA"
     polyA_site      8410
                     /gene="INPP4B"
ORIGIN      
        1 agcctgagcc ccaggagatt tccttcagtg ctgtagctaa gttcactttc agcccggcgc
       61 agaagttttc cctgagatat ggtgttagtt tcttttcttt ctgtctcctc tgccgttgcc
      121 agcatgcaag gatctcgtgg ctcctgtccg tgatcgtaaa ctgaatacac tggtgcagat
      181 ctccgtaatc caccccgtgg agcagagtct gacaagatac tccagcaccg aaattgtgga
      241 gggaacaagg gacccactgt ttttgactgg tgtcacattc ccatctgagt atcccatcta
      301 tgaggagacc aaaataaaac taacagtcta tgatgtcaag gataagtctc atgacaccgt
      361 tcgaaccagt gtcctaccag aacataagga tcccccgcca gaagttgggc gaagtttctt
      421 gggctatgcc agttttaaag tgggagagct gctgaagtca aaggagcaat tgctggtcct
      481 gagcctgaga acttcagatg gtggcaaagt ggttggcacc atagaagtca gtgtcgtgaa
      541 gatgggggag attgaggatg gggaagccga ccacatcacc acagatgtac agggacaaaa
      601 gtgtgccctg gtatgtgaat gtacagcccc ggaaagtgtg agcggaaaag ataacttacc
      661 ttttttgaat tcagtgttaa agaacccagt atgtaaatta tatagatttc ccacatctga
      721 caataagtgg atgcgaattc gagagcagat gtcagagagc attctttcct ttcatattcc
      781 taaggaattg atttcccttc acattaaaga agatttgtgc agaaaccagg agataaaaga
      841 acttggtgag ctttctccac attgggacaa tctgcgaaaa aatgtcctta ctcactgtga
      901 tcaaatggtg aatatgtacc aagacattct gacagaactt agcaaggaaa cagggtcctc
      961 tttcaaatca agcagcagca aaggagagaa aacattagaa tttgttccaa taaatctaca
     1021 tctgcaaaga atgcaggtac acagccctca cttgaaagat atctcaagtg ggattccgca
     1081 aattgatgct ctctacgatg tcatcactgt gggagcccca gctgcccatt ttcagggatt
     1141 taagaatggt ggtcttcgga agctactcca tagatttgaa acagaaagaa gaaataccgg
     1201 ataccagttt atttactatt cacctgaaaa cacagccaaa gcaaaggaag ttctcagcaa
     1261 catcaatcaa ctacaacctc ttatagcaac ccatgcagac ctactgctta attctgcaag
     1321 ccagcattct ccagacagct tgaagaattc tttaaagatg ctttcagaaa aaacagagct
     1381 ttttgtacat gccttcaagg atcaacttgt caggagtgct cttttagcac tctacactgc
     1441 aaggccagga ggcattctta agaagccacc ctctcctaag agcagcacag aggagagcag
     1501 tccccaagac caacccccag tgatgagagg gcaggactcc ataccacatc attcagacta
     1561 tgatgaggaa gagtgggaca gggtgtgggc caatgtgggg aagagcctga actgcattat
     1621 tgctatggtg gacaaactga ttgaaagaga tggtggcagt gaaggcagtg gcggcaacaa
     1681 tgatggagaa aaggaacctt cattaacaga tgccattccc tctcacccaa gagaggactg
     1741 gtatgaacag ttgtatcccc tcatccttac cctgaaggac tgcatgggag aagtggtgaa
     1801 ccgagccaag cagtccctga catttgtgct ccttcaggaa cttgcgtaca gcttgcccca
     1861 gtgtctgatg ctgacgctaa gaagagacat cgtcttcagc caagcacttg ctggattggt
     1921 ttgtggtttt atcatcaaat tacagacaag tctgtatgac ccaggcttcc tacagcagct
     1981 tcacacagtg gggttgatag tacaatatga aggactgcta agtacataca gcgatgaaat
     2041 tggaatgcta gaggacatgg ccgttggcat ttccgattta aagaaagttg catttaaaat
     2101 aattgaagcc aaatccaatg atgtgttgcc agttataaca ggaagacgag aacattacgt
     2161 ggtagaggtc aagcttccag ccagaatgtt tgagtcacta cctctacaga ttaaagaagg
     2221 acagttgctt catgtgtatc cagtactttt taatgttgga atcaatgaac agcaaactct
     2281 ggctgaaagg tttggagatg tctctttgca agaaagtatt aatcaggaaa acttcgaact
     2341 tctacaagaa tattacaaga tatttatgga aaagatgcct cctgattata tttcacattt
     2401 tcaggaacaa aatgatttaa aagcattgct agaaaatctc cttcaaaata tccaatccaa
     2461 aaaaagaaag aatgtagaaa ttatgtggct ggctgcaacg atttgccgca aactgaatgg
     2521 tattcgtttc acctgttgta aaagtgccaa agacaggaca tcgatgtcag tgacacttga
     2581 acaatgctca atcttgagag atgagcacca gttacacaag gacttcttta tccgagcgct
     2641 ggattgcatg agaagagaag gatgccgcat agagaatgta ctgaagaata tcaaatgcag
     2701 aaagtatgct ttcaacatgc tacagctgat ggctttcccc aagtactaca gacctccaga
     2761 ggggacttat ggaaaagctg acacctaagt ttaccaacat gttaataaac aggaacacaa
     2821 atacatttca gttggataat cttcaccttg gtcttttttg tttgttttta ttgtcatgaa
     2881 tttgtggtgg gggagatgat cacagatgtt tcccaaaatc taggaactac ttcaattcat
     2941 catcagcata ttgctctgaa agaaatccat tttaaaaaat cttacatgat tcagtactgt
     3001 catttctagt tctaagcttc tatgtgttga gcctagctga ttgagattgg ttcacaaagt
     3061 gtaaatttca ttcatgagta tttaaatgtt tctgaggaaa catggatcat ttcaatagga
     3121 ctaggggtga ttcacagagc accactctcc aaccaaatgg aagagaggag agggggaaaa
     3181 ggaacatatt ttttttgtga tacaacttaa tagcctatga gaacacagtc aacctgagaa
     3241 tcaatgtaag ggatttaaaa aaaatgtgta gccactcaat taggtagagt taactcatga
     3301 tctggaatac tgaggcagtt tgcaggtatg ttccacaatg atctctatca tccagtcaag
     3361 gtgtgactcc tcccttgcaa caggcatatg catggagtga gtaaagtggt caacagacct
     3421 ttcaaaacca tggcatcttt tcagaactct gacttgggtt gtgtgatcta gctgtgaatg
     3481 tagcaatata gaacgtttaa tagaatgata agcaaaacac tgcaatgatc taaaattaca
     3541 aataaaataa aaatgaacaa cattttgata cccaaaatga aaattcccat cagcctgaac
     3601 tttatgttgt gaagttcatg aatgtcagtg aggtatctct gagatgtttc ttagcagtca
     3661 tcctggtgta agcatgcagt tatggcatag gtttgtgtgt gttaataagc ctttaaaaca
     3721 tatgcaacca caacaaatga taaagtaaaa caattatttt ctgttgccct gaatatcaaa
     3781 cttgcccttg cccttactca gcaaaataac atttataagt tttccaaaat cccaaagtag
     3841 aagtttcctt aaaaaaatca tcttgtataa taccagtatt caaacatggg taaggttaat
     3901 cacccccaat cactcaggag atagttgcag aatttgaatt acaatctctt cttactttcc
     3961 tagcctgtgg cttgtcactt ctccaaattg ccatgctaaa tatgcatgaa aattgaggga
     4021 gaatgctagt taaaaagaaa ttaggattta tcactggaat tgaaactaag agtacaaaag
     4081 tctgaacgaa tgaaactttt ctccaaattt tacaaattct tgttcctttc tcattagaag
     4141 agcatgctat ccaaagcata aatctccctt gaaaataaca gaggcttctt aagccctctc
     4201 ttagctatga tcaatggatg atattatgct tcccatagct aatgtgatag ctccttgcct
     4261 aggattcctg ttgaaataag gattctagcc ccatgttaag tttttcaaat tactacaaat
     4321 tttagataag catttggagc tttttatact agaattatca attttttatt ttagctaatt
     4381 acctgtgggc attatacttg aggcaggtac caaactactt acagcctttt taatgaaaat
     4441 gtgctgtgta ctttgaatcc attcatagac aaaattacct tgatgttctc ttaactcatt
     4501 ctttatttta gtgattaaat acaacctttg agttgttcaa tatcatttga aaatggtagg
     4561 atttgtggtt attttcatta ccctattaga tttaagatag gctgggatga cagaggcctc
     4621 cttgaatagc tatgaagcct cattcagcat atcaaatggt agtctgagtt ctaagaaacc
     4681 ttaagtaatt tatcattctg taaatactct tataagcaat aatttttatt tgtatttttg
     4741 aaaacaaact acttaaatat ggaaaaatat taactggaaa gccagcagta gggttttcta
     4801 tttttaaaag acatttcaag gatttcctgt aatcccagca ctttgggagc caaggtggat
     4861 agatcacctg aggtcaggaa ttggagatca gcctggccaa catggtgaaa ccccatctct
     4921 actaaagata caaaaattag ctggatgtgg tggcacacac gtgtaatccc agctacttgg
     4981 gaggctgagg caagagaatc gcttgaaccc cggaggcgga ggttgcagtg agctgagatc
     5041 atgccattgc actccagcct gggtgaaaag agcgaaactc catctttaaa taagtaaata
     5101 aatgaataat atagaagtct caaattatag tgcttactgt aatacaaatg cttatgaatt
     5161 ttcattcatt accatagtca tctgcatttc cttatagaaa gcctgtactg gtgcaaactt
     5221 ctaaaagtgg atttcatcaa gaaaatgtgt ttcatagaga caacaatatt gcttttttcc
     5281 tgagaggcag ttcattctta aacaaccact tcactatttc ttaagttatt aaggctaaat
     5341 caaagagcaa atgttaaagt gtttaaatct ctcttgaaca aacacagcca cagtcatgct
     5401 attctatcta tattttcact taaaagatac accagcagac ctattttagg aggtcatatt
     5461 gagccaaaaa atgaactgag caaatgacat ttccaaactc tttttttgct caaaaataat
     5521 atgttcccct ttgatattaa atgcagatat caattctgga ttagctattt actgagccct
     5581 aggaaaaaca tatttaaaga caaggaaacc attcatttac atctcatatc attgcttttt
     5641 gcttttaaat atcgccttga ggtttgtcta cactctgcca aaacaatccc tgaacataag
     5701 tttggtcagc ctcataattc agtgagtcga gcaaccattt gttccaagtg ataaattgta
     5761 ctaaatgaca aactgcccaa tcagggcaga gctccatgga cccagcctcc agcccttatt
     5821 ttataagact aacccctctt ctgaaaaact ctgaaggctt aaaagctagc atttggatgg
     5881 aggatacttc ctttttatcc ttcagctatg tatggcactt tacataaaat aagaggtaaa
     5941 aaaggagaga aactgatgtg tataaagtaa tgcctttctt cccaagcaaa tcaaacctct
     6001 ccctatgtaa aagttgatag tgtaccaaga gacacaatac cactggtggg ctggaactag
     6061 ctcgttctga tgcataaaag ttgataatta aagtaccaga aattttgtaa gctagttgtt
     6121 aaacattacc attattaaat atgaaattat aaaacacagt ggaatacatt aaaaaccaat
     6181 gtaataatca aaacatacca cttcccaatt attttactac cttatactat ttattagtac
     6241 tcttgagtct atttaggtct attacatctt tacagtgaaa acaggataca atattgtgct
     6301 actgtgggtc tcttcctgac tgcagattca gtaacatggt gttcgtagct tgaaactgtc
     6361 cacagtggga gtatttaaca ccatagaaac tggctggcaa atgctacaaa ctagcaattt
     6421 taattcctgg aaaggcaatt gttgagcatt taccagcaca caatgaatgc catattcttt
     6481 tttttttatt aggaaataaa ttattggagg cagtataaaa ttatttaaaa agtatcaaat
     6541 gcaatccctt atcttcagat ggctataatt ttggttatat aaatgttttg gtttttacct
     6601 tctttaaaga ctcctattag gttaaaagtc atatttgatg actatatttt attcataatt
     6661 aaattattaa atcacctttt ctcctgataa tgctttgcca gagaattctt agcaattcaa
     6721 ctgtagtcta agcaataact cagggctaaa ttcagggaac tgttagccca atcagatatc
     6781 actaaaaatg tacttcacca tctattttgg agtttataat tttggcattt gctaaaagta
     6841 ggaaaaacag taacatatta ctgtgcccag attctaataa atatagctca attgaaacca
     6901 aaactgttac attaaacaaa ttacactctg gcactatgct aaatcaccac agatgtttta
     6961 ggtgtttgat ttccaagcag gatggtatat catttgtttg gttcaatata tgaggcacca
     7021 tttgtagtct tttaggaaat aaattagctt ttatcacaga tttaggaaac ttgtctaaaa
     7081 aaactgtgat catcagttac agagggaagg aaacatattg aacacaaggc atcatagtag
     7141 ctggaggcct taaaaattat gcacgaccaa aaagaatgat ttggtgagag atgtgtagct
     7201 gattgacaat tttagtgtga attcatattc atttaaccca gcagcaatct acataagcta
     7261 tgctttttcc cacctgtatt tatgtttctt agcttataaa gtcccaatat attatatctt
     7321 ttgttgcttt ggcagtttta atttagagct ctgcgttcac agagatgcca cctatagcaa
     7381 aaactatctt taagaattgg aaaataaaat gaatgtttta gataaaatat tgcaagccat
     7441 tatgtgtaga gttaatgtat ggaaatttgc atttgttttt ctgaatcatg gtgtacatta
     7501 atcactcatt gaattctatt tctaagcaaa taagagaatc aaacatttct aaaaggaaca
     7561 tatgtcttgc tattaataac aaggagacag gaaaaatagt aaggtaatat aagcaaaaaa
     7621 aaaaatgtaa tgaatttagc tatcctaaat tggaattttt acagattgca tgcatactta
     7681 gaattttaaa tttttaaaag atttacaatt gagtatggta cccacagaga gtgagtacca
     7741 agggaaggaa gacctaatac aagtgatgtt gcctgataaa tcacatcttg ccaaaaaaaa
     7801 tatattttag taaatacagt tctttaggaa gaaaaatgtt gccctttcac actcacagtg
     7861 taaatacatt cataatattc cttcaatcat ctaaattacc gccaggtcat gaaaggacgc
     7921 gatcaatgat gacctattgc actcacaggt aacattgact caaattttgg caatattgct
     7981 atattatcta gataattctt gtgatgtttt tatgtcacta tcaacattaa aaatattttg
     8041 ttaaacaact atgaaacttt caaaagtttg catataactg tatgggcact ctcatttcac
     8101 tgcatacata caatactttg tatacacata cttctcgtgt ggatatttta taattttatt
     8161 taatctaaca tttaactttt aggtttttgt ggtactcatc tgaaaggttg gcatttgttt
     8221 tctttttatg ttatatatgt attttagatg aatcaataat gtgtattcct agaaattttt
     8281 tctaggcata aatagatcat tttatgttgg catttaagag atatcatttt tgttttattg
     8341 ttctgtgtaa accatattca ttgtacactg tgtgtatatt tttgtttaaa taaatgattt
     8401 ttatttttta
//
