LOCUS       NM_001385382            8407 bp    mRNA    linear   PRI 07-DEC-2024
DEFINITION  Homo sapiens inositol polyphosphate-4-phosphatase type II B
            (INPP4B), transcript variant 24, mRNA.
ACCESSION   NM_001385382
VERSION     NM_001385382.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8407)
  AUTHORS   Saffi,G.T., To,L., Kleine,N., Melo,C.M.P., Chen,K., Genc,G.,
            Lee,K.C.D., Chow,J.T., Jang,G.H., Gallinger,S., Botelho,R.J. and
            Salmena,L.
  TITLE     INPP4B promotes PDAC aggressiveness via PIKfyve and
            TRPML-1-mediated lysosomal exocytosis
  JOURNAL   J Cell Biol 223 (11) (2024)
   PUBMED   39120584
  REMARK    GeneRIF: INPP4B promotes PDAC aggressiveness via PIKfyve and
            TRPML-1-mediated lysosomal exocytosis.
REFERENCE   2  (bases 1 to 8407)
  AUTHORS   Lai,M., Mao,Z., Tang,D., Lan,S., Yan,R., Xiang,Q., Zhao,X., Su,M.
            and Wang,Y.
  TITLE     [Preliminary Study of the Role of INPP4B in Promoting Colorectal
            Cancer Metastasis and the Mechanisms Involved]
  JOURNAL   Sichuan Da Xue Xue Bao Yi Xue Ban 55 (5), 1186-1194 (2024)
   PUBMED   39507966
  REMARK    GeneRIF: [Preliminary Study of the Role of INPP4B in Promoting
            Colorectal Cancer Metastasis and the Mechanisms Involved].
REFERENCE   3  (bases 1 to 8407)
  AUTHORS   Zhao,J., Du,X.M., Si,W., Zhao,X.H. and Zhou,Z.Q.
  TITLE     Role of INPP4B in the proliferation, migration, invasion, and
            survival of human endometrial cancer cells
  JOURNAL   Histol Histopathol 39 (9), 1197-1208 (2024)
   PUBMED   38318760
  REMARK    GeneRIF: Role of INPP4B in the proliferation, migration, invasion,
            and survival of human endometrial cancer cells.
REFERENCE   4  (bases 1 to 8407)
  AUTHORS   Gorji,M., Farsani,M.A., Kargar,M., Garavand,J. and Mohammadi,M.H.
  TITLE     Investigating the multifaceted cooperation of autophagy, PI3K/AKT
            signaling pathways, and INPP4B gene in de novo acute myeloid
            leukemia patients
  JOURNAL   Curr Res Transl Med 72 (2), 103429 (2024)
   PUBMED   38246071
  REMARK    GeneRIF: Investigating the multifaceted cooperation of autophagy,
            PI3K/AKT signaling pathways, and INPP4B gene in de novo acute
            myeloid leukemia patients.
REFERENCE   5  (bases 1 to 8407)
  AUTHORS   Xu,M., Ren,J., Jia,W., Wang,S., Liu,Y., Chen,X., Shi,J. and Wang,H.
  TITLE     Regulation of B-1 cell numbers and B cell-mediated antibody
            production by Inpp4b
  JOURNAL   Scand J Immunol 98 (4), e13309 (2023)
   PUBMED   37389566
  REMARK    GeneRIF: Regulation of B-1 cell numbers and B cell-mediated
            antibody production by Inpp4b.
REFERENCE   6  (bases 1 to 8407)
  AUTHORS   Rampersaud,E., Damcott,C.M., Fu,M., Shen,H., McArdle,P., Shi,X.,
            Shelton,J., Yin,J., Chang,Y.P., Ott,S.H., Zhang,L., Zhao,Y.,
            Mitchell,B.D., O'Connell,J. and Shuldiner,A.R.
  TITLE     Identification of novel candidate genes for type 2 diabetes from a
            genome-wide association scan in the Old Order Amish: evidence for
            replication from diabetes-related quantitative traits and from
            independent populations
  JOURNAL   Diabetes 56 (12), 3053-3062 (2007)
   PUBMED   17846126
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 8407)
  AUTHORS   Munday,A.D., Norris,F.A., Caldwell,K.K., Brown,S., Majerus,P.W. and
            Mitchell,C.A.
  TITLE     The inositol polyphosphate 4-phosphatase forms a complex with
            phosphatidylinositol 3-kinase in human platelet cytosol
  JOURNAL   Proc Natl Acad Sci U S A 96 (7), 3640-3645 (1999)
   PUBMED   10097090
REFERENCE   8  (bases 1 to 8407)
  AUTHORS   Zhang,X. and Majerus,P.W.
  TITLE     Phosphatidylinositol signalling reactions
  JOURNAL   Semin Cell Dev Biol 9 (2), 153-160 (1998)
   PUBMED   9599410
  REMARK    Review article
REFERENCE   9  (bases 1 to 8407)
  AUTHORS   Norris,F.A., Atkins,R.C. and Majerus,P.W.
  TITLE     The cDNA cloning and characterization of inositol polyphosphate
            4-phosphatase type II. Evidence for conserved alternative splicing
            in the 4-phosphatase family
  JOURNAL   J Biol Chem 272 (38), 23859-23864 (1997)
   PUBMED   9295334
REFERENCE   10 (bases 1 to 8407)
  AUTHORS   Norris,F.A., Auethavekiat,V. and Majerus,P.W.
  TITLE     The isolation and characterization of cDNA encoding human and rat
            brain inositol polyphosphate 4-phosphatase
  JOURNAL   J Biol Chem 270 (27), 16128-16133 (1995)
   PUBMED   7608176
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC108060.3, AC093860.3 and
            AC108077.3.
            
            Summary: INPP4B encodes the inositol polyphosphate 4-phosphatase
            type II, one of the enzymes involved in phosphatidylinositol
            signaling pathways. This enzyme removes the phosphate group at
            position 4 of the inositol ring from inositol 3,4-bisphosphate.
            There is limited data to suggest that the human type II enzyme is
            subject to alternative splicing, as has been established for the
            type I enzyme. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA1965299, SAMEA1966682
                              [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-241               AC108060.3         86724-86964         c
            242-358             AC108060.3         84456-84572         c
            359-409             AC093860.3         187670-187720       c
            410-489             AC093860.3         178416-178495       c
            490-601             AC093860.3         143621-143732       c
            602-674             AC093860.3         133450-133522       c
            675-822             AC093860.3         110822-110969       c
            823-953             AC093860.3         81854-81984         c
            954-1058            AC093860.3         81383-81487         c
            1059-1167           AC093860.3         66045-66153         c
            1168-1345           AC093860.3         46590-46767         c
            1346-1549           AC093860.3         33316-33519         c
            1550-1706           AC093860.3         18798-18954         c
            1707-1879           AC108077.3         102529-102701       c
            1880-2003           AC108077.3         101233-101356       c
            2004-2121           AC108077.3         100069-100186       c
            2122-2262           AC108077.3         90483-90623         c
            2263-2360           AC108077.3         86034-86131         c
            2361-2473           AC108077.3         64085-64197         c
            2474-2628           AC108077.3         59972-60126         c
            2629-8407           AC108077.3         1101-6879           c
FEATURES             Location/Qualifiers
     source          1..8407
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q31.21"
     gene            1..8407
                     /gene="INPP4B"
                     /note="inositol polyphosphate-4-phosphatase type II B"
                     /db_xref="GeneID:8821"
                     /db_xref="HGNC:HGNC:6075"
                     /db_xref="MIM:607494"
     exon            1..241
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     exon            242..358
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     exon            359..409
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     exon            410..489
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     exon            490..601
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     CDS             542..2785
                     /gene="INPP4B"
                     /EC_number="3.1.3.66"
                     /note="isoform 9 is encoded by transcript variant 24;
                     inositol polyphosphate 4-phosphatase II; 4-phosphatase II;
                     type II inositol 3,4-bisphosphate 4-phosphatase; inositol
                     polyphosphate-4-phosphatase, type II, 105kDa"
                     /codon_start=1
                     /product="inositol polyphosphate 4-phosphatase type II
                     isoform 9"
                     /protein_id="NP_001372311.1"
                     /db_xref="GeneID:8821"
                     /db_xref="HGNC:HGNC:6075"
                     /db_xref="MIM:607494"
                     /translation="MGEIEDGEADHITTDVQGQKCALVCECTAPESVSGKDNLPFLNS
                     VLKNPVCKLYRFPTSDNKWMRIREQMSESILSFHIPKELISLHIKEDLCRNQEIKELG
                     ELSPHWDNLRKNVLTHCDQMVNMYQDILTELSKETGSSFKSSSSKGEKTLEFVPINLH
                     LQRMQVHSPHLKDALYDVITVGAPAAHFQGFKNGGLRKLLHRFETERRNTGYQFIYYS
                     PENTAKAKEVLSNINQLQPLIATHADLLLNSASQHSPDSLKNSLKMLSEKTELFVHAF
                     KDQLVRSALLALYTARPGGILKKPPSPKSSTEESSPQDQPPVMRGQDSIPHHSDYDEE
                     EWDRVWANVGKSLNCIIAMVDKLIERDGGSEGSGGNNDGEKEPSLTDAIPSHPREDWY
                     EQLYPLILTLKDCMGEVVNRAKQSLTFVLLQELAYSLPQCLMLTLRRDIVFSQALAGL
                     VCGFIIKLQTSLYDPGFLQQLHTVGLIVQYEGLLSTYSDEIGMLEDMAVGISDLKKVA
                     FKIIEAKSNDVLPVITGRREHYVVEVKLPARMFESLPLQIKEGQLLHVYPVLFNVGIN
                     EQQTLAERFGDVSLQESINQENFELLQEYYKIFMEKMPPDYISHFQEQNDLKALLENL
                     LQNIQSKKRKNVEIMWLAATICRKLNGIRFTCCKSAKDRTSMSVTLEQCSILRDEHQL
                     HKDFFIRALDCMRSCTFSPFTREGCRIENVLKNIKCRKYAFNMLQLMAFPKYYRPPEG
                     TYGKADT"
     exon            602..674
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     exon            675..822
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     exon            823..953
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     exon            954..1058
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     exon            1059..1167
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     exon            1168..1345
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     exon            1346..1549
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     exon            1550..1706
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     exon            1707..1879
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     exon            1880..2003
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     exon            2004..2121
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     exon            2122..2262
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     exon            2263..2360
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     exon            2361..2473
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     exon            2474..2628
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     exon            2629..8407
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2801..2806
                     /regulatory_class="polyA_signal_sequence"
                     /gene="INPP4B"
                     /note="hexamer: AATAAA"
     regulatory      2817..2822
                     /regulatory_class="polyA_signal_sequence"
                     /gene="INPP4B"
                     /note="hexamer: AATACA"
     polyA_site      2827
                     /gene="INPP4B"
     polyA_site      2842
                     /gene="INPP4B"
                     /note="major polyA site"
     regulatory      8386..8391
                     /regulatory_class="polyA_signal_sequence"
                     /gene="INPP4B"
                     /note="hexamer: AATAAA"
     polyA_site      8407
                     /gene="INPP4B"
ORIGIN      
        1 agcctgagcc ccaggagatt tccttcagtg ctgtagctaa gttcactttc agcccggcgc
       61 agaagttttc cctgagatat ggtgttagtt tcttttcttt ctgtctcctc tgccgttgcc
      121 agcatgcaag gatctcgtgg ctcctgtccg tgatcgtaaa ctgaatacac tggtgcagat
      181 ctccgtaatc caccccgtgg agcagagtct gacaagatac tccagcaccg aaattgtgga
      241 gggaacaagg gacccactgt ttttgactgg tgtcacattc ccatctgagt atcccatcta
      301 tgaggagacc aaaataaaac taacagtcta tgatgtcaag gataagtctc atgacaccgt
      361 tcgaaccagt gtcctaccag aacataagga tcccccgcca gaagttgggc gaagtttctt
      421 gggctatgcc agttttaaag tgggagagct gctgaagtca aaggagcaat tgctggtcct
      481 gagcctgaga acttcagatg gtggcaaagt ggttggcacc atagaagtca gtgtcgtgaa
      541 gatgggggag attgaggatg gggaagccga ccacatcacc acagatgtac agggacaaaa
      601 gtgtgccctg gtatgtgaat gtacagcccc ggaaagtgtg agcggaaaag ataacttacc
      661 ttttttgaat tcagtgttaa agaacccagt atgtaaatta tatagatttc ccacatctga
      721 caataagtgg atgcgaattc gagagcagat gtcagagagc attctttcct ttcatattcc
      781 taaggaattg atttcccttc acattaaaga agatttgtgc agaaaccagg agataaaaga
      841 acttggtgag ctttctccac attgggacaa tctgcgaaaa aatgtcctta ctcactgtga
      901 tcaaatggtg aatatgtacc aagacattct gacagaactt agcaaggaaa cagggtcctc
      961 tttcaaatca agcagcagca aaggagagaa aacattagaa tttgttccaa taaatctaca
     1021 tctgcaaaga atgcaggtac acagccctca cttgaaagat gctctctacg atgtcatcac
     1081 tgtgggagcc ccagctgccc attttcaggg atttaagaat ggtggtcttc ggaagctact
     1141 ccatagattt gaaacagaaa gaagaaatac cggataccag tttatttact attcacctga
     1201 aaacacagcc aaagcaaagg aagttctcag caacatcaat caactacaac ctcttatagc
     1261 aacccatgca gacctactgc ttaattctgc aagccagcat tctccagaca gcttgaagaa
     1321 ttctttaaag atgctttcag aaaaaacaga gctttttgta catgccttca aggatcaact
     1381 tgtcaggagt gctcttttag cactctacac tgcaaggcca ggaggcattc ttaagaagcc
     1441 accctctcct aagagcagca cagaggagag cagtccccaa gaccaacccc cagtgatgag
     1501 agggcaggac tccataccac atcattcaga ctatgatgag gaagagtggg acagggtgtg
     1561 ggccaatgtg gggaagagcc tgaactgcat tattgctatg gtggacaaac tgattgaaag
     1621 agatggtggc agtgaaggca gtggcggcaa caatgatgga gaaaaggaac cttcattaac
     1681 agatgccatt ccctctcacc caagagagga ctggtatgaa cagttgtatc ccctcatcct
     1741 taccctgaag gactgcatgg gagaagtggt gaaccgagcc aagcagtccc tgacatttgt
     1801 gctccttcag gaacttgcgt acagcttgcc ccagtgtctg atgctgacgc taagaagaga
     1861 catcgtcttc agccaagcac ttgctggatt ggtttgtggt tttatcatca aattacagac
     1921 aagtctgtat gacccaggct tcctacagca gcttcacaca gtggggttga tagtacaata
     1981 tgaaggactg ctaagtacat acagcgatga aattggaatg ctagaggaca tggccgttgg
     2041 catttccgat ttaaagaaag ttgcatttaa aataattgaa gccaaatcca atgatgtgtt
     2101 gccagttata acaggaagac gagaacatta cgtggtagag gtcaagcttc cagccagaat
     2161 gtttgagtca ctacctctac agattaaaga aggacagttg cttcatgtgt atccagtact
     2221 ttttaatgtt ggaatcaatg aacagcaaac tctggctgaa aggtttggag atgtctcttt
     2281 gcaagaaagt attaatcagg aaaacttcga acttctacaa gaatattaca agatatttat
     2341 ggaaaagatg cctcctgatt atatttcaca ttttcaggaa caaaatgatt taaaagcatt
     2401 gctagaaaat ctccttcaaa atatccaatc caaaaaaaga aagaatgtag aaattatgtg
     2461 gctggctgca acgatttgcc gcaaactgaa tggtattcgt ttcacctgtt gtaaaagtgc
     2521 caaagacagg acatcgatgt cagtgacact tgaacaatgc tcaatcttga gagatgagca
     2581 ccagttacac aaggacttct ttatccgagc gctggattgc atgagaagtt gtactttttc
     2641 ccctttcacc agagaaggat gccgcataga gaatgtactg aagaatatca aatgcagaaa
     2701 gtatgctttc aacatgctac agctgatggc tttccccaag tactacagac ctccagaggg
     2761 gacttatgga aaagctgaca cctaagttta ccaacatgtt aataaacagg aacacaaata
     2821 catttcagtt ggataatctt caccttggtc ttttttgttt gtttttattg tcatgaattt
     2881 gtggtggggg agatgatcac agatgtttcc caaaatctag gaactacttc aattcatcat
     2941 cagcatattg ctctgaaaga aatccatttt aaaaaatctt acatgattca gtactgtcat
     3001 ttctagttct aagcttctat gtgttgagcc tagctgattg agattggttc acaaagtgta
     3061 aatttcattc atgagtattt aaatgtttct gaggaaacat ggatcatttc aataggacta
     3121 ggggtgattc acagagcacc actctccaac caaatggaag agaggagagg gggaaaagga
     3181 acatattttt tttgtgatac aacttaatag cctatgagaa cacagtcaac ctgagaatca
     3241 atgtaaggga tttaaaaaaa atgtgtagcc actcaattag gtagagttaa ctcatgatct
     3301 ggaatactga ggcagtttgc aggtatgttc cacaatgatc tctatcatcc agtcaaggtg
     3361 tgactcctcc cttgcaacag gcatatgcat ggagtgagta aagtggtcaa cagacctttc
     3421 aaaaccatgg catcttttca gaactctgac ttgggttgtg tgatctagct gtgaatgtag
     3481 caatatagaa cgtttaatag aatgataagc aaaacactgc aatgatctaa aattacaaat
     3541 aaaataaaaa tgaacaacat tttgataccc aaaatgaaaa ttcccatcag cctgaacttt
     3601 atgttgtgaa gttcatgaat gtcagtgagg tatctctgag atgtttctta gcagtcatcc
     3661 tggtgtaagc atgcagttat ggcataggtt tgtgtgtgtt aataagcctt taaaacatat
     3721 gcaaccacaa caaatgataa agtaaaacaa ttattttctg ttgccctgaa tatcaaactt
     3781 gcccttgccc ttactcagca aaataacatt tataagtttt ccaaaatccc aaagtagaag
     3841 tttccttaaa aaaatcatct tgtataatac cagtattcaa acatgggtaa ggttaatcac
     3901 ccccaatcac tcaggagata gttgcagaat ttgaattaca atctcttctt actttcctag
     3961 cctgtggctt gtcacttctc caaattgcca tgctaaatat gcatgaaaat tgagggagaa
     4021 tgctagttaa aaagaaatta ggatttatca ctggaattga aactaagagt acaaaagtct
     4081 gaacgaatga aacttttctc caaattttac aaattcttgt tcctttctca ttagaagagc
     4141 atgctatcca aagcataaat ctcccttgaa aataacagag gcttcttaag ccctctctta
     4201 gctatgatca atggatgata ttatgcttcc catagctaat gtgatagctc cttgcctagg
     4261 attcctgttg aaataaggat tctagcccca tgttaagttt ttcaaattac tacaaatttt
     4321 agataagcat ttggagcttt ttatactaga attatcaatt ttttatttta gctaattacc
     4381 tgtgggcatt atacttgagg caggtaccaa actacttaca gcctttttaa tgaaaatgtg
     4441 ctgtgtactt tgaatccatt catagacaaa attaccttga tgttctctta actcattctt
     4501 tattttagtg attaaataca acctttgagt tgttcaatat catttgaaaa tggtaggatt
     4561 tgtggttatt ttcattaccc tattagattt aagataggct gggatgacag aggcctcctt
     4621 gaatagctat gaagcctcat tcagcatatc aaatggtagt ctgagttcta agaaacctta
     4681 agtaatttat cattctgtaa atactcttat aagcaataat ttttatttgt atttttgaaa
     4741 acaaactact taaatatgga aaaatattaa ctggaaagcc agcagtaggg ttttctattt
     4801 ttaaaagaca tttcaaggat ttcctgtaat cccagcactt tgggagccaa ggtggataga
     4861 tcacctgagg tcaggaattg gagatcagcc tggccaacat ggtgaaaccc catctctact
     4921 aaagatacaa aaattagctg gatgtggtgg cacacacgtg taatcccagc tacttgggag
     4981 gctgaggcaa gagaatcgct tgaaccccgg aggcggaggt tgcagtgagc tgagatcatg
     5041 ccattgcact ccagcctggg tgaaaagagc gaaactccat ctttaaataa gtaaataaat
     5101 gaataatata gaagtctcaa attatagtgc ttactgtaat acaaatgctt atgaattttc
     5161 attcattacc atagtcatct gcatttcctt atagaaagcc tgtactggtg caaacttcta
     5221 aaagtggatt tcatcaagaa aatgtgtttc atagagacaa caatattgct tttttcctga
     5281 gaggcagttc attcttaaac aaccacttca ctatttctta agttattaag gctaaatcaa
     5341 agagcaaatg ttaaagtgtt taaatctctc ttgaacaaac acagccacag tcatgctatt
     5401 ctatctatat tttcacttaa aagatacacc agcagaccta ttttaggagg tcatattgag
     5461 ccaaaaaatg aactgagcaa atgacatttc caaactcttt ttttgctcaa aaataatatg
     5521 ttcccctttg atattaaatg cagatatcaa ttctggatta gctatttact gagccctagg
     5581 aaaaacatat ttaaagacaa ggaaaccatt catttacatc tcatatcatt gctttttgct
     5641 tttaaatatc gccttgaggt ttgtctacac tctgccaaaa caatccctga acataagttt
     5701 ggtcagcctc ataattcagt gagtcgagca accatttgtt ccaagtgata aattgtacta
     5761 aatgacaaac tgcccaatca gggcagagct ccatggaccc agcctccagc ccttatttta
     5821 taagactaac ccctcttctg aaaaactctg aaggcttaaa agctagcatt tggatggagg
     5881 atacttcctt tttatccttc agctatgtat ggcactttac ataaaataag aggtaaaaaa
     5941 ggagagaaac tgatgtgtat aaagtaatgc ctttcttccc aagcaaatca aacctctccc
     6001 tatgtaaaag ttgatagtgt accaagagac acaataccac tggtgggctg gaactagctc
     6061 gttctgatgc ataaaagttg ataattaaag taccagaaat tttgtaagct agttgttaaa
     6121 cattaccatt attaaatatg aaattataaa acacagtgga atacattaaa aaccaatgta
     6181 ataatcaaaa cataccactt cccaattatt ttactacctt atactattta ttagtactct
     6241 tgagtctatt taggtctatt acatctttac agtgaaaaca ggatacaata ttgtgctact
     6301 gtgggtctct tcctgactgc agattcagta acatggtgtt cgtagcttga aactgtccac
     6361 agtgggagta tttaacacca tagaaactgg ctggcaaatg ctacaaacta gcaattttaa
     6421 ttcctggaaa ggcaattgtt gagcatttac cagcacacaa tgaatgccat attctttttt
     6481 ttttattagg aaataaatta ttggaggcag tataaaatta tttaaaaagt atcaaatgca
     6541 atcccttatc ttcagatggc tataattttg gttatataaa tgttttggtt tttaccttct
     6601 ttaaagactc ctattaggtt aaaagtcata tttgatgact atattttatt cataattaaa
     6661 ttattaaatc accttttctc ctgataatgc tttgccagag aattcttagc aattcaactg
     6721 tagtctaagc aataactcag ggctaaattc agggaactgt tagcccaatc agatatcact
     6781 aaaaatgtac ttcaccatct attttggagt ttataatttt ggcatttgct aaaagtagga
     6841 aaaacagtaa catattactg tgcccagatt ctaataaata tagctcaatt gaaaccaaaa
     6901 ctgttacatt aaacaaatta cactctggca ctatgctaaa tcaccacaga tgttttaggt
     6961 gtttgatttc caagcaggat ggtatatcat ttgtttggtt caatatatga ggcaccattt
     7021 gtagtctttt aggaaataaa ttagctttta tcacagattt aggaaacttg tctaaaaaaa
     7081 ctgtgatcat cagttacaga gggaaggaaa catattgaac acaaggcatc atagtagctg
     7141 gaggccttaa aaattatgca cgaccaaaaa gaatgatttg gtgagagatg tgtagctgat
     7201 tgacaatttt agtgtgaatt catattcatt taacccagca gcaatctaca taagctatgc
     7261 tttttcccac ctgtatttat gtttcttagc ttataaagtc ccaatatatt atatcttttg
     7321 ttgctttggc agttttaatt tagagctctg cgttcacaga gatgccacct atagcaaaaa
     7381 ctatctttaa gaattggaaa ataaaatgaa tgttttagat aaaatattgc aagccattat
     7441 gtgtagagtt aatgtatgga aatttgcatt tgtttttctg aatcatggtg tacattaatc
     7501 actcattgaa ttctatttct aagcaaataa gagaatcaaa catttctaaa aggaacatat
     7561 gtcttgctat taataacaag gagacaggaa aaatagtaag gtaatataag caaaaaaaaa
     7621 aatgtaatga atttagctat cctaaattgg aatttttaca gattgcatgc atacttagaa
     7681 ttttaaattt ttaaaagatt tacaattgag tatggtaccc acagagagtg agtaccaagg
     7741 gaaggaagac ctaatacaag tgatgttgcc tgataaatca catcttgcca aaaaaaatat
     7801 attttagtaa atacagttct ttaggaagaa aaatgttgcc ctttcacact cacagtgtaa
     7861 atacattcat aatattcctt caatcatcta aattaccgcc aggtcatgaa aggacgcgat
     7921 caatgatgac ctattgcact cacaggtaac attgactcaa attttggcaa tattgctata
     7981 ttatctagat aattcttgtg atgtttttat gtcactatca acattaaaaa tattttgtta
     8041 aacaactatg aaactttcaa aagtttgcat ataactgtat gggcactctc atttcactgc
     8101 atacatacaa tactttgtat acacatactt ctcgtgtgga tattttataa ttttatttaa
     8161 tctaacattt aacttttagg tttttgtggt actcatctga aaggttggca tttgttttct
     8221 ttttatgtta tatatgtatt ttagatgaat caataatgtg tattcctaga aattttttct
     8281 aggcataaat agatcatttt atgttggcat ttaagagata tcatttttgt tttattgttc
     8341 tgtgtaaacc atattcattg tacactgtgt gtatattttt gtttaaataa atgattttta
     8401 tttttta
//
