LOCUS       NM_001385379            8545 bp    mRNA    linear   PRI 07-DEC-2024
DEFINITION  Homo sapiens inositol polyphosphate-4-phosphatase type II B
            (INPP4B), transcript variant 21, mRNA.
ACCESSION   NM_001385379
VERSION     NM_001385379.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8545)
  AUTHORS   Saffi,G.T., To,L., Kleine,N., Melo,C.M.P., Chen,K., Genc,G.,
            Lee,K.C.D., Chow,J.T., Jang,G.H., Gallinger,S., Botelho,R.J. and
            Salmena,L.
  TITLE     INPP4B promotes PDAC aggressiveness via PIKfyve and
            TRPML-1-mediated lysosomal exocytosis
  JOURNAL   J Cell Biol 223 (11) (2024)
   PUBMED   39120584
  REMARK    GeneRIF: INPP4B promotes PDAC aggressiveness via PIKfyve and
            TRPML-1-mediated lysosomal exocytosis.
REFERENCE   2  (bases 1 to 8545)
  AUTHORS   Lai,M., Mao,Z., Tang,D., Lan,S., Yan,R., Xiang,Q., Zhao,X., Su,M.
            and Wang,Y.
  TITLE     [Preliminary Study of the Role of INPP4B in Promoting Colorectal
            Cancer Metastasis and the Mechanisms Involved]
  JOURNAL   Sichuan Da Xue Xue Bao Yi Xue Ban 55 (5), 1186-1194 (2024)
   PUBMED   39507966
  REMARK    GeneRIF: [Preliminary Study of the Role of INPP4B in Promoting
            Colorectal Cancer Metastasis and the Mechanisms Involved].
REFERENCE   3  (bases 1 to 8545)
  AUTHORS   Zhao,J., Du,X.M., Si,W., Zhao,X.H. and Zhou,Z.Q.
  TITLE     Role of INPP4B in the proliferation, migration, invasion, and
            survival of human endometrial cancer cells
  JOURNAL   Histol Histopathol 39 (9), 1197-1208 (2024)
   PUBMED   38318760
  REMARK    GeneRIF: Role of INPP4B in the proliferation, migration, invasion,
            and survival of human endometrial cancer cells.
REFERENCE   4  (bases 1 to 8545)
  AUTHORS   Gorji,M., Farsani,M.A., Kargar,M., Garavand,J. and Mohammadi,M.H.
  TITLE     Investigating the multifaceted cooperation of autophagy, PI3K/AKT
            signaling pathways, and INPP4B gene in de novo acute myeloid
            leukemia patients
  JOURNAL   Curr Res Transl Med 72 (2), 103429 (2024)
   PUBMED   38246071
  REMARK    GeneRIF: Investigating the multifaceted cooperation of autophagy,
            PI3K/AKT signaling pathways, and INPP4B gene in de novo acute
            myeloid leukemia patients.
REFERENCE   5  (bases 1 to 8545)
  AUTHORS   Xu,M., Ren,J., Jia,W., Wang,S., Liu,Y., Chen,X., Shi,J. and Wang,H.
  TITLE     Regulation of B-1 cell numbers and B cell-mediated antibody
            production by Inpp4b
  JOURNAL   Scand J Immunol 98 (4), e13309 (2023)
   PUBMED   37389566
  REMARK    GeneRIF: Regulation of B-1 cell numbers and B cell-mediated
            antibody production by Inpp4b.
REFERENCE   6  (bases 1 to 8545)
  AUTHORS   Rampersaud,E., Damcott,C.M., Fu,M., Shen,H., McArdle,P., Shi,X.,
            Shelton,J., Yin,J., Chang,Y.P., Ott,S.H., Zhang,L., Zhao,Y.,
            Mitchell,B.D., O'Connell,J. and Shuldiner,A.R.
  TITLE     Identification of novel candidate genes for type 2 diabetes from a
            genome-wide association scan in the Old Order Amish: evidence for
            replication from diabetes-related quantitative traits and from
            independent populations
  JOURNAL   Diabetes 56 (12), 3053-3062 (2007)
   PUBMED   17846126
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 8545)
  AUTHORS   Munday,A.D., Norris,F.A., Caldwell,K.K., Brown,S., Majerus,P.W. and
            Mitchell,C.A.
  TITLE     The inositol polyphosphate 4-phosphatase forms a complex with
            phosphatidylinositol 3-kinase in human platelet cytosol
  JOURNAL   Proc Natl Acad Sci U S A 96 (7), 3640-3645 (1999)
   PUBMED   10097090
REFERENCE   8  (bases 1 to 8545)
  AUTHORS   Zhang,X. and Majerus,P.W.
  TITLE     Phosphatidylinositol signalling reactions
  JOURNAL   Semin Cell Dev Biol 9 (2), 153-160 (1998)
   PUBMED   9599410
  REMARK    Review article
REFERENCE   9  (bases 1 to 8545)
  AUTHORS   Norris,F.A., Atkins,R.C. and Majerus,P.W.
  TITLE     The cDNA cloning and characterization of inositol polyphosphate
            4-phosphatase type II. Evidence for conserved alternative splicing
            in the 4-phosphatase family
  JOURNAL   J Biol Chem 272 (38), 23859-23864 (1997)
   PUBMED   9295334
REFERENCE   10 (bases 1 to 8545)
  AUTHORS   Norris,F.A., Auethavekiat,V. and Majerus,P.W.
  TITLE     The isolation and characterization of cDNA encoding human and rat
            brain inositol polyphosphate 4-phosphatase
  JOURNAL   J Biol Chem 270 (27), 16128-16133 (1995)
   PUBMED   7608176
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC108060.3, AC093860.3 and
            AC108077.3.
            
            Summary: INPP4B encodes the inositol polyphosphate 4-phosphatase
            type II, one of the enzymes involved in phosphatidylinositol
            signaling pathways. This enzyme removes the phosphate group at
            position 4 of the inositol ring from inositol 3,4-bisphosphate.
            There is limited data to suggest that the human type II enzyme is
            subject to alternative splicing, as has been established for the
            type I enzyme. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: SRR14038196.1059630.1,
                                    SRR14038194.2051072.1 [ECO:0000331]
            RNAseq introns       :: mixed sample support SAMEA1965299,
                                    SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-241               AC108060.3         86724-86964         c
            242-358             AC108060.3         84456-84572         c
            359-520             AC108060.3         79030-79191         c
            521-571             AC093860.3         187670-187720       c
            572-651             AC093860.3         178416-178495       c
            652-763             AC093860.3         143621-143732       c
            764-836             AC093860.3         133450-133522       c
            837-984             AC093860.3         110822-110969       c
            985-1115            AC093860.3         81854-81984         c
            1116-1220           AC093860.3         81383-81487         c
            1221-1329           AC093860.3         66045-66153         c
            1330-1507           AC093860.3         46590-46767         c
            1508-1711           AC093860.3         33316-33519         c
            1712-1868           AC093860.3         18798-18954         c
            1869-2041           AC108077.3         102529-102701       c
            2042-2165           AC108077.3         101233-101356       c
            2166-2283           AC108077.3         100069-100186       c
            2284-2424           AC108077.3         90483-90623         c
            2425-2522           AC108077.3         86034-86131         c
            2523-2635           AC108077.3         64085-64197         c
            2636-2790           AC108077.3         59972-60126         c
            2791-8545           AC108077.3         1101-6855           c
FEATURES             Location/Qualifiers
     source          1..8545
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q31.21"
     gene            1..8545
                     /gene="INPP4B"
                     /note="inositol polyphosphate-4-phosphatase type II B"
                     /db_xref="GeneID:8821"
                     /db_xref="HGNC:HGNC:6075"
                     /db_xref="MIM:607494"
     exon            1..241
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     exon            242..358
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     exon            359..520
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     exon            521..571
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     exon            572..651
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     exon            652..763
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     CDS             704..2923
                     /gene="INPP4B"
                     /EC_number="3.1.3.66"
                     /note="isoform 10 is encoded by transcript variant 21;
                     inositol polyphosphate 4-phosphatase II; 4-phosphatase II;
                     type II inositol 3,4-bisphosphate 4-phosphatase; inositol
                     polyphosphate-4-phosphatase, type II, 105kDa"
                     /codon_start=1
                     /product="inositol polyphosphate 4-phosphatase type II
                     isoform 10"
                     /protein_id="NP_001372308.1"
                     /db_xref="GeneID:8821"
                     /db_xref="HGNC:HGNC:6075"
                     /db_xref="MIM:607494"
                     /translation="MGEIEDGEADHITTDVQGQKCALVCECTAPESVSGKDNLPFLNS
                     VLKNPVCKLYRFPTSDNKWMRIREQMSESILSFHIPKELISLHIKEDLCRNQEIKELG
                     ELSPHWDNLRKNVLTHCDQMVNMYQDILTELSKETGSSFKSSSSKGEKTLEFVPINLH
                     LQRMQVHSPHLKDALYDVITVGAPAAHFQGFKNGGLRKLLHRFETERRNTGYQFIYYS
                     PENTAKAKEVLSNINQLQPLIATHADLLLNSASQHSPDSLKNSLKMLSEKTELFVHAF
                     KDQLVRSALLALYTARPGGILKKPPSPKSSTEESSPQDQPPVMRGQDSIPHHSDYDEE
                     EWDRVWANVGKSLNCIIAMVDKLIERDGGSEGSGGNNDGEKEPSLTDAIPSHPREDWY
                     EQLYPLILTLKDCMGEVVNRAKQSLTFVLLQELAYSLPQCLMLTLRRDIVFSQALAGL
                     VCGFIIKLQTSLYDPGFLQQLHTVGLIVQYEGLLSTYSDEIGMLEDMAVGISDLKKVA
                     FKIIEAKSNDVLPVITGRREHYVVEVKLPARMFESLPLQIKEGQLLHVYPVLFNVGIN
                     EQQTLAERFGDVSLQESINQENFELLQEYYKIFMEKMPPDYISHFQEQNDLKALLENL
                     LQNIQSKKRKNVEIMWLAATICRKLNGIRFTCCKSAKDRTSMSVTLEQCSILRDEHQL
                     HKDFFIRALDCMRREGCRIENVLKNIKCRKYAFNMLQLMAFPKYYRPPEGTYGKADT"
     exon            764..836
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     exon            837..984
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     exon            985..1115
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     exon            1116..1220
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     exon            1221..1329
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     exon            1330..1507
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     exon            1508..1711
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     exon            1712..1868
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     exon            1869..2041
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     exon            2042..2165
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     exon            2166..2283
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     exon            2284..2424
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     exon            2425..2522
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     exon            2523..2635
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     exon            2636..2790
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     exon            2791..8545
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2939..2944
                     /regulatory_class="polyA_signal_sequence"
                     /gene="INPP4B"
                     /note="hexamer: AATAAA"
     regulatory      2955..2960
                     /regulatory_class="polyA_signal_sequence"
                     /gene="INPP4B"
                     /note="hexamer: AATACA"
     polyA_site      2965
                     /gene="INPP4B"
     polyA_site      2980
                     /gene="INPP4B"
                     /note="major polyA site"
     regulatory      8524..8529
                     /regulatory_class="polyA_signal_sequence"
                     /gene="INPP4B"
                     /note="hexamer: AATAAA"
     polyA_site      8545
                     /gene="INPP4B"
ORIGIN      
        1 agcctgagcc ccaggagatt tccttcagtg ctgtagctaa gttcactttc agcccggcgc
       61 agaagttttc cctgagatat ggtgttagtt tcttttcttt ctgtctcctc tgccgttgcc
      121 agcatgcaag gatctcgtgg ctcctgtccg tgatcgtaaa ctgaatacac tggtgcagat
      181 ctccgtaatc caccccgtgg agcagagtct gacaagatac tccagcaccg aaattgtgga
      241 gggaacaagg gacccactgt ttttgactgg tgtcacattc ccatctgagt atcccatcta
      301 tgaggagacc aaaataaaac taacagtcta tgatgtcaag gataagtctc atgacaccta
      361 gagacggggg tttcaccgtg ttggccagga tggtctcatc tcctgacctc gtgatccgtc
      421 cgcttcggcc tcccaaagtg ctgggattac aggcacgagt catcacaccc ggccgcatgt
      481 ttcttttgaa gcttacaagt tgatcaatta ctaaaacaag gttcgaacca gtgtcctacc
      541 agaacataag gatcccccgc cagaagttgg gcgaagtttc ttgggctatg ccagttttaa
      601 agtgggagag ctgctgaagt caaaggagca attgctggtc ctgagcctga gaacttcaga
      661 tggtggcaaa gtggttggca ccatagaagt cagtgtcgtg aagatggggg agattgagga
      721 tggggaagcc gaccacatca ccacagatgt acagggacaa aagtgtgccc tggtatgtga
      781 atgtacagcc ccggaaagtg tgagcggaaa agataactta ccttttttga attcagtgtt
      841 aaagaaccca gtatgtaaat tatatagatt tcccacatct gacaataagt ggatgcgaat
      901 tcgagagcag atgtcagaga gcattctttc ctttcatatt cctaaggaat tgatttccct
      961 tcacattaaa gaagatttgt gcagaaacca ggagataaaa gaacttggtg agctttctcc
     1021 acattgggac aatctgcgaa aaaatgtcct tactcactgt gatcaaatgg tgaatatgta
     1081 ccaagacatt ctgacagaac ttagcaagga aacagggtcc tctttcaaat caagcagcag
     1141 caaaggagag aaaacattag aatttgttcc aataaatcta catctgcaaa gaatgcaggt
     1201 acacagccct cacttgaaag atgctctcta cgatgtcatc actgtgggag ccccagctgc
     1261 ccattttcag ggatttaaga atggtggtct tcggaagcta ctccatagat ttgaaacaga
     1321 aagaagaaat accggatacc agtttattta ctattcacct gaaaacacag ccaaagcaaa
     1381 ggaagttctc agcaacatca atcaactaca acctcttata gcaacccatg cagacctact
     1441 gcttaattct gcaagccagc attctccaga cagcttgaag aattctttaa agatgctttc
     1501 agaaaaaaca gagctttttg tacatgcctt caaggatcaa cttgtcagga gtgctctttt
     1561 agcactctac actgcaaggc caggaggcat tcttaagaag ccaccctctc ctaagagcag
     1621 cacagaggag agcagtcccc aagaccaacc cccagtgatg agagggcagg actccatacc
     1681 acatcattca gactatgatg aggaagagtg ggacagggtg tgggccaatg tggggaagag
     1741 cctgaactgc attattgcta tggtggacaa actgattgaa agagatggtg gcagtgaagg
     1801 cagtggcggc aacaatgatg gagaaaagga accttcatta acagatgcca ttccctctca
     1861 cccaagagag gactggtatg aacagttgta tcccctcatc cttaccctga aggactgcat
     1921 gggagaagtg gtgaaccgag ccaagcagtc cctgacattt gtgctccttc aggaacttgc
     1981 gtacagcttg ccccagtgtc tgatgctgac gctaagaaga gacatcgtct tcagccaagc
     2041 acttgctgga ttggtttgtg gttttatcat caaattacag acaagtctgt atgacccagg
     2101 cttcctacag cagcttcaca cagtggggtt gatagtacaa tatgaaggac tgctaagtac
     2161 atacagcgat gaaattggaa tgctagagga catggccgtt ggcatttccg atttaaagaa
     2221 agttgcattt aaaataattg aagccaaatc caatgatgtg ttgccagtta taacaggaag
     2281 acgagaacat tacgtggtag aggtcaagct tccagccaga atgtttgagt cactacctct
     2341 acagattaaa gaaggacagt tgcttcatgt gtatccagta ctttttaatg ttggaatcaa
     2401 tgaacagcaa actctggctg aaaggtttgg agatgtctct ttgcaagaaa gtattaatca
     2461 ggaaaacttc gaacttctac aagaatatta caagatattt atggaaaaga tgcctcctga
     2521 ttatatttca cattttcagg aacaaaatga tttaaaagca ttgctagaaa atctccttca
     2581 aaatatccaa tccaaaaaaa gaaagaatgt agaaattatg tggctggctg caacgatttg
     2641 ccgcaaactg aatggtattc gtttcacctg ttgtaaaagt gccaaagaca ggacatcgat
     2701 gtcagtgaca cttgaacaat gctcaatctt gagagatgag caccagttac acaaggactt
     2761 ctttatccga gcgctggatt gcatgagaag agaaggatgc cgcatagaga atgtactgaa
     2821 gaatatcaaa tgcagaaagt atgctttcaa catgctacag ctgatggctt tccccaagta
     2881 ctacagacct ccagagggga cttatggaaa agctgacacc taagtttacc aacatgttaa
     2941 taaacaggaa cacaaataca tttcagttgg ataatcttca ccttggtctt ttttgtttgt
     3001 ttttattgtc atgaatttgt ggtgggggag atgatcacag atgtttccca aaatctagga
     3061 actacttcaa ttcatcatca gcatattgct ctgaaagaaa tccattttaa aaaatcttac
     3121 atgattcagt actgtcattt ctagttctaa gcttctatgt gttgagccta gctgattgag
     3181 attggttcac aaagtgtaaa tttcattcat gagtatttaa atgtttctga ggaaacatgg
     3241 atcatttcaa taggactagg ggtgattcac agagcaccac tctccaacca aatggaagag
     3301 aggagagggg gaaaaggaac atattttttt tgtgatacaa cttaatagcc tatgagaaca
     3361 cagtcaacct gagaatcaat gtaagggatt taaaaaaaat gtgtagccac tcaattaggt
     3421 agagttaact catgatctgg aatactgagg cagtttgcag gtatgttcca caatgatctc
     3481 tatcatccag tcaaggtgtg actcctccct tgcaacaggc atatgcatgg agtgagtaaa
     3541 gtggtcaaca gacctttcaa aaccatggca tcttttcaga actctgactt gggttgtgtg
     3601 atctagctgt gaatgtagca atatagaacg tttaatagaa tgataagcaa aacactgcaa
     3661 tgatctaaaa ttacaaataa aataaaaatg aacaacattt tgatacccaa aatgaaaatt
     3721 cccatcagcc tgaactttat gttgtgaagt tcatgaatgt cagtgaggta tctctgagat
     3781 gtttcttagc agtcatcctg gtgtaagcat gcagttatgg cataggtttg tgtgtgttaa
     3841 taagccttta aaacatatgc aaccacaaca aatgataaag taaaacaatt attttctgtt
     3901 gccctgaata tcaaacttgc ccttgccctt actcagcaaa ataacattta taagttttcc
     3961 aaaatcccaa agtagaagtt tccttaaaaa aatcatcttg tataatacca gtattcaaac
     4021 atgggtaagg ttaatcaccc ccaatcactc aggagatagt tgcagaattt gaattacaat
     4081 ctcttcttac tttcctagcc tgtggcttgt cacttctcca aattgccatg ctaaatatgc
     4141 atgaaaattg agggagaatg ctagttaaaa agaaattagg atttatcact ggaattgaaa
     4201 ctaagagtac aaaagtctga acgaatgaaa cttttctcca aattttacaa attcttgttc
     4261 ctttctcatt agaagagcat gctatccaaa gcataaatct cccttgaaaa taacagaggc
     4321 ttcttaagcc ctctcttagc tatgatcaat ggatgatatt atgcttccca tagctaatgt
     4381 gatagctcct tgcctaggat tcctgttgaa ataaggattc tagccccatg ttaagttttt
     4441 caaattacta caaattttag ataagcattt ggagcttttt atactagaat tatcaatttt
     4501 ttattttagc taattacctg tgggcattat acttgaggca ggtaccaaac tacttacagc
     4561 ctttttaatg aaaatgtgct gtgtactttg aatccattca tagacaaaat taccttgatg
     4621 ttctcttaac tcattcttta ttttagtgat taaatacaac ctttgagttg ttcaatatca
     4681 tttgaaaatg gtaggatttg tggttatttt cattacccta ttagatttaa gataggctgg
     4741 gatgacagag gcctccttga atagctatga agcctcattc agcatatcaa atggtagtct
     4801 gagttctaag aaaccttaag taatttatca ttctgtaaat actcttataa gcaataattt
     4861 ttatttgtat ttttgaaaac aaactactta aatatggaaa aatattaact ggaaagccag
     4921 cagtagggtt ttctattttt aaaagacatt tcaaggattt cctgtaatcc cagcactttg
     4981 ggagccaagg tggatagatc acctgaggtc aggaattgga gatcagcctg gccaacatgg
     5041 tgaaacccca tctctactaa agatacaaaa attagctgga tgtggtggca cacacgtgta
     5101 atcccagcta cttgggaggc tgaggcaaga gaatcgcttg aaccccggag gcggaggttg
     5161 cagtgagctg agatcatgcc attgcactcc agcctgggtg aaaagagcga aactccatct
     5221 ttaaataagt aaataaatga ataatataga agtctcaaat tatagtgctt actgtaatac
     5281 aaatgcttat gaattttcat tcattaccat agtcatctgc atttccttat agaaagcctg
     5341 tactggtgca aacttctaaa agtggatttc atcaagaaaa tgtgtttcat agagacaaca
     5401 atattgcttt tttcctgaga ggcagttcat tcttaaacaa ccacttcact atttcttaag
     5461 ttattaaggc taaatcaaag agcaaatgtt aaagtgttta aatctctctt gaacaaacac
     5521 agccacagtc atgctattct atctatattt tcacttaaaa gatacaccag cagacctatt
     5581 ttaggaggtc atattgagcc aaaaaatgaa ctgagcaaat gacatttcca aactcttttt
     5641 ttgctcaaaa ataatatgtt cccctttgat attaaatgca gatatcaatt ctggattagc
     5701 tatttactga gccctaggaa aaacatattt aaagacaagg aaaccattca tttacatctc
     5761 atatcattgc tttttgcttt taaatatcgc cttgaggttt gtctacactc tgccaaaaca
     5821 atccctgaac ataagtttgg tcagcctcat aattcagtga gtcgagcaac catttgttcc
     5881 aagtgataaa ttgtactaaa tgacaaactg cccaatcagg gcagagctcc atggacccag
     5941 cctccagccc ttattttata agactaaccc ctcttctgaa aaactctgaa ggcttaaaag
     6001 ctagcatttg gatggaggat acttcctttt tatccttcag ctatgtatgg cactttacat
     6061 aaaataagag gtaaaaaagg agagaaactg atgtgtataa agtaatgcct ttcttcccaa
     6121 gcaaatcaaa cctctcccta tgtaaaagtt gatagtgtac caagagacac aataccactg
     6181 gtgggctgga actagctcgt tctgatgcat aaaagttgat aattaaagta ccagaaattt
     6241 tgtaagctag ttgttaaaca ttaccattat taaatatgaa attataaaac acagtggaat
     6301 acattaaaaa ccaatgtaat aatcaaaaca taccacttcc caattatttt actaccttat
     6361 actatttatt agtactcttg agtctattta ggtctattac atctttacag tgaaaacagg
     6421 atacaatatt gtgctactgt gggtctcttc ctgactgcag attcagtaac atggtgttcg
     6481 tagcttgaaa ctgtccacag tgggagtatt taacaccata gaaactggct ggcaaatgct
     6541 acaaactagc aattttaatt cctggaaagg caattgttga gcatttacca gcacacaatg
     6601 aatgccatat tctttttttt ttattaggaa ataaattatt ggaggcagta taaaattatt
     6661 taaaaagtat caaatgcaat cccttatctt cagatggcta taattttggt tatataaatg
     6721 ttttggtttt taccttcttt aaagactcct attaggttaa aagtcatatt tgatgactat
     6781 attttattca taattaaatt attaaatcac cttttctcct gataatgctt tgccagagaa
     6841 ttcttagcaa ttcaactgta gtctaagcaa taactcaggg ctaaattcag ggaactgtta
     6901 gcccaatcag atatcactaa aaatgtactt caccatctat tttggagttt ataattttgg
     6961 catttgctaa aagtaggaaa aacagtaaca tattactgtg cccagattct aataaatata
     7021 gctcaattga aaccaaaact gttacattaa acaaattaca ctctggcact atgctaaatc
     7081 accacagatg ttttaggtgt ttgatttcca agcaggatgg tatatcattt gtttggttca
     7141 atatatgagg caccatttgt agtcttttag gaaataaatt agcttttatc acagatttag
     7201 gaaacttgtc taaaaaaact gtgatcatca gttacagagg gaaggaaaca tattgaacac
     7261 aaggcatcat agtagctgga ggccttaaaa attatgcacg accaaaaaga atgatttggt
     7321 gagagatgtg tagctgattg acaattttag tgtgaattca tattcattta acccagcagc
     7381 aatctacata agctatgctt tttcccacct gtatttatgt ttcttagctt ataaagtccc
     7441 aatatattat atcttttgtt gctttggcag ttttaattta gagctctgcg ttcacagaga
     7501 tgccacctat agcaaaaact atctttaaga attggaaaat aaaatgaatg ttttagataa
     7561 aatattgcaa gccattatgt gtagagttaa tgtatggaaa tttgcatttg tttttctgaa
     7621 tcatggtgta cattaatcac tcattgaatt ctatttctaa gcaaataaga gaatcaaaca
     7681 tttctaaaag gaacatatgt cttgctatta ataacaagga gacaggaaaa atagtaaggt
     7741 aatataagca aaaaaaaaaa tgtaatgaat ttagctatcc taaattggaa tttttacaga
     7801 ttgcatgcat acttagaatt ttaaattttt aaaagattta caattgagta tggtacccac
     7861 agagagtgag taccaaggga aggaagacct aatacaagtg atgttgcctg ataaatcaca
     7921 tcttgccaaa aaaaatatat tttagtaaat acagttcttt aggaagaaaa atgttgccct
     7981 ttcacactca cagtgtaaat acattcataa tattccttca atcatctaaa ttaccgccag
     8041 gtcatgaaag gacgcgatca atgatgacct attgcactca caggtaacat tgactcaaat
     8101 tttggcaata ttgctatatt atctagataa ttcttgtgat gtttttatgt cactatcaac
     8161 attaaaaata ttttgttaaa caactatgaa actttcaaaa gtttgcatat aactgtatgg
     8221 gcactctcat ttcactgcat acatacaata ctttgtatac acatacttct cgtgtggata
     8281 ttttataatt ttatttaatc taacatttaa cttttaggtt tttgtggtac tcatctgaaa
     8341 ggttggcatt tgttttcttt ttatgttata tatgtatttt agatgaatca ataatgtgta
     8401 ttcctagaaa ttttttctag gcataaatag atcattttat gttggcattt aagagatatc
     8461 atttttgttt tattgttctg tgtaaaccat attcattgta cactgtgtgt atatttttgt
     8521 ttaaataaat gatttttatt tttta
//
