LOCUS       NM_001385348            9107 bp    mRNA    linear   PRI 07-DEC-2024
DEFINITION  Homo sapiens inositol polyphosphate-4-phosphatase type II B
            (INPP4B), transcript variant 16, mRNA.
ACCESSION   NM_001385348
VERSION     NM_001385348.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 9107)
  AUTHORS   Saffi,G.T., To,L., Kleine,N., Melo,C.M.P., Chen,K., Genc,G.,
            Lee,K.C.D., Chow,J.T., Jang,G.H., Gallinger,S., Botelho,R.J. and
            Salmena,L.
  TITLE     INPP4B promotes PDAC aggressiveness via PIKfyve and
            TRPML-1-mediated lysosomal exocytosis
  JOURNAL   J Cell Biol 223 (11) (2024)
   PUBMED   39120584
  REMARK    GeneRIF: INPP4B promotes PDAC aggressiveness via PIKfyve and
            TRPML-1-mediated lysosomal exocytosis.
REFERENCE   2  (bases 1 to 9107)
  AUTHORS   Lai,M., Mao,Z., Tang,D., Lan,S., Yan,R., Xiang,Q., Zhao,X., Su,M.
            and Wang,Y.
  TITLE     [Preliminary Study of the Role of INPP4B in Promoting Colorectal
            Cancer Metastasis and the Mechanisms Involved]
  JOURNAL   Sichuan Da Xue Xue Bao Yi Xue Ban 55 (5), 1186-1194 (2024)
   PUBMED   39507966
  REMARK    GeneRIF: [Preliminary Study of the Role of INPP4B in Promoting
            Colorectal Cancer Metastasis and the Mechanisms Involved].
REFERENCE   3  (bases 1 to 9107)
  AUTHORS   Zhao,J., Du,X.M., Si,W., Zhao,X.H. and Zhou,Z.Q.
  TITLE     Role of INPP4B in the proliferation, migration, invasion, and
            survival of human endometrial cancer cells
  JOURNAL   Histol Histopathol 39 (9), 1197-1208 (2024)
   PUBMED   38318760
  REMARK    GeneRIF: Role of INPP4B in the proliferation, migration, invasion,
            and survival of human endometrial cancer cells.
REFERENCE   4  (bases 1 to 9107)
  AUTHORS   Gorji,M., Farsani,M.A., Kargar,M., Garavand,J. and Mohammadi,M.H.
  TITLE     Investigating the multifaceted cooperation of autophagy, PI3K/AKT
            signaling pathways, and INPP4B gene in de novo acute myeloid
            leukemia patients
  JOURNAL   Curr Res Transl Med 72 (2), 103429 (2024)
   PUBMED   38246071
  REMARK    GeneRIF: Investigating the multifaceted cooperation of autophagy,
            PI3K/AKT signaling pathways, and INPP4B gene in de novo acute
            myeloid leukemia patients.
REFERENCE   5  (bases 1 to 9107)
  AUTHORS   Xu,M., Ren,J., Jia,W., Wang,S., Liu,Y., Chen,X., Shi,J. and Wang,H.
  TITLE     Regulation of B-1 cell numbers and B cell-mediated antibody
            production by Inpp4b
  JOURNAL   Scand J Immunol 98 (4), e13309 (2023)
   PUBMED   37389566
  REMARK    GeneRIF: Regulation of B-1 cell numbers and B cell-mediated
            antibody production by Inpp4b.
REFERENCE   6  (bases 1 to 9107)
  AUTHORS   Rampersaud,E., Damcott,C.M., Fu,M., Shen,H., McArdle,P., Shi,X.,
            Shelton,J., Yin,J., Chang,Y.P., Ott,S.H., Zhang,L., Zhao,Y.,
            Mitchell,B.D., O'Connell,J. and Shuldiner,A.R.
  TITLE     Identification of novel candidate genes for type 2 diabetes from a
            genome-wide association scan in the Old Order Amish: evidence for
            replication from diabetes-related quantitative traits and from
            independent populations
  JOURNAL   Diabetes 56 (12), 3053-3062 (2007)
   PUBMED   17846126
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 9107)
  AUTHORS   Munday,A.D., Norris,F.A., Caldwell,K.K., Brown,S., Majerus,P.W. and
            Mitchell,C.A.
  TITLE     The inositol polyphosphate 4-phosphatase forms a complex with
            phosphatidylinositol 3-kinase in human platelet cytosol
  JOURNAL   Proc Natl Acad Sci U S A 96 (7), 3640-3645 (1999)
   PUBMED   10097090
REFERENCE   8  (bases 1 to 9107)
  AUTHORS   Zhang,X. and Majerus,P.W.
  TITLE     Phosphatidylinositol signalling reactions
  JOURNAL   Semin Cell Dev Biol 9 (2), 153-160 (1998)
   PUBMED   9599410
  REMARK    Review article
REFERENCE   9  (bases 1 to 9107)
  AUTHORS   Norris,F.A., Atkins,R.C. and Majerus,P.W.
  TITLE     The cDNA cloning and characterization of inositol polyphosphate
            4-phosphatase type II. Evidence for conserved alternative splicing
            in the 4-phosphatase family
  JOURNAL   J Biol Chem 272 (38), 23859-23864 (1997)
   PUBMED   9295334
REFERENCE   10 (bases 1 to 9107)
  AUTHORS   Norris,F.A., Auethavekiat,V. and Majerus,P.W.
  TITLE     The isolation and characterization of cDNA encoding human and rat
            brain inositol polyphosphate 4-phosphatase
  JOURNAL   J Biol Chem 270 (27), 16128-16133 (1995)
   PUBMED   7608176
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC139720.1, AC108060.3,
            AC093860.3 and AC108077.3.
            
            Summary: INPP4B encodes the inositol polyphosphate 4-phosphatase
            type II, one of the enzymes involved in phosphatidylinositol
            signaling pathways. This enzyme removes the phosphate group at
            position 4 of the inositol ring from inositol 3,4-bisphosphate.
            There is limited data to suggest that the human type II enzyme is
            subject to alternative splicing, as has been established for the
            type I enzyme. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-360               AC139720.1         19278-19637         c
            361-424             AC139720.1         7879-7942           c
            425-641             AC108060.3         112687-112903       c
            642-686             AC108060.3         110691-110735       c
            687-805             AC108060.3         86724-86842         c
            806-922             AC108060.3         84456-84572         c
            923-973             AC093860.3         187670-187720       c
            974-1053            AC093860.3         178416-178495       c
            1054-1165           AC093860.3         143621-143732       c
            1166-1238           AC093860.3         133450-133522       c
            1239-1386           AC093860.3         110822-110969       c
            1387-1517           AC093860.3         81854-81984         c
            1518-1622           AC093860.3         81383-81487         c
            1623-1731           AC093860.3         66045-66153         c
            1732-1909           AC093860.3         46590-46767         c
            1910-2113           AC093860.3         33316-33519         c
            2114-2270           AC093860.3         18798-18954         c
            2271-2443           AC108077.3         102529-102701       c
            2444-2567           AC108077.3         101233-101356       c
            2568-2685           AC108077.3         100069-100186       c
            2686-2826           AC108077.3         90483-90623         c
            2827-2924           AC108077.3         86034-86131         c
            2925-3037           AC108077.3         64085-64197         c
            3038-3192           AC108077.3         59972-60126         c
            3193-3352           AC108077.3         47796-47955         c
            3353-9107           AC108077.3         1101-6855           c
FEATURES             Location/Qualifiers
     source          1..9107
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q31.21"
     gene            1..9107
                     /gene="INPP4B"
                     /note="inositol polyphosphate-4-phosphatase type II B"
                     /db_xref="GeneID:8821"
                     /db_xref="HGNC:HGNC:6075"
                     /db_xref="MIM:607494"
     exon            1..360
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     exon            361..424
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     exon            425..641
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     CDS             551..3313
                     /gene="INPP4B"
                     /EC_number="3.1.3.66"
                     /note="isoform 4 is encoded by transcript variant 16;
                     inositol polyphosphate 4-phosphatase II; 4-phosphatase II;
                     type II inositol 3,4-bisphosphate 4-phosphatase; inositol
                     polyphosphate-4-phosphatase, type II, 105kDa"
                     /codon_start=1
                     /product="inositol polyphosphate 4-phosphatase type II
                     isoform 4"
                     /protein_id="NP_001372277.1"
                     /db_xref="GeneID:8821"
                     /db_xref="HGNC:HGNC:6075"
                     /db_xref="MIM:607494"
                     /translation="MEIKEEGASEEGQHFLPTAQANDPGDCQFTSIQKTPNEPQLEFI
                     LACKDLVAPVRDRKLNTLVQISVIHPVEQSLTRYSSTEIVEGTRDPLFLTGVTFPSEY
                     PIYEETKIKLTVYDVKDKSHDTVRTSVLPEHKDPPPEVGRSFLGYASFKVGELLKSKE
                     QLLVLSLRTSDGGKVVGTIEVSVVKMGEIEDGEADHITTDVQGQKCALVCECTAPESV
                     SGKDNLPFLNSVLKNPVCKLYRFPTSDNKWMRIREQMSESILSFHIPKELISLHIKED
                     LCRNQEIKELGELSPHWDNLRKNVLTHCDQMVNMYQDILTELSKETGSSFKSSSSKGE
                     KTLEFVPINLHLQRMQVHSPHLKDALYDVITVGAPAAHFQGFKNGGLRKLLHRFETER
                     RNTGYQFIYYSPENTAKAKEVLSNINQLQPLIATHADLLLNSASQHSPDSLKNSLKML
                     SEKTELFVHAFKDQLVRSALLALYTARPGGILKKPPSPKSSTEESSPQDQPPVMRGQD
                     SIPHHSDYDEEEWDRVWANVGKSLNCIIAMVDKLIERDGGSEGSGGNNDGEKEPSLTD
                     AIPSHPREDWYEQLYPLILTLKDCMGEVVNRAKQSLTFVLLQELAYSLPQCLMLTLRR
                     DIVFSQALAGLVCGFIIKLQTSLYDPGFLQQLHTVGLIVQYEGLLSTYSDEIGMLEDM
                     AVGISDLKKVAFKIIEAKSNDVLPVITGRREHYVVEVKLPARMFESLPLQIKEGQLLH
                     VYPVLFNVGINEQQTLAERFGDVSLQESINQENFELLQEYYKIFMEKMPPDYISHFQE
                     QNDLKALLENLLQNIQSKKRKNVEIMWLAATICRKLNGIRFTCCKSAKDRTSMSVTLE
                     QCSILRDEHQLHKDFFIRALDCMRRLWYEDDAGLINELGRRIPSFSFDWNGFRRNGTS
                     SCLYLW"
     exon            642..686
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     exon            687..805
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     exon            806..922
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     exon            923..973
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     exon            974..1053
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     exon            1054..1165
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     exon            1166..1238
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     exon            1239..1386
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     exon            1387..1517
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     exon            1518..1622
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     exon            1623..1731
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     exon            1732..1909
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     exon            1910..2113
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     exon            2114..2270
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     exon            2271..2443
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     exon            2444..2567
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     exon            2568..2685
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     exon            2686..2826
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     exon            2827..2924
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     exon            2925..3037
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     exon            3038..3192
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     exon            3193..3352
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     exon            3353..9107
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3501..3506
                     /regulatory_class="polyA_signal_sequence"
                     /gene="INPP4B"
                     /note="hexamer: AATAAA"
     regulatory      3517..3522
                     /regulatory_class="polyA_signal_sequence"
                     /gene="INPP4B"
                     /note="hexamer: AATACA"
     polyA_site      3527
                     /gene="INPP4B"
     polyA_site      3542
                     /gene="INPP4B"
                     /note="major polyA site"
     regulatory      9086..9091
                     /regulatory_class="polyA_signal_sequence"
                     /gene="INPP4B"
                     /note="hexamer: AATAAA"
     polyA_site      9107
                     /gene="INPP4B"
ORIGIN      
        1 gccttctgag ctcagacagc agaaggatca ctgggctgga agctctaaca ggcattgcca
       61 gcctagctac ctgcagtttg aggcaagggc agggtcactt accctgctgt ctgaatgtct
      121 cctgggacaa caggaggctg cactcactgg ctgagttcag acagaagagg gatcatcgga
      181 ctggaagctc tggcaggtat ggctagcctg gttacccgta gtgagaatgg agagggccac
      241 ctgcccagct acacagatgt ttcccaggac aacaggaggc tgtgtccact gacagttcag
      301 acagaagtgg aaccactgga ccggaagctc tagcaagtgt tgcccacctg gctactagtg
      361 agccttgaaa ccagcgaaac aataatcaaa gagcagttct gtcaaagaaa acaacataaa
      421 tcaggtacag aatttcagag tgggatatca gatctttagt gtgaagatac atctacatta
      481 aaccaggaat cactagaact gacatttgga caagaaaatt tggaaaattt taaaactgtg
      541 aaggttgatc atggaaatta aagaggaagg ggcatcagaa gaagggcagc actttcttcc
      601 tacagcccag gccaatgatc ccggggactg tcagttcaca agtatccaga agactccaaa
      661 tgaaccgcag ttggaattca tccttgcatg caaggatctc gtggctcctg tccgtgatcg
      721 taaactgaat acactggtgc agatctccgt aatccacccc gtggagcaga gtctgacaag
      781 atactccagc accgaaattg tggagggaac aagggaccca ctgtttttga ctggtgtcac
      841 attcccatct gagtatccca tctatgagga gaccaaaata aaactaacag tctatgatgt
      901 caaggataag tctcatgaca ccgttcgaac cagtgtccta ccagaacata aggatccccc
      961 gccagaagtt gggcgaagtt tcttgggcta tgccagtttt aaagtgggag agctgctgaa
     1021 gtcaaaggag caattgctgg tcctgagcct gagaacttca gatggtggca aagtggttgg
     1081 caccatagaa gtcagtgtcg tgaagatggg ggagattgag gatggggaag ccgaccacat
     1141 caccacagat gtacagggac aaaagtgtgc cctggtatgt gaatgtacag ccccggaaag
     1201 tgtgagcgga aaagataact tacctttttt gaattcagtg ttaaagaacc cagtatgtaa
     1261 attatataga tttcccacat ctgacaataa gtggatgcga attcgagagc agatgtcaga
     1321 gagcattctt tcctttcata ttcctaagga attgatttcc cttcacatta aagaagattt
     1381 gtgcagaaac caggagataa aagaacttgg tgagctttct ccacattggg acaatctgcg
     1441 aaaaaatgtc cttactcact gtgatcaaat ggtgaatatg taccaagaca ttctgacaga
     1501 acttagcaag gaaacagggt cctctttcaa atcaagcagc agcaaaggag agaaaacatt
     1561 agaatttgtt ccaataaatc tacatctgca aagaatgcag gtacacagcc ctcacttgaa
     1621 agatgctctc tacgatgtca tcactgtggg agccccagct gcccattttc agggatttaa
     1681 gaatggtggt cttcggaagc tactccatag atttgaaaca gaaagaagaa ataccggata
     1741 ccagtttatt tactattcac ctgaaaacac agccaaagca aaggaagttc tcagcaacat
     1801 caatcaacta caacctctta tagcaaccca tgcagaccta ctgcttaatt ctgcaagcca
     1861 gcattctcca gacagcttga agaattcttt aaagatgctt tcagaaaaaa cagagctttt
     1921 tgtacatgcc ttcaaggatc aacttgtcag gagtgctctt ttagcactct acactgcaag
     1981 gccaggaggc attcttaaga agccaccctc tcctaagagc agcacagagg agagcagtcc
     2041 ccaagaccaa cccccagtga tgagagggca ggactccata ccacatcatt cagactatga
     2101 tgaggaagag tgggacaggg tgtgggccaa tgtggggaag agcctgaact gcattattgc
     2161 tatggtggac aaactgattg aaagagatgg tggcagtgaa ggcagtggcg gcaacaatga
     2221 tggagaaaag gaaccttcat taacagatgc cattccctct cacccaagag aggactggta
     2281 tgaacagttg tatcccctca tccttaccct gaaggactgc atgggagaag tggtgaaccg
     2341 agccaagcag tccctgacat ttgtgctcct tcaggaactt gcgtacagct tgccccagtg
     2401 tctgatgctg acgctaagaa gagacatcgt cttcagccaa gcacttgctg gattggtttg
     2461 tggttttatc atcaaattac agacaagtct gtatgaccca ggcttcctac agcagcttca
     2521 cacagtgggg ttgatagtac aatatgaagg actgctaagt acatacagcg atgaaattgg
     2581 aatgctagag gacatggccg ttggcatttc cgatttaaag aaagttgcat ttaaaataat
     2641 tgaagccaaa tccaatgatg tgttgccagt tataacagga agacgagaac attacgtggt
     2701 agaggtcaag cttccagcca gaatgtttga gtcactacct ctacagatta aagaaggaca
     2761 gttgcttcat gtgtatccag tactttttaa tgttggaatc aatgaacagc aaactctggc
     2821 tgaaaggttt ggagatgtct ctttgcaaga aagtattaat caggaaaact tcgaacttct
     2881 acaagaatat tacaagatat ttatggaaaa gatgcctcct gattatattt cacattttca
     2941 ggaacaaaat gatttaaaag cattgctaga aaatctcctt caaaatatcc aatccaaaaa
     3001 aagaaagaat gtagaaatta tgtggctggc tgcaacgatt tgccgcaaac tgaatggtat
     3061 tcgtttcacc tgttgtaaaa gtgccaaaga caggacatcg atgtcagtga cacttgaaca
     3121 atgctcaatc ttgagagatg agcaccagtt acacaaggac ttctttatcc gagcgctgga
     3181 ttgcatgaga aggctttggt atgaagatga tgctggcctc ataaatgagt tagggaggag
     3241 gattccctct ttttcttttg attggaatgg tttcagaaga aacggtacca gttcctgttt
     3301 gtacctctgg tagattttgg ctgtgaatac atctggtcct ggactttttt tgagaaggat
     3361 gccgcataga gaatgtactg aagaatatca aatgcagaaa gtatgctttc aacatgctac
     3421 agctgatggc tttccccaag tactacagac ctccagaggg gacttatgga aaagctgaca
     3481 cctaagttta ccaacatgtt aataaacagg aacacaaata catttcagtt ggataatctt
     3541 caccttggtc ttttttgttt gtttttattg tcatgaattt gtggtggggg agatgatcac
     3601 agatgtttcc caaaatctag gaactacttc aattcatcat cagcatattg ctctgaaaga
     3661 aatccatttt aaaaaatctt acatgattca gtactgtcat ttctagttct aagcttctat
     3721 gtgttgagcc tagctgattg agattggttc acaaagtgta aatttcattc atgagtattt
     3781 aaatgtttct gaggaaacat ggatcatttc aataggacta ggggtgattc acagagcacc
     3841 actctccaac caaatggaag agaggagagg gggaaaagga acatattttt tttgtgatac
     3901 aacttaatag cctatgagaa cacagtcaac ctgagaatca atgtaaggga tttaaaaaaa
     3961 atgtgtagcc actcaattag gtagagttaa ctcatgatct ggaatactga ggcagtttgc
     4021 aggtatgttc cacaatgatc tctatcatcc agtcaaggtg tgactcctcc cttgcaacag
     4081 gcatatgcat ggagtgagta aagtggtcaa cagacctttc aaaaccatgg catcttttca
     4141 gaactctgac ttgggttgtg tgatctagct gtgaatgtag caatatagaa cgtttaatag
     4201 aatgataagc aaaacactgc aatgatctaa aattacaaat aaaataaaaa tgaacaacat
     4261 tttgataccc aaaatgaaaa ttcccatcag cctgaacttt atgttgtgaa gttcatgaat
     4321 gtcagtgagg tatctctgag atgtttctta gcagtcatcc tggtgtaagc atgcagttat
     4381 ggcataggtt tgtgtgtgtt aataagcctt taaaacatat gcaaccacaa caaatgataa
     4441 agtaaaacaa ttattttctg ttgccctgaa tatcaaactt gcccttgccc ttactcagca
     4501 aaataacatt tataagtttt ccaaaatccc aaagtagaag tttccttaaa aaaatcatct
     4561 tgtataatac cagtattcaa acatgggtaa ggttaatcac ccccaatcac tcaggagata
     4621 gttgcagaat ttgaattaca atctcttctt actttcctag cctgtggctt gtcacttctc
     4681 caaattgcca tgctaaatat gcatgaaaat tgagggagaa tgctagttaa aaagaaatta
     4741 ggatttatca ctggaattga aactaagagt acaaaagtct gaacgaatga aacttttctc
     4801 caaattttac aaattcttgt tcctttctca ttagaagagc atgctatcca aagcataaat
     4861 ctcccttgaa aataacagag gcttcttaag ccctctctta gctatgatca atggatgata
     4921 ttatgcttcc catagctaat gtgatagctc cttgcctagg attcctgttg aaataaggat
     4981 tctagcccca tgttaagttt ttcaaattac tacaaatttt agataagcat ttggagcttt
     5041 ttatactaga attatcaatt ttttatttta gctaattacc tgtgggcatt atacttgagg
     5101 caggtaccaa actacttaca gcctttttaa tgaaaatgtg ctgtgtactt tgaatccatt
     5161 catagacaaa attaccttga tgttctctta actcattctt tattttagtg attaaataca
     5221 acctttgagt tgttcaatat catttgaaaa tggtaggatt tgtggttatt ttcattaccc
     5281 tattagattt aagataggct gggatgacag aggcctcctt gaatagctat gaagcctcat
     5341 tcagcatatc aaatggtagt ctgagttcta agaaacctta agtaatttat cattctgtaa
     5401 atactcttat aagcaataat ttttatttgt atttttgaaa acaaactact taaatatgga
     5461 aaaatattaa ctggaaagcc agcagtaggg ttttctattt ttaaaagaca tttcaaggat
     5521 ttcctgtaat cccagcactt tgggagccaa ggtggataga tcacctgagg tcaggaattg
     5581 gagatcagcc tggccaacat ggtgaaaccc catctctact aaagatacaa aaattagctg
     5641 gatgtggtgg cacacacgtg taatcccagc tacttgggag gctgaggcaa gagaatcgct
     5701 tgaaccccgg aggcggaggt tgcagtgagc tgagatcatg ccattgcact ccagcctggg
     5761 tgaaaagagc gaaactccat ctttaaataa gtaaataaat gaataatata gaagtctcaa
     5821 attatagtgc ttactgtaat acaaatgctt atgaattttc attcattacc atagtcatct
     5881 gcatttcctt atagaaagcc tgtactggtg caaacttcta aaagtggatt tcatcaagaa
     5941 aatgtgtttc atagagacaa caatattgct tttttcctga gaggcagttc attcttaaac
     6001 aaccacttca ctatttctta agttattaag gctaaatcaa agagcaaatg ttaaagtgtt
     6061 taaatctctc ttgaacaaac acagccacag tcatgctatt ctatctatat tttcacttaa
     6121 aagatacacc agcagaccta ttttaggagg tcatattgag ccaaaaaatg aactgagcaa
     6181 atgacatttc caaactcttt ttttgctcaa aaataatatg ttcccctttg atattaaatg
     6241 cagatatcaa ttctggatta gctatttact gagccctagg aaaaacatat ttaaagacaa
     6301 ggaaaccatt catttacatc tcatatcatt gctttttgct tttaaatatc gccttgaggt
     6361 ttgtctacac tctgccaaaa caatccctga acataagttt ggtcagcctc ataattcagt
     6421 gagtcgagca accatttgtt ccaagtgata aattgtacta aatgacaaac tgcccaatca
     6481 gggcagagct ccatggaccc agcctccagc ccttatttta taagactaac ccctcttctg
     6541 aaaaactctg aaggcttaaa agctagcatt tggatggagg atacttcctt tttatccttc
     6601 agctatgtat ggcactttac ataaaataag aggtaaaaaa ggagagaaac tgatgtgtat
     6661 aaagtaatgc ctttcttccc aagcaaatca aacctctccc tatgtaaaag ttgatagtgt
     6721 accaagagac acaataccac tggtgggctg gaactagctc gttctgatgc ataaaagttg
     6781 ataattaaag taccagaaat tttgtaagct agttgttaaa cattaccatt attaaatatg
     6841 aaattataaa acacagtgga atacattaaa aaccaatgta ataatcaaaa cataccactt
     6901 cccaattatt ttactacctt atactattta ttagtactct tgagtctatt taggtctatt
     6961 acatctttac agtgaaaaca ggatacaata ttgtgctact gtgggtctct tcctgactgc
     7021 agattcagta acatggtgtt cgtagcttga aactgtccac agtgggagta tttaacacca
     7081 tagaaactgg ctggcaaatg ctacaaacta gcaattttaa ttcctggaaa ggcaattgtt
     7141 gagcatttac cagcacacaa tgaatgccat attctttttt ttttattagg aaataaatta
     7201 ttggaggcag tataaaatta tttaaaaagt atcaaatgca atcccttatc ttcagatggc
     7261 tataattttg gttatataaa tgttttggtt tttaccttct ttaaagactc ctattaggtt
     7321 aaaagtcata tttgatgact atattttatt cataattaaa ttattaaatc accttttctc
     7381 ctgataatgc tttgccagag aattcttagc aattcaactg tagtctaagc aataactcag
     7441 ggctaaattc agggaactgt tagcccaatc agatatcact aaaaatgtac ttcaccatct
     7501 attttggagt ttataatttt ggcatttgct aaaagtagga aaaacagtaa catattactg
     7561 tgcccagatt ctaataaata tagctcaatt gaaaccaaaa ctgttacatt aaacaaatta
     7621 cactctggca ctatgctaaa tcaccacaga tgttttaggt gtttgatttc caagcaggat
     7681 ggtatatcat ttgtttggtt caatatatga ggcaccattt gtagtctttt aggaaataaa
     7741 ttagctttta tcacagattt aggaaacttg tctaaaaaaa ctgtgatcat cagttacaga
     7801 gggaaggaaa catattgaac acaaggcatc atagtagctg gaggccttaa aaattatgca
     7861 cgaccaaaaa gaatgatttg gtgagagatg tgtagctgat tgacaatttt agtgtgaatt
     7921 catattcatt taacccagca gcaatctaca taagctatgc tttttcccac ctgtatttat
     7981 gtttcttagc ttataaagtc ccaatatatt atatcttttg ttgctttggc agttttaatt
     8041 tagagctctg cgttcacaga gatgccacct atagcaaaaa ctatctttaa gaattggaaa
     8101 ataaaatgaa tgttttagat aaaatattgc aagccattat gtgtagagtt aatgtatgga
     8161 aatttgcatt tgtttttctg aatcatggtg tacattaatc actcattgaa ttctatttct
     8221 aagcaaataa gagaatcaaa catttctaaa aggaacatat gtcttgctat taataacaag
     8281 gagacaggaa aaatagtaag gtaatataag caaaaaaaaa aatgtaatga atttagctat
     8341 cctaaattgg aatttttaca gattgcatgc atacttagaa ttttaaattt ttaaaagatt
     8401 tacaattgag tatggtaccc acagagagtg agtaccaagg gaaggaagac ctaatacaag
     8461 tgatgttgcc tgataaatca catcttgcca aaaaaaatat attttagtaa atacagttct
     8521 ttaggaagaa aaatgttgcc ctttcacact cacagtgtaa atacattcat aatattcctt
     8581 caatcatcta aattaccgcc aggtcatgaa aggacgcgat caatgatgac ctattgcact
     8641 cacaggtaac attgactcaa attttggcaa tattgctata ttatctagat aattcttgtg
     8701 atgtttttat gtcactatca acattaaaaa tattttgtta aacaactatg aaactttcaa
     8761 aagtttgcat ataactgtat gggcactctc atttcactgc atacatacaa tactttgtat
     8821 acacatactt ctcgtgtgga tattttataa ttttatttaa tctaacattt aacttttagg
     8881 tttttgtggt actcatctga aaggttggca tttgttttct ttttatgtta tatatgtatt
     8941 ttagatgaat caataatgtg tattcctaga aattttttct aggcataaat agatcatttt
     9001 atgttggcat ttaagagata tcatttttgt tttattgttc tgtgtaaacc atattcattg
     9061 tacactgtgt gtatattttt gtttaaataa atgattttta tttttta
//
