LOCUS       NM_001385338            8886 bp    mRNA    linear   PRI 07-DEC-2024
DEFINITION  Homo sapiens inositol polyphosphate-4-phosphatase type II B
            (INPP4B), transcript variant 8, mRNA.
ACCESSION   NM_001385338
VERSION     NM_001385338.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8886)
  AUTHORS   Saffi,G.T., To,L., Kleine,N., Melo,C.M.P., Chen,K., Genc,G.,
            Lee,K.C.D., Chow,J.T., Jang,G.H., Gallinger,S., Botelho,R.J. and
            Salmena,L.
  TITLE     INPP4B promotes PDAC aggressiveness via PIKfyve and
            TRPML-1-mediated lysosomal exocytosis
  JOURNAL   J Cell Biol 223 (11) (2024)
   PUBMED   39120584
  REMARK    GeneRIF: INPP4B promotes PDAC aggressiveness via PIKfyve and
            TRPML-1-mediated lysosomal exocytosis.
REFERENCE   2  (bases 1 to 8886)
  AUTHORS   Lai,M., Mao,Z., Tang,D., Lan,S., Yan,R., Xiang,Q., Zhao,X., Su,M.
            and Wang,Y.
  TITLE     [Preliminary Study of the Role of INPP4B in Promoting Colorectal
            Cancer Metastasis and the Mechanisms Involved]
  JOURNAL   Sichuan Da Xue Xue Bao Yi Xue Ban 55 (5), 1186-1194 (2024)
   PUBMED   39507966
  REMARK    GeneRIF: [Preliminary Study of the Role of INPP4B in Promoting
            Colorectal Cancer Metastasis and the Mechanisms Involved].
REFERENCE   3  (bases 1 to 8886)
  AUTHORS   Zhao,J., Du,X.M., Si,W., Zhao,X.H. and Zhou,Z.Q.
  TITLE     Role of INPP4B in the proliferation, migration, invasion, and
            survival of human endometrial cancer cells
  JOURNAL   Histol Histopathol 39 (9), 1197-1208 (2024)
   PUBMED   38318760
  REMARK    GeneRIF: Role of INPP4B in the proliferation, migration, invasion,
            and survival of human endometrial cancer cells.
REFERENCE   4  (bases 1 to 8886)
  AUTHORS   Gorji,M., Farsani,M.A., Kargar,M., Garavand,J. and Mohammadi,M.H.
  TITLE     Investigating the multifaceted cooperation of autophagy, PI3K/AKT
            signaling pathways, and INPP4B gene in de novo acute myeloid
            leukemia patients
  JOURNAL   Curr Res Transl Med 72 (2), 103429 (2024)
   PUBMED   38246071
  REMARK    GeneRIF: Investigating the multifaceted cooperation of autophagy,
            PI3K/AKT signaling pathways, and INPP4B gene in de novo acute
            myeloid leukemia patients.
REFERENCE   5  (bases 1 to 8886)
  AUTHORS   Xu,M., Ren,J., Jia,W., Wang,S., Liu,Y., Chen,X., Shi,J. and Wang,H.
  TITLE     Regulation of B-1 cell numbers and B cell-mediated antibody
            production by Inpp4b
  JOURNAL   Scand J Immunol 98 (4), e13309 (2023)
   PUBMED   37389566
  REMARK    GeneRIF: Regulation of B-1 cell numbers and B cell-mediated
            antibody production by Inpp4b.
REFERENCE   6  (bases 1 to 8886)
  AUTHORS   Rampersaud,E., Damcott,C.M., Fu,M., Shen,H., McArdle,P., Shi,X.,
            Shelton,J., Yin,J., Chang,Y.P., Ott,S.H., Zhang,L., Zhao,Y.,
            Mitchell,B.D., O'Connell,J. and Shuldiner,A.R.
  TITLE     Identification of novel candidate genes for type 2 diabetes from a
            genome-wide association scan in the Old Order Amish: evidence for
            replication from diabetes-related quantitative traits and from
            independent populations
  JOURNAL   Diabetes 56 (12), 3053-3062 (2007)
   PUBMED   17846126
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 8886)
  AUTHORS   Munday,A.D., Norris,F.A., Caldwell,K.K., Brown,S., Majerus,P.W. and
            Mitchell,C.A.
  TITLE     The inositol polyphosphate 4-phosphatase forms a complex with
            phosphatidylinositol 3-kinase in human platelet cytosol
  JOURNAL   Proc Natl Acad Sci U S A 96 (7), 3640-3645 (1999)
   PUBMED   10097090
REFERENCE   8  (bases 1 to 8886)
  AUTHORS   Zhang,X. and Majerus,P.W.
  TITLE     Phosphatidylinositol signalling reactions
  JOURNAL   Semin Cell Dev Biol 9 (2), 153-160 (1998)
   PUBMED   9599410
  REMARK    Review article
REFERENCE   9  (bases 1 to 8886)
  AUTHORS   Norris,F.A., Atkins,R.C. and Majerus,P.W.
  TITLE     The cDNA cloning and characterization of inositol polyphosphate
            4-phosphatase type II. Evidence for conserved alternative splicing
            in the 4-phosphatase family
  JOURNAL   J Biol Chem 272 (38), 23859-23864 (1997)
   PUBMED   9295334
REFERENCE   10 (bases 1 to 8886)
  AUTHORS   Norris,F.A., Auethavekiat,V. and Majerus,P.W.
  TITLE     The isolation and characterization of cDNA encoding human and rat
            brain inositol polyphosphate 4-phosphatase
  JOURNAL   J Biol Chem 270 (27), 16128-16133 (1995)
   PUBMED   7608176
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC139720.1, AC108060.3,
            AC093860.3 and AC108077.3.
            
            Summary: INPP4B encodes the inositol polyphosphate 4-phosphatase
            type II, one of the enzymes involved in phosphatidylinositol
            signaling pathways. This enzyme removes the phosphate group at
            position 4 of the inositol ring from inositol 3,4-bisphosphate.
            There is limited data to suggest that the human type II enzyme is
            subject to alternative splicing, as has been established for the
            type I enzyme. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038194.2259744.1,
                                           SRR14372079.156894.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0000350]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-299               AC139720.1         105673-105971       c
            300-363             AC139720.1         7879-7942           c
            364-580             AC108060.3         112687-112903       c
            581-625             AC108060.3         110691-110735       c
            626-744             AC108060.3         86724-86842         c
            745-861             AC108060.3         84456-84572         c
            862-912             AC093860.3         187670-187720       c
            913-992             AC093860.3         178416-178495       c
            993-1104            AC093860.3         143621-143732       c
            1105-1177           AC093860.3         133450-133522       c
            1178-1325           AC093860.3         110822-110969       c
            1326-1456           AC093860.3         81854-81984         c
            1457-1561           AC093860.3         81383-81487         c
            1562-1670           AC093860.3         66045-66153         c
            1671-1848           AC093860.3         46590-46767         c
            1849-2052           AC093860.3         33316-33519         c
            2053-2209           AC093860.3         18798-18954         c
            2210-2382           AC108077.3         102529-102701       c
            2383-2506           AC108077.3         101233-101356       c
            2507-2624           AC108077.3         100069-100186       c
            2625-2765           AC108077.3         90483-90623         c
            2766-2863           AC108077.3         86034-86131         c
            2864-2976           AC108077.3         64085-64197         c
            2977-3131           AC108077.3         59972-60126         c
            3132-8886           AC108077.3         1101-6855           c
FEATURES             Location/Qualifiers
     source          1..8886
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q31.21"
     gene            1..8886
                     /gene="INPP4B"
                     /note="inositol polyphosphate-4-phosphatase type II B"
                     /db_xref="GeneID:8821"
                     /db_xref="HGNC:HGNC:6075"
                     /db_xref="MIM:607494"
     exon            1..299
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     exon            300..363
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     exon            364..580
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     CDS             490..3264
                     /gene="INPP4B"
                     /EC_number="3.1.3.66"
                     /note="isoform 1 is encoded by transcript variant 8;
                     inositol polyphosphate 4-phosphatase II; 4-phosphatase II;
                     type II inositol 3,4-bisphosphate 4-phosphatase; inositol
                     polyphosphate-4-phosphatase, type II, 105kDa"
                     /codon_start=1
                     /product="inositol polyphosphate 4-phosphatase type II
                     isoform 1"
                     /protein_id="NP_001372267.1"
                     /db_xref="CCDS:CCDS3757.1"
                     /db_xref="GeneID:8821"
                     /db_xref="HGNC:HGNC:6075"
                     /db_xref="MIM:607494"
                     /translation="MEIKEEGASEEGQHFLPTAQANDPGDCQFTSIQKTPNEPQLEFI
                     LACKDLVAPVRDRKLNTLVQISVIHPVEQSLTRYSSTEIVEGTRDPLFLTGVTFPSEY
                     PIYEETKIKLTVYDVKDKSHDTVRTSVLPEHKDPPPEVGRSFLGYASFKVGELLKSKE
                     QLLVLSLRTSDGGKVVGTIEVSVVKMGEIEDGEADHITTDVQGQKCALVCECTAPESV
                     SGKDNLPFLNSVLKNPVCKLYRFPTSDNKWMRIREQMSESILSFHIPKELISLHIKED
                     LCRNQEIKELGELSPHWDNLRKNVLTHCDQMVNMYQDILTELSKETGSSFKSSSSKGE
                     KTLEFVPINLHLQRMQVHSPHLKDALYDVITVGAPAAHFQGFKNGGLRKLLHRFETER
                     RNTGYQFIYYSPENTAKAKEVLSNINQLQPLIATHADLLLNSASQHSPDSLKNSLKML
                     SEKTELFVHAFKDQLVRSALLALYTARPGGILKKPPSPKSSTEESSPQDQPPVMRGQD
                     SIPHHSDYDEEEWDRVWANVGKSLNCIIAMVDKLIERDGGSEGSGGNNDGEKEPSLTD
                     AIPSHPREDWYEQLYPLILTLKDCMGEVVNRAKQSLTFVLLQELAYSLPQCLMLTLRR
                     DIVFSQALAGLVCGFIIKLQTSLYDPGFLQQLHTVGLIVQYEGLLSTYSDEIGMLEDM
                     AVGISDLKKVAFKIIEAKSNDVLPVITGRREHYVVEVKLPARMFESLPLQIKEGQLLH
                     VYPVLFNVGINEQQTLAERFGDVSLQESINQENFELLQEYYKIFMEKMPPDYISHFQE
                     QNDLKALLENLLQNIQSKKRKNVEIMWLAATICRKLNGIRFTCCKSAKDRTSMSVTLE
                     QCSILRDEHQLHKDFFIRALDCMRREGCRIENVLKNIKCRKYAFNMLQLMAFPKYYRP
                     PEGTYGKADT"
     exon            581..625
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     exon            626..744
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     exon            745..861
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     exon            862..912
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     exon            913..992
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     exon            993..1104
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     exon            1105..1177
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     exon            1178..1325
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     exon            1326..1456
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     exon            1457..1561
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     exon            1562..1670
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     exon            1671..1848
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     exon            1849..2052
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     exon            2053..2209
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     exon            2210..2382
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     exon            2383..2506
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     exon            2507..2624
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     exon            2625..2765
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     exon            2766..2863
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     exon            2864..2976
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     exon            2977..3131
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     exon            3132..8886
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3280..3285
                     /regulatory_class="polyA_signal_sequence"
                     /gene="INPP4B"
                     /note="hexamer: AATAAA"
     regulatory      3296..3301
                     /regulatory_class="polyA_signal_sequence"
                     /gene="INPP4B"
                     /note="hexamer: AATACA"
     polyA_site      3306
                     /gene="INPP4B"
     polyA_site      3321
                     /gene="INPP4B"
                     /note="major polyA site"
     regulatory      8865..8870
                     /regulatory_class="polyA_signal_sequence"
                     /gene="INPP4B"
                     /note="hexamer: AATAAA"
     polyA_site      8886
                     /gene="INPP4B"
ORIGIN      
        1 gtcagtgcag ctaggataaa gcaggcagaa gatgttggaa agagcagact tgctgagtct
       61 tctgagcttc atctttctcc tgtgctggat gtttcctgcc ctcgaacatc agaatccatg
      121 tttttcagct tttgggctct tggacttaca ccagtggttt gccagggccc cccagccttc
      181 gaccacagat tgaaggctac actgttggcc tccctacttt tgaggttttg gaacttggac
      241 tggcttcctt gctcctcagt ttgcagacag cctattgtgg aacttcacct tgtgatcgta
      301 gccttgaaac cagcgaaaca ataatcaaag agcagttctg tcaaagaaaa caacataaat
      361 caggtacaga atttcagagt gggatatcag atctttagtg tgaagataca tctacattaa
      421 accaggaatc actagaactg acatttggac aagaaaattt ggaaaatttt aaaactgtga
      481 aggttgatca tggaaattaa agaggaaggg gcatcagaag aagggcagca ctttcttcct
      541 acagcccagg ccaatgatcc cggggactgt cagttcacaa gtatccagaa gactccaaat
      601 gaaccgcagt tggaattcat ccttgcatgc aaggatctcg tggctcctgt ccgtgatcgt
      661 aaactgaata cactggtgca gatctccgta atccaccccg tggagcagag tctgacaaga
      721 tactccagca ccgaaattgt ggagggaaca agggacccac tgtttttgac tggtgtcaca
      781 ttcccatctg agtatcccat ctatgaggag accaaaataa aactaacagt ctatgatgtc
      841 aaggataagt ctcatgacac cgttcgaacc agtgtcctac cagaacataa ggatcccccg
      901 ccagaagttg ggcgaagttt cttgggctat gccagtttta aagtgggaga gctgctgaag
      961 tcaaaggagc aattgctggt cctgagcctg agaacttcag atggtggcaa agtggttggc
     1021 accatagaag tcagtgtcgt gaagatgggg gagattgagg atggggaagc cgaccacatc
     1081 accacagatg tacagggaca aaagtgtgcc ctggtatgtg aatgtacagc cccggaaagt
     1141 gtgagcggaa aagataactt accttttttg aattcagtgt taaagaaccc agtatgtaaa
     1201 ttatatagat ttcccacatc tgacaataag tggatgcgaa ttcgagagca gatgtcagag
     1261 agcattcttt cctttcatat tcctaaggaa ttgatttccc ttcacattaa agaagatttg
     1321 tgcagaaacc aggagataaa agaacttggt gagctttctc cacattggga caatctgcga
     1381 aaaaatgtcc ttactcactg tgatcaaatg gtgaatatgt accaagacat tctgacagaa
     1441 cttagcaagg aaacagggtc ctctttcaaa tcaagcagca gcaaaggaga gaaaacatta
     1501 gaatttgttc caataaatct acatctgcaa agaatgcagg tacacagccc tcacttgaaa
     1561 gatgctctct acgatgtcat cactgtggga gccccagctg cccattttca gggatttaag
     1621 aatggtggtc ttcggaagct actccataga tttgaaacag aaagaagaaa taccggatac
     1681 cagtttattt actattcacc tgaaaacaca gccaaagcaa aggaagttct cagcaacatc
     1741 aatcaactac aacctcttat agcaacccat gcagacctac tgcttaattc tgcaagccag
     1801 cattctccag acagcttgaa gaattcttta aagatgcttt cagaaaaaac agagcttttt
     1861 gtacatgcct tcaaggatca acttgtcagg agtgctcttt tagcactcta cactgcaagg
     1921 ccaggaggca ttcttaagaa gccaccctct cctaagagca gcacagagga gagcagtccc
     1981 caagaccaac ccccagtgat gagagggcag gactccatac cacatcattc agactatgat
     2041 gaggaagagt gggacagggt gtgggccaat gtggggaaga gcctgaactg cattattgct
     2101 atggtggaca aactgattga aagagatggt ggcagtgaag gcagtggcgg caacaatgat
     2161 ggagaaaagg aaccttcatt aacagatgcc attccctctc acccaagaga ggactggtat
     2221 gaacagttgt atcccctcat ccttaccctg aaggactgca tgggagaagt ggtgaaccga
     2281 gccaagcagt ccctgacatt tgtgctcctt caggaacttg cgtacagctt gccccagtgt
     2341 ctgatgctga cgctaagaag agacatcgtc ttcagccaag cacttgctgg attggtttgt
     2401 ggttttatca tcaaattaca gacaagtctg tatgacccag gcttcctaca gcagcttcac
     2461 acagtggggt tgatagtaca atatgaagga ctgctaagta catacagcga tgaaattgga
     2521 atgctagagg acatggccgt tggcatttcc gatttaaaga aagttgcatt taaaataatt
     2581 gaagccaaat ccaatgatgt gttgccagtt ataacaggaa gacgagaaca ttacgtggta
     2641 gaggtcaagc ttccagccag aatgtttgag tcactacctc tacagattaa agaaggacag
     2701 ttgcttcatg tgtatccagt actttttaat gttggaatca atgaacagca aactctggct
     2761 gaaaggtttg gagatgtctc tttgcaagaa agtattaatc aggaaaactt cgaacttcta
     2821 caagaatatt acaagatatt tatggaaaag atgcctcctg attatatttc acattttcag
     2881 gaacaaaatg atttaaaagc attgctagaa aatctccttc aaaatatcca atccaaaaaa
     2941 agaaagaatg tagaaattat gtggctggct gcaacgattt gccgcaaact gaatggtatt
     3001 cgtttcacct gttgtaaaag tgccaaagac aggacatcga tgtcagtgac acttgaacaa
     3061 tgctcaatct tgagagatga gcaccagtta cacaaggact tctttatccg agcgctggat
     3121 tgcatgagaa gagaaggatg ccgcatagag aatgtactga agaatatcaa atgcagaaag
     3181 tatgctttca acatgctaca gctgatggct ttccccaagt actacagacc tccagagggg
     3241 acttatggaa aagctgacac ctaagtttac caacatgtta ataaacagga acacaaatac
     3301 atttcagttg gataatcttc accttggtct tttttgtttg tttttattgt catgaatttg
     3361 tggtggggga gatgatcaca gatgtttccc aaaatctagg aactacttca attcatcatc
     3421 agcatattgc tctgaaagaa atccatttta aaaaatctta catgattcag tactgtcatt
     3481 tctagttcta agcttctatg tgttgagcct agctgattga gattggttca caaagtgtaa
     3541 atttcattca tgagtattta aatgtttctg aggaaacatg gatcatttca ataggactag
     3601 gggtgattca cagagcacca ctctccaacc aaatggaaga gaggagaggg ggaaaaggaa
     3661 catatttttt ttgtgataca acttaatagc ctatgagaac acagtcaacc tgagaatcaa
     3721 tgtaagggat ttaaaaaaaa tgtgtagcca ctcaattagg tagagttaac tcatgatctg
     3781 gaatactgag gcagtttgca ggtatgttcc acaatgatct ctatcatcca gtcaaggtgt
     3841 gactcctccc ttgcaacagg catatgcatg gagtgagtaa agtggtcaac agacctttca
     3901 aaaccatggc atcttttcag aactctgact tgggttgtgt gatctagctg tgaatgtagc
     3961 aatatagaac gtttaataga atgataagca aaacactgca atgatctaaa attacaaata
     4021 aaataaaaat gaacaacatt ttgataccca aaatgaaaat tcccatcagc ctgaacttta
     4081 tgttgtgaag ttcatgaatg tcagtgaggt atctctgaga tgtttcttag cagtcatcct
     4141 ggtgtaagca tgcagttatg gcataggttt gtgtgtgtta ataagccttt aaaacatatg
     4201 caaccacaac aaatgataaa gtaaaacaat tattttctgt tgccctgaat atcaaacttg
     4261 cccttgccct tactcagcaa aataacattt ataagttttc caaaatccca aagtagaagt
     4321 ttccttaaaa aaatcatctt gtataatacc agtattcaaa catgggtaag gttaatcacc
     4381 cccaatcact caggagatag ttgcagaatt tgaattacaa tctcttctta ctttcctagc
     4441 ctgtggcttg tcacttctcc aaattgccat gctaaatatg catgaaaatt gagggagaat
     4501 gctagttaaa aagaaattag gatttatcac tggaattgaa actaagagta caaaagtctg
     4561 aacgaatgaa acttttctcc aaattttaca aattcttgtt cctttctcat tagaagagca
     4621 tgctatccaa agcataaatc tcccttgaaa ataacagagg cttcttaagc cctctcttag
     4681 ctatgatcaa tggatgatat tatgcttccc atagctaatg tgatagctcc ttgcctagga
     4741 ttcctgttga aataaggatt ctagccccat gttaagtttt tcaaattact acaaatttta
     4801 gataagcatt tggagctttt tatactagaa ttatcaattt tttattttag ctaattacct
     4861 gtgggcatta tacttgaggc aggtaccaaa ctacttacag cctttttaat gaaaatgtgc
     4921 tgtgtacttt gaatccattc atagacaaaa ttaccttgat gttctcttaa ctcattcttt
     4981 attttagtga ttaaatacaa cctttgagtt gttcaatatc atttgaaaat ggtaggattt
     5041 gtggttattt tcattaccct attagattta agataggctg ggatgacaga ggcctccttg
     5101 aatagctatg aagcctcatt cagcatatca aatggtagtc tgagttctaa gaaaccttaa
     5161 gtaatttatc attctgtaaa tactcttata agcaataatt tttatttgta tttttgaaaa
     5221 caaactactt aaatatggaa aaatattaac tggaaagcca gcagtagggt tttctatttt
     5281 taaaagacat ttcaaggatt tcctgtaatc ccagcacttt gggagccaag gtggatagat
     5341 cacctgaggt caggaattgg agatcagcct ggccaacatg gtgaaacccc atctctacta
     5401 aagatacaaa aattagctgg atgtggtggc acacacgtgt aatcccagct acttgggagg
     5461 ctgaggcaag agaatcgctt gaaccccgga ggcggaggtt gcagtgagct gagatcatgc
     5521 cattgcactc cagcctgggt gaaaagagcg aaactccatc tttaaataag taaataaatg
     5581 aataatatag aagtctcaaa ttatagtgct tactgtaata caaatgctta tgaattttca
     5641 ttcattacca tagtcatctg catttcctta tagaaagcct gtactggtgc aaacttctaa
     5701 aagtggattt catcaagaaa atgtgtttca tagagacaac aatattgctt ttttcctgag
     5761 aggcagttca ttcttaaaca accacttcac tatttcttaa gttattaagg ctaaatcaaa
     5821 gagcaaatgt taaagtgttt aaatctctct tgaacaaaca cagccacagt catgctattc
     5881 tatctatatt ttcacttaaa agatacacca gcagacctat tttaggaggt catattgagc
     5941 caaaaaatga actgagcaaa tgacatttcc aaactctttt tttgctcaaa aataatatgt
     6001 tcccctttga tattaaatgc agatatcaat tctggattag ctatttactg agccctagga
     6061 aaaacatatt taaagacaag gaaaccattc atttacatct catatcattg ctttttgctt
     6121 ttaaatatcg ccttgaggtt tgtctacact ctgccaaaac aatccctgaa cataagtttg
     6181 gtcagcctca taattcagtg agtcgagcaa ccatttgttc caagtgataa attgtactaa
     6241 atgacaaact gcccaatcag ggcagagctc catggaccca gcctccagcc cttattttat
     6301 aagactaacc cctcttctga aaaactctga aggcttaaaa gctagcattt ggatggagga
     6361 tacttccttt ttatccttca gctatgtatg gcactttaca taaaataaga ggtaaaaaag
     6421 gagagaaact gatgtgtata aagtaatgcc tttcttccca agcaaatcaa acctctccct
     6481 atgtaaaagt tgatagtgta ccaagagaca caataccact ggtgggctgg aactagctcg
     6541 ttctgatgca taaaagttga taattaaagt accagaaatt ttgtaagcta gttgttaaac
     6601 attaccatta ttaaatatga aattataaaa cacagtggaa tacattaaaa accaatgtaa
     6661 taatcaaaac ataccacttc ccaattattt tactacctta tactatttat tagtactctt
     6721 gagtctattt aggtctatta catctttaca gtgaaaacag gatacaatat tgtgctactg
     6781 tgggtctctt cctgactgca gattcagtaa catggtgttc gtagcttgaa actgtccaca
     6841 gtgggagtat ttaacaccat agaaactggc tggcaaatgc tacaaactag caattttaat
     6901 tcctggaaag gcaattgttg agcatttacc agcacacaat gaatgccata ttcttttttt
     6961 tttattagga aataaattat tggaggcagt ataaaattat ttaaaaagta tcaaatgcaa
     7021 tcccttatct tcagatggct ataattttgg ttatataaat gttttggttt ttaccttctt
     7081 taaagactcc tattaggtta aaagtcatat ttgatgacta tattttattc ataattaaat
     7141 tattaaatca ccttttctcc tgataatgct ttgccagaga attcttagca attcaactgt
     7201 agtctaagca ataactcagg gctaaattca gggaactgtt agcccaatca gatatcacta
     7261 aaaatgtact tcaccatcta ttttggagtt tataattttg gcatttgcta aaagtaggaa
     7321 aaacagtaac atattactgt gcccagattc taataaatat agctcaattg aaaccaaaac
     7381 tgttacatta aacaaattac actctggcac tatgctaaat caccacagat gttttaggtg
     7441 tttgatttcc aagcaggatg gtatatcatt tgtttggttc aatatatgag gcaccatttg
     7501 tagtctttta ggaaataaat tagcttttat cacagattta ggaaacttgt ctaaaaaaac
     7561 tgtgatcatc agttacagag ggaaggaaac atattgaaca caaggcatca tagtagctgg
     7621 aggccttaaa aattatgcac gaccaaaaag aatgatttgg tgagagatgt gtagctgatt
     7681 gacaatttta gtgtgaattc atattcattt aacccagcag caatctacat aagctatgct
     7741 ttttcccacc tgtatttatg tttcttagct tataaagtcc caatatatta tatcttttgt
     7801 tgctttggca gttttaattt agagctctgc gttcacagag atgccaccta tagcaaaaac
     7861 tatctttaag aattggaaaa taaaatgaat gttttagata aaatattgca agccattatg
     7921 tgtagagtta atgtatggaa atttgcattt gtttttctga atcatggtgt acattaatca
     7981 ctcattgaat tctatttcta agcaaataag agaatcaaac atttctaaaa ggaacatatg
     8041 tcttgctatt aataacaagg agacaggaaa aatagtaagg taatataagc aaaaaaaaaa
     8101 atgtaatgaa tttagctatc ctaaattgga atttttacag attgcatgca tacttagaat
     8161 tttaaatttt taaaagattt acaattgagt atggtaccca cagagagtga gtaccaaggg
     8221 aaggaagacc taatacaagt gatgttgcct gataaatcac atcttgccaa aaaaaatata
     8281 ttttagtaaa tacagttctt taggaagaaa aatgttgccc tttcacactc acagtgtaaa
     8341 tacattcata atattccttc aatcatctaa attaccgcca ggtcatgaaa ggacgcgatc
     8401 aatgatgacc tattgcactc acaggtaaca ttgactcaaa ttttggcaat attgctatat
     8461 tatctagata attcttgtga tgtttttatg tcactatcaa cattaaaaat attttgttaa
     8521 acaactatga aactttcaaa agtttgcata taactgtatg ggcactctca tttcactgca
     8581 tacatacaat actttgtata cacatacttc tcgtgtggat attttataat tttatttaat
     8641 ctaacattta acttttaggt ttttgtggta ctcatctgaa aggttggcat ttgttttctt
     8701 tttatgttat atatgtattt tagatgaatc aataatgtgt attcctagaa attttttcta
     8761 ggcataaata gatcatttta tgttggcatt taagagatat catttttgtt ttattgttct
     8821 gtgtaaacca tattcattgt acactgtgtg tatatttttg tttaaataaa tgatttttat
     8881 ttttta
//
