LOCUS       NM_001385335            4272 bp    mRNA    linear   PRI 07-DEC-2024
DEFINITION  Homo sapiens inositol polyphosphate-4-phosphatase type II B
            (INPP4B), transcript variant 5, mRNA.
ACCESSION   NM_001385335
VERSION     NM_001385335.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4272)
  AUTHORS   Saffi,G.T., To,L., Kleine,N., Melo,C.M.P., Chen,K., Genc,G.,
            Lee,K.C.D., Chow,J.T., Jang,G.H., Gallinger,S., Botelho,R.J. and
            Salmena,L.
  TITLE     INPP4B promotes PDAC aggressiveness via PIKfyve and
            TRPML-1-mediated lysosomal exocytosis
  JOURNAL   J Cell Biol 223 (11) (2024)
   PUBMED   39120584
  REMARK    GeneRIF: INPP4B promotes PDAC aggressiveness via PIKfyve and
            TRPML-1-mediated lysosomal exocytosis.
REFERENCE   2  (bases 1 to 4272)
  AUTHORS   Lai,M., Mao,Z., Tang,D., Lan,S., Yan,R., Xiang,Q., Zhao,X., Su,M.
            and Wang,Y.
  TITLE     [Preliminary Study of the Role of INPP4B in Promoting Colorectal
            Cancer Metastasis and the Mechanisms Involved]
  JOURNAL   Sichuan Da Xue Xue Bao Yi Xue Ban 55 (5), 1186-1194 (2024)
   PUBMED   39507966
  REMARK    GeneRIF: [Preliminary Study of the Role of INPP4B in Promoting
            Colorectal Cancer Metastasis and the Mechanisms Involved].
REFERENCE   3  (bases 1 to 4272)
  AUTHORS   Zhao,J., Du,X.M., Si,W., Zhao,X.H. and Zhou,Z.Q.
  TITLE     Role of INPP4B in the proliferation, migration, invasion, and
            survival of human endometrial cancer cells
  JOURNAL   Histol Histopathol 39 (9), 1197-1208 (2024)
   PUBMED   38318760
  REMARK    GeneRIF: Role of INPP4B in the proliferation, migration, invasion,
            and survival of human endometrial cancer cells.
REFERENCE   4  (bases 1 to 4272)
  AUTHORS   Gorji,M., Farsani,M.A., Kargar,M., Garavand,J. and Mohammadi,M.H.
  TITLE     Investigating the multifaceted cooperation of autophagy, PI3K/AKT
            signaling pathways, and INPP4B gene in de novo acute myeloid
            leukemia patients
  JOURNAL   Curr Res Transl Med 72 (2), 103429 (2024)
   PUBMED   38246071
  REMARK    GeneRIF: Investigating the multifaceted cooperation of autophagy,
            PI3K/AKT signaling pathways, and INPP4B gene in de novo acute
            myeloid leukemia patients.
REFERENCE   5  (bases 1 to 4272)
  AUTHORS   Xu,M., Ren,J., Jia,W., Wang,S., Liu,Y., Chen,X., Shi,J. and Wang,H.
  TITLE     Regulation of B-1 cell numbers and B cell-mediated antibody
            production by Inpp4b
  JOURNAL   Scand J Immunol 98 (4), e13309 (2023)
   PUBMED   37389566
  REMARK    GeneRIF: Regulation of B-1 cell numbers and B cell-mediated
            antibody production by Inpp4b.
REFERENCE   6  (bases 1 to 4272)
  AUTHORS   Rampersaud,E., Damcott,C.M., Fu,M., Shen,H., McArdle,P., Shi,X.,
            Shelton,J., Yin,J., Chang,Y.P., Ott,S.H., Zhang,L., Zhao,Y.,
            Mitchell,B.D., O'Connell,J. and Shuldiner,A.R.
  TITLE     Identification of novel candidate genes for type 2 diabetes from a
            genome-wide association scan in the Old Order Amish: evidence for
            replication from diabetes-related quantitative traits and from
            independent populations
  JOURNAL   Diabetes 56 (12), 3053-3062 (2007)
   PUBMED   17846126
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 4272)
  AUTHORS   Munday,A.D., Norris,F.A., Caldwell,K.K., Brown,S., Majerus,P.W. and
            Mitchell,C.A.
  TITLE     The inositol polyphosphate 4-phosphatase forms a complex with
            phosphatidylinositol 3-kinase in human platelet cytosol
  JOURNAL   Proc Natl Acad Sci U S A 96 (7), 3640-3645 (1999)
   PUBMED   10097090
REFERENCE   8  (bases 1 to 4272)
  AUTHORS   Zhang,X. and Majerus,P.W.
  TITLE     Phosphatidylinositol signalling reactions
  JOURNAL   Semin Cell Dev Biol 9 (2), 153-160 (1998)
   PUBMED   9599410
  REMARK    Review article
REFERENCE   9  (bases 1 to 4272)
  AUTHORS   Norris,F.A., Atkins,R.C. and Majerus,P.W.
  TITLE     The cDNA cloning and characterization of inositol polyphosphate
            4-phosphatase type II. Evidence for conserved alternative splicing
            in the 4-phosphatase family
  JOURNAL   J Biol Chem 272 (38), 23859-23864 (1997)
   PUBMED   9295334
REFERENCE   10 (bases 1 to 4272)
  AUTHORS   Norris,F.A., Auethavekiat,V. and Majerus,P.W.
  TITLE     The isolation and characterization of cDNA encoding human and rat
            brain inositol polyphosphate 4-phosphatase
  JOURNAL   J Biol Chem 270 (27), 16128-16133 (1995)
   PUBMED   7608176
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC093885.3, AC139720.1,
            AC108060.3, AC093860.3 and AC108077.3.
            
            Summary: INPP4B encodes the inositol polyphosphate 4-phosphatase
            type II, one of the enzymes involved in phosphatidylinositol
            signaling pathways. This enzyme removes the phosphate group at
            position 4 of the inositol ring from inositol 3,4-bisphosphate.
            There is limited data to suggest that the human type II enzyme is
            subject to alternative splicing, as has been established for the
            type I enzyme. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.186426.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0000350]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-93                AC093885.3         114691-114783       c
            94-157              AC139720.1         7879-7942           c
            158-374             AC108060.3         112687-112903       c
            375-419             AC108060.3         110691-110735       c
            420-538             AC108060.3         86724-86842         c
            539-655             AC108060.3         84456-84572         c
            656-706             AC093860.3         187670-187720       c
            707-786             AC093860.3         178416-178495       c
            787-898             AC093860.3         143621-143732       c
            899-971             AC093860.3         133450-133522       c
            972-1119            AC093860.3         110822-110969       c
            1120-1250           AC093860.3         81854-81984         c
            1251-1355           AC093860.3         81383-81487         c
            1356-1464           AC093860.3         66045-66153         c
            1465-1642           AC093860.3         46590-46767         c
            1643-1846           AC093860.3         33316-33519         c
            1847-2003           AC093860.3         18798-18954         c
            2004-2176           AC108077.3         102529-102701       c
            2177-2300           AC108077.3         101233-101356       c
            2301-2418           AC108077.3         100069-100186       c
            2419-2559           AC108077.3         90483-90623         c
            2560-2657           AC108077.3         86034-86131         c
            2658-2770           AC108077.3         64085-64197         c
            2771-2925           AC108077.3         59972-60126         c
            2926-4272           AC108077.3         6897-8243           c
FEATURES             Location/Qualifiers
     source          1..4272
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q31.21"
     gene            1..4272
                     /gene="INPP4B"
                     /note="inositol polyphosphate-4-phosphatase type II B"
                     /db_xref="GeneID:8821"
                     /db_xref="HGNC:HGNC:6075"
                     /db_xref="MIM:607494"
     exon            1..93
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     exon            94..157
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     exon            158..374
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     CDS             284..3100
                     /gene="INPP4B"
                     /EC_number="3.1.3.66"
                     /note="isoform 2 is encoded by transcript variant 5;
                     inositol polyphosphate 4-phosphatase II; 4-phosphatase II;
                     type II inositol 3,4-bisphosphate 4-phosphatase; inositol
                     polyphosphate-4-phosphatase, type II, 105kDa"
                     /codon_start=1
                     /product="inositol polyphosphate 4-phosphatase type II
                     isoform 2"
                     /protein_id="NP_001372264.1"
                     /db_xref="CCDS:CCDS82958.1"
                     /db_xref="GeneID:8821"
                     /db_xref="HGNC:HGNC:6075"
                     /db_xref="MIM:607494"
                     /translation="MEIKEEGASEEGQHFLPTAQANDPGDCQFTSIQKTPNEPQLEFI
                     LACKDLVAPVRDRKLNTLVQISVIHPVEQSLTRYSSTEIVEGTRDPLFLTGVTFPSEY
                     PIYEETKIKLTVYDVKDKSHDTVRTSVLPEHKDPPPEVGRSFLGYASFKVGELLKSKE
                     QLLVLSLRTSDGGKVVGTIEVSVVKMGEIEDGEADHITTDVQGQKCALVCECTAPESV
                     SGKDNLPFLNSVLKNPVCKLYRFPTSDNKWMRIREQMSESILSFHIPKELISLHIKED
                     LCRNQEIKELGELSPHWDNLRKNVLTHCDQMVNMYQDILTELSKETGSSFKSSSSKGE
                     KTLEFVPINLHLQRMQVHSPHLKDALYDVITVGAPAAHFQGFKNGGLRKLLHRFETER
                     RNTGYQFIYYSPENTAKAKEVLSNINQLQPLIATHADLLLNSASQHSPDSLKNSLKML
                     SEKTELFVHAFKDQLVRSALLALYTARPGGILKKPPSPKSSTEESSPQDQPPVMRGQD
                     SIPHHSDYDEEEWDRVWANVGKSLNCIIAMVDKLIERDGGSEGSGGNNDGEKEPSLTD
                     AIPSHPREDWYEQLYPLILTLKDCMGEVVNRAKQSLTFVLLQELAYSLPQCLMLTLRR
                     DIVFSQALAGLVCGFIIKLQTSLYDPGFLQQLHTVGLIVQYEGLLSTYSDEIGMLEDM
                     AVGISDLKKVAFKIIEAKSNDVLPVITGRREHYVVEVKLPARMFESLPLQIKEGQLLH
                     VYPVLFNVGINEQQTLAERFGDVSLQESINQENFELLQEYYKIFMEKMPPDYISHFQE
                     QNDLKALLENLLQNIQSKKRKNVEIMWLAATICRKLNGIRFTCCKSAKDRTSMSVTLE
                     QCSILRDEHQLHKDFFIRALDCMRSRQTQGALNESDDPETGCLTDNKPTSRHFYPVAL
                     LLVSSHLLVVWLILSLALLLAKYQ"
     exon            375..419
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     exon            420..538
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     exon            539..655
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     exon            656..706
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     exon            707..786
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     exon            787..898
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     exon            899..971
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     exon            972..1119
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     exon            1120..1250
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     exon            1251..1355
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     exon            1356..1464
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     exon            1465..1642
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     exon            1643..1846
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     exon            1847..2003
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     exon            2004..2176
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     exon            2177..2300
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     exon            2301..2418
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     exon            2419..2559
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     exon            2560..2657
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     exon            2658..2770
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     exon            2771..2925
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     exon            2926..4272
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4254..4259
                     /regulatory_class="polyA_signal_sequence"
                     /gene="INPP4B"
                     /note="hexamer: AATAAA"
     polyA_site      4272
                     /gene="INPP4B"
                     /note="major polyA site"
ORIGIN      
        1 gcgcacacgc tcacacgctc gcaagcgaac gcaggaaagt caggctaaaa gtgtctgctg
       61 ctgctgccgc cccccactcc gcctccggga gagagccttg aaaccagcga aacaataatc
      121 aaagagcagt tctgtcaaag aaaacaacat aaatcaggta cagaatttca gagtgggata
      181 tcagatcttt agtgtgaaga tacatctaca ttaaaccagg aatcactaga actgacattt
      241 ggacaagaaa atttggaaaa ttttaaaact gtgaaggttg atcatggaaa ttaaagagga
      301 aggggcatca gaagaagggc agcactttct tcctacagcc caggccaatg atcccgggga
      361 ctgtcagttc acaagtatcc agaagactcc aaatgaaccg cagttggaat tcatccttgc
      421 atgcaaggat ctcgtggctc ctgtccgtga tcgtaaactg aatacactgg tgcagatctc
      481 cgtaatccac cccgtggagc agagtctgac aagatactcc agcaccgaaa ttgtggaggg
      541 aacaagggac ccactgtttt tgactggtgt cacattccca tctgagtatc ccatctatga
      601 ggagaccaaa ataaaactaa cagtctatga tgtcaaggat aagtctcatg acaccgttcg
      661 aaccagtgtc ctaccagaac ataaggatcc cccgccagaa gttgggcgaa gtttcttggg
      721 ctatgccagt tttaaagtgg gagagctgct gaagtcaaag gagcaattgc tggtcctgag
      781 cctgagaact tcagatggtg gcaaagtggt tggcaccata gaagtcagtg tcgtgaagat
      841 gggggagatt gaggatgggg aagccgacca catcaccaca gatgtacagg gacaaaagtg
      901 tgccctggta tgtgaatgta cagccccgga aagtgtgagc ggaaaagata acttaccttt
      961 tttgaattca gtgttaaaga acccagtatg taaattatat agatttccca catctgacaa
     1021 taagtggatg cgaattcgag agcagatgtc agagagcatt ctttcctttc atattcctaa
     1081 ggaattgatt tcccttcaca ttaaagaaga tttgtgcaga aaccaggaga taaaagaact
     1141 tggtgagctt tctccacatt gggacaatct gcgaaaaaat gtccttactc actgtgatca
     1201 aatggtgaat atgtaccaag acattctgac agaacttagc aaggaaacag ggtcctcttt
     1261 caaatcaagc agcagcaaag gagagaaaac attagaattt gttccaataa atctacatct
     1321 gcaaagaatg caggtacaca gccctcactt gaaagatgct ctctacgatg tcatcactgt
     1381 gggagcccca gctgcccatt ttcagggatt taagaatggt ggtcttcgga agctactcca
     1441 tagatttgaa acagaaagaa gaaataccgg ataccagttt atttactatt cacctgaaaa
     1501 cacagccaaa gcaaaggaag ttctcagcaa catcaatcaa ctacaacctc ttatagcaac
     1561 ccatgcagac ctactgctta attctgcaag ccagcattct ccagacagct tgaagaattc
     1621 tttaaagatg ctttcagaaa aaacagagct ttttgtacat gccttcaagg atcaacttgt
     1681 caggagtgct cttttagcac tctacactgc aaggccagga ggcattctta agaagccacc
     1741 ctctcctaag agcagcacag aggagagcag tccccaagac caacccccag tgatgagagg
     1801 gcaggactcc ataccacatc attcagacta tgatgaggaa gagtgggaca gggtgtgggc
     1861 caatgtgggg aagagcctga actgcattat tgctatggtg gacaaactga ttgaaagaga
     1921 tggtggcagt gaaggcagtg gcggcaacaa tgatggagaa aaggaacctt cattaacaga
     1981 tgccattccc tctcacccaa gagaggactg gtatgaacag ttgtatcccc tcatccttac
     2041 cctgaaggac tgcatgggag aagtggtgaa ccgagccaag cagtccctga catttgtgct
     2101 ccttcaggaa cttgcgtaca gcttgcccca gtgtctgatg ctgacgctaa gaagagacat
     2161 cgtcttcagc caagcacttg ctggattggt ttgtggtttt atcatcaaat tacagacaag
     2221 tctgtatgac ccaggcttcc tacagcagct tcacacagtg gggttgatag tacaatatga
     2281 aggactgcta agtacataca gcgatgaaat tggaatgcta gaggacatgg ccgttggcat
     2341 ttccgattta aagaaagttg catttaaaat aattgaagcc aaatccaatg atgtgttgcc
     2401 agttataaca ggaagacgag aacattacgt ggtagaggtc aagcttccag ccagaatgtt
     2461 tgagtcacta cctctacaga ttaaagaagg acagttgctt catgtgtatc cagtactttt
     2521 taatgttgga atcaatgaac agcaaactct ggctgaaagg tttggagatg tctctttgca
     2581 agaaagtatt aatcaggaaa acttcgaact tctacaagaa tattacaaga tatttatgga
     2641 aaagatgcct cctgattata tttcacattt tcaggaacaa aatgatttaa aagcattgct
     2701 agaaaatctc cttcaaaata tccaatccaa aaaaagaaag aatgtagaaa ttatgtggct
     2761 ggctgcaacg atttgccgca aactgaatgg tattcgtttc acctgttgta aaagtgccaa
     2821 agacaggaca tcgatgtcag tgacacttga acaatgctca atcttgagag atgagcacca
     2881 gttacacaag gacttcttta tccgagcgct ggattgcatg agaagcagac aaacccaggg
     2941 agcactgaat gaatccgatg atcctgaaac aggctgtcta actgataaca agccaacttc
     3001 tcgacacttc tatcctgtcg ccttgctgct tgtcagctca cacctgctag ttgtgtggct
     3061 tattttaagt ctggcgttac tcttagccaa ataccaataa gttttatgtt gtattccttt
     3121 ttcttttcta caaatgacaa tgaactttaa attatgggga caatgctgta atatttttac
     3181 attttcaaat tcacagaatt taaaaaatgt taaattgtgt ttagtttgtt tttcctaaaa
     3241 tctaaaaaac aaaaagtact atgcattagg tggattattt tgctcttttg ttcatggaaa
     3301 ggtgtttccc actgttaact agctcaagaa gaatttttaa attactgtct ttggaataag
     3361 acaaagaaca gaatcctgaa agcttgaagt tctgaacctc ctgtcctcat cccactaaat
     3421 ttattaaaga aattaagact gaaatttgca caaacactga aaccctgaga caagttctag
     3481 agatgtggga ggttgcagac tttatttcca ctgtgctaat atcatagatg ccatctgctg
     3541 atagaaattt tttttaacct gttttacttc tttgctgcaa ttaactcttt tctgtcaagt
     3601 aactttatgg agagaatggc tatttatgtt ttgtaattaa attacctgtt tgtatctctt
     3661 gtttgggttg atttggcttt cagaggactt ttctattctt tttaacaagg tcttgtttgt
     3721 gtcttgatgt accattccca gcacttgtga cttttgtact gtccgtggac aagcactctt
     3781 cctttataaa gctgagactt ggcccaggct gttcagaaag ccattttctc tcttccttgc
     3841 acagctaaaa taataaaata gagatgaaat ttttctttaa aaatctatag ggccagactt
     3901 aataaattaa atgccttatt tctagaacct gcatccttag ggctacatat agattttaat
     3961 gtgttttaaa gagactgaga aattaatttg tggaaatgtt ataaaaaggc agatatattt
     4021 atgaaactaa agtggagctg tattgtggag caaattatat ttaaagagtt tattaaattt
     4081 taaatgttaa gagtaaagag acttaagtca tctctttcag agggcaataa tggtattggg
     4141 cctggcctag gatttaattt tgtaagatgt atcatcactt gtggaaaaaa aaaatgtaga
     4201 gttgaatctt tgttattttt acttggatgg ttgctgcaac tctgcattaa acaaataaag
     4261 catatttatt ta
//
