LOCUS       NM_001101669            8743 bp    mRNA    linear   PRI 07-DEC-2024
DEFINITION  Homo sapiens inositol polyphosphate-4-phosphatase type II B
            (INPP4B), transcript variant 2, mRNA.
ACCESSION   NM_001101669
VERSION     NM_001101669.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8743)
  AUTHORS   Saffi,G.T., To,L., Kleine,N., Melo,C.M.P., Chen,K., Genc,G.,
            Lee,K.C.D., Chow,J.T., Jang,G.H., Gallinger,S., Botelho,R.J. and
            Salmena,L.
  TITLE     INPP4B promotes PDAC aggressiveness via PIKfyve and
            TRPML-1-mediated lysosomal exocytosis
  JOURNAL   J Cell Biol 223 (11) (2024)
   PUBMED   39120584
  REMARK    GeneRIF: INPP4B promotes PDAC aggressiveness via PIKfyve and
            TRPML-1-mediated lysosomal exocytosis.
REFERENCE   2  (bases 1 to 8743)
  AUTHORS   Lai,M., Mao,Z., Tang,D., Lan,S., Yan,R., Xiang,Q., Zhao,X., Su,M.
            and Wang,Y.
  TITLE     [Preliminary Study of the Role of INPP4B in Promoting Colorectal
            Cancer Metastasis and the Mechanisms Involved]
  JOURNAL   Sichuan Da Xue Xue Bao Yi Xue Ban 55 (5), 1186-1194 (2024)
   PUBMED   39507966
  REMARK    GeneRIF: [Preliminary Study of the Role of INPP4B in Promoting
            Colorectal Cancer Metastasis and the Mechanisms Involved].
REFERENCE   3  (bases 1 to 8743)
  AUTHORS   Zhao,J., Du,X.M., Si,W., Zhao,X.H. and Zhou,Z.Q.
  TITLE     Role of INPP4B in the proliferation, migration, invasion, and
            survival of human endometrial cancer cells
  JOURNAL   Histol Histopathol 39 (9), 1197-1208 (2024)
   PUBMED   38318760
  REMARK    GeneRIF: Role of INPP4B in the proliferation, migration, invasion,
            and survival of human endometrial cancer cells.
REFERENCE   4  (bases 1 to 8743)
  AUTHORS   Gorji,M., Farsani,M.A., Kargar,M., Garavand,J. and Mohammadi,M.H.
  TITLE     Investigating the multifaceted cooperation of autophagy, PI3K/AKT
            signaling pathways, and INPP4B gene in de novo acute myeloid
            leukemia patients
  JOURNAL   Curr Res Transl Med 72 (2), 103429 (2024)
   PUBMED   38246071
  REMARK    GeneRIF: Investigating the multifaceted cooperation of autophagy,
            PI3K/AKT signaling pathways, and INPP4B gene in de novo acute
            myeloid leukemia patients.
REFERENCE   5  (bases 1 to 8743)
  AUTHORS   Xu,M., Ren,J., Jia,W., Wang,S., Liu,Y., Chen,X., Shi,J. and Wang,H.
  TITLE     Regulation of B-1 cell numbers and B cell-mediated antibody
            production by Inpp4b
  JOURNAL   Scand J Immunol 98 (4), e13309 (2023)
   PUBMED   37389566
  REMARK    GeneRIF: Regulation of B-1 cell numbers and B cell-mediated
            antibody production by Inpp4b.
REFERENCE   6  (bases 1 to 8743)
  AUTHORS   Rampersaud,E., Damcott,C.M., Fu,M., Shen,H., McArdle,P., Shi,X.,
            Shelton,J., Yin,J., Chang,Y.P., Ott,S.H., Zhang,L., Zhao,Y.,
            Mitchell,B.D., O'Connell,J. and Shuldiner,A.R.
  TITLE     Identification of novel candidate genes for type 2 diabetes from a
            genome-wide association scan in the Old Order Amish: evidence for
            replication from diabetes-related quantitative traits and from
            independent populations
  JOURNAL   Diabetes 56 (12), 3053-3062 (2007)
   PUBMED   17846126
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 8743)
  AUTHORS   Munday,A.D., Norris,F.A., Caldwell,K.K., Brown,S., Majerus,P.W. and
            Mitchell,C.A.
  TITLE     The inositol polyphosphate 4-phosphatase forms a complex with
            phosphatidylinositol 3-kinase in human platelet cytosol
  JOURNAL   Proc Natl Acad Sci U S A 96 (7), 3640-3645 (1999)
   PUBMED   10097090
REFERENCE   8  (bases 1 to 8743)
  AUTHORS   Zhang,X. and Majerus,P.W.
  TITLE     Phosphatidylinositol signalling reactions
  JOURNAL   Semin Cell Dev Biol 9 (2), 153-160 (1998)
   PUBMED   9599410
  REMARK    Review article
REFERENCE   9  (bases 1 to 8743)
  AUTHORS   Norris,F.A., Atkins,R.C. and Majerus,P.W.
  TITLE     The cDNA cloning and characterization of inositol polyphosphate
            4-phosphatase type II. Evidence for conserved alternative splicing
            in the 4-phosphatase family
  JOURNAL   J Biol Chem 272 (38), 23859-23864 (1997)
   PUBMED   9295334
REFERENCE   10 (bases 1 to 8743)
  AUTHORS   Norris,F.A., Auethavekiat,V. and Majerus,P.W.
  TITLE     The isolation and characterization of cDNA encoding human and rat
            brain inositol polyphosphate 4-phosphatase
  JOURNAL   J Biol Chem 270 (27), 16128-16133 (1995)
   PUBMED   7608176
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA695719.1, BP360389.1,
            BC072447.1, BX649090.1, BC017924.2, AC108077.3 and AI198719.1.
            
            On Nov 30, 2019 this sequence version replaced NM_001101669.2.
            
            Summary: INPP4B encodes the inositol polyphosphate 4-phosphatase
            type II, one of the enzymes involved in phosphatidylinositol
            signaling pathways. This enzyme removes the phosphate group at
            position 4 of the inositol ring from inositol 3,4-bisphosphate.
            There is limited data to suggest that the human type II enzyme is
            subject to alternative splicing, as has been established for the
            type I enzyme. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1 and 2 encode the same isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14372080.4553427.1,
                                           SRR1660803.98851.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000262992.9/ ENSP00000262992.4
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-11                DA695719.1         235-245
            12-432              BP360389.1         162-582
            433-2798            BC072447.1         490-2855
            2799-3737           BX649090.1         2889-3827
            3738-3863           BC017924.2         1374-1499
            3864-3875           BX649090.1         3954-3965
            3876-8508           AC108077.3         1336-5968           c
            8509-8743           AI198719.1         8-242               c
FEATURES             Location/Qualifiers
     source          1..8743
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q31.21"
     gene            1..8743
                     /gene="INPP4B"
                     /note="inositol polyphosphate-4-phosphatase type II B"
                     /db_xref="GeneID:8821"
                     /db_xref="HGNC:HGNC:6075"
                     /db_xref="MIM:607494"
     exon            1..93
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     exon            94..156
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     exon            157..220
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     exon            221..437
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     CDS             347..3121
                     /gene="INPP4B"
                     /EC_number="3.1.3.66"
                     /note="isoform 1 is encoded by transcript variant 2;
                     inositol polyphosphate 4-phosphatase II; 4-phosphatase II;
                     type II inositol 3,4-bisphosphate 4-phosphatase; inositol
                     polyphosphate-4-phosphatase, type II, 105kDa"
                     /codon_start=1
                     /product="inositol polyphosphate 4-phosphatase type II
                     isoform 1"
                     /protein_id="NP_001095139.1"
                     /db_xref="CCDS:CCDS3757.1"
                     /db_xref="GeneID:8821"
                     /db_xref="HGNC:HGNC:6075"
                     /db_xref="MIM:607494"
                     /translation="MEIKEEGASEEGQHFLPTAQANDPGDCQFTSIQKTPNEPQLEFI
                     LACKDLVAPVRDRKLNTLVQISVIHPVEQSLTRYSSTEIVEGTRDPLFLTGVTFPSEY
                     PIYEETKIKLTVYDVKDKSHDTVRTSVLPEHKDPPPEVGRSFLGYASFKVGELLKSKE
                     QLLVLSLRTSDGGKVVGTIEVSVVKMGEIEDGEADHITTDVQGQKCALVCECTAPESV
                     SGKDNLPFLNSVLKNPVCKLYRFPTSDNKWMRIREQMSESILSFHIPKELISLHIKED
                     LCRNQEIKELGELSPHWDNLRKNVLTHCDQMVNMYQDILTELSKETGSSFKSSSSKGE
                     KTLEFVPINLHLQRMQVHSPHLKDALYDVITVGAPAAHFQGFKNGGLRKLLHRFETER
                     RNTGYQFIYYSPENTAKAKEVLSNINQLQPLIATHADLLLNSASQHSPDSLKNSLKML
                     SEKTELFVHAFKDQLVRSALLALYTARPGGILKKPPSPKSSTEESSPQDQPPVMRGQD
                     SIPHHSDYDEEEWDRVWANVGKSLNCIIAMVDKLIERDGGSEGSGGNNDGEKEPSLTD
                     AIPSHPREDWYEQLYPLILTLKDCMGEVVNRAKQSLTFVLLQELAYSLPQCLMLTLRR
                     DIVFSQALAGLVCGFIIKLQTSLYDPGFLQQLHTVGLIVQYEGLLSTYSDEIGMLEDM
                     AVGISDLKKVAFKIIEAKSNDVLPVITGRREHYVVEVKLPARMFESLPLQIKEGQLLH
                     VYPVLFNVGINEQQTLAERFGDVSLQESINQENFELLQEYYKIFMEKMPPDYISHFQE
                     QNDLKALLENLLQNIQSKKRKNVEIMWLAATICRKLNGIRFTCCKSAKDRTSMSVTLE
                     QCSILRDEHQLHKDFFIRALDCMRREGCRIENVLKNIKCRKYAFNMLQLMAFPKYYRP
                     PEGTYGKADT"
     exon            438..482
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     exon            483..601
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     exon            602..718
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     exon            719..769
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     exon            770..849
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     exon            850..961
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     exon            962..1034
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     exon            1035..1182
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     exon            1183..1313
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     exon            1314..1418
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     exon            1419..1527
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     exon            1528..1705
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     exon            1706..1909
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     exon            1910..2066
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     exon            2067..2239
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     exon            2240..2363
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     exon            2364..2481
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     exon            2482..2622
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     exon            2623..2720
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     exon            2721..2833
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     exon            2834..2988
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     exon            2989..8743
                     /gene="INPP4B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3137..3142
                     /regulatory_class="polyA_signal_sequence"
                     /gene="INPP4B"
                     /note="hexamer: AATAAA"
     regulatory      3153..3158
                     /regulatory_class="polyA_signal_sequence"
                     /gene="INPP4B"
                     /note="hexamer: AATACA"
     polyA_site      3163
                     /gene="INPP4B"
     polyA_site      3178
                     /gene="INPP4B"
                     /note="major polyA site"
     regulatory      8722..8727
                     /regulatory_class="polyA_signal_sequence"
                     /gene="INPP4B"
                     /note="hexamer: AATAAA"
     polyA_site      8743
                     /gene="INPP4B"
ORIGIN      
        1 gcgcacacgc tcacacgctc gcaagcgaac gcaggaaagt caggctaaaa gtgtctgctg
       61 ctgctgccgc cccccactcc gcctccggga gagaatacaa agaaatggtg ttacctggca
      121 agaggtcttc tgtcttttat gaaaaattag acaaagagcc ttgaaaccag cgaaacaata
      181 atcaaagagc agttctgtca aagaaaacaa cataaatcag gtacagaatt tcagagtggg
      241 atatcagatc tttagtgtga agatacatct acattaaacc aggaatcact agaactgaca
      301 tttggacaag aaaatttgga aaattttaaa actgtgaagg ttgatcatgg aaattaaaga
      361 ggaaggggca tcagaagaag ggcagcactt tcttcctaca gcccaggcca atgatcccgg
      421 ggactgtcag ttcacaagta tccagaagac tccaaatgaa ccgcagttgg aattcatcct
      481 tgcatgcaag gatctcgtgg ctcctgtccg tgatcgtaaa ctgaatacac tggtgcagat
      541 ctccgtaatc caccccgtgg agcagagtct gacaagatac tccagcaccg aaattgtgga
      601 gggaacaagg gacccactgt ttttgactgg tgtcacattc ccatctgagt atcccatcta
      661 tgaggagacc aaaataaaac taacagtcta tgatgtcaag gataagtctc atgacaccgt
      721 tcgaaccagt gtcctaccag aacataagga tcccccgcca gaagttgggc gaagtttctt
      781 gggctatgcc agttttaaag tgggagagct gctgaagtca aaggagcaat tgctggtcct
      841 gagcctgaga acttcagatg gtggcaaagt ggttggcacc atagaagtca gtgtcgtgaa
      901 gatgggggag attgaggatg gggaagccga ccacatcacc acagatgtac agggacaaaa
      961 gtgtgccctg gtatgtgaat gtacagcccc ggaaagtgtg agcggaaaag ataacttacc
     1021 ttttttgaat tcagtgttaa agaacccagt atgtaaatta tatagatttc ccacatctga
     1081 caataagtgg atgcgaattc gagagcagat gtcagagagc attctttcct ttcatattcc
     1141 taaggaattg atttcccttc acattaaaga agatttgtgc agaaaccagg agataaaaga
     1201 acttggtgag ctttctccac attgggacaa tctgcgaaaa aatgtcctta ctcactgtga
     1261 tcaaatggtg aatatgtacc aagacattct gacagaactt agcaaggaaa cagggtcctc
     1321 tttcaaatca agcagcagca aaggagagaa aacattagaa tttgttccaa taaatctaca
     1381 tctgcaaaga atgcaggtac acagccctca cttgaaagat gctctctacg atgtcatcac
     1441 tgtgggagcc ccagctgccc attttcaggg atttaagaat ggtggtcttc ggaagctact
     1501 ccatagattt gaaacagaaa gaagaaatac cggataccag tttatttact attcacctga
     1561 aaacacagcc aaagcaaagg aagttctcag caacatcaat caactacaac ctcttatagc
     1621 aacccatgca gacctactgc ttaattctgc aagccagcat tctccagaca gcttgaagaa
     1681 ttctttaaag atgctttcag aaaaaacaga gctttttgta catgccttca aggatcaact
     1741 tgtcaggagt gctcttttag cactctacac tgcaaggcca ggaggcattc ttaagaagcc
     1801 accctctcct aagagcagca cagaggagag cagtccccaa gaccaacccc cagtgatgag
     1861 agggcaggac tccataccac atcattcaga ctatgatgag gaagagtggg acagggtgtg
     1921 ggccaatgtg gggaagagcc tgaactgcat tattgctatg gtggacaaac tgattgaaag
     1981 agatggtggc agtgaaggca gtggcggcaa caatgatgga gaaaaggaac cttcattaac
     2041 agatgccatt ccctctcacc caagagagga ctggtatgaa cagttgtatc ccctcatcct
     2101 taccctgaag gactgcatgg gagaagtggt gaaccgagcc aagcagtccc tgacatttgt
     2161 gctccttcag gaacttgcgt acagcttgcc ccagtgtctg atgctgacgc taagaagaga
     2221 catcgtcttc agccaagcac ttgctggatt ggtttgtggt tttatcatca aattacagac
     2281 aagtctgtat gacccaggct tcctacagca gcttcacaca gtggggttga tagtacaata
     2341 tgaaggactg ctaagtacat acagcgatga aattggaatg ctagaggaca tggccgttgg
     2401 catttccgat ttaaagaaag ttgcatttaa aataattgaa gccaaatcca atgatgtgtt
     2461 gccagttata acaggaagac gagaacatta cgtggtagag gtcaagcttc cagccagaat
     2521 gtttgagtca ctacctctac agattaaaga aggacagttg cttcatgtgt atccagtact
     2581 ttttaatgtt ggaatcaatg aacagcaaac tctggctgaa aggtttggag atgtctcttt
     2641 gcaagaaagt attaatcagg aaaacttcga acttctacaa gaatattaca agatatttat
     2701 ggaaaagatg cctcctgatt atatttcaca ttttcaggaa caaaatgatt taaaagcatt
     2761 gctagaaaat ctccttcaaa atatccaatc caaaaaaaga aagaatgtag aaattatgtg
     2821 gctggctgca acgatttgcc gcaaactgaa tggtattcgt ttcacctgtt gtaaaagtgc
     2881 caaagacagg acatcgatgt cagtgacact tgaacaatgc tcaatcttga gagatgagca
     2941 ccagttacac aaggacttct ttatccgagc gctggattgc atgagaagag aaggatgccg
     3001 catagagaat gtactgaaga atatcaaatg cagaaagtat gctttcaaca tgctacagct
     3061 gatggctttc cccaagtact acagacctcc agaggggact tatggaaaag ctgacaccta
     3121 agtttaccaa catgttaata aacaggaaca caaatacatt tcagttggat aatcttcacc
     3181 ttggtctttt ttgtttgttt ttattgtcat gaatttgtgg tgggggagat gatcacagat
     3241 gtttcccaaa atctaggaac tacttcaatt catcatcagc atattgctct gaaagaaatc
     3301 cattttaaaa aatcttacat gattcagtac tgtcatttct agttctaagc ttctatgtgt
     3361 tgagcctagc tgattgagat tggttcacaa agtgtaaatt tcattcatga gtatttaaat
     3421 gtttctgagg aaacatggat catttcaata ggactagggg tgattcacag agcaccactc
     3481 tccaaccaaa tggaagagag gagaggggga aaaggaacat attttttttg tgatacaact
     3541 taatagccta tgagaacaca gtcaacctga gaatcaatgt aagggattta aaaaaaatgt
     3601 gtagccactc aattaggtag agttaactca tgatctggaa tactgaggca gtttgcaggt
     3661 atgttccaca atgatctcta tcatccagtc aaggtgtgac tcctcccttg caacaggcat
     3721 atgcatggag tgagtaaagt ggtcaacaga cctttcaaaa ccatggcatc ttttcagaac
     3781 tctgacttgg gttgtgtgat ctagctgtga atgtagcaat atagaacgtt taatagaatg
     3841 ataagcaaaa cactgcaatg atctaaaatt acaaataaaa taaaaatgaa caacattttg
     3901 atacccaaaa tgaaaattcc catcagcctg aactttatgt tgtgaagttc atgaatgtca
     3961 gtgaggtatc tctgagatgt ttcttagcag tcatcctggt gtaagcatgc agttatggca
     4021 taggtttgtg tgtgttaata agcctttaaa acatatgcaa ccacaacaaa tgataaagta
     4081 aaacaattat tttctgttgc cctgaatatc aaacttgccc ttgcccttac tcagcaaaat
     4141 aacatttata agttttccaa aatcccaaag tagaagtttc cttaaaaaaa tcatcttgta
     4201 taataccagt attcaaacat gggtaaggtt aatcaccccc aatcactcag gagatagttg
     4261 cagaatttga attacaatct cttcttactt tcctagcctg tggcttgtca cttctccaaa
     4321 ttgccatgct aaatatgcat gaaaattgag ggagaatgct agttaaaaag aaattaggat
     4381 ttatcactgg aattgaaact aagagtacaa aagtctgaac gaatgaaact tttctccaaa
     4441 ttttacaaat tcttgttcct ttctcattag aagagcatgc tatccaaagc ataaatctcc
     4501 cttgaaaata acagaggctt cttaagccct ctcttagcta tgatcaatgg atgatattat
     4561 gcttcccata gctaatgtga tagctccttg cctaggattc ctgttgaaat aaggattcta
     4621 gccccatgtt aagtttttca aattactaca aattttagat aagcatttgg agctttttat
     4681 actagaatta tcaatttttt attttagcta attacctgtg ggcattatac ttgaggcagg
     4741 taccaaacta cttacagcct ttttaatgaa aatgtgctgt gtactttgaa tccattcata
     4801 gacaaaatta ccttgatgtt ctcttaactc attctttatt ttagtgatta aatacaacct
     4861 ttgagttgtt caatatcatt tgaaaatggt aggatttgtg gttattttca ttaccctatt
     4921 agatttaaga taggctggga tgacagaggc ctccttgaat agctatgaag cctcattcag
     4981 catatcaaat ggtagtctga gttctaagaa accttaagta atttatcatt ctgtaaatac
     5041 tcttataagc aataattttt atttgtattt ttgaaaacaa actacttaaa tatggaaaaa
     5101 tattaactgg aaagccagca gtagggtttt ctatttttaa aagacatttc aaggatttcc
     5161 tgtaatccca gcactttggg agccaaggtg gatagatcac ctgaggtcag gaattggaga
     5221 tcagcctggc caacatggtg aaaccccatc tctactaaag atacaaaaat tagctggatg
     5281 tggtggcaca cacgtgtaat cccagctact tgggaggctg aggcaagaga atcgcttgaa
     5341 ccccggaggc ggaggttgca gtgagctgag atcatgccat tgcactccag cctgggtgaa
     5401 aagagcgaaa ctccatcttt aaataagtaa ataaatgaat aatatagaag tctcaaatta
     5461 tagtgcttac tgtaatacaa atgcttatga attttcattc attaccatag tcatctgcat
     5521 ttccttatag aaagcctgta ctggtgcaaa cttctaaaag tggatttcat caagaaaatg
     5581 tgtttcatag agacaacaat attgcttttt tcctgagagg cagttcattc ttaaacaacc
     5641 acttcactat ttcttaagtt attaaggcta aatcaaagag caaatgttaa agtgtttaaa
     5701 tctctcttga acaaacacag ccacagtcat gctattctat ctatattttc acttaaaaga
     5761 tacaccagca gacctatttt aggaggtcat attgagccaa aaaatgaact gagcaaatga
     5821 catttccaaa ctcttttttt gctcaaaaat aatatgttcc cctttgatat taaatgcaga
     5881 tatcaattct ggattagcta tttactgagc cctaggaaaa acatatttaa agacaaggaa
     5941 accattcatt tacatctcat atcattgctt tttgctttta aatatcgcct tgaggtttgt
     6001 ctacactctg ccaaaacaat ccctgaacat aagtttggtc agcctcataa ttcagtgagt
     6061 cgagcaacca tttgttccaa gtgataaatt gtactaaatg acaaactgcc caatcagggc
     6121 agagctccat ggacccagcc tccagccctt attttataag actaacccct cttctgaaaa
     6181 actctgaagg cttaaaagct agcatttgga tggaggatac ttccttttta tccttcagct
     6241 atgtatggca ctttacataa aataagaggt aaaaaaggag agaaactgat gtgtataaag
     6301 taatgccttt cttcccaagc aaatcaaacc tctccctatg taaaagttga tagtgtacca
     6361 agagacacaa taccactggt gggctggaac tagctcgttc tgatgcataa aagttgataa
     6421 ttaaagtacc agaaattttg taagctagtt gttaaacatt accattatta aatatgaaat
     6481 tataaaacac agtggaatac attaaaaacc aatgtaataa tcaaaacata ccacttccca
     6541 attattttac taccttatac tatttattag tactcttgag tctatttagg tctattacat
     6601 ctttacagtg aaaacaggat acaatattgt gctactgtgg gtctcttcct gactgcagat
     6661 tcagtaacat ggtgttcgta gcttgaaact gtccacagtg ggagtattta acaccataga
     6721 aactggctgg caaatgctac aaactagcaa ttttaattcc tggaaaggca attgttgagc
     6781 atttaccagc acacaatgaa tgccatattc tttttttttt attaggaaat aaattattgg
     6841 aggcagtata aaattattta aaaagtatca aatgcaatcc cttatcttca gatggctata
     6901 attttggtta tataaatgtt ttggttttta ccttctttaa agactcctat taggttaaaa
     6961 gtcatatttg atgactatat tttattcata attaaattat taaatcacct tttctcctga
     7021 taatgctttg ccagagaatt cttagcaatt caactgtagt ctaagcaata actcagggct
     7081 aaattcaggg aactgttagc ccaatcagat atcactaaaa atgtacttca ccatctattt
     7141 tggagtttat aattttggca tttgctaaaa gtaggaaaaa cagtaacata ttactgtgcc
     7201 cagattctaa taaatatagc tcaattgaaa ccaaaactgt tacattaaac aaattacact
     7261 ctggcactat gctaaatcac cacagatgtt ttaggtgttt gatttccaag caggatggta
     7321 tatcatttgt ttggttcaat atatgaggca ccatttgtag tcttttagga aataaattag
     7381 cttttatcac agatttagga aacttgtcta aaaaaactgt gatcatcagt tacagaggga
     7441 aggaaacata ttgaacacaa ggcatcatag tagctggagg ccttaaaaat tatgcacgac
     7501 caaaaagaat gatttggtga gagatgtgta gctgattgac aattttagtg tgaattcata
     7561 ttcatttaac ccagcagcaa tctacataag ctatgctttt tcccacctgt atttatgttt
     7621 cttagcttat aaagtcccaa tatattatat cttttgttgc tttggcagtt ttaatttaga
     7681 gctctgcgtt cacagagatg ccacctatag caaaaactat ctttaagaat tggaaaataa
     7741 aatgaatgtt ttagataaaa tattgcaagc cattatgtgt agagttaatg tatggaaatt
     7801 tgcatttgtt tttctgaatc atggtgtaca ttaatcactc attgaattct atttctaagc
     7861 aaataagaga atcaaacatt tctaaaagga acatatgtct tgctattaat aacaaggaga
     7921 caggaaaaat agtaaggtaa tataagcaaa aaaaaaaatg taatgaattt agctatccta
     7981 aattggaatt tttacagatt gcatgcatac ttagaatttt aaatttttaa aagatttaca
     8041 attgagtatg gtacccacag agagtgagta ccaagggaag gaagacctaa tacaagtgat
     8101 gttgcctgat aaatcacatc ttgccaaaaa aaatatattt tagtaaatac agttctttag
     8161 gaagaaaaat gttgcccttt cacactcaca gtgtaaatac attcataata ttccttcaat
     8221 catctaaatt accgccaggt catgaaagga cgcgatcaat gatgacctat tgcactcaca
     8281 ggtaacattg actcaaattt tggcaatatt gctatattat ctagataatt cttgtgatgt
     8341 ttttatgtca ctatcaacat taaaaatatt ttgttaaaca actatgaaac tttcaaaagt
     8401 ttgcatataa ctgtatgggc actctcattt cactgcatac atacaatact ttgtatacac
     8461 atacttctcg tgtggatatt ttataatttt atttaatcta acatttaact tttaggtttt
     8521 tgtggtactc atctgaaagg ttggcatttg ttttcttttt atgttatata tgtattttag
     8581 atgaatcaat aatgtgtatt cctagaaatt ttttctaggc ataaatagat cattttatgt
     8641 tggcatttaa gagatatcat ttttgtttta ttgttctgtg taaaccatat tcattgtaca
     8701 ctgtgtgtat atttttgttt aaataaatga tttttatttt tta
//
