LOCUS       NP_001095139             924 aa            linear   PRI 07-DEC-2024
DEFINITION  inositol polyphosphate 4-phosphatase type II isoform 1 [Homo
            sapiens].
ACCESSION   NP_001095139
VERSION     NP_001095139.1
DBSOURCE    REFSEQ: accession NM_001101669.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 924)
  AUTHORS   Saffi,G.T., To,L., Kleine,N., Melo,C.M.P., Chen,K., Genc,G.,
            Lee,K.C.D., Chow,J.T., Jang,G.H., Gallinger,S., Botelho,R.J. and
            Salmena,L.
  TITLE     INPP4B promotes PDAC aggressiveness via PIKfyve and
            TRPML-1-mediated lysosomal exocytosis
  JOURNAL   J Cell Biol 223 (11) (2024)
   PUBMED   39120584
  REMARK    GeneRIF: INPP4B promotes PDAC aggressiveness via PIKfyve and
            TRPML-1-mediated lysosomal exocytosis.
REFERENCE   2  (residues 1 to 924)
  AUTHORS   Lai,M., Mao,Z., Tang,D., Lan,S., Yan,R., Xiang,Q., Zhao,X., Su,M.
            and Wang,Y.
  TITLE     [Preliminary Study of the Role of INPP4B in Promoting Colorectal
            Cancer Metastasis and the Mechanisms Involved]
  JOURNAL   Sichuan Da Xue Xue Bao Yi Xue Ban 55 (5), 1186-1194 (2024)
   PUBMED   39507966
  REMARK    GeneRIF: [Preliminary Study of the Role of INPP4B in Promoting
            Colorectal Cancer Metastasis and the Mechanisms Involved].
REFERENCE   3  (residues 1 to 924)
  AUTHORS   Zhao,J., Du,X.M., Si,W., Zhao,X.H. and Zhou,Z.Q.
  TITLE     Role of INPP4B in the proliferation, migration, invasion, and
            survival of human endometrial cancer cells
  JOURNAL   Histol Histopathol 39 (9), 1197-1208 (2024)
   PUBMED   38318760
  REMARK    GeneRIF: Role of INPP4B in the proliferation, migration, invasion,
            and survival of human endometrial cancer cells.
REFERENCE   4  (residues 1 to 924)
  AUTHORS   Gorji,M., Farsani,M.A., Kargar,M., Garavand,J. and Mohammadi,M.H.
  TITLE     Investigating the multifaceted cooperation of autophagy, PI3K/AKT
            signaling pathways, and INPP4B gene in de novo acute myeloid
            leukemia patients
  JOURNAL   Curr Res Transl Med 72 (2), 103429 (2024)
   PUBMED   38246071
  REMARK    GeneRIF: Investigating the multifaceted cooperation of autophagy,
            PI3K/AKT signaling pathways, and INPP4B gene in de novo acute
            myeloid leukemia patients.
REFERENCE   5  (residues 1 to 924)
  AUTHORS   Xu,M., Ren,J., Jia,W., Wang,S., Liu,Y., Chen,X., Shi,J. and Wang,H.
  TITLE     Regulation of B-1 cell numbers and B cell-mediated antibody
            production by Inpp4b
  JOURNAL   Scand J Immunol 98 (4), e13309 (2023)
   PUBMED   37389566
  REMARK    GeneRIF: Regulation of B-1 cell numbers and B cell-mediated
            antibody production by Inpp4b.
REFERENCE   6  (residues 1 to 924)
  AUTHORS   Rampersaud,E., Damcott,C.M., Fu,M., Shen,H., McArdle,P., Shi,X.,
            Shelton,J., Yin,J., Chang,Y.P., Ott,S.H., Zhang,L., Zhao,Y.,
            Mitchell,B.D., O'Connell,J. and Shuldiner,A.R.
  TITLE     Identification of novel candidate genes for type 2 diabetes from a
            genome-wide association scan in the Old Order Amish: evidence for
            replication from diabetes-related quantitative traits and from
            independent populations
  JOURNAL   Diabetes 56 (12), 3053-3062 (2007)
   PUBMED   17846126
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (residues 1 to 924)
  AUTHORS   Munday,A.D., Norris,F.A., Caldwell,K.K., Brown,S., Majerus,P.W. and
            Mitchell,C.A.
  TITLE     The inositol polyphosphate 4-phosphatase forms a complex with
            phosphatidylinositol 3-kinase in human platelet cytosol
  JOURNAL   Proc Natl Acad Sci U S A 96 (7), 3640-3645 (1999)
   PUBMED   10097090
REFERENCE   8  (residues 1 to 924)
  AUTHORS   Zhang,X. and Majerus,P.W.
  TITLE     Phosphatidylinositol signalling reactions
  JOURNAL   Semin Cell Dev Biol 9 (2), 153-160 (1998)
   PUBMED   9599410
  REMARK    Review article
REFERENCE   9  (residues 1 to 924)
  AUTHORS   Norris,F.A., Atkins,R.C. and Majerus,P.W.
  TITLE     The cDNA cloning and characterization of inositol polyphosphate
            4-phosphatase type II. Evidence for conserved alternative splicing
            in the 4-phosphatase family
  JOURNAL   J Biol Chem 272 (38), 23859-23864 (1997)
   PUBMED   9295334
REFERENCE   10 (residues 1 to 924)
  AUTHORS   Norris,F.A., Auethavekiat,V. and Majerus,P.W.
  TITLE     The isolation and characterization of cDNA encoding human and rat
            brain inositol polyphosphate 4-phosphatase
  JOURNAL   J Biol Chem 270 (27), 16128-16133 (1995)
   PUBMED   7608176
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA695719.1, BP360389.1,
            BC072447.1, BX649090.1, BC017924.2, AC108077.3 and AI198719.1.
            
            Summary: INPP4B encodes the inositol polyphosphate 4-phosphatase
            type II, one of the enzymes involved in phosphatidylinositol
            signaling pathways. This enzyme removes the phosphate group at
            position 4 of the inositol ring from inositol 3,4-bisphosphate.
            There is limited data to suggest that the human type II enzyme is
            subject to alternative splicing, as has been established for the
            type I enzyme. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1 and 2 encode the same isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14372080.4553427.1,
                                           SRR1660803.98851.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000262992.9/ ENSP00000262992.4
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..924
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q31.21"
     Protein         1..924
                     /product="inositol polyphosphate 4-phosphatase type II
                     isoform 1"
                     /EC_number="3.1.3.66"
                     /note="inositol polyphosphate 4-phosphatase II;
                     4-phosphatase II; type II inositol 3,4-bisphosphate
                     4-phosphatase; inositol polyphosphate-4-phosphatase, type
                     II, 105kDa"
                     /calculated_mol_wt=104607
     Region          1..24
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (O15327.4)"
     Region          39..175
                     /region_name="C2A_Copine"
                     /note="C2 domain first repeat in Copine; cd04048"
                     /db_xref="CDD:176013"
     Site            order(54,60,116,118,135)
                     /site_type="other"
                     /note="putative Ca2+ binding site [ion binding]"
                     /db_xref="CDD:176013"
     Region          481..516
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (O15327.4)"
     Region          546..570
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (O15327.4)"
     CDS             1..924
                     /gene="INPP4B"
                     /coded_by="NM_001101669.3:347..3121"
                     /note="isoform 1 is encoded by transcript variant 2"
                     /db_xref="CCDS:CCDS3757.1"
                     /db_xref="GeneID:8821"
                     /db_xref="HGNC:HGNC:6075"
                     /db_xref="MIM:607494"
ORIGIN      
        1 meikeegase egqhflptaq andpgdcqft siqktpnepq lefilackdl vapvrdrkln
       61 tlvqisvihp veqsltryss teivegtrdp lfltgvtfps eypiyeetki kltvydvkdk
      121 shdtvrtsvl pehkdpppev grsflgyasf kvgellkske qllvlslrts dggkvvgtie
      181 vsvvkmgeie dgeadhittd vqgqkcalvc ectapesvsg kdnlpflnsv lknpvcklyr
      241 fptsdnkwmr ireqmsesil sfhipkelis lhikedlcrn qeikelgels phwdnlrknv
      301 lthcdqmvnm yqdiltelsk etgssfksss skgektlefv pinlhlqrmq vhsphlkdal
      361 ydvitvgapa ahfqgfkngg lrkllhrfet errntgyqfi yyspentaka kevlsninql
      421 qpliathadl llnsasqhsp dslknslkml sektelfvha fkdqlvrsal lalytarpgg
      481 ilkkppspks steesspqdq ppvmrgqdsi phhsdydeee wdrvwanvgk slnciiamvd
      541 klierdggse gsggnndgek epsltdaips hpredwyeql ypliltlkdc mgevvnrakq
      601 sltfvllqel ayslpqclml tlrrdivfsq alaglvcgfi iklqtslydp gflqqlhtvg
      661 livqyeglls tysdeigmle dmavgisdlk kvafkiieak sndvlpvitg rrehyvvevk
      721 lparmfeslp lqikegqllh vypvlfnvgi neqqtlaerf gdvslqesin qenfellqey
      781 ykifmekmpp dyishfqeqn dlkallenll qniqskkrkn veimwlaati crklngirft
      841 ccksakdrts msvtleqcsi lrdehqlhkd ffiraldcmr regcrienvl knikcrkyaf
      901 nmlqlmafpk yyrppegtyg kadt
//
