LOCUS       NM_004027               9994 bp    mRNA    linear   PRI 06-APR-2024
DEFINITION  Homo sapiens inositol polyphosphate-4-phosphatase type I A
            (INPP4A), transcript variant a, mRNA.
ACCESSION   NM_004027
VERSION     NM_004027.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 9994)
  AUTHORS   Xu,Y., Tong,X., Liu,P., Huang,J., Chen,S., Liu,D., Gu,T., Xie,Y.,
            Guo,D. and Xu,Y.
  TITLE     Deficiency of INPP4A promotes M2 macrophage polarization in
            eosinophilic chronic rhinosinusitis with nasal polyps
  JOURNAL   Inflamm Res 73 (4), 581-595 (2024)
   PUBMED   38363325
  REMARK    GeneRIF: Deficiency of INPP4A promotes M2 macrophage polarization
            in eosinophilic chronic rhinosinusitis with nasal polyps.
REFERENCE   2  (bases 1 to 9994)
  AUTHORS   Maruyama,N., Umikawa,M., Matsumoto,H., Maruyama,T., Nishihara,K.,
            Nakasone,T., Matayoshi,A., Goto,T., Hirano,F., Arasaki,A.,
            Nakamura,H., Matsuzaki,G. and Takaesu,G.
  TITLE     miR-935 Inhibits Oral Squamous Cell Carcinoma and Targets Inositol
            Polyphosphate-4-phosphatase Type IA (INPP4A)
  JOURNAL   Anticancer Res 40 (11), 6101-6113 (2020)
   PUBMED   33109548
  REMARK    GeneRIF: miR-935 Inhibits Oral Squamous Cell Carcinoma and Targets
            Inositol Polyphosphate-4-phosphatase Type IA (INPP4A).
REFERENCE   3  (bases 1 to 9994)
  AUTHORS   Banihashemi,S., Tahmasebi-Birgani,M., Mohammadiasl,J. and
            Hajjari,M.
  TITLE     Whole exome sequencing identified a novel nonsense INPP4A mutation
            in a family with intellectual disability
  JOURNAL   Eur J Med Genet 63 (4), 103846 (2020)
   PUBMED   31978615
  REMARK    GeneRIF: Whole exome sequencing identified a novel nonsense INPP4A
            mutation in a family with intellectual disability.
REFERENCE   4  (bases 1 to 9994)
  AUTHORS   Khanna,K., Chaudhuri,R., Aich,J., Pattnaik,B., Panda,L.,
            Prakash,Y.S., Mabalirajan,U., Ghosh,B. and Agrawal,A.
  TITLE     Secretory Inositol Polyphosphate 4-Phosphatase Protects against
            Airway Inflammation and Remodeling
  JOURNAL   Am J Respir Cell Mol Biol 60 (4), 399-412 (2019)
   PUBMED   30335467
  REMARK    GeneRIF: INPP4A is secreted by airway epithelial cells and
            extracellular INPP4A critically inhibits airway inflammation and
            remodeling.
REFERENCE   5  (bases 1 to 9994)
  AUTHORS   Huang,Y., Xiao,W., Jiang,X. and Li,H.
  TITLE     MicroRNA-935 acts as a prognostic marker and promotes cell
            proliferation, migration, and invasion in colorectal cancer
  JOURNAL   Cancer Biomark 26 (2), 229-237 (2019)
   PUBMED   31524145
  REMARK    GeneRIF: Low INPP4A expression is associated with cell
            proliferation, migration, and invasion in colorectal cancer.
REFERENCE   6  (bases 1 to 9994)
  AUTHORS   Munday,A.D., Norris,F.A., Caldwell,K.K., Brown,S., Majerus,P.W. and
            Mitchell,C.A.
  TITLE     The inositol polyphosphate 4-phosphatase forms a complex with
            phosphatidylinositol 3-kinase in human platelet cytosol
  JOURNAL   Proc Natl Acad Sci U S A 96 (7), 3640-3645 (1999)
   PUBMED   10097090
REFERENCE   7  (bases 1 to 9994)
  AUTHORS   Zhang,X. and Majerus,P.W.
  TITLE     Phosphatidylinositol signalling reactions
  JOURNAL   Semin Cell Dev Biol 9 (2), 153-160 (1998)
   PUBMED   9599410
  REMARK    Review article
REFERENCE   8  (bases 1 to 9994)
  AUTHORS   Norris,F.A., Atkins,R.C. and Majerus,P.W.
  TITLE     The cDNA cloning and characterization of inositol polyphosphate
            4-phosphatase type II. Evidence for conserved alternative splicing
            in the 4-phosphatase family
  JOURNAL   J Biol Chem 272 (38), 23859-23864 (1997)
   PUBMED   9295334
REFERENCE   9  (bases 1 to 9994)
  AUTHORS   Norris,F.A., Atkins,R.C. and Majerus,P.W.
  TITLE     Inositol polyphosphate 4-phosphatase is inactivated by
            calpain-mediated proteolysis in stimulated human platelets
  JOURNAL   J Biol Chem 272 (17), 10987-10989 (1997)
   PUBMED   9110986
REFERENCE   10 (bases 1 to 9994)
  AUTHORS   Norris,F.A., Auethavekiat,V. and Majerus,P.W.
  TITLE     The isolation and characterization of cDNA encoding human and rat
            brain inositol polyphosphate 4-phosphatase
  JOURNAL   J Biol Chem 270 (27), 16128-16133 (1995)
   PUBMED   7608176
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC028361.2, U26398.1 and
            AC010134.5.
            
            On Jun 2, 2019 this sequence version replaced NM_004027.2.
            
            Summary: This gene encodes an Mg++ independent enzyme that
            hydrolyzes the 4-position phosphate from the inositol ring of
            phosphatidylinositol 3,4-bisphosphate, inositol
            1,3,4-trisphosphate, and inositol 3,4-bisphosphate. Multiple
            transcript variants encoding distinct isoforms have been described.
            [provided by RefSeq, Aug 2008].
            
            Transcript Variant: This variant (a) encodes the shortest isoform
            (a). Variants a and h both encode the same isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: U26398.1 [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMEA2142348, SAMEA2144335 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-347               BC028361.2         1-347
            348-3257            U26398.1           249-3158
            3258-6635           AC010134.5         174429-177806
            6636-9994           AC010134.5         177807-181165
FEATURES             Location/Qualifiers
     source          1..9994
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q11.2"
     gene            1..9994
                     /gene="INPP4A"
                     /gene_synonym="INPP4; TVAS1"
                     /note="inositol polyphosphate-4-phosphatase type I A"
                     /db_xref="GeneID:3631"
                     /db_xref="HGNC:HGNC:6074"
                     /db_xref="MIM:600916"
     exon            1..228
                     /gene="INPP4A"
                     /gene_synonym="INPP4; TVAS1"
                     /inference="alignment:Splign:2.1.0"
     exon            229..290
                     /gene="INPP4A"
                     /gene_synonym="INPP4; TVAS1"
                     /inference="alignment:Splign:2.1.0"
     exon            291..499
                     /gene="INPP4A"
                     /gene_synonym="INPP4; TVAS1"
                     /inference="alignment:Splign:2.1.0"
     CDS             394..3210
                     /gene="INPP4A"
                     /gene_synonym="INPP4; TVAS1"
                     /EC_number="3.1.3.66"
                     /note="isoform a is encoded by transcript variant a; type
                     I inositol 3,4-bisphosphate 4-phosphatase; inositol
                     polyphosphate-4-phosphatase, type I, 107kD; inositol
                     polyphosphate-4-phosphatase, type I, 107kDa"
                     /codon_start=1
                     /product="inositol polyphosphate-4-phosphatase type I A
                     isoform a"
                     /protein_id="NP_004018.1"
                     /db_xref="CCDS:CCDS46370.1"
                     /db_xref="GeneID:3631"
                     /db_xref="HGNC:HGNC:6074"
                     /db_xref="MIM:600916"
                     /translation="MTAREHSPRHGARARAMQRASTIDVAADMLGLSLAGNIQDPDEP
                     ILEFSLACSELHTPSLDRKPNSFVAVSVTTPPQAFWTKHAQTEIIEGTNNPIFLSSIA
                     FFQDSLINQMTQVKLSVYDVKDRSQGTMYLLGSGTFIVKDLLQDRHHRLHLTLRSAES
                     DRVGNITVIGWQMEEKSDQRPPVTRSVDTVNGRMVLPVDESLTEALGIRSKYASLRKD
                     TLLKSVFGGAICRMYRFPTTDGNHLRILEQMAESVLSLHVPRQFVKLLLEEDAARVCE
                     LEELGELSPCWESLRRQIVTQYQTIILTYQENLTDLHQYRGPSFKASSLKADKKLEFV
                     PTNLHIQRMRVQDDGGSDQNYDIVTIGAPAAHCQGFKSGGLRKKLHKFEETKKHFEEC
                     CTSSGCQSIIYIPQDVVRAKEIIAQINTLKTQVSYYAERLSRAAKDRSATGLERTLAI
                     LADKTRQLVTVCDCKLLANSIHGLNAARPDYIASKASPTSTEEEQVMLRNDQDTLMAR
                     WTGRNSRSSLQVDWHEEEWEKVWLNVDKSLECIIQRVDKLLQKERLHGEGCEDVFPCA
                     GSCTSKKDCSPPPEESSPGEWSEALYPLLTTLTDCVAMMSDKAKKAMVFLLMQDSAPT
                     IATYLSLQYRRDVVFCQTLTALICGFIIKLRNCLHDDGFLRQLYTIGLLAQFESLLST
                     YGEELAMLEDMSLGIMDLRNVTFKVTQATSSASADMLPVITGNRDGFNVRVPLPGPLF
                     DALPREIQSGMLLRVQPVLFNVGINEQQTLAERFGDTSLQEVINVESLVRLNSYFEQF
                     KEVLPEDCLPRSRSQTCLPELLRFLGQNVHARKNKNVDILWQAAEICRRLNGVRFTSC
                     KSAKDRTAMSVTLEQCLILQHEHGMAPQVFTQALECMRSEGCRRENTMKNVGSRKYAF
                     NSLQLKAFPKHYRPPEGTYGKVET"
     exon            500..544
                     /gene="INPP4A"
                     /gene_synonym="INPP4; TVAS1"
                     /inference="alignment:Splign:2.1.0"
     exon            545..663
                     /gene="INPP4A"
                     /gene_synonym="INPP4; TVAS1"
                     /inference="alignment:Splign:2.1.0"
     exon            664..780
                     /gene="INPP4A"
                     /gene_synonym="INPP4; TVAS1"
                     /inference="alignment:Splign:2.1.0"
     exon            781..860
                     /gene="INPP4A"
                     /gene_synonym="INPP4; TVAS1"
                     /inference="alignment:Splign:2.1.0"
     exon            861..972
                     /gene="INPP4A"
                     /gene_synonym="INPP4; TVAS1"
                     /inference="alignment:Splign:2.1.0"
     exon            973..1063
                     /gene="INPP4A"
                     /gene_synonym="INPP4; TVAS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1064..1211
                     /gene="INPP4A"
                     /gene_synonym="INPP4; TVAS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1212..1342
                     /gene="INPP4A"
                     /gene_synonym="INPP4; TVAS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1343..1447
                     /gene="INPP4A"
                     /gene_synonym="INPP4; TVAS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1448..1556
                     /gene="INPP4A"
                     /gene_synonym="INPP4; TVAS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1557..1571
                     /gene="INPP4A"
                     /gene_synonym="INPP4; TVAS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1572..1755
                     /gene="INPP4A"
                     /gene_synonym="INPP4; TVAS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1756..1974
                     /gene="INPP4A"
                     /gene_synonym="INPP4; TVAS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1975..2113
                     /gene="INPP4A"
                     /gene_synonym="INPP4; TVAS1"
                     /inference="alignment:Splign:2.1.0"
     exon            2114..2146
                     /gene="INPP4A"
                     /gene_synonym="INPP4; TVAS1"
                     /inference="alignment:Splign:2.1.0"
     exon            2147..2319
                     /gene="INPP4A"
                     /gene_synonym="INPP4; TVAS1"
                     /inference="alignment:Splign:2.1.0"
     exon            2320..2443
                     /gene="INPP4A"
                     /gene_synonym="INPP4; TVAS1"
                     /inference="alignment:Splign:2.1.0"
     exon            2444..2570
                     /gene="INPP4A"
                     /gene_synonym="INPP4; TVAS1"
                     /inference="alignment:Splign:2.1.0"
     exon            2571..2711
                     /gene="INPP4A"
                     /gene_synonym="INPP4; TVAS1"
                     /inference="alignment:Splign:2.1.0"
     exon            2712..2809
                     /gene="INPP4A"
                     /gene_synonym="INPP4; TVAS1"
                     /inference="alignment:Splign:2.1.0"
     exon            2810..2922
                     /gene="INPP4A"
                     /gene_synonym="INPP4; TVAS1"
                     /inference="alignment:Splign:2.1.0"
     exon            2923..3077
                     /gene="INPP4A"
                     /gene_synonym="INPP4; TVAS1"
                     /inference="alignment:Splign:2.1.0"
     exon            3078..9994
                     /gene="INPP4A"
                     /gene_synonym="INPP4; TVAS1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5734..5739
                     /regulatory_class="polyA_signal_sequence"
                     /gene="INPP4A"
                     /gene_synonym="INPP4; TVAS1"
                     /note="hexamer: AATAAA"
     polyA_site      5758
                     /gene="INPP4A"
                     /gene_synonym="INPP4; TVAS1"
                     /note="major polyA site"
     regulatory      6364..6369
                     /regulatory_class="polyA_signal_sequence"
                     /gene="INPP4A"
                     /gene_synonym="INPP4; TVAS1"
                     /note="hexamer: ATTAAA"
     polyA_site      6388
                     /gene="INPP4A"
                     /gene_synonym="INPP4; TVAS1"
                     /note="major polyA site"
     polyA_site      6931
                     /gene="INPP4A"
                     /gene_synonym="INPP4; TVAS1"
     regulatory      9650..9655
                     /regulatory_class="polyA_signal_sequence"
                     /gene="INPP4A"
                     /gene_synonym="INPP4; TVAS1"
                     /note="hexamer: AATAAA"
     polyA_site      9667
                     /gene="INPP4A"
                     /gene_synonym="INPP4; TVAS1"
     regulatory      9976..9981
                     /regulatory_class="polyA_signal_sequence"
                     /gene="INPP4A"
                     /gene_synonym="INPP4; TVAS1"
                     /note="hexamer: ATTAAA"
     polyA_site      9994
                     /gene="INPP4A"
                     /gene_synonym="INPP4; TVAS1"
ORIGIN      
        1 gtctagagcg gcggcggctg gctagggctg cggcgcgcgt ggagggttcg ctgctggttt
       61 gccgccgggt cgggctccgt gggccggggc aggaggacca gcacctgagg ccgggcccgc
      121 agcccgcgac ttcacagcca ggcggcggcg ctgctgctgc tgcggggctc tggcgcgcag
      181 cccggcggga cagcggggcg gctggcgccg ggggccgggg agcgccagat gatggatttg
      241 gacatgcttc tatgaagaaa tgccacatgg tccgagagca aacatgtcca ggctactgcc
      301 actttagtgg actagggctc ggtgccagca cttcccgggt aatcaggcgt ggtctgaccg
      361 aggatcaaga agcacatcat caccaatgac atcatgacag caagagagca cagccctcgc
      421 catggtgcca gggcccgtgc aatgcagcgg gcttccacca tcgacgtggc ggccgacatg
      481 ctgggcctct ctctggcagg aaatatacaa gacccagatg agcccatttt agaatttagc
      541 ttagcttgca gtgagctgca tactccatcg ctagatcgaa agccaaatag ttttgttgcg
      601 gtgagtgtca ccacccctcc tcaggcattc tggacgaagc atgcacagac ggagatcatt
      661 gagggaacca acaatcctat atttctaagc agtattgcct tctttcaaga ctctcttatc
      721 aatcagatga cacaagtcaa actctccgtg tatgatgtca aagatagatc tcagggaaca
      781 atgtatttac tgggctctgg aacgttcatt gtcaaagatc tgctccagga caggcatcat
      841 aggttgcatt taacactaag gtctgcagag agtgaccgtg taggtaacat caccgtgatt
      901 ggctggcaga tggaggagaa gtcagaccaa cggccccctg tgacccggtc tgtggacact
      961 gtcaatggga ggatggttct tcctgtcgat gagagcttga cggaggcgtt aggaatccga
     1021 tccaaatacg cttcattgcg aaaggacact ttgctgaaat cggtgttcgg tggtgccatc
     1081 tgccgcatgt accggtttcc aaccactgat ggtaaccatt tgcggatcct ggagcagatg
     1141 gcagagagcg tgctctccct gcacgtgccc cggcagttcg tgaagctcct actagaggaa
     1201 gatgcagcca gagtgtgtga gctggaggag ctgggagagc tgtccccttg ctgggagagc
     1261 ctccggcgcc aaattgtcac ccagtaccag accatcatcc tcacatacca ggagaacctg
     1321 accgacctcc atcagtacag agggccctcg tttaaagcaa gcagtttgaa agcagataaa
     1381 aagttagaat ttgttcccac aaacttgcac atacaaagga tgagagttca agacgatgga
     1441 ggatcagatc agaactacga catcgtcacc attggggcgc cagcagcaca ctgccaaggt
     1501 tttaagtcag gaggtctccg caaaaagctg cacaaatttg aagagaccaa gaaacatttt
     1561 gaggagtgtt gtacatcatc tggctgccag tccataatct acatacccca ggatgttgtc
     1621 agagccaagg agatcatcgc ccagatcaac accctgaaaa cccaagtgag ttactacgca
     1681 gagcggctgt caagggcagc caaggacagg tctgccactg gccttgagag gacactcgcc
     1741 atcttggcag acaagacacg gcagctggtc acggtctgcg actgcaagct cctggccaac
     1801 tccatccatg ggctgaacgc tgcacggcct gactacattg cctccaaggc ctctcccact
     1861 tcgactgagg aggagcaggt gatgcttaga aatgaccagg acaccctcat ggcccggtgg
     1921 acagggagaa acagccgatc ttccctgcag gtggactggc acgaggagga gtgggagaaa
     1981 gtgtggctga acgtggacaa gagcctagag tgcatcattc agcgtgtgga caagctgctg
     2041 cagaaggagc ggctgcatgg cgagggctgt gaggatgtct tcccctgtgc aggcagctgc
     2101 accagcaaga aagattgcag tccccctcct gaagagtcca gcccaggtga atggagtgag
     2161 gccctttacc cgctgctgac cactctcacc gactgcgtgg ccatgatgag tgacaaggcc
     2221 aagaaggcca tggtattcct gctcatgcag gacagcgcgc ccaccatagc cacctacctg
     2281 agcctgcagt accgccgtga cgtggtcttc tgccagacgc tgaccgccct catctgcggc
     2341 ttcatcatta agctgaggaa ctgcctgcat gacgacggct tcctgcgcca gctctacacc
     2401 atcgggctgc tggcccagtt cgagagcctg ctgagcacct acggggagga gctggcaatg
     2461 ctggaggaca tgagccttgg gatcatggac ttgaggaacg tgaccttcaa agtcactcag
     2521 gccacttcca gcgcctccgc agacatgctg cccgtcatca caggaaatcg cgacgggttt
     2581 aacgtgcggg tccctctgcc gggcccgctg tttgacgcct tgccccggga gatccagagt
     2641 ggcatgctgc tgcgagtgca gcccgtcctc ttcaacgtgg gcatcaatga gcagcagaca
     2701 ctggccgaga ggtttggcga tacgtcttta caagaagtca tcaacgtgga gagtttggtg
     2761 cggttaaatt cctactttga gcagtttaag gaagttttgc ctgaggattg cctgcctcgg
     2821 tctcgcagtc agacgtgcct gccagagctg ctgcggtttc tgggtcagaa cgtgcatgcc
     2881 cggaagaata agaacgtcga cattctctgg caagctgctg agatctgccg ccgccttaat
     2941 ggggtccggt tcaccagctg caagagcgct aaggaccgta cagccatgtc ggtgacactg
     3001 gagcagtgcc tgatcctgca acacgagcat ggcatggccc cgcaggtctt cacccaggcc
     3061 ctggagtgca tgcgcagtga gggttgtcga agagaaaata caatgaagaa tgttggaagt
     3121 cgcaaatatg catttaattc cctgcagctg aaggctttcc ccaagcatta caggcctccc
     3181 gaagggactt acggaaaagt tgaaacgtga acacacggtt tcctctaatt agctgttaca
     3241 taataaatgt gggtaccctc tagtgtcata tatgaattct tcaagaagac ctgaaggatt
     3301 ggtttttatt ttttgtggtt tttttaaaaa aaacatttca ctaaagagtc tctggagcat
     3361 gttttttgtt ttttgggttt ttttccccat tggaatcaat aggaggtaat gtttggctca
     3421 atagtgtgga tagtaacaac tgcctattta aattaaatag cctttggctg taactacaca
     3481 gatctcatca atagttacct acatgaatca agctaggttt gtctgaaatg ctagaagact
     3541 ttttcaaatg cctgcttgct cacttacttt tctacagagt aactcaaaag taaccattga
     3601 attacaatcc actttgtaaa aatctgaatg taaaacagta aataataaat taaataattg
     3661 gatcctaggc ataccaataa atgttatttg gggaaagaag ctagcactat ctcatgcagt
     3721 gagaataacg ggttctagtg aattatccta tctacactac cacctgaaga agttgaaaga
     3781 aagattgata aatcaacggg agataagact ttattagaag gtaacacctg caaggtaccc
     3841 cacatagttg gggccactct tttttctgtc ccttatgagt tacagaacag ggagtctgct
     3901 ggagacacaa agccagcagt aaggtccctt tagcctgtct cctgttctct gaagctccct
     3961 gccgaggctc cctcacgccc agaggacaca tctccccttc ttctctagat gttaatgtag
     4021 ggcctcagat gtggcatgtc aacactccca tggggaattt atgaccatag agatagtaga
     4081 aacctaaata ttttcagaaa aaaaattttt tttgcaggat ttccaattta tctttgaaaa
     4141 gacagtacaa tcatgtttga atgtctgatg aaagtgtctt atttttaggt ttgcaataat
     4201 tgttactttc ttattctcat tcttatgtaa gatgactatt gagaaacagt tgaaatttat
     4261 tctcctcaaa tgagattttg aaagggattt atgggccata aaacttagga atttcataga
     4321 aaattttgtc tggtcatctt ttataagatg atgatgagtc ttatctgcac atagcagagt
     4381 ttgtttctta ggagtttata tgttttattg attctgttta cgatgtttac atgttcttga
     4441 aaaggttgta aaagaaatac atatggcaca tattaatgat gctgatccta atgatttgtg
     4501 aacctcttag aaattctttt gtctaaaagc ctagagattc ttctggttcc tttagaaaca
     4561 tgtaacaaac ttgggccagg ggtgctgagg catggggagg actgcttatt ggcaggaaca
     4621 cagagggggt gggcatcagg tagggtggaa ctggatgacc ttccagaccc cctcctactc
     4681 agaagtcagc atgcaagcag cgcctgctgt ctcccgatgc ctgcagggag gaaaatgtct
     4741 gtgaaggaca ctttaatgaa ggacgaagct ctctgctgct ccctcaaagc tgagttcact
     4801 gtggcaggca ggaagcagag aagctcctgc ccgccaaacc cactgcacag gtggctgctg
     4861 ctggtatcag attctccttt ttaagtgtca atttctgttc acagacagtt tgttttcaat
     4921 atggctgatt taccctttca cctctccacc atctcattta atttgtaaat ttttagttct
     4981 gtcttttctc attttaactt ttaaaaaatc tccttgcttt ttaaaaataa atattaccca
     5041 catagttttc agatcttttt tgtctggaga gcattaaata tctgcactca tcaaagggaa
     5101 tatagcaaat gttgatcatc tgtcagcagt tttgcatgtg acacctttat atgaattatt
     5161 ttcccaattt ttgctctatg taatgggtca ccataaaact gtaagacttg gcaaatgcta
     5221 tagaaaaggt tcaggtttca gtattctctc tgaaggcatc attcctgggc ttccggcagc
     5281 atcacacgct tccagtgcct gcagggtgag ggtgtgtggc acagaggcaa gcagctcctc
     5341 tcttctgtag gagctttggg ttttcagagg tgcagggaag gcagttttac aggttaccgt
     5401 aaaacagagg ttccgtccag tgttccttat gatgcctccc catttaaaaa gaaaagagat
     5461 ctatggaaaa ctgggaatgt aatgtggatt ctgtcagagc tcctacagag cacagttgcc
     5521 tttagtttcc tttaaagatg taaaaatatt gtataataca gttttgtccc tacacaattg
     5581 tatttgccaa gcttagtgca ttatgatacc tttatttatt tgttttgggc agtattacta
     5641 tatatatata aacatacagt tactgtttta tatattctta ggtcattcaa agccatgtat
     5701 gctgtaaatg tgctagtctt tagaatgaca cataataaat aactgacaag atattaaatg
     5761 tggtcttgcc tgattcatcc tattaggagg actagttcta tgtgaccagc ctgtgactgg
     5821 accattgttc ttgggcattg cattgagtgc tcgggtgctg aatacatgtt tgtaaacatg
     5881 ggaccatggg agacttccat tttataagct tgtttctgcc taatttgaag cagaggggca
     5941 acagcgttga ggttaagagc acggactttg ggagcacaca gaccaggtcc caatcctggt
     6001 tctgcccctg actggctggt gactctgagc aagttgcttg acctctccaa gcctccgttt
     6061 cctcatgtgc aaagtgtgga caacaacagt accttcctca taaggaacgt gcgacgcgcc
     6121 tcagaagtac gtgttcataa atggtagcca ttgttgttac cttcccgtct gtgaacatgg
     6181 atcacatcat ctctgtgggt aacccagtcc tcgttgtatg acttgtcaaa atgcagttcc
     6241 acttgtatta atattgaccc tgttcatcgt caccaggact gcatcttgca ccactgtgcc
     6301 gtcttctagg cacacacgac ccgttatctc ccttggaaaa attcctctca ctggaaatgt
     6361 acaattaaag gatgattgaa atgtttaact cttggagttt ttagtattac caaactccta
     6421 gaaatttaag ctaccaccaa aaataacatg tgccttttcc ctttattctc attgatggta
     6481 gcagtgcacc tcgtttcagt gtcctgattc cttgattact gtgaacactg aacatctttt
     6541 atacctttat gatatttcta tgtttgtgac ttcattggaa tgttgatcta tttcatatag
     6601 attgttttta atatacaatg tattagcccc tgtcatatgt tgcacacttt ttaacctatt
     6661 tgtcagctgt cttttggtct gtggtaggag ttatacagta ttttaaatgg tttatgtagt
     6721 cacatatacc tgtctttcat tttgatgctt gttctgaaat ggagtcctgg cttcaccatg
     6781 gaaggtggga catatgggac agccatgtcc ttgtgggcat ggtggtgtgg ctgcgtgccc
     6841 acgacgaggg gctggactaa agtgctcact ggcaccttgc ttggtgcatg ggccatgctc
     6901 agtttaatat tattaacagt ttctaccttc actctcatgt ctcaggatta ttttttcagc
     6961 atttacctgt tcttatttct aggatgttta tggtttcagt cctacattta gatcaatcca
     7021 tctggaatca tcttggtgta agtcctgtgt tgtgcttaca gtatgtaaag tcagagggaa
     7081 tccctcaagg tcaggcctaa ttttgcttct ctttaaagtt aagccaagaa gaagacatgt
     7141 caggacgccc agacatcagc taccgtgagc ttcttcctgc cctccctccg catgccattc
     7201 tggtgctgcg cttcagtttc ctgttgagtc tctgcttagt agatgacttg gcacaatctg
     7261 gctgcccaga tctaggggag ttgtcccagg gaggctttgc gctggaggaa ggtaagagga
     7321 gctggaggtt ggagcttccc gatttgtgat ttttccaaga acagaaatga ttagccatgt
     7381 ggggaggtta cttcattgta cattgttcta ctgcataacc tccctctatt ctttaccagc
     7441 atcacacagc aggttggcac catttttgaa tagaggtttc tcacagtatc ctcagcagca
     7501 ttgagtgttc ctaatgttgt agtaatgagc agtagatgtc tctcagtggg cagtgtgacc
     7561 tctttggtca ctctaaaggg ctgccagcat ttctcttaag ctggggggag aagagctgtt
     7621 ctgtgtatag gggtattggg aacacatgga cagaaggaac tggcctcaca tgccatcgtg
     7681 ttcctgggat ggctcttcca agaccagcag ttcctcctgg caggcaggcc ctcacagaac
     7741 tctgcatttg gagatggaca aactctcttc ttcttatcac tttctcccca aaatgtcctc
     7801 ttctaccagc ccctcttaag agccgatttt ctgtaagtta tagtgagggc actgctctgc
     7861 tgtgcacaga aggaacccca gcccagaagc acacgctccc tgtggaacct gcaggggtgg
     7921 cagtgatgac agaaccaagg gggtcaagga agattggaga ggagtgggca gcaggaaaca
     7981 gctcaggctg cctgacctgg cccccggctg cccatgaggg cctccagaga ggggcagagc
     8041 tggcttatcg ggatccatga tggtttttac acttttaaaa gtgccctctt ctcagagacc
     8101 ctggttattt ccaaaagtag gaagtaatca aatttacagt ggataaaatc cagtatttga
     8161 aatcaggaag acagaaaaaa aagcaaaata gcatcctttt ctgagaggta tatgctgacc
     8221 aaaaagatct ttcattcctg tgaacaccaa gcagcgcggc ctctggcaga gagagcgctg
     8281 ggttgtacag atggaaactt gtgtttagca ggctgtctgc tcccaatagt ggccctggct
     8341 gcaactgacc tcctgatgcc ctgctgacgc taactgtggg taccaaccag caccgtggac
     8401 atcggcccca ggatcagtct acgatttgtc tggtggccaa atgatgactt ttgagtggga
     8461 aaagctggtg ggggctacac cgtgctctgc agtgtagtgg gatcctgtga gctggcctgc
     8521 acaggcactc cctcccctgc caggggcccc agggaggctt ctccagcctg aggctgcacc
     8581 ctccatacga ttccaccccc catcctgtgc caacagtagg caaacggaga gtagcttggt
     8641 cttgttttta ttagctgttg ccctccaggc tacgacaggg ttcccagggt gtagcctgaa
     8701 aacacccata ctctagattc cctccactgg aaccctgtct ttgccatgat ttcttcctgc
     8761 atcaggcccc tgtgggcctt gcaggccagt ccaggcaggt ctttcacact gttgtcccac
     8821 ataacagaaa aagctgagca gacagggtag gaaacacact tgcatctcca tggctccaaa
     8881 gaggatgcct gtgttagatg gatgtagaca gacacagcac ttcactgctt cctcctcctc
     8941 gccacccagc cctccctcgg tgtctgtggc ctgactctct cctggtggtc ctacgtctct
     9001 gaccatccct cctcactctc aaattttatg ttgcccacca cctgccacta atggcgtggt
     9061 gttctcctgg gttccctttc tcacttaaga tgatcttcct gaaaaatctt acacattcct
     9121 gttgaacaaa tggtcactta tatggtagtg actcctaaat ttctaggtcc atcccagact
     9181 ctcccccaag gtccagatta cctatacatc taagcaccat gcctgtcttg caggcatctc
     9241 aaatacagca tgctcatgcc tctcctcctc caagctggct gagtctccct ctaatagacg
     9301 accttgggat cattttctcc tccacatccc atcaatcagc cactgaacct gtatctcttg
     9361 agaaccatcc cataatttcc atccatgcac cccaaggcct ggtctgtatc agtcccctcg
     9421 gatctggacc tctcctgagc atcctcaccc ctcctgcaag gctagtctca ggtctgcctt
     9481 cctctatggt gatttctccc cacaaatgaa gttggccctt tcaaaaaaac ttcctctcct
     9541 tcattgttga ctatgaagat tctttcatgc atgtcctgtc cactgtcagt cccctctgta
     9601 ttcacaagag caagtgtaat gcccgctgtg aaggagctaa agtttgttga ataaacacat
     9661 gaacaaatgg tggttttgtg gtgttcaact gaaatatttc ctatttcagc actggaccac
     9721 gctgtttttc tcactacata atcggttacg ctaaatgcat cacgagccaa attcaaaagg
     9781 tcaaaggaga aggcaaatgg cagagtgtgg taaaggggcg agtgagaggg tctctgaaaa
     9841 aagtcaggct aaaattacag ggggttcagg caatgttatc ttgatctgga tggccagtta
     9901 catgacagat tactttgttc ttaacatacg aacatcctat tcactttttg gtatactggt
     9961 tgtttaacag taaaaattaa atgtttaaaa ccca
//
