LOCUS       NM_001351429            9859 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens inositol polyphosphate-4-phosphatase type I A
            (INPP4A), transcript variant j, mRNA.
ACCESSION   NM_001351429 XM_017004002
VERSION     NM_001351429.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 9859)
  AUTHORS   Xu,Y., Tong,X., Liu,P., Huang,J., Chen,S., Liu,D., Gu,T., Xie,Y.,
            Guo,D. and Xu,Y.
  TITLE     Deficiency of INPP4A promotes M2 macrophage polarization in
            eosinophilic chronic rhinosinusitis with nasal polyps
  JOURNAL   Inflamm Res 73 (4), 581-595 (2024)
   PUBMED   38363325
  REMARK    GeneRIF: Deficiency of INPP4A promotes M2 macrophage polarization
            in eosinophilic chronic rhinosinusitis with nasal polyps.
REFERENCE   2  (bases 1 to 9859)
  AUTHORS   Maruyama,N., Umikawa,M., Matsumoto,H., Maruyama,T., Nishihara,K.,
            Nakasone,T., Matayoshi,A., Goto,T., Hirano,F., Arasaki,A.,
            Nakamura,H., Matsuzaki,G. and Takaesu,G.
  TITLE     miR-935 Inhibits Oral Squamous Cell Carcinoma and Targets Inositol
            Polyphosphate-4-phosphatase Type IA (INPP4A)
  JOURNAL   Anticancer Res 40 (11), 6101-6113 (2020)
   PUBMED   33109548
  REMARK    GeneRIF: miR-935 Inhibits Oral Squamous Cell Carcinoma and Targets
            Inositol Polyphosphate-4-phosphatase Type IA (INPP4A).
REFERENCE   3  (bases 1 to 9859)
  AUTHORS   Banihashemi,S., Tahmasebi-Birgani,M., Mohammadiasl,J. and
            Hajjari,M.
  TITLE     Whole exome sequencing identified a novel nonsense INPP4A mutation
            in a family with intellectual disability
  JOURNAL   Eur J Med Genet 63 (4), 103846 (2020)
   PUBMED   31978615
  REMARK    GeneRIF: Whole exome sequencing identified a novel nonsense INPP4A
            mutation in a family with intellectual disability.
REFERENCE   4  (bases 1 to 9859)
  AUTHORS   Khanna,K., Chaudhuri,R., Aich,J., Pattnaik,B., Panda,L.,
            Prakash,Y.S., Mabalirajan,U., Ghosh,B. and Agrawal,A.
  TITLE     Secretory Inositol Polyphosphate 4-Phosphatase Protects against
            Airway Inflammation and Remodeling
  JOURNAL   Am J Respir Cell Mol Biol 60 (4), 399-412 (2019)
   PUBMED   30335467
  REMARK    GeneRIF: INPP4A is secreted by airway epithelial cells and
            extracellular INPP4A critically inhibits airway inflammation and
            remodeling.
REFERENCE   5  (bases 1 to 9859)
  AUTHORS   Huang,Y., Xiao,W., Jiang,X. and Li,H.
  TITLE     MicroRNA-935 acts as a prognostic marker and promotes cell
            proliferation, migration, and invasion in colorectal cancer
  JOURNAL   Cancer Biomark 26 (2), 229-237 (2019)
   PUBMED   31524145
  REMARK    GeneRIF: Low INPP4A expression is associated with cell
            proliferation, migration, and invasion in colorectal cancer.
REFERENCE   6  (bases 1 to 9859)
  AUTHORS   Munday,A.D., Norris,F.A., Caldwell,K.K., Brown,S., Majerus,P.W. and
            Mitchell,C.A.
  TITLE     The inositol polyphosphate 4-phosphatase forms a complex with
            phosphatidylinositol 3-kinase in human platelet cytosol
  JOURNAL   Proc Natl Acad Sci U S A 96 (7), 3640-3645 (1999)
   PUBMED   10097090
REFERENCE   7  (bases 1 to 9859)
  AUTHORS   Zhang,X. and Majerus,P.W.
  TITLE     Phosphatidylinositol signalling reactions
  JOURNAL   Semin Cell Dev Biol 9 (2), 153-160 (1998)
   PUBMED   9599410
  REMARK    Review article
REFERENCE   8  (bases 1 to 9859)
  AUTHORS   Norris,F.A., Atkins,R.C. and Majerus,P.W.
  TITLE     The cDNA cloning and characterization of inositol polyphosphate
            4-phosphatase type II. Evidence for conserved alternative splicing
            in the 4-phosphatase family
  JOURNAL   J Biol Chem 272 (38), 23859-23864 (1997)
   PUBMED   9295334
REFERENCE   9  (bases 1 to 9859)
  AUTHORS   Norris,F.A., Atkins,R.C. and Majerus,P.W.
  TITLE     Inositol polyphosphate 4-phosphatase is inactivated by
            calpain-mediated proteolysis in stimulated human platelets
  JOURNAL   J Biol Chem 272 (17), 10987-10989 (1997)
   PUBMED   9110986
REFERENCE   10 (bases 1 to 9859)
  AUTHORS   Norris,F.A., Auethavekiat,V. and Majerus,P.W.
  TITLE     The isolation and characterization of cDNA encoding human and rat
            brain inositol polyphosphate 4-phosphatase
  JOURNAL   J Biol Chem 270 (27), 16128-16133 (1995)
   PUBMED   7608176
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC010134.5.
            
            On Aug 14, 2020 this sequence version replaced NM_001351429.1.
            
            Summary: This gene encodes an Mg++ independent enzyme that
            hydrolyzes the 4-position phosphate from the inositol ring of
            phosphatidylinositol 3,4-bisphosphate, inositol
            1,3,4-trisphosphate, and inositol 3,4-bisphosphate. Multiple
            transcript variants encoding distinct isoforms have been described.
            [provided by RefSeq, Aug 2008].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803613.267655.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN03465402, SAMN03465403
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-141               AC010134.5         32783-32923
            142-203             AC010134.5         105737-105798
            204-412             AC010134.5         106719-106927
            413-457             AC010134.5         107460-107504
            458-576             AC010134.5         120150-120268
            577-693             AC010134.5         122502-122618
            694-773             AC010134.5         122902-122981
            774-885             AC010134.5         124636-124747
            886-976             AC010134.5         125664-125754
            977-1124            AC010134.5         126301-126448
            1125-1255           AC010134.5         130650-130780
            1256-1360           AC010134.5         132742-132846
            1361-1469           AC010134.5         133359-133467
            1470-1653           AC010134.5         139559-139742
            1654-1872           AC010134.5         141044-141262
            1873-2011           AC010134.5         142326-142464
            2012-2184           AC010134.5         150238-150410
            2185-2308           AC010134.5         151413-151536
            2309-2435           AC010134.5         152413-152539
            2436-2576           AC010134.5         152802-152942
            2577-2674           AC010134.5         155344-155441
            2675-2787           AC010134.5         159588-159700
            2788-2942           AC010134.5         163762-163916
            2943-9859           AC010134.5         174249-181165
FEATURES             Location/Qualifiers
     source          1..9859
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q11.2"
     gene            1..9859
                     /gene="INPP4A"
                     /gene_synonym="INPP4; TVAS1"
                     /note="inositol polyphosphate-4-phosphatase type I A"
                     /db_xref="GeneID:3631"
                     /db_xref="HGNC:HGNC:6074"
                     /db_xref="MIM:600916"
     exon            1..141
                     /gene="INPP4A"
                     /gene_synonym="INPP4; TVAS1"
                     /inference="alignment:Splign:2.1.0"
     exon            142..203
                     /gene="INPP4A"
                     /gene_synonym="INPP4; TVAS1"
                     /inference="alignment:Splign:2.1.0"
     exon            204..412
                     /gene="INPP4A"
                     /gene_synonym="INPP4; TVAS1"
                     /inference="alignment:Splign:2.1.0"
     CDS             307..3075
                     /gene="INPP4A"
                     /gene_synonym="INPP4; TVAS1"
                     /EC_number="3.1.3.66"
                     /note="isoform h is encoded by transcript variant j; type
                     I inositol 3,4-bisphosphate 4-phosphatase; inositol
                     polyphosphate-4-phosphatase, type I, 107kD; inositol
                     polyphosphate-4-phosphatase, type I, 107kDa"
                     /codon_start=1
                     /product="inositol polyphosphate-4-phosphatase type I A
                     isoform h"
                     /protein_id="NP_001338358.1"
                     /db_xref="GeneID:3631"
                     /db_xref="HGNC:HGNC:6074"
                     /db_xref="MIM:600916"
                     /translation="MTAREHSPRHGARARAMQRASTIDVAADMLGLSLAGNIQDPDEP
                     ILEFSLACSELHTPSLDRKPNSFVAVSVTTPPQAFWTKHAQTEIIEGTNNPIFLSSIA
                     FFQDSLINQMTQVKLSVYDVKDRSQGTMYLLGSGTFIVKDLLQDRHHRLHLTLRSAES
                     DRVGNITVIGWQMEEKSDQRPPVTRSVDTVNGRMVLPVDESLTEALGIRSKYASLRKD
                     TLLKSVFGGAICRMYRFPTTDGNHLRILEQMAESVLSLHVPRQFVKLLLEEDAARVCE
                     LEELGELSPCWESLRRQIVTQYQTIILTYQENLTDLHQYRGPSFKASSLKADKKLEFV
                     PTNLHIQRMRVQDDGGSDQNYDIVTIGAPAAHCQGFKSGGLRKKLHKFEETKKHTSSG
                     CQSIIYIPQDVVRAKEIIAQINTLKTQVSYYAERLSRAAKDRSATGLERTLAILADKT
                     RQLVTVCDCKLLANSIHGLNAARPDYIASKASPTSTEEEQVMLRNDQDTLMARWTGRN
                     SRSSLQVDWHEEEWEKVWLNVDKSLECIIQRVDKLLQKERLHGEGCEDVFPCAGSCTS
                     KKGEWSEALYPLLTTLTDCVAMMSDKAKKAMVFLLMQDSAPTIATYLSLQYRRDVVFC
                     QTLTALICGFIIKLRNCLHDDGFLRQLYTIGLLAQFESLLSTYGEELAMLEDMSLGIM
                     DLRNVTFKVTQATSSASADMLPVITGNRDGFNVRVPLPGPLFDALPREIQSGMLLRVQ
                     PVLFNVGINEQQTLAERFGDTSLQEVINVESLVRLNSYFEQFKEVLPEDCLPRSRSQT
                     CLPELLRFLGQNVHARKNKNVDILWQAAEICRRLNGVRFTSCKSAKDRTAMSVTLEQC
                     LILQHEHGMAPQVFTQALECMRSEGCRRENTMKNVGSRKYAFNSLQLKAFPKHYRPPE
                     GTYGKVET"
     exon            413..457
                     /gene="INPP4A"
                     /gene_synonym="INPP4; TVAS1"
                     /inference="alignment:Splign:2.1.0"
     exon            458..576
                     /gene="INPP4A"
                     /gene_synonym="INPP4; TVAS1"
                     /inference="alignment:Splign:2.1.0"
     exon            577..693
                     /gene="INPP4A"
                     /gene_synonym="INPP4; TVAS1"
                     /inference="alignment:Splign:2.1.0"
     exon            694..773
                     /gene="INPP4A"
                     /gene_synonym="INPP4; TVAS1"
                     /inference="alignment:Splign:2.1.0"
     exon            774..885
                     /gene="INPP4A"
                     /gene_synonym="INPP4; TVAS1"
                     /inference="alignment:Splign:2.1.0"
     exon            886..976
                     /gene="INPP4A"
                     /gene_synonym="INPP4; TVAS1"
                     /inference="alignment:Splign:2.1.0"
     exon            977..1124
                     /gene="INPP4A"
                     /gene_synonym="INPP4; TVAS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1125..1255
                     /gene="INPP4A"
                     /gene_synonym="INPP4; TVAS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1256..1360
                     /gene="INPP4A"
                     /gene_synonym="INPP4; TVAS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1361..1469
                     /gene="INPP4A"
                     /gene_synonym="INPP4; TVAS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1470..1653
                     /gene="INPP4A"
                     /gene_synonym="INPP4; TVAS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1654..1872
                     /gene="INPP4A"
                     /gene_synonym="INPP4; TVAS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1873..2011
                     /gene="INPP4A"
                     /gene_synonym="INPP4; TVAS1"
                     /inference="alignment:Splign:2.1.0"
     exon            2012..2184
                     /gene="INPP4A"
                     /gene_synonym="INPP4; TVAS1"
                     /inference="alignment:Splign:2.1.0"
     exon            2185..2308
                     /gene="INPP4A"
                     /gene_synonym="INPP4; TVAS1"
                     /inference="alignment:Splign:2.1.0"
     exon            2309..2435
                     /gene="INPP4A"
                     /gene_synonym="INPP4; TVAS1"
                     /inference="alignment:Splign:2.1.0"
     exon            2436..2576
                     /gene="INPP4A"
                     /gene_synonym="INPP4; TVAS1"
                     /inference="alignment:Splign:2.1.0"
     exon            2577..2674
                     /gene="INPP4A"
                     /gene_synonym="INPP4; TVAS1"
                     /inference="alignment:Splign:2.1.0"
     exon            2675..2787
                     /gene="INPP4A"
                     /gene_synonym="INPP4; TVAS1"
                     /inference="alignment:Splign:2.1.0"
     exon            2788..2942
                     /gene="INPP4A"
                     /gene_synonym="INPP4; TVAS1"
                     /inference="alignment:Splign:2.1.0"
     exon            2943..9859
                     /gene="INPP4A"
                     /gene_synonym="INPP4; TVAS1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5599..5604
                     /regulatory_class="polyA_signal_sequence"
                     /gene="INPP4A"
                     /gene_synonym="INPP4; TVAS1"
                     /note="hexamer: AATAAA"
     polyA_site      5623
                     /gene="INPP4A"
                     /gene_synonym="INPP4; TVAS1"
                     /note="major polyA site"
     regulatory      6229..6234
                     /regulatory_class="polyA_signal_sequence"
                     /gene="INPP4A"
                     /gene_synonym="INPP4; TVAS1"
                     /note="hexamer: ATTAAA"
     polyA_site      6253
                     /gene="INPP4A"
                     /gene_synonym="INPP4; TVAS1"
                     /note="major polyA site"
     polyA_site      6796
                     /gene="INPP4A"
                     /gene_synonym="INPP4; TVAS1"
     regulatory      9515..9520
                     /regulatory_class="polyA_signal_sequence"
                     /gene="INPP4A"
                     /gene_synonym="INPP4; TVAS1"
                     /note="hexamer: AATAAA"
     polyA_site      9532
                     /gene="INPP4A"
                     /gene_synonym="INPP4; TVAS1"
     regulatory      9841..9846
                     /regulatory_class="polyA_signal_sequence"
                     /gene="INPP4A"
                     /gene_synonym="INPP4; TVAS1"
                     /note="hexamer: ATTAAA"
     polyA_site      9859
                     /gene="INPP4A"
                     /gene_synonym="INPP4; TVAS1"
ORIGIN      
        1 agagaaattc tgactggtcc atctgttcac agtgggttgt gtggaccatg gggaagccag
       61 tggggttgag gacagagtgg gttgacttcg gtgtgaatca tggttctgcc gcttgctgac
      121 tctggttctt atctctaaaa gatgatggat ttggacatgc ttctatgaag aaatgccaca
      181 tggtccgaga gcaaacatgt ccaggctact gccactttag tggactaggg ctcggtgcca
      241 gcacttcccg ggtaatcagg cgtggtctga ccgaggatca agaagcacat catcaccaat
      301 gacatcatga cagcaagaga gcacagccct cgccatggtg ccagggcccg tgcaatgcag
      361 cgggcttcca ccatcgacgt ggcggccgac atgctgggcc tctctctggc aggaaatata
      421 caagacccag atgagcccat tttagaattt agcttagctt gcagtgagct gcatactcca
      481 tcgctagatc gaaagccaaa tagttttgtt gcggtgagtg tcaccacccc tcctcaggca
      541 ttctggacga agcatgcaca gacggagatc attgagggaa ccaacaatcc tatatttcta
      601 agcagtattg ccttctttca agactctctt atcaatcaga tgacacaagt caaactctcc
      661 gtgtatgatg tcaaagatag atctcaggga acaatgtatt tactgggctc tggaacgttc
      721 attgtcaaag atctgctcca ggacaggcat cataggttgc atttaacact aaggtctgca
      781 gagagtgacc gtgtaggtaa catcaccgtg attggctggc agatggagga gaagtcagac
      841 caacggcccc ctgtgacccg gtctgtggac actgtcaatg ggaggatggt tcttcctgtc
      901 gatgagagct tgacggaggc gttaggaatc cgatccaaat acgcttcatt gcgaaaggac
      961 actttgctga aatcggtgtt cggtggtgcc atctgccgca tgtaccggtt tccaaccact
     1021 gatggtaacc atttgcggat cctggagcag atggcagaga gcgtgctctc cctgcacgtg
     1081 ccccggcagt tcgtgaagct cctactagag gaagatgcag ccagagtgtg tgagctggag
     1141 gagctgggag agctgtcccc ttgctgggag agcctccggc gccaaattgt cacccagtac
     1201 cagaccatca tcctcacata ccaggagaac ctgaccgacc tccatcagta cagagggccc
     1261 tcgtttaaag caagcagttt gaaagcagat aaaaagttag aatttgttcc cacaaacttg
     1321 cacatacaaa ggatgagagt tcaagacgat ggaggatcag atcagaacta cgacatcgtc
     1381 accattgggg cgccagcagc acactgccaa ggttttaagt caggaggtct ccgcaaaaag
     1441 ctgcacaaat ttgaagagac caagaaacat acatcatctg gctgccagtc cataatctac
     1501 ataccccagg atgttgtcag agccaaggag atcatcgccc agatcaacac cctgaaaacc
     1561 caagtgagtt actacgcaga gcggctgtca agggcagcca aggacaggtc tgccactggc
     1621 cttgagagga cactcgccat cttggcagac aagacacggc agctggtcac ggtctgcgac
     1681 tgcaagctcc tggccaactc catccatggg ctgaacgctg cacggcctga ctacattgcc
     1741 tccaaggcct ctcccacttc gactgaggag gagcaggtga tgcttagaaa tgaccaggac
     1801 accctcatgg cccggtggac agggagaaac agccgatctt ccctgcaggt ggactggcac
     1861 gaggaggagt gggagaaagt gtggctgaac gtggacaaga gcctagagtg catcattcag
     1921 cgtgtggaca agctgctgca gaaggagcgg ctgcatggcg agggctgtga ggatgtcttc
     1981 ccctgtgcag gcagctgcac cagcaagaaa ggtgaatgga gtgaggccct ttacccgctg
     2041 ctgaccactc tcaccgactg cgtggccatg atgagtgaca aggccaagaa ggccatggta
     2101 ttcctgctca tgcaggacag cgcgcccacc atagccacct acctgagcct gcagtaccgc
     2161 cgtgacgtgg tcttctgcca gacgctgacc gccctcatct gcggcttcat cattaagctg
     2221 aggaactgcc tgcatgacga cggcttcctg cgccagctct acaccatcgg gctgctggcc
     2281 cagttcgaga gcctgctgag cacctacggg gaggagctgg caatgctgga ggacatgagc
     2341 cttgggatca tggacttgag gaacgtgacc ttcaaagtca ctcaggccac ttccagcgcc
     2401 tccgcagaca tgctgcccgt catcacagga aatcgcgacg ggtttaacgt gcgggtccct
     2461 ctgccgggcc cgctgtttga cgccttgccc cgggagatcc agagtggcat gctgctgcga
     2521 gtgcagcccg tcctcttcaa cgtgggcatc aatgagcagc agacactggc cgagaggttt
     2581 ggcgatacgt ctttacaaga agtcatcaac gtggagagtt tggtgcggtt aaattcctac
     2641 tttgagcagt ttaaggaagt tttgcctgag gattgcctgc ctcggtctcg cagtcagacg
     2701 tgcctgccag agctgctgcg gtttctgggt cagaacgtgc atgcccggaa gaataagaac
     2761 gtcgacattc tctggcaagc tgctgagatc tgccgccgcc ttaatggggt ccggttcacc
     2821 agctgcaaga gcgctaagga ccgtacagcc atgtcggtga cactggagca gtgcctgatc
     2881 ctgcaacacg agcatggcat ggccccgcag gtcttcaccc aggccctgga gtgcatgcgc
     2941 agtgagggtt gtcgaagaga aaatacaatg aagaatgttg gaagtcgcaa atatgcattt
     3001 aattccctgc agctgaaggc tttccccaag cattacaggc ctcccgaagg gacttacgga
     3061 aaagttgaaa cgtgaacaca cggtttcctc taattagctg ttacataata aatgtgggta
     3121 ccctctagtg tcatatatga attcttcaag aagacctgaa ggattggttt ttattttttg
     3181 tggttttttt aaaaaaaaca tttcactaaa gagtctctgg agcatgtttt ttgttttttg
     3241 ggtttttttc cccattggaa tcaataggag gtaatgtttg gctcaatagt gtggatagta
     3301 acaactgcct atttaaatta aatagccttt ggctgtaact acacagatct catcaatagt
     3361 tacctacatg aatcaagcta ggtttgtctg aaatgctaga agactttttc aaatgcctgc
     3421 ttgctcactt acttttctac agagtaactc aaaagtaacc attgaattac aatccacttt
     3481 gtaaaaatct gaatgtaaaa cagtaaataa taaattaaat aattggatcc taggcatacc
     3541 aataaatgtt atttggggaa agaagctagc actatctcat gcagtgagaa taacgggttc
     3601 tagtgaatta tcctatctac actaccacct gaagaagttg aaagaaagat tgataaatca
     3661 acgggagata agactttatt agaaggtaac acctgcaagg taccccacat agttggggcc
     3721 actctttttt ctgtccctta tgagttacag aacagggagt ctgctggaga cacaaagcca
     3781 gcagtaaggt ccctttagcc tgtctcctgt tctctgaagc tccctgccga ggctccctca
     3841 cgcccagagg acacatctcc ccttcttctc tagatgttaa tgtagggcct cagatgtggc
     3901 atgtcaacac tcccatgggg aatttatgac catagagata gtagaaacct aaatattttc
     3961 agaaaaaaaa ttttttttgc aggatttcca atttatcttt gaaaagacag tacaatcatg
     4021 tttgaatgtc tgatgaaagt gtcttatttt taggtttgca ataattgtta ctttcttatt
     4081 ctcattctta tgtaagatga ctattgagaa acagttgaaa tttattctcc tcaaatgaga
     4141 ttttgaaagg gatttatggg ccataaaact taggaatttc atagaaaatt ttgtctggtc
     4201 atcttttata agatgatgat gagtcttatc tgcacatagc agagtttgtt tcttaggagt
     4261 ttatatgttt tattgattct gtttacgatg tttacatgtt cttgaaaagg ttgtaaaaga
     4321 aatacatatg gcacatatta atgatgctga tcctaatgat ttgtgaacct cttagaaatt
     4381 cttttgtcta aaagcctaga gattcttctg gttcctttag aaacatgtaa caaacttggg
     4441 ccaggggtgc tgaggcatgg ggaggactgc ttattggcag gaacacagag ggggtgggca
     4501 tcaggtaggg tggaactgga tgaccttcca gaccccctcc tactcagaag tcagcatgca
     4561 agcagcgcct gctgtctccc gatgcctgca gggaggaaaa tgtctgtgaa ggacacttta
     4621 atgaaggacg aagctctctg ctgctccctc aaagctgagt tcactgtggc aggcaggaag
     4681 cagagaagct cctgcccgcc aaacccactg cacaggtggc tgctgctggt atcagattct
     4741 cctttttaag tgtcaatttc tgttcacaga cagtttgttt tcaatatggc tgatttaccc
     4801 tttcacctct ccaccatctc atttaatttg taaattttta gttctgtctt ttctcatttt
     4861 aacttttaaa aaatctcctt gctttttaaa aataaatatt acccacatag ttttcagatc
     4921 ttttttgtct ggagagcatt aaatatctgc actcatcaaa gggaatatag caaatgttga
     4981 tcatctgtca gcagttttgc atgtgacacc tttatatgaa ttattttccc aatttttgct
     5041 ctatgtaatg ggtcaccata aaactgtaag acttggcaaa tgctatagaa aaggttcagg
     5101 tttcagtatt ctctctgaag gcatcattcc tgggcttccg gcagcatcac acgcttccag
     5161 tgcctgcagg gtgagggtgt gtggcacaga ggcaagcagc tcctctcttc tgtaggagct
     5221 ttgggttttc agaggtgcag ggaaggcagt tttacaggtt accgtaaaac agaggttccg
     5281 tccagtgttc cttatgatgc ctccccattt aaaaagaaaa gagatctatg gaaaactggg
     5341 aatgtaatgt ggattctgtc agagctccta cagagcacag ttgcctttag tttcctttaa
     5401 agatgtaaaa atattgtata atacagtttt gtccctacac aattgtattt gccaagctta
     5461 gtgcattatg atacctttat ttatttgttt tgggcagtat tactatatat atataaacat
     5521 acagttactg ttttatatat tcttaggtca ttcaaagcca tgtatgctgt aaatgtgcta
     5581 gtctttagaa tgacacataa taaataactg acaagatatt aaatgtggtc ttgcctgatt
     5641 catcctatta ggaggactag ttctatgtga ccagcctgtg actggaccat tgttcttggg
     5701 cattgcattg agtgctcggg tgctgaatac atgtttgtaa acatgggacc atgggagact
     5761 tccattttat aagcttgttt ctgcctaatt tgaagcagag gggcaacagc gttgaggtta
     5821 agagcacgga ctttgggagc acacagacca ggtcccaatc ctggttctgc ccctgactgg
     5881 ctggtgactc tgagcaagtt gcttgacctc tccaagcctc cgtttcctca tgtgcaaagt
     5941 gtggacaaca acagtacctt cctcataagg aacgtgcgac gcgcctcaga agtacgtgtt
     6001 cataaatggt agccattgtt gttaccttcc cgtctgtgaa catggatcac atcatctctg
     6061 tgggtaaccc agtcctcgtt gtatgacttg tcaaaatgca gttccacttg tattaatatt
     6121 gaccctgttc atcgtcacca ggactgcatc ttgcaccact gtgccgtctt ctaggcacac
     6181 acgacccgtt atctcccttg gaaaaattcc tctcactgga aatgtacaat taaaggatga
     6241 ttgaaatgtt taactcttgg agtttttagt attaccaaac tcctagaaat ttaagctacc
     6301 accaaaaata acatgtgcct tttcccttta ttctcattga tggtagcagt gcacctcgtt
     6361 tcagtgtcct gattccttga ttactgtgaa cactgaacat cttttatacc tttatgatat
     6421 ttctatgttt gtgacttcat tggaatgttg atctatttca tatagattgt ttttaatata
     6481 caatgtatta gcccctgtca tatgttgcac actttttaac ctatttgtca gctgtctttt
     6541 ggtctgtggt aggagttata cagtatttta aatggtttat gtagtcacat atacctgtct
     6601 ttcattttga tgcttgttct gaaatggagt cctggcttca ccatggaagg tgggacatat
     6661 gggacagcca tgtccttgtg ggcatggtgg tgtggctgcg tgcccacgac gaggggctgg
     6721 actaaagtgc tcactggcac cttgcttggt gcatgggcca tgctcagttt aatattatta
     6781 acagtttcta ccttcactct catgtctcag gattattttt tcagcattta cctgttctta
     6841 tttctaggat gtttatggtt tcagtcctac atttagatca atccatctgg aatcatcttg
     6901 gtgtaagtcc tgtgttgtgc ttacagtatg taaagtcaga gggaatccct caaggtcagg
     6961 cctaattttg cttctcttta aagttaagcc aagaagaaga catgtcagga cgcccagaca
     7021 tcagctaccg tgagcttctt cctgccctcc ctccgcatgc cattctggtg ctgcgcttca
     7081 gtttcctgtt gagtctctgc ttagtagatg acttggcaca atctggctgc ccagatctag
     7141 gggagttgtc ccagggaggc tttgcgctgg aggaaggtaa gaggagctgg aggttggagc
     7201 ttcccgattt gtgatttttc caagaacaga aatgattagc catgtgggga ggttacttca
     7261 ttgtacattg ttctactgca taacctccct ctattcttta ccagcatcac acagcaggtt
     7321 ggcaccattt ttgaatagag gtttctcaca gtatcctcag cagcattgag tgttcctaat
     7381 gttgtagtaa tgagcagtag atgtctctca gtgggcagtg tgacctcttt ggtcactcta
     7441 aagggctgcc agcatttctc ttaagctggg gggagaagag ctgttctgtg tataggggta
     7501 ttgggaacac atggacagaa ggaactggcc tcacatgcca tcgtgttcct gggatggctc
     7561 ttccaagacc agcagttcct cctggcaggc aggccctcac agaactctgc atttggagat
     7621 ggacaaactc tcttcttctt atcactttct ccccaaaatg tcctcttcta ccagcccctc
     7681 ttaagagccg attttctgta agttatagtg agggcactgc tctgctgtgc acagaaggaa
     7741 ccccagccca gaagcacacg ctccctgtgg aacctgcagg ggtggcagtg atgacagaac
     7801 caagggggtc aaggaagatt ggagaggagt gggcagcagg aaacagctca ggctgcctga
     7861 cctggccccc ggctgcccat gagggcctcc agagaggggc agagctggct tatcgggatc
     7921 catgatggtt tttacacttt taaaagtgcc ctcttctcag agaccctggt tatttccaaa
     7981 agtaggaagt aatcaaattt acagtggata aaatccagta tttgaaatca ggaagacaga
     8041 aaaaaaagca aaatagcatc cttttctgag aggtatatgc tgaccaaaaa gatctttcat
     8101 tcctgtgaac accaagcagc gcggcctctg gcagagagag cgctgggttg tacagatgga
     8161 aacttgtgtt tagcaggctg tctgctccca atagtggccc tggctgcaac tgacctcctg
     8221 atgccctgct gacgctaact gtgggtacca accagcaccg tggacatcgg ccccaggatc
     8281 agtctacgat ttgtctggtg gccaaatgat gacttttgag tgggaaaagc tggtgggggc
     8341 tacaccgtgc tctgcagtgt agtgggatcc tgtgagctgg cctgcacagg cactccctcc
     8401 cctgccaggg gccccaggga ggcttctcca gcctgaggct gcaccctcca tacgattcca
     8461 ccccccatcc tgtgccaaca gtaggcaaac ggagagtagc ttggtcttgt ttttattagc
     8521 tgttgccctc caggctacga cagggttccc agggtgtagc ctgaaaacac ccatactcta
     8581 gattccctcc actggaaccc tgtctttgcc atgatttctt cctgcatcag gcccctgtgg
     8641 gccttgcagg ccagtccagg caggtctttc acactgttgt cccacataac agaaaaagct
     8701 gagcagacag ggtaggaaac acacttgcat ctccatggct ccaaagagga tgcctgtgtt
     8761 agatggatgt agacagacac agcacttcac tgcttcctcc tcctcgccac ccagccctcc
     8821 ctcggtgtct gtggcctgac tctctcctgg tggtcctacg tctctgacca tccctcctca
     8881 ctctcaaatt ttatgttgcc caccacctgc cactaatggc gtggtgttct cctgggttcc
     8941 ctttctcact taagatgatc ttcctgaaaa atcttacaca ttcctgttga acaaatggtc
     9001 acttatatgg tagtgactcc taaatttcta ggtccatccc agactctccc ccaaggtcca
     9061 gattacctat acatctaagc accatgcctg tcttgcaggc atctcaaata cagcatgctc
     9121 atgcctctcc tcctccaagc tggctgagtc tccctctaat agacgacctt gggatcattt
     9181 tctcctccac atcccatcaa tcagccactg aacctgtatc tcttgagaac catcccataa
     9241 tttccatcca tgcaccccaa ggcctggtct gtatcagtcc cctcggatct ggacctctcc
     9301 tgagcatcct cacccctcct gcaaggctag tctcaggtct gccttcctct atggtgattt
     9361 ctccccacaa atgaagttgg ccctttcaaa aaaacttcct ctccttcatt gttgactatg
     9421 aagattcttt catgcatgtc ctgtccactg tcagtcccct ctgtattcac aagagcaagt
     9481 gtaatgcccg ctgtgaagga gctaaagttt gttgaataaa cacatgaaca aatggtggtt
     9541 ttgtggtgtt caactgaaat atttcctatt tcagcactgg accacgctgt ttttctcact
     9601 acataatcgg ttacgctaaa tgcatcacga gccaaattca aaaggtcaaa ggagaaggca
     9661 aatggcagag tgtggtaaag gggcgagtga gagggtctct gaaaaaagtc aggctaaaat
     9721 tacagggggt tcaggcaatg ttatcttgat ctggatggcc agttacatga cagattactt
     9781 tgttcttaac atacgaacat cctattcact ttttggtata ctggttgttt aacagtaaaa
     9841 attaaatgtt taaaaccca
//
