LOCUS       NM_001351428            9892 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens inositol polyphosphate-4-phosphatase type I A
            (INPP4A), transcript variant i, mRNA.
ACCESSION   NM_001351428 XM_017003999
VERSION     NM_001351428.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 9892)
  AUTHORS   Xu,Y., Tong,X., Liu,P., Huang,J., Chen,S., Liu,D., Gu,T., Xie,Y.,
            Guo,D. and Xu,Y.
  TITLE     Deficiency of INPP4A promotes M2 macrophage polarization in
            eosinophilic chronic rhinosinusitis with nasal polyps
  JOURNAL   Inflamm Res 73 (4), 581-595 (2024)
   PUBMED   38363325
  REMARK    GeneRIF: Deficiency of INPP4A promotes M2 macrophage polarization
            in eosinophilic chronic rhinosinusitis with nasal polyps.
REFERENCE   2  (bases 1 to 9892)
  AUTHORS   Maruyama,N., Umikawa,M., Matsumoto,H., Maruyama,T., Nishihara,K.,
            Nakasone,T., Matayoshi,A., Goto,T., Hirano,F., Arasaki,A.,
            Nakamura,H., Matsuzaki,G. and Takaesu,G.
  TITLE     miR-935 Inhibits Oral Squamous Cell Carcinoma and Targets Inositol
            Polyphosphate-4-phosphatase Type IA (INPP4A)
  JOURNAL   Anticancer Res 40 (11), 6101-6113 (2020)
   PUBMED   33109548
  REMARK    GeneRIF: miR-935 Inhibits Oral Squamous Cell Carcinoma and Targets
            Inositol Polyphosphate-4-phosphatase Type IA (INPP4A).
REFERENCE   3  (bases 1 to 9892)
  AUTHORS   Banihashemi,S., Tahmasebi-Birgani,M., Mohammadiasl,J. and
            Hajjari,M.
  TITLE     Whole exome sequencing identified a novel nonsense INPP4A mutation
            in a family with intellectual disability
  JOURNAL   Eur J Med Genet 63 (4), 103846 (2020)
   PUBMED   31978615
  REMARK    GeneRIF: Whole exome sequencing identified a novel nonsense INPP4A
            mutation in a family with intellectual disability.
REFERENCE   4  (bases 1 to 9892)
  AUTHORS   Khanna,K., Chaudhuri,R., Aich,J., Pattnaik,B., Panda,L.,
            Prakash,Y.S., Mabalirajan,U., Ghosh,B. and Agrawal,A.
  TITLE     Secretory Inositol Polyphosphate 4-Phosphatase Protects against
            Airway Inflammation and Remodeling
  JOURNAL   Am J Respir Cell Mol Biol 60 (4), 399-412 (2019)
   PUBMED   30335467
  REMARK    GeneRIF: INPP4A is secreted by airway epithelial cells and
            extracellular INPP4A critically inhibits airway inflammation and
            remodeling.
REFERENCE   5  (bases 1 to 9892)
  AUTHORS   Huang,Y., Xiao,W., Jiang,X. and Li,H.
  TITLE     MicroRNA-935 acts as a prognostic marker and promotes cell
            proliferation, migration, and invasion in colorectal cancer
  JOURNAL   Cancer Biomark 26 (2), 229-237 (2019)
   PUBMED   31524145
  REMARK    GeneRIF: Low INPP4A expression is associated with cell
            proliferation, migration, and invasion in colorectal cancer.
REFERENCE   6  (bases 1 to 9892)
  AUTHORS   Munday,A.D., Norris,F.A., Caldwell,K.K., Brown,S., Majerus,P.W. and
            Mitchell,C.A.
  TITLE     The inositol polyphosphate 4-phosphatase forms a complex with
            phosphatidylinositol 3-kinase in human platelet cytosol
  JOURNAL   Proc Natl Acad Sci U S A 96 (7), 3640-3645 (1999)
   PUBMED   10097090
REFERENCE   7  (bases 1 to 9892)
  AUTHORS   Zhang,X. and Majerus,P.W.
  TITLE     Phosphatidylinositol signalling reactions
  JOURNAL   Semin Cell Dev Biol 9 (2), 153-160 (1998)
   PUBMED   9599410
  REMARK    Review article
REFERENCE   8  (bases 1 to 9892)
  AUTHORS   Norris,F.A., Atkins,R.C. and Majerus,P.W.
  TITLE     The cDNA cloning and characterization of inositol polyphosphate
            4-phosphatase type II. Evidence for conserved alternative splicing
            in the 4-phosphatase family
  JOURNAL   J Biol Chem 272 (38), 23859-23864 (1997)
   PUBMED   9295334
REFERENCE   9  (bases 1 to 9892)
  AUTHORS   Norris,F.A., Atkins,R.C. and Majerus,P.W.
  TITLE     Inositol polyphosphate 4-phosphatase is inactivated by
            calpain-mediated proteolysis in stimulated human platelets
  JOURNAL   J Biol Chem 272 (17), 10987-10989 (1997)
   PUBMED   9110986
REFERENCE   10 (bases 1 to 9892)
  AUTHORS   Norris,F.A., Auethavekiat,V. and Majerus,P.W.
  TITLE     The isolation and characterization of cDNA encoding human and rat
            brain inositol polyphosphate 4-phosphatase
  JOURNAL   J Biol Chem 270 (27), 16128-16133 (1995)
   PUBMED   7608176
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC010134.5.
            
            On Aug 13, 2020 this sequence version replaced NM_001351428.1.
            
            Summary: This gene encodes an Mg++ independent enzyme that
            hydrolyzes the 4-position phosphate from the inositol ring of
            phosphatidylinositol 3,4-bisphosphate, inositol
            1,3,4-trisphosphate, and inositol 3,4-bisphosphate. Multiple
            transcript variants encoding distinct isoforms have been described.
            [provided by RefSeq, Aug 2008].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803616.216529.1,
                                           SRR14038192.1226124.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN03465402, SAMN03465403
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-141               AC010134.5         32783-32923
            142-203             AC010134.5         105737-105798
            204-412             AC010134.5         106719-106927
            413-457             AC010134.5         107460-107504
            458-576             AC010134.5         120150-120268
            577-693             AC010134.5         122502-122618
            694-773             AC010134.5         122902-122981
            774-885             AC010134.5         124636-124747
            886-976             AC010134.5         125664-125754
            977-1124            AC010134.5         126301-126448
            1125-1255           AC010134.5         130650-130780
            1256-1360           AC010134.5         132742-132846
            1361-1469           AC010134.5         133359-133467
            1470-1653           AC010134.5         139559-139742
            1654-1872           AC010134.5         141044-141262
            1873-2011           AC010134.5         142326-142464
            2012-2044           AC010134.5         146236-146268
            2045-2217           AC010134.5         150238-150410
            2218-2341           AC010134.5         151413-151536
            2342-2468           AC010134.5         152413-152539
            2469-2609           AC010134.5         152802-152942
            2610-2707           AC010134.5         155344-155441
            2708-2820           AC010134.5         159588-159700
            2821-2975           AC010134.5         163762-163916
            2976-9892           AC010134.5         174249-181165
FEATURES             Location/Qualifiers
     source          1..9892
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q11.2"
     gene            1..9892
                     /gene="INPP4A"
                     /gene_synonym="INPP4; TVAS1"
                     /note="inositol polyphosphate-4-phosphatase type I A"
                     /db_xref="GeneID:3631"
                     /db_xref="HGNC:HGNC:6074"
                     /db_xref="MIM:600916"
     exon            1..141
                     /gene="INPP4A"
                     /gene_synonym="INPP4; TVAS1"
                     /inference="alignment:Splign:2.1.0"
     exon            142..203
                     /gene="INPP4A"
                     /gene_synonym="INPP4; TVAS1"
                     /inference="alignment:Splign:2.1.0"
     exon            204..412
                     /gene="INPP4A"
                     /gene_synonym="INPP4; TVAS1"
                     /inference="alignment:Splign:2.1.0"
     CDS             307..3108
                     /gene="INPP4A"
                     /gene_synonym="INPP4; TVAS1"
                     /EC_number="3.1.3.66"
                     /note="isoform g is encoded by transcript variant i; type
                     I inositol 3,4-bisphosphate 4-phosphatase; inositol
                     polyphosphate-4-phosphatase, type I, 107kD; inositol
                     polyphosphate-4-phosphatase, type I, 107kDa"
                     /codon_start=1
                     /product="inositol polyphosphate-4-phosphatase type I A
                     isoform g"
                     /protein_id="NP_001338357.1"
                     /db_xref="GeneID:3631"
                     /db_xref="HGNC:HGNC:6074"
                     /db_xref="MIM:600916"
                     /translation="MTAREHSPRHGARARAMQRASTIDVAADMLGLSLAGNIQDPDEP
                     ILEFSLACSELHTPSLDRKPNSFVAVSVTTPPQAFWTKHAQTEIIEGTNNPIFLSSIA
                     FFQDSLINQMTQVKLSVYDVKDRSQGTMYLLGSGTFIVKDLLQDRHHRLHLTLRSAES
                     DRVGNITVIGWQMEEKSDQRPPVTRSVDTVNGRMVLPVDESLTEALGIRSKYASLRKD
                     TLLKSVFGGAICRMYRFPTTDGNHLRILEQMAESVLSLHVPRQFVKLLLEEDAARVCE
                     LEELGELSPCWESLRRQIVTQYQTIILTYQENLTDLHQYRGPSFKASSLKADKKLEFV
                     PTNLHIQRMRVQDDGGSDQNYDIVTIGAPAAHCQGFKSGGLRKKLHKFEETKKHTSSG
                     CQSIIYIPQDVVRAKEIIAQINTLKTQVSYYAERLSRAAKDRSATGLERTLAILADKT
                     RQLVTVCDCKLLANSIHGLNAARPDYIASKASPTSTEEEQVMLRNDQDTLMARWTGRN
                     SRSSLQVDWHEEEWEKVWLNVDKSLECIIQRVDKLLQKERLHGEGCEDVFPCAGSCTS
                     KKDCSPPPEESSPGEWSEALYPLLTTLTDCVAMMSDKAKKAMVFLLMQDSAPTIATYL
                     SLQYRRDVVFCQTLTALICGFIIKLRNCLHDDGFLRQLYTIGLLAQFESLLSTYGEEL
                     AMLEDMSLGIMDLRNVTFKVTQATSSASADMLPVITGNRDGFNVRVPLPGPLFDALPR
                     EIQSGMLLRVQPVLFNVGINEQQTLAERFGDTSLQEVINVESLVRLNSYFEQFKEVLP
                     EDCLPRSRSQTCLPELLRFLGQNVHARKNKNVDILWQAAEICRRLNGVRFTSCKSAKD
                     RTAMSVTLEQCLILQHEHGMAPQVFTQALECMRSEGCRRENTMKNVGSRKYAFNSLQL
                     KAFPKHYRPPEGTYGKVET"
     exon            413..457
                     /gene="INPP4A"
                     /gene_synonym="INPP4; TVAS1"
                     /inference="alignment:Splign:2.1.0"
     exon            458..576
                     /gene="INPP4A"
                     /gene_synonym="INPP4; TVAS1"
                     /inference="alignment:Splign:2.1.0"
     exon            577..693
                     /gene="INPP4A"
                     /gene_synonym="INPP4; TVAS1"
                     /inference="alignment:Splign:2.1.0"
     exon            694..773
                     /gene="INPP4A"
                     /gene_synonym="INPP4; TVAS1"
                     /inference="alignment:Splign:2.1.0"
     exon            774..885
                     /gene="INPP4A"
                     /gene_synonym="INPP4; TVAS1"
                     /inference="alignment:Splign:2.1.0"
     exon            886..976
                     /gene="INPP4A"
                     /gene_synonym="INPP4; TVAS1"
                     /inference="alignment:Splign:2.1.0"
     exon            977..1124
                     /gene="INPP4A"
                     /gene_synonym="INPP4; TVAS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1125..1255
                     /gene="INPP4A"
                     /gene_synonym="INPP4; TVAS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1256..1360
                     /gene="INPP4A"
                     /gene_synonym="INPP4; TVAS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1361..1469
                     /gene="INPP4A"
                     /gene_synonym="INPP4; TVAS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1470..1653
                     /gene="INPP4A"
                     /gene_synonym="INPP4; TVAS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1654..1872
                     /gene="INPP4A"
                     /gene_synonym="INPP4; TVAS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1873..2011
                     /gene="INPP4A"
                     /gene_synonym="INPP4; TVAS1"
                     /inference="alignment:Splign:2.1.0"
     exon            2012..2044
                     /gene="INPP4A"
                     /gene_synonym="INPP4; TVAS1"
                     /inference="alignment:Splign:2.1.0"
     exon            2045..2217
                     /gene="INPP4A"
                     /gene_synonym="INPP4; TVAS1"
                     /inference="alignment:Splign:2.1.0"
     exon            2218..2341
                     /gene="INPP4A"
                     /gene_synonym="INPP4; TVAS1"
                     /inference="alignment:Splign:2.1.0"
     exon            2342..2468
                     /gene="INPP4A"
                     /gene_synonym="INPP4; TVAS1"
                     /inference="alignment:Splign:2.1.0"
     exon            2469..2609
                     /gene="INPP4A"
                     /gene_synonym="INPP4; TVAS1"
                     /inference="alignment:Splign:2.1.0"
     exon            2610..2707
                     /gene="INPP4A"
                     /gene_synonym="INPP4; TVAS1"
                     /inference="alignment:Splign:2.1.0"
     exon            2708..2820
                     /gene="INPP4A"
                     /gene_synonym="INPP4; TVAS1"
                     /inference="alignment:Splign:2.1.0"
     exon            2821..2975
                     /gene="INPP4A"
                     /gene_synonym="INPP4; TVAS1"
                     /inference="alignment:Splign:2.1.0"
     exon            2976..9892
                     /gene="INPP4A"
                     /gene_synonym="INPP4; TVAS1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5632..5637
                     /regulatory_class="polyA_signal_sequence"
                     /gene="INPP4A"
                     /gene_synonym="INPP4; TVAS1"
                     /note="hexamer: AATAAA"
     polyA_site      5656
                     /gene="INPP4A"
                     /gene_synonym="INPP4; TVAS1"
                     /note="major polyA site"
     regulatory      6262..6267
                     /regulatory_class="polyA_signal_sequence"
                     /gene="INPP4A"
                     /gene_synonym="INPP4; TVAS1"
                     /note="hexamer: ATTAAA"
     polyA_site      6286
                     /gene="INPP4A"
                     /gene_synonym="INPP4; TVAS1"
                     /note="major polyA site"
     polyA_site      6829
                     /gene="INPP4A"
                     /gene_synonym="INPP4; TVAS1"
     regulatory      9548..9553
                     /regulatory_class="polyA_signal_sequence"
                     /gene="INPP4A"
                     /gene_synonym="INPP4; TVAS1"
                     /note="hexamer: AATAAA"
     polyA_site      9565
                     /gene="INPP4A"
                     /gene_synonym="INPP4; TVAS1"
     regulatory      9874..9879
                     /regulatory_class="polyA_signal_sequence"
                     /gene="INPP4A"
                     /gene_synonym="INPP4; TVAS1"
                     /note="hexamer: ATTAAA"
     polyA_site      9892
                     /gene="INPP4A"
                     /gene_synonym="INPP4; TVAS1"
ORIGIN      
        1 agagaaattc tgactggtcc atctgttcac agtgggttgt gtggaccatg gggaagccag
       61 tggggttgag gacagagtgg gttgacttcg gtgtgaatca tggttctgcc gcttgctgac
      121 tctggttctt atctctaaaa gatgatggat ttggacatgc ttctatgaag aaatgccaca
      181 tggtccgaga gcaaacatgt ccaggctact gccactttag tggactaggg ctcggtgcca
      241 gcacttcccg ggtaatcagg cgtggtctga ccgaggatca agaagcacat catcaccaat
      301 gacatcatga cagcaagaga gcacagccct cgccatggtg ccagggcccg tgcaatgcag
      361 cgggcttcca ccatcgacgt ggcggccgac atgctgggcc tctctctggc aggaaatata
      421 caagacccag atgagcccat tttagaattt agcttagctt gcagtgagct gcatactcca
      481 tcgctagatc gaaagccaaa tagttttgtt gcggtgagtg tcaccacccc tcctcaggca
      541 ttctggacga agcatgcaca gacggagatc attgagggaa ccaacaatcc tatatttcta
      601 agcagtattg ccttctttca agactctctt atcaatcaga tgacacaagt caaactctcc
      661 gtgtatgatg tcaaagatag atctcaggga acaatgtatt tactgggctc tggaacgttc
      721 attgtcaaag atctgctcca ggacaggcat cataggttgc atttaacact aaggtctgca
      781 gagagtgacc gtgtaggtaa catcaccgtg attggctggc agatggagga gaagtcagac
      841 caacggcccc ctgtgacccg gtctgtggac actgtcaatg ggaggatggt tcttcctgtc
      901 gatgagagct tgacggaggc gttaggaatc cgatccaaat acgcttcatt gcgaaaggac
      961 actttgctga aatcggtgtt cggtggtgcc atctgccgca tgtaccggtt tccaaccact
     1021 gatggtaacc atttgcggat cctggagcag atggcagaga gcgtgctctc cctgcacgtg
     1081 ccccggcagt tcgtgaagct cctactagag gaagatgcag ccagagtgtg tgagctggag
     1141 gagctgggag agctgtcccc ttgctgggag agcctccggc gccaaattgt cacccagtac
     1201 cagaccatca tcctcacata ccaggagaac ctgaccgacc tccatcagta cagagggccc
     1261 tcgtttaaag caagcagttt gaaagcagat aaaaagttag aatttgttcc cacaaacttg
     1321 cacatacaaa ggatgagagt tcaagacgat ggaggatcag atcagaacta cgacatcgtc
     1381 accattgggg cgccagcagc acactgccaa ggttttaagt caggaggtct ccgcaaaaag
     1441 ctgcacaaat ttgaagagac caagaaacat acatcatctg gctgccagtc cataatctac
     1501 ataccccagg atgttgtcag agccaaggag atcatcgccc agatcaacac cctgaaaacc
     1561 caagtgagtt actacgcaga gcggctgtca agggcagcca aggacaggtc tgccactggc
     1621 cttgagagga cactcgccat cttggcagac aagacacggc agctggtcac ggtctgcgac
     1681 tgcaagctcc tggccaactc catccatggg ctgaacgctg cacggcctga ctacattgcc
     1741 tccaaggcct ctcccacttc gactgaggag gagcaggtga tgcttagaaa tgaccaggac
     1801 accctcatgg cccggtggac agggagaaac agccgatctt ccctgcaggt ggactggcac
     1861 gaggaggagt gggagaaagt gtggctgaac gtggacaaga gcctagagtg catcattcag
     1921 cgtgtggaca agctgctgca gaaggagcgg ctgcatggcg agggctgtga ggatgtcttc
     1981 ccctgtgcag gcagctgcac cagcaagaaa gattgcagtc cccctcctga agagtccagc
     2041 ccaggtgaat ggagtgaggc cctttacccg ctgctgacca ctctcaccga ctgcgtggcc
     2101 atgatgagtg acaaggccaa gaaggccatg gtattcctgc tcatgcagga cagcgcgccc
     2161 accatagcca cctacctgag cctgcagtac cgccgtgacg tggtcttctg ccagacgctg
     2221 accgccctca tctgcggctt catcattaag ctgaggaact gcctgcatga cgacggcttc
     2281 ctgcgccagc tctacaccat cgggctgctg gcccagttcg agagcctgct gagcacctac
     2341 ggggaggagc tggcaatgct ggaggacatg agccttggga tcatggactt gaggaacgtg
     2401 accttcaaag tcactcaggc cacttccagc gcctccgcag acatgctgcc cgtcatcaca
     2461 ggaaatcgcg acgggtttaa cgtgcgggtc cctctgccgg gcccgctgtt tgacgccttg
     2521 ccccgggaga tccagagtgg catgctgctg cgagtgcagc ccgtcctctt caacgtgggc
     2581 atcaatgagc agcagacact ggccgagagg tttggcgata cgtctttaca agaagtcatc
     2641 aacgtggaga gtttggtgcg gttaaattcc tactttgagc agtttaagga agttttgcct
     2701 gaggattgcc tgcctcggtc tcgcagtcag acgtgcctgc cagagctgct gcggtttctg
     2761 ggtcagaacg tgcatgcccg gaagaataag aacgtcgaca ttctctggca agctgctgag
     2821 atctgccgcc gccttaatgg ggtccggttc accagctgca agagcgctaa ggaccgtaca
     2881 gccatgtcgg tgacactgga gcagtgcctg atcctgcaac acgagcatgg catggccccg
     2941 caggtcttca cccaggccct ggagtgcatg cgcagtgagg gttgtcgaag agaaaataca
     3001 atgaagaatg ttggaagtcg caaatatgca tttaattccc tgcagctgaa ggctttcccc
     3061 aagcattaca ggcctcccga agggacttac ggaaaagttg aaacgtgaac acacggtttc
     3121 ctctaattag ctgttacata ataaatgtgg gtaccctcta gtgtcatata tgaattcttc
     3181 aagaagacct gaaggattgg tttttatttt ttgtggtttt tttaaaaaaa acatttcact
     3241 aaagagtctc tggagcatgt tttttgtttt ttgggttttt ttccccattg gaatcaatag
     3301 gaggtaatgt ttggctcaat agtgtggata gtaacaactg cctatttaaa ttaaatagcc
     3361 tttggctgta actacacaga tctcatcaat agttacctac atgaatcaag ctaggtttgt
     3421 ctgaaatgct agaagacttt ttcaaatgcc tgcttgctca cttacttttc tacagagtaa
     3481 ctcaaaagta accattgaat tacaatccac tttgtaaaaa tctgaatgta aaacagtaaa
     3541 taataaatta aataattgga tcctaggcat accaataaat gttatttggg gaaagaagct
     3601 agcactatct catgcagtga gaataacggg ttctagtgaa ttatcctatc tacactacca
     3661 cctgaagaag ttgaaagaaa gattgataaa tcaacgggag ataagacttt attagaaggt
     3721 aacacctgca aggtacccca catagttggg gccactcttt tttctgtccc ttatgagtta
     3781 cagaacaggg agtctgctgg agacacaaag ccagcagtaa ggtcccttta gcctgtctcc
     3841 tgttctctga agctccctgc cgaggctccc tcacgcccag aggacacatc tccccttctt
     3901 ctctagatgt taatgtaggg cctcagatgt ggcatgtcaa cactcccatg gggaatttat
     3961 gaccatagag atagtagaaa cctaaatatt ttcagaaaaa aaattttttt tgcaggattt
     4021 ccaatttatc tttgaaaaga cagtacaatc atgtttgaat gtctgatgaa agtgtcttat
     4081 ttttaggttt gcaataattg ttactttctt attctcattc ttatgtaaga tgactattga
     4141 gaaacagttg aaatttattc tcctcaaatg agattttgaa agggatttat gggccataaa
     4201 acttaggaat ttcatagaaa attttgtctg gtcatctttt ataagatgat gatgagtctt
     4261 atctgcacat agcagagttt gtttcttagg agtttatatg ttttattgat tctgtttacg
     4321 atgtttacat gttcttgaaa aggttgtaaa agaaatacat atggcacata ttaatgatgc
     4381 tgatcctaat gatttgtgaa cctcttagaa attcttttgt ctaaaagcct agagattctt
     4441 ctggttcctt tagaaacatg taacaaactt gggccagggg tgctgaggca tggggaggac
     4501 tgcttattgg caggaacaca gagggggtgg gcatcaggta gggtggaact ggatgacctt
     4561 ccagaccccc tcctactcag aagtcagcat gcaagcagcg cctgctgtct cccgatgcct
     4621 gcagggagga aaatgtctgt gaaggacact ttaatgaagg acgaagctct ctgctgctcc
     4681 ctcaaagctg agttcactgt ggcaggcagg aagcagagaa gctcctgccc gccaaaccca
     4741 ctgcacaggt ggctgctgct ggtatcagat tctccttttt aagtgtcaat ttctgttcac
     4801 agacagtttg ttttcaatat ggctgattta ccctttcacc tctccaccat ctcatttaat
     4861 ttgtaaattt ttagttctgt cttttctcat tttaactttt aaaaaatctc cttgcttttt
     4921 aaaaataaat attacccaca tagttttcag atcttttttg tctggagagc attaaatatc
     4981 tgcactcatc aaagggaata tagcaaatgt tgatcatctg tcagcagttt tgcatgtgac
     5041 acctttatat gaattatttt cccaattttt gctctatgta atgggtcacc ataaaactgt
     5101 aagacttggc aaatgctata gaaaaggttc aggtttcagt attctctctg aaggcatcat
     5161 tcctgggctt ccggcagcat cacacgcttc cagtgcctgc agggtgaggg tgtgtggcac
     5221 agaggcaagc agctcctctc ttctgtagga gctttgggtt ttcagaggtg cagggaaggc
     5281 agttttacag gttaccgtaa aacagaggtt ccgtccagtg ttccttatga tgcctcccca
     5341 tttaaaaaga aaagagatct atggaaaact gggaatgtaa tgtggattct gtcagagctc
     5401 ctacagagca cagttgcctt tagtttcctt taaagatgta aaaatattgt ataatacagt
     5461 tttgtcccta cacaattgta tttgccaagc ttagtgcatt atgatacctt tatttatttg
     5521 ttttgggcag tattactata tatatataaa catacagtta ctgttttata tattcttagg
     5581 tcattcaaag ccatgtatgc tgtaaatgtg ctagtcttta gaatgacaca taataaataa
     5641 ctgacaagat attaaatgtg gtcttgcctg attcatccta ttaggaggac tagttctatg
     5701 tgaccagcct gtgactggac cattgttctt gggcattgca ttgagtgctc gggtgctgaa
     5761 tacatgtttg taaacatggg accatgggag acttccattt tataagcttg tttctgccta
     5821 atttgaagca gaggggcaac agcgttgagg ttaagagcac ggactttggg agcacacaga
     5881 ccaggtccca atcctggttc tgcccctgac tggctggtga ctctgagcaa gttgcttgac
     5941 ctctccaagc ctccgtttcc tcatgtgcaa agtgtggaca acaacagtac cttcctcata
     6001 aggaacgtgc gacgcgcctc agaagtacgt gttcataaat ggtagccatt gttgttacct
     6061 tcccgtctgt gaacatggat cacatcatct ctgtgggtaa cccagtcctc gttgtatgac
     6121 ttgtcaaaat gcagttccac ttgtattaat attgaccctg ttcatcgtca ccaggactgc
     6181 atcttgcacc actgtgccgt cttctaggca cacacgaccc gttatctccc ttggaaaaat
     6241 tcctctcact ggaaatgtac aattaaagga tgattgaaat gtttaactct tggagttttt
     6301 agtattacca aactcctaga aatttaagct accaccaaaa ataacatgtg ccttttccct
     6361 ttattctcat tgatggtagc agtgcacctc gtttcagtgt cctgattcct tgattactgt
     6421 gaacactgaa catcttttat acctttatga tatttctatg tttgtgactt cattggaatg
     6481 ttgatctatt tcatatagat tgtttttaat atacaatgta ttagcccctg tcatatgttg
     6541 cacacttttt aacctatttg tcagctgtct tttggtctgt ggtaggagtt atacagtatt
     6601 ttaaatggtt tatgtagtca catatacctg tctttcattt tgatgcttgt tctgaaatgg
     6661 agtcctggct tcaccatgga aggtgggaca tatgggacag ccatgtcctt gtgggcatgg
     6721 tggtgtggct gcgtgcccac gacgaggggc tggactaaag tgctcactgg caccttgctt
     6781 ggtgcatggg ccatgctcag tttaatatta ttaacagttt ctaccttcac tctcatgtct
     6841 caggattatt ttttcagcat ttacctgttc ttatttctag gatgtttatg gtttcagtcc
     6901 tacatttaga tcaatccatc tggaatcatc ttggtgtaag tcctgtgttg tgcttacagt
     6961 atgtaaagtc agagggaatc cctcaaggtc aggcctaatt ttgcttctct ttaaagttaa
     7021 gccaagaaga agacatgtca ggacgcccag acatcagcta ccgtgagctt cttcctgccc
     7081 tccctccgca tgccattctg gtgctgcgct tcagtttcct gttgagtctc tgcttagtag
     7141 atgacttggc acaatctggc tgcccagatc taggggagtt gtcccaggga ggctttgcgc
     7201 tggaggaagg taagaggagc tggaggttgg agcttcccga tttgtgattt ttccaagaac
     7261 agaaatgatt agccatgtgg ggaggttact tcattgtaca ttgttctact gcataacctc
     7321 cctctattct ttaccagcat cacacagcag gttggcacca tttttgaata gaggtttctc
     7381 acagtatcct cagcagcatt gagtgttcct aatgttgtag taatgagcag tagatgtctc
     7441 tcagtgggca gtgtgacctc tttggtcact ctaaagggct gccagcattt ctcttaagct
     7501 ggggggagaa gagctgttct gtgtataggg gtattgggaa cacatggaca gaaggaactg
     7561 gcctcacatg ccatcgtgtt cctgggatgg ctcttccaag accagcagtt cctcctggca
     7621 ggcaggccct cacagaactc tgcatttgga gatggacaaa ctctcttctt cttatcactt
     7681 tctccccaaa atgtcctctt ctaccagccc ctcttaagag ccgattttct gtaagttata
     7741 gtgagggcac tgctctgctg tgcacagaag gaaccccagc ccagaagcac acgctccctg
     7801 tggaacctgc aggggtggca gtgatgacag aaccaagggg gtcaaggaag attggagagg
     7861 agtgggcagc aggaaacagc tcaggctgcc tgacctggcc cccggctgcc catgagggcc
     7921 tccagagagg ggcagagctg gcttatcggg atccatgatg gtttttacac ttttaaaagt
     7981 gccctcttct cagagaccct ggttatttcc aaaagtagga agtaatcaaa tttacagtgg
     8041 ataaaatcca gtatttgaaa tcaggaagac agaaaaaaaa gcaaaatagc atccttttct
     8101 gagaggtata tgctgaccaa aaagatcttt cattcctgtg aacaccaagc agcgcggcct
     8161 ctggcagaga gagcgctggg ttgtacagat ggaaacttgt gtttagcagg ctgtctgctc
     8221 ccaatagtgg ccctggctgc aactgacctc ctgatgccct gctgacgcta actgtgggta
     8281 ccaaccagca ccgtggacat cggccccagg atcagtctac gatttgtctg gtggccaaat
     8341 gatgactttt gagtgggaaa agctggtggg ggctacaccg tgctctgcag tgtagtggga
     8401 tcctgtgagc tggcctgcac aggcactccc tcccctgcca ggggccccag ggaggcttct
     8461 ccagcctgag gctgcaccct ccatacgatt ccacccccca tcctgtgcca acagtaggca
     8521 aacggagagt agcttggtct tgtttttatt agctgttgcc ctccaggcta cgacagggtt
     8581 cccagggtgt agcctgaaaa cacccatact ctagattccc tccactggaa ccctgtcttt
     8641 gccatgattt cttcctgcat caggcccctg tgggccttgc aggccagtcc aggcaggtct
     8701 ttcacactgt tgtcccacat aacagaaaaa gctgagcaga cagggtagga aacacacttg
     8761 catctccatg gctccaaaga ggatgcctgt gttagatgga tgtagacaga cacagcactt
     8821 cactgcttcc tcctcctcgc cacccagccc tccctcggtg tctgtggcct gactctctcc
     8881 tggtggtcct acgtctctga ccatccctcc tcactctcaa attttatgtt gcccaccacc
     8941 tgccactaat ggcgtggtgt tctcctgggt tccctttctc acttaagatg atcttcctga
     9001 aaaatcttac acattcctgt tgaacaaatg gtcacttata tggtagtgac tcctaaattt
     9061 ctaggtccat cccagactct cccccaaggt ccagattacc tatacatcta agcaccatgc
     9121 ctgtcttgca ggcatctcaa atacagcatg ctcatgcctc tcctcctcca agctggctga
     9181 gtctccctct aatagacgac cttgggatca ttttctcctc cacatcccat caatcagcca
     9241 ctgaacctgt atctcttgag aaccatccca taatttccat ccatgcaccc caaggcctgg
     9301 tctgtatcag tcccctcgga tctggacctc tcctgagcat cctcacccct cctgcaaggc
     9361 tagtctcagg tctgccttcc tctatggtga tttctcccca caaatgaagt tggccctttc
     9421 aaaaaaactt cctctccttc attgttgact atgaagattc tttcatgcat gtcctgtcca
     9481 ctgtcagtcc cctctgtatt cacaagagca agtgtaatgc ccgctgtgaa ggagctaaag
     9541 tttgttgaat aaacacatga acaaatggtg gttttgtggt gttcaactga aatatttcct
     9601 atttcagcac tggaccacgc tgtttttctc actacataat cggttacgct aaatgcatca
     9661 cgagccaaat tcaaaaggtc aaaggagaag gcaaatggca gagtgtggta aaggggcgag
     9721 tgagagggtc tctgaaaaaa gtcaggctaa aattacaggg ggttcaggca atgttatctt
     9781 gatctggatg gccagttaca tgacagatta ctttgttctt aacatacgaa catcctattc
     9841 actttttggt atactggttg tttaacagta aaaattaaat gtttaaaacc ca
//
