LOCUS       NM_001134225           10096 bp    mRNA    linear   PRI 06-APR-2024
DEFINITION  Homo sapiens inositol polyphosphate-4-phosphatase type I A
            (INPP4A), transcript variant c, mRNA.
ACCESSION   NM_001134225
VERSION     NM_001134225.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 10096)
  AUTHORS   Xu,Y., Tong,X., Liu,P., Huang,J., Chen,S., Liu,D., Gu,T., Xie,Y.,
            Guo,D. and Xu,Y.
  TITLE     Deficiency of INPP4A promotes M2 macrophage polarization in
            eosinophilic chronic rhinosinusitis with nasal polyps
  JOURNAL   Inflamm Res 73 (4), 581-595 (2024)
   PUBMED   38363325
  REMARK    GeneRIF: Deficiency of INPP4A promotes M2 macrophage polarization
            in eosinophilic chronic rhinosinusitis with nasal polyps.
REFERENCE   2  (bases 1 to 10096)
  AUTHORS   Maruyama,N., Umikawa,M., Matsumoto,H., Maruyama,T., Nishihara,K.,
            Nakasone,T., Matayoshi,A., Goto,T., Hirano,F., Arasaki,A.,
            Nakamura,H., Matsuzaki,G. and Takaesu,G.
  TITLE     miR-935 Inhibits Oral Squamous Cell Carcinoma and Targets Inositol
            Polyphosphate-4-phosphatase Type IA (INPP4A)
  JOURNAL   Anticancer Res 40 (11), 6101-6113 (2020)
   PUBMED   33109548
  REMARK    GeneRIF: miR-935 Inhibits Oral Squamous Cell Carcinoma and Targets
            Inositol Polyphosphate-4-phosphatase Type IA (INPP4A).
REFERENCE   3  (bases 1 to 10096)
  AUTHORS   Banihashemi,S., Tahmasebi-Birgani,M., Mohammadiasl,J. and
            Hajjari,M.
  TITLE     Whole exome sequencing identified a novel nonsense INPP4A mutation
            in a family with intellectual disability
  JOURNAL   Eur J Med Genet 63 (4), 103846 (2020)
   PUBMED   31978615
  REMARK    GeneRIF: Whole exome sequencing identified a novel nonsense INPP4A
            mutation in a family with intellectual disability.
REFERENCE   4  (bases 1 to 10096)
  AUTHORS   Khanna,K., Chaudhuri,R., Aich,J., Pattnaik,B., Panda,L.,
            Prakash,Y.S., Mabalirajan,U., Ghosh,B. and Agrawal,A.
  TITLE     Secretory Inositol Polyphosphate 4-Phosphatase Protects against
            Airway Inflammation and Remodeling
  JOURNAL   Am J Respir Cell Mol Biol 60 (4), 399-412 (2019)
   PUBMED   30335467
  REMARK    GeneRIF: INPP4A is secreted by airway epithelial cells and
            extracellular INPP4A critically inhibits airway inflammation and
            remodeling.
REFERENCE   5  (bases 1 to 10096)
  AUTHORS   Huang,Y., Xiao,W., Jiang,X. and Li,H.
  TITLE     MicroRNA-935 acts as a prognostic marker and promotes cell
            proliferation, migration, and invasion in colorectal cancer
  JOURNAL   Cancer Biomark 26 (2), 229-237 (2019)
   PUBMED   31524145
  REMARK    GeneRIF: Low INPP4A expression is associated with cell
            proliferation, migration, and invasion in colorectal cancer.
REFERENCE   6  (bases 1 to 10096)
  AUTHORS   Munday,A.D., Norris,F.A., Caldwell,K.K., Brown,S., Majerus,P.W. and
            Mitchell,C.A.
  TITLE     The inositol polyphosphate 4-phosphatase forms a complex with
            phosphatidylinositol 3-kinase in human platelet cytosol
  JOURNAL   Proc Natl Acad Sci U S A 96 (7), 3640-3645 (1999)
   PUBMED   10097090
REFERENCE   7  (bases 1 to 10096)
  AUTHORS   Zhang,X. and Majerus,P.W.
  TITLE     Phosphatidylinositol signalling reactions
  JOURNAL   Semin Cell Dev Biol 9 (2), 153-160 (1998)
   PUBMED   9599410
  REMARK    Review article
REFERENCE   8  (bases 1 to 10096)
  AUTHORS   Norris,F.A., Atkins,R.C. and Majerus,P.W.
  TITLE     The cDNA cloning and characterization of inositol polyphosphate
            4-phosphatase type II. Evidence for conserved alternative splicing
            in the 4-phosphatase family
  JOURNAL   J Biol Chem 272 (38), 23859-23864 (1997)
   PUBMED   9295334
REFERENCE   9  (bases 1 to 10096)
  AUTHORS   Norris,F.A., Atkins,R.C. and Majerus,P.W.
  TITLE     Inositol polyphosphate 4-phosphatase is inactivated by
            calpain-mediated proteolysis in stimulated human platelets
  JOURNAL   J Biol Chem 272 (17), 10987-10989 (1997)
   PUBMED   9110986
REFERENCE   10 (bases 1 to 10096)
  AUTHORS   Norris,F.A., Auethavekiat,V. and Majerus,P.W.
  TITLE     The isolation and characterization of cDNA encoding human and rat
            brain inositol polyphosphate 4-phosphatase
  JOURNAL   J Biol Chem 270 (27), 16128-16133 (1995)
   PUBMED   7608176
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC028361.2 and AC010134.5.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_001134225.1.
            
            Summary: This gene encodes an Mg++ independent enzyme that
            hydrolyzes the 4-position phosphate from the inositol ring of
            phosphatidylinositol 3,4-bisphosphate, inositol
            1,3,4-trisphosphate, and inositol 3,4-bisphosphate. Multiple
            transcript variants encoding distinct isoforms have been described.
            [provided by RefSeq, Aug 2008].
            
            Transcript Variant: This variant (c) lacks an alternate exon and
            uses an alternate, in-frame splice site in the coding region
            compared to variant a. The resulting isoform (c) is longer but has
            the same N- and C-termini compared to isoform a.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC028361.2, SRR11853561.16482.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000409851.8/ ENSP00000386777.4
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2677              BC028361.2         1-2677
            2678-2696           AC010134.5         152807-152825
            2697-3365           BC028361.2         2697-3365
            3366-6737           AC010134.5         174435-177806
            6738-10096          AC010134.5         177807-181165
FEATURES             Location/Qualifiers
     source          1..10096
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q11.2"
     gene            1..10096
                     /gene="INPP4A"
                     /gene_synonym="INPP4; TVAS1"
                     /note="inositol polyphosphate-4-phosphatase type I A"
                     /db_xref="GeneID:3631"
                     /db_xref="HGNC:HGNC:6074"
                     /db_xref="MIM:600916"
     exon            1..228
                     /gene="INPP4A"
                     /gene_synonym="INPP4; TVAS1"
                     /inference="alignment:Splign:2.1.0"
     exon            229..290
                     /gene="INPP4A"
                     /gene_synonym="INPP4; TVAS1"
                     /inference="alignment:Splign:2.1.0"
     exon            291..499
                     /gene="INPP4A"
                     /gene_synonym="INPP4; TVAS1"
                     /inference="alignment:Splign:2.1.0"
     CDS             394..3312
                     /gene="INPP4A"
                     /gene_synonym="INPP4; TVAS1"
                     /EC_number="3.1.3.66"
                     /note="isoform c is encoded by transcript variant c; type
                     I inositol 3,4-bisphosphate 4-phosphatase; inositol
                     polyphosphate-4-phosphatase, type I, 107kD; inositol
                     polyphosphate-4-phosphatase, type I, 107kDa"
                     /codon_start=1
                     /product="inositol polyphosphate-4-phosphatase type I A
                     isoform c"
                     /protein_id="NP_001127697.1"
                     /db_xref="CCDS:CCDS46371.1"
                     /db_xref="GeneID:3631"
                     /db_xref="HGNC:HGNC:6074"
                     /db_xref="MIM:600916"
                     /translation="MTAREHSPRHGARARAMQRASTIDVAADMLGLSLAGNIQDPDEP
                     ILEFSLACSELHTPSLDRKPNSFVAVSVTTPPQAFWTKHAQTEIIEGTNNPIFLSSIA
                     FFQDSLINQMTQVKLSVYDVKDRSQGTMYLLGSGTFIVKDLLQDRHHRLHLTLRSAES
                     DRVGNITVIGWQMEEKSDQRPPVTRSVDTVNGRMVLPVDESLTEALGIRSKYASLRKD
                     TLLKSVFGGAICRMYRFPTTDGNHLRILEQMAESVLSLHVPRQFVKLLLEEDAARVCE
                     LEELGELSPCWESLRRQIVTQYQTIILTYQENLTDLHQYRGPSFKASSLKADKKLEFV
                     PTNLHIQRMRVQDDGGSDQNYDIVTIGAPAAHCQGFKSGGLRKKLHKFEETKKHTSSG
                     CQSIIYIPQDVVRAKEIIAQINTLKTQVSYYAERLSRAAKDRSATGLERTLAILADKT
                     RQLVTVCDCKLLANSIHGLNAARPDYIASKASPTSTEEEQVMLRNDQDTLMARWTGRN
                     SRSSLQVDWHEEEWEKVWLNVDKSLECIIQRVDKLLQKERLHGEGCEDVFPCAGSCTS
                     KKGNPDSHAYWIRPEDPFCDVPSSPCPSTMPSTACHPHLTTHCSPPPEESSPGEWSEA
                     LYPLLTTLTDCVAMMSDKAKKAMVFLLMQDSAPTIATYLSLQYRRDVVFCQTLTALIC
                     GFIIKLRNCLHDDGFLRQLYTIGLLAQFESLLSTYGEELAMLEDMSLGIMDLRNVTFK
                     VTQATSSASADMLPVITGNRDGFNVRVPLPGPLFDALPREIQSGMLLRVQPVLFNVGI
                     NEQQTLAERFGDTSLQEVINVESLVRLNSYFEQFKEVLPEDCLPRSRSQTCLPELLRF
                     LGQNVHARKNKNVDILWQAAEICRRLNGVRFTSCKSAKDRTAMSVTLEQCLILQHEHG
                     MAPQVFTQALECMRSEGCRRENTMKNVGSRKYAFNSLQLKAFPKHYRPPEGTYGKVET
                     "
     exon            500..544
                     /gene="INPP4A"
                     /gene_synonym="INPP4; TVAS1"
                     /inference="alignment:Splign:2.1.0"
     exon            545..663
                     /gene="INPP4A"
                     /gene_synonym="INPP4; TVAS1"
                     /inference="alignment:Splign:2.1.0"
     exon            664..780
                     /gene="INPP4A"
                     /gene_synonym="INPP4; TVAS1"
                     /inference="alignment:Splign:2.1.0"
     exon            781..860
                     /gene="INPP4A"
                     /gene_synonym="INPP4; TVAS1"
                     /inference="alignment:Splign:2.1.0"
     exon            861..972
                     /gene="INPP4A"
                     /gene_synonym="INPP4; TVAS1"
                     /inference="alignment:Splign:2.1.0"
     exon            973..1063
                     /gene="INPP4A"
                     /gene_synonym="INPP4; TVAS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1064..1211
                     /gene="INPP4A"
                     /gene_synonym="INPP4; TVAS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1212..1342
                     /gene="INPP4A"
                     /gene_synonym="INPP4; TVAS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1343..1447
                     /gene="INPP4A"
                     /gene_synonym="INPP4; TVAS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1448..1556
                     /gene="INPP4A"
                     /gene_synonym="INPP4; TVAS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1557..1740
                     /gene="INPP4A"
                     /gene_synonym="INPP4; TVAS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1741..1959
                     /gene="INPP4A"
                     /gene_synonym="INPP4; TVAS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1960..2215
                     /gene="INPP4A"
                     /gene_synonym="INPP4; TVAS1"
                     /inference="alignment:Splign:2.1.0"
     exon            2216..2248
                     /gene="INPP4A"
                     /gene_synonym="INPP4; TVAS1"
                     /inference="alignment:Splign:2.1.0"
     exon            2249..2421
                     /gene="INPP4A"
                     /gene_synonym="INPP4; TVAS1"
                     /inference="alignment:Splign:2.1.0"
     exon            2422..2545
                     /gene="INPP4A"
                     /gene_synonym="INPP4; TVAS1"
                     /inference="alignment:Splign:2.1.0"
     exon            2546..2672
                     /gene="INPP4A"
                     /gene_synonym="INPP4; TVAS1"
                     /inference="alignment:Splign:2.1.0"
     exon            2673..2813
                     /gene="INPP4A"
                     /gene_synonym="INPP4; TVAS1"
                     /inference="alignment:Splign:2.1.0"
     exon            2814..2911
                     /gene="INPP4A"
                     /gene_synonym="INPP4; TVAS1"
                     /inference="alignment:Splign:2.1.0"
     exon            2912..3024
                     /gene="INPP4A"
                     /gene_synonym="INPP4; TVAS1"
                     /inference="alignment:Splign:2.1.0"
     exon            3025..3179
                     /gene="INPP4A"
                     /gene_synonym="INPP4; TVAS1"
                     /inference="alignment:Splign:2.1.0"
     exon            3180..10096
                     /gene="INPP4A"
                     /gene_synonym="INPP4; TVAS1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5836..5841
                     /regulatory_class="polyA_signal_sequence"
                     /gene="INPP4A"
                     /gene_synonym="INPP4; TVAS1"
                     /note="hexamer: AATAAA"
     polyA_site      5860
                     /gene="INPP4A"
                     /gene_synonym="INPP4; TVAS1"
                     /note="major polyA site"
     regulatory      6466..6471
                     /regulatory_class="polyA_signal_sequence"
                     /gene="INPP4A"
                     /gene_synonym="INPP4; TVAS1"
                     /note="hexamer: ATTAAA"
     polyA_site      6490
                     /gene="INPP4A"
                     /gene_synonym="INPP4; TVAS1"
                     /note="major polyA site"
     polyA_site      7033
                     /gene="INPP4A"
                     /gene_synonym="INPP4; TVAS1"
     regulatory      9752..9757
                     /regulatory_class="polyA_signal_sequence"
                     /gene="INPP4A"
                     /gene_synonym="INPP4; TVAS1"
                     /note="hexamer: AATAAA"
     polyA_site      9769
                     /gene="INPP4A"
                     /gene_synonym="INPP4; TVAS1"
     regulatory      10078..10083
                     /regulatory_class="polyA_signal_sequence"
                     /gene="INPP4A"
                     /gene_synonym="INPP4; TVAS1"
                     /note="hexamer: ATTAAA"
     polyA_site      10096
                     /gene="INPP4A"
                     /gene_synonym="INPP4; TVAS1"
ORIGIN      
        1 gtctagagcg gcggcggctg gctagggctg cggcgcgcgt ggagggttcg ctgctggttt
       61 gccgccgggt cgggctccgt gggccggggc aggaggacca gcacctgagg ccgggcccgc
      121 agcccgcgac ttcacagcca ggcggcggcg ctgctgctgc tgcggggctc tggcgcgcag
      181 cccggcggga cagcggggcg gctggcgccg ggggccgggg agcgccagat gatggatttg
      241 gacatgcttc tatgaagaaa tgccacatgg tccgagagca aacatgtcca ggctactgcc
      301 actttagtgg actagggctc ggtgccagca cttcccgggt aatcaggcgt ggtctgaccg
      361 aggatcaaga agcacatcat caccaatgac atcatgacag caagagagca cagccctcgc
      421 catggtgcca gggcccgtgc aatgcagcgg gcttccacca tcgacgtggc ggccgacatg
      481 ctgggcctct ctctggcagg aaatatacaa gacccagatg agcccatttt agaatttagc
      541 ttagcttgca gtgagctgca tactccatcg ctagatcgaa agccaaatag ttttgttgcg
      601 gtgagtgtca ccacccctcc tcaggcattc tggacgaagc atgcacagac ggagatcatt
      661 gagggaacca acaatcctat atttctaagc agtattgcct tctttcaaga ctctcttatc
      721 aatcagatga cacaagtcaa actctccgtg tatgatgtca aagatagatc tcagggaaca
      781 atgtatttac tgggctctgg aacgttcatt gtcaaagatc tgctccagga caggcatcat
      841 aggttgcatt taacactaag gtctgcagag agtgaccgtg taggtaacat caccgtgatt
      901 ggctggcaga tggaggagaa gtcagaccaa cggccccctg tgacccggtc tgtggacact
      961 gtcaatggga ggatggttct tcctgtcgat gagagcttga cggaggcgtt aggaatccga
     1021 tccaaatacg cttcattgcg aaaggacact ttgctgaaat cggtgttcgg tggtgccatc
     1081 tgccgcatgt accggtttcc aaccactgat ggtaaccatt tgcggatcct ggagcagatg
     1141 gcagagagcg tgctctccct gcacgtgccc cggcagttcg tgaagctcct actagaggaa
     1201 gatgcagcca gagtgtgtga gctggaggag ctgggagagc tgtccccttg ctgggagagc
     1261 ctccggcgcc aaattgtcac ccagtaccag accatcatcc tcacatacca ggagaacctg
     1321 accgacctcc atcagtacag agggccctcg tttaaagcaa gcagtttgaa agcagataaa
     1381 aagttagaat ttgttcccac aaacttgcac atacaaagga tgagagttca agacgatgga
     1441 ggatcagatc agaactacga catcgtcacc attggggcgc cagcagcaca ctgccaaggt
     1501 tttaagtcag gaggtctccg caaaaagctg cacaaatttg aagagaccaa gaaacataca
     1561 tcatctggct gccagtccat aatctacata ccccaggatg ttgtcagagc caaggagatc
     1621 atcgcccaga tcaacaccct gaaaacccaa gtgagttact acgcagagcg gctgtcaagg
     1681 gcagccaagg acaggtctgc cactggcctt gagaggacac tcgccatctt ggcagacaag
     1741 acacggcagc tggtcacggt ctgcgactgc aagctcctgg ccaactccat ccatgggctg
     1801 aacgctgcac ggcctgacta cattgcctcc aaggcctctc ccacttcgac tgaggaggag
     1861 caggtgatgc ttagaaatga ccaggacacc ctcatggccc ggtggacagg gagaaacagc
     1921 cgatcttccc tgcaggtgga ctggcacgag gaggagtggg agaaagtgtg gctgaacgtg
     1981 gacaagagcc tagagtgcat cattcagcgt gtggacaagc tgctgcagaa ggagcggctg
     2041 catggcgagg gctgtgagga tgtcttcccc tgtgcaggca gctgcaccag caagaaaggt
     2101 aacccggaca gccacgccta ctggatcaga ccagaagacc ccttctgtga tgtcccctcc
     2161 tcaccatgcc cctccaccat gccctccact gcatgccatc ctcatctgac cacacattgc
     2221 agtccccctc ctgaagagtc cagcccaggt gaatggagtg aggcccttta cccgctgctg
     2281 accactctca ccgactgcgt ggccatgatg agtgacaagg ccaagaaggc catggtattc
     2341 ctgctcatgc aggacagcgc gcccaccata gccacctacc tgagcctgca gtaccgccgt
     2401 gacgtggtct tctgccagac gctgaccgcc ctcatctgcg gcttcatcat taagctgagg
     2461 aactgcctgc atgacgacgg cttcctgcgc cagctctaca ccatcgggct gctggcccag
     2521 ttcgagagcc tgctgagcac ctacggggag gagctggcaa tgctggagga catgagcctt
     2581 gggatcatgg acttgaggaa cgtgaccttc aaagtcactc aggccacttc cagcgcctcc
     2641 gcagacatgc tgcccgtcat cacaggaaat cgcgacgggt ttaacgtgcg ggtccctctg
     2701 ccgggcccgc tgtttgacgc cttgccccgg gagatccaga gtggcatgct gctgcgagtg
     2761 cagcccgtcc tcttcaacgt gggcatcaat gagcagcaga cactggccga gaggtttggc
     2821 gatacgtctt tacaagaagt catcaacgtg gagagtttgg tgcggttaaa ttcctacttt
     2881 gagcagttta aggaagtttt gcctgaggat tgcctgcctc ggtctcgcag tcagacgtgc
     2941 ctgccagagc tgctgcggtt tctgggtcag aacgtgcatg cccggaagaa taagaacgtc
     3001 gacattctct ggcaagctgc tgagatctgc cgccgcctta atggggtccg gttcaccagc
     3061 tgcaagagcg ctaaggaccg tacagccatg tcggtgacac tggagcagtg cctgatcctg
     3121 caacacgagc atggcatggc cccgcaggtc ttcacccagg ccctggagtg catgcgcagt
     3181 gagggttgtc gaagagaaaa tacaatgaag aatgttggaa gtcgcaaata tgcatttaat
     3241 tccctgcagc tgaaggcttt ccccaagcat tacaggcctc ccgaagggac ttacggaaaa
     3301 gttgaaacgt gaacacacgg tttcctctaa ttagctgtta cataataaat gtgggtaccc
     3361 tctagtgtca tatatgaatt cttcaagaag acctgaagga ttggttttta ttttttgtgg
     3421 tttttttaaa aaaaacattt cactaaagag tctctggagc atgttttttg ttttttgggt
     3481 ttttttcccc attggaatca ataggaggta atgtttggct caatagtgtg gatagtaaca
     3541 actgcctatt taaattaaat agcctttggc tgtaactaca cagatctcat caatagttac
     3601 ctacatgaat caagctaggt ttgtctgaaa tgctagaaga ctttttcaaa tgcctgcttg
     3661 ctcacttact tttctacaga gtaactcaaa agtaaccatt gaattacaat ccactttgta
     3721 aaaatctgaa tgtaaaacag taaataataa attaaataat tggatcctag gcataccaat
     3781 aaatgttatt tggggaaaga agctagcact atctcatgca gtgagaataa cgggttctag
     3841 tgaattatcc tatctacact accacctgaa gaagttgaaa gaaagattga taaatcaacg
     3901 ggagataaga ctttattaga aggtaacacc tgcaaggtac cccacatagt tggggccact
     3961 cttttttctg tcccttatga gttacagaac agggagtctg ctggagacac aaagccagca
     4021 gtaaggtccc tttagcctgt ctcctgttct ctgaagctcc ctgccgaggc tccctcacgc
     4081 ccagaggaca catctcccct tcttctctag atgttaatgt agggcctcag atgtggcatg
     4141 tcaacactcc catggggaat ttatgaccat agagatagta gaaacctaaa tattttcaga
     4201 aaaaaaattt tttttgcagg atttccaatt tatctttgaa aagacagtac aatcatgttt
     4261 gaatgtctga tgaaagtgtc ttatttttag gtttgcaata attgttactt tcttattctc
     4321 attcttatgt aagatgacta ttgagaaaca gttgaaattt attctcctca aatgagattt
     4381 tgaaagggat ttatgggcca taaaacttag gaatttcata gaaaattttg tctggtcatc
     4441 ttttataaga tgatgatgag tcttatctgc acatagcaga gtttgtttct taggagttta
     4501 tatgttttat tgattctgtt tacgatgttt acatgttctt gaaaaggttg taaaagaaat
     4561 acatatggca catattaatg atgctgatcc taatgatttg tgaacctctt agaaattctt
     4621 ttgtctaaaa gcctagagat tcttctggtt cctttagaaa catgtaacaa acttgggcca
     4681 ggggtgctga ggcatgggga ggactgctta ttggcaggaa cacagagggg gtgggcatca
     4741 ggtagggtgg aactggatga ccttccagac cccctcctac tcagaagtca gcatgcaagc
     4801 agcgcctgct gtctcccgat gcctgcaggg aggaaaatgt ctgtgaagga cactttaatg
     4861 aaggacgaag ctctctgctg ctccctcaaa gctgagttca ctgtggcagg caggaagcag
     4921 agaagctcct gcccgccaaa cccactgcac aggtggctgc tgctggtatc agattctcct
     4981 ttttaagtgt caatttctgt tcacagacag tttgttttca atatggctga tttacccttt
     5041 cacctctcca ccatctcatt taatttgtaa atttttagtt ctgtcttttc tcattttaac
     5101 ttttaaaaaa tctccttgct ttttaaaaat aaatattacc cacatagttt tcagatcttt
     5161 tttgtctgga gagcattaaa tatctgcact catcaaaggg aatatagcaa atgttgatca
     5221 tctgtcagca gttttgcatg tgacaccttt atatgaatta ttttcccaat ttttgctcta
     5281 tgtaatgggt caccataaaa ctgtaagact tggcaaatgc tatagaaaag gttcaggttt
     5341 cagtattctc tctgaaggca tcattcctgg gcttccggca gcatcacacg cttccagtgc
     5401 ctgcagggtg agggtgtgtg gcacagaggc aagcagctcc tctcttctgt aggagctttg
     5461 ggttttcaga ggtgcaggga aggcagtttt acaggttacc gtaaaacaga ggttccgtcc
     5521 agtgttcctt atgatgcctc cccatttaaa aagaaaagag atctatggaa aactgggaat
     5581 gtaatgtgga ttctgtcaga gctcctacag agcacagttg cctttagttt cctttaaaga
     5641 tgtaaaaata ttgtataata cagttttgtc cctacacaat tgtatttgcc aagcttagtg
     5701 cattatgata cctttattta tttgttttgg gcagtattac tatatatata taaacataca
     5761 gttactgttt tatatattct taggtcattc aaagccatgt atgctgtaaa tgtgctagtc
     5821 tttagaatga cacataataa ataactgaca agatattaaa tgtggtcttg cctgattcat
     5881 cctattagga ggactagttc tatgtgacca gcctgtgact ggaccattgt tcttgggcat
     5941 tgcattgagt gctcgggtgc tgaatacatg tttgtaaaca tgggaccatg ggagacttcc
     6001 attttataag cttgtttctg cctaatttga agcagagggg caacagcgtt gaggttaaga
     6061 gcacggactt tgggagcaca cagaccaggt cccaatcctg gttctgcccc tgactggctg
     6121 gtgactctga gcaagttgct tgacctctcc aagcctccgt ttcctcatgt gcaaagtgtg
     6181 gacaacaaca gtaccttcct cataaggaac gtgcgacgcg cctcagaagt acgtgttcat
     6241 aaatggtagc cattgttgtt accttcccgt ctgtgaacat ggatcacatc atctctgtgg
     6301 gtaacccagt cctcgttgta tgacttgtca aaatgcagtt ccacttgtat taatattgac
     6361 cctgttcatc gtcaccagga ctgcatcttg caccactgtg ccgtcttcta ggcacacacg
     6421 acccgttatc tcccttggaa aaattcctct cactggaaat gtacaattaa aggatgattg
     6481 aaatgtttaa ctcttggagt ttttagtatt accaaactcc tagaaattta agctaccacc
     6541 aaaaataaca tgtgcctttt ccctttattc tcattgatgg tagcagtgca cctcgtttca
     6601 gtgtcctgat tccttgatta ctgtgaacac tgaacatctt ttataccttt atgatatttc
     6661 tatgtttgtg acttcattgg aatgttgatc tatttcatat agattgtttt taatatacaa
     6721 tgtattagcc cctgtcatat gttgcacact ttttaaccta tttgtcagct gtcttttggt
     6781 ctgtggtagg agttatacag tattttaaat ggtttatgta gtcacatata cctgtctttc
     6841 attttgatgc ttgttctgaa atggagtcct ggcttcacca tggaaggtgg gacatatggg
     6901 acagccatgt ccttgtgggc atggtggtgt ggctgcgtgc ccacgacgag gggctggact
     6961 aaagtgctca ctggcacctt gcttggtgca tgggccatgc tcagtttaat attattaaca
     7021 gtttctacct tcactctcat gtctcaggat tattttttca gcatttacct gttcttattt
     7081 ctaggatgtt tatggtttca gtcctacatt tagatcaatc catctggaat catcttggtg
     7141 taagtcctgt gttgtgctta cagtatgtaa agtcagaggg aatccctcaa ggtcaggcct
     7201 aattttgctt ctctttaaag ttaagccaag aagaagacat gtcaggacgc ccagacatca
     7261 gctaccgtga gcttcttcct gccctccctc cgcatgccat tctggtgctg cgcttcagtt
     7321 tcctgttgag tctctgctta gtagatgact tggcacaatc tggctgccca gatctagggg
     7381 agttgtccca gggaggcttt gcgctggagg aaggtaagag gagctggagg ttggagcttc
     7441 ccgatttgtg atttttccaa gaacagaaat gattagccat gtggggaggt tacttcattg
     7501 tacattgttc tactgcataa cctccctcta ttctttacca gcatcacaca gcaggttggc
     7561 accatttttg aatagaggtt tctcacagta tcctcagcag cattgagtgt tcctaatgtt
     7621 gtagtaatga gcagtagatg tctctcagtg ggcagtgtga cctctttggt cactctaaag
     7681 ggctgccagc atttctctta agctgggggg agaagagctg ttctgtgtat aggggtattg
     7741 ggaacacatg gacagaagga actggcctca catgccatcg tgttcctggg atggctcttc
     7801 caagaccagc agttcctcct ggcaggcagg ccctcacaga actctgcatt tggagatgga
     7861 caaactctct tcttcttatc actttctccc caaaatgtcc tcttctacca gcccctctta
     7921 agagccgatt ttctgtaagt tatagtgagg gcactgctct gctgtgcaca gaaggaaccc
     7981 cagcccagaa gcacacgctc cctgtggaac ctgcaggggt ggcagtgatg acagaaccaa
     8041 gggggtcaag gaagattgga gaggagtggg cagcaggaaa cagctcaggc tgcctgacct
     8101 ggcccccggc tgcccatgag ggcctccaga gaggggcaga gctggcttat cgggatccat
     8161 gatggttttt acacttttaa aagtgccctc ttctcagaga ccctggttat ttccaaaagt
     8221 aggaagtaat caaatttaca gtggataaaa tccagtattt gaaatcagga agacagaaaa
     8281 aaaagcaaaa tagcatcctt ttctgagagg tatatgctga ccaaaaagat ctttcattcc
     8341 tgtgaacacc aagcagcgcg gcctctggca gagagagcgc tgggttgtac agatggaaac
     8401 ttgtgtttag caggctgtct gctcccaata gtggccctgg ctgcaactga cctcctgatg
     8461 ccctgctgac gctaactgtg ggtaccaacc agcaccgtgg acatcggccc caggatcagt
     8521 ctacgatttg tctggtggcc aaatgatgac ttttgagtgg gaaaagctgg tgggggctac
     8581 accgtgctct gcagtgtagt gggatcctgt gagctggcct gcacaggcac tccctcccct
     8641 gccaggggcc ccagggaggc ttctccagcc tgaggctgca ccctccatac gattccaccc
     8701 cccatcctgt gccaacagta ggcaaacgga gagtagcttg gtcttgtttt tattagctgt
     8761 tgccctccag gctacgacag ggttcccagg gtgtagcctg aaaacaccca tactctagat
     8821 tccctccact ggaaccctgt ctttgccatg atttcttcct gcatcaggcc cctgtgggcc
     8881 ttgcaggcca gtccaggcag gtctttcaca ctgttgtccc acataacaga aaaagctgag
     8941 cagacagggt aggaaacaca cttgcatctc catggctcca aagaggatgc ctgtgttaga
     9001 tggatgtaga cagacacagc acttcactgc ttcctcctcc tcgccaccca gccctccctc
     9061 ggtgtctgtg gcctgactct ctcctggtgg tcctacgtct ctgaccatcc ctcctcactc
     9121 tcaaatttta tgttgcccac cacctgccac taatggcgtg gtgttctcct gggttccctt
     9181 tctcacttaa gatgatcttc ctgaaaaatc ttacacattc ctgttgaaca aatggtcact
     9241 tatatggtag tgactcctaa atttctaggt ccatcccaga ctctccccca aggtccagat
     9301 tacctataca tctaagcacc atgcctgtct tgcaggcatc tcaaatacag catgctcatg
     9361 cctctcctcc tccaagctgg ctgagtctcc ctctaataga cgaccttggg atcattttct
     9421 cctccacatc ccatcaatca gccactgaac ctgtatctct tgagaaccat cccataattt
     9481 ccatccatgc accccaaggc ctggtctgta tcagtcccct cggatctgga cctctcctga
     9541 gcatcctcac ccctcctgca aggctagtct caggtctgcc ttcctctatg gtgatttctc
     9601 cccacaaatg aagttggccc tttcaaaaaa acttcctctc cttcattgtt gactatgaag
     9661 attctttcat gcatgtcctg tccactgtca gtcccctctg tattcacaag agcaagtgta
     9721 atgcccgctg tgaaggagct aaagtttgtt gaataaacac atgaacaaat ggtggttttg
     9781 tggtgttcaa ctgaaatatt tcctatttca gcactggacc acgctgtttt tctcactaca
     9841 taatcggtta cgctaaatgc atcacgagcc aaattcaaaa ggtcaaagga gaaggcaaat
     9901 ggcagagtgt ggtaaagggg cgagtgagag ggtctctgaa aaaagtcagg ctaaaattac
     9961 agggggttca ggcaatgtta tcttgatctg gatggccagt tacatgacag attactttgt
    10021 tcttaacata cgaacatcct attcactttt tggtatactg gttgtttaac agtaaaaatt
    10081 aaatgtttaa aaccca
//
