LOCUS       NM_002194               1900 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens inositol polyphosphate-1-phosphatase (INPP1),
            transcript variant 2, mRNA.
ACCESSION   NM_002194
VERSION     NM_002194.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1900)
  AUTHORS   Bozorgmehr,A., Ghadirivasfi,M., Tavakoli,M., Rahmani,H., Heydari,F.
            and Shahsavand Ananloo,E.
  TITLE     Integrated analysis of the genetic basis of suicidal behavior: what
            has been shown by structural genetic studies so far
  JOURNAL   Psychiatr Genet 28 (2), 31-37 (2018)
   PUBMED   29381655
  REMARK    GeneRIF: We found the suicide-associated gene coexpression network.
            The reconstructed network consisted of 104 genes. Topological
            analysis showed that in total, CCK, INPP1, DDC, and NPY genes are
            the most fundamental hubs in the network
REFERENCE   2  (bases 1 to 1900)
  AUTHORS   Yang,X., Coulombe-Huntington,J., Kang,S., Sheynkman,G.M., Hao,T.,
            Richardson,A., Sun,S., Yang,F., Shen,Y.A., Murray,R.R., Spirohn,K.,
            Begg,B.E., Duran-Frigola,M., MacWilliams,A., Pevzner,S.J.,
            Zhong,Q., Wanamaker,S.A., Tam,S., Ghamsari,L., Sahni,N., Yi,S.,
            Rodriguez,M.D., Balcha,D., Tan,G., Costanzo,M., Andrews,B.,
            Boone,C., Zhou,X.J., Salehi-Ashtiani,K., Charloteaux,B., Chen,A.A.,
            Calderwood,M.A., Aloy,P., Roth,F.P., Hill,D.E., Iakoucheva,L.M.,
            Xia,Y. and Vidal,M.
  TITLE     Widespread Expansion of Protein Interaction Capabilities by
            Alternative Splicing
  JOURNAL   Cell 164 (4), 805-817 (2016)
   PUBMED   26871637
REFERENCE   3  (bases 1 to 1900)
  AUTHORS   Benjamin,D.I., Louie,S.M., Mulvihill,M.M., Kohnz,R.A., Li,D.S.,
            Chan,L.G., Sorrentino,A., Bandyopadhyay,S., Cozzo,A., Ohiri,A.,
            Goga,A., Ng,S.W. and Nomura,D.K.
  TITLE     Inositol phosphate recycling regulates glycolytic and lipid
            metabolism that drives cancer aggressiveness
  JOURNAL   ACS Chem Biol 9 (6), 1340-1350 (2014)
   PUBMED   24738946
  REMARK    GeneRIF: High INPP1 expression is associated with cancer
            aggressiveness.
REFERENCE   4  (bases 1 to 1900)
  AUTHORS   Corominas,R., Yang,X., Lin,G.N., Kang,S., Shen,Y., Ghamsari,L.,
            Broly,M., Rodriguez,M., Tam,S., Wanamaker,S.A., Fan,C., Yi,S.,
            Tasan,M., Lemmens,I., Kuang,X., Zhao,N., Malhotra,D.,
            Michaelson,J.J., Vacic,V., Calderwood,M.A., Roth,F.P.,
            Tavernier,J., Horvath,S., Salehi-Ashtiani,K., Korkin,D., Sebat,J.,
            Hill,D.E., Hao,T., Vidal,M. and Iakoucheva,L.M.
  TITLE     Protein interaction network of alternatively spliced isoforms from
            brain links genetic risk factors for autism
  JOURNAL   Nat Commun 5, 3650 (2014)
   PUBMED   24722188
  REMARK    Erratum:[Nat Commun. 2023 Feb 2;14(1):569. doi:
            10.1038/s41467-023-36264-y.. PMID: 36732511]
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1900)
  AUTHORS   Jimenez,E., Arias,B., Mitjans,M., Goikolea,J.M., Roda,E.,
            Saiz,P.A., Garcia-Portilla,M.P., Buron,P., Bobes,J., Oquendo,M.A.,
            Vieta,E. and Benabarre,A.
  TITLE     Genetic variability at IMPA2, INPP1 and GSK3beta increases the risk
            of suicidal behavior in bipolar patients
  JOURNAL   Eur Neuropsychopharmacol 23 (11), 1452-1462 (2013)
   PUBMED   23453640
  REMARK    GeneRIF: results suggest that genetic variability at
            rs669838-IMPA2,rs4853694-INPP1, rs1732170-GSK3b and
            rs11921360-GSK3b genes is associated with a higher risk of
            attempting suicide in bipolar patients.
REFERENCE   6  (bases 1 to 1900)
  AUTHORS   Lovlie,R., Gulbrandsen,A.K., Molven,A. and Steen,V.M.
  TITLE     Genomic structure and sequence analysis of a human inositol
            polyphosphate 1-phosphatase gene (INPP1)
  JOURNAL   Pharmacogenetics 9 (4), 517-528 (1999)
   PUBMED   10780272
REFERENCE   7  (bases 1 to 1900)
  AUTHORS   Steen,V.M., Lovlie,R., Osher,Y., Belmaker,R.H., Berle,J.O. and
            Gulbrandsen,A.K.
  TITLE     The polymorphic inositol polyphosphate 1-phosphatase gene as a
            candidate for pharmacogenetic prediction of lithium-responsive
            manic-depressive illness
  JOURNAL   Pharmacogenetics 8 (3), 259-268 (1998)
   PUBMED   9682271
REFERENCE   8  (bases 1 to 1900)
  AUTHORS   Zhang,X. and Majerus,P.W.
  TITLE     Phosphatidylinositol signalling reactions
  JOURNAL   Semin Cell Dev Biol 9 (2), 153-160 (1998)
   PUBMED   9599410
  REMARK    Review article
REFERENCE   9  (bases 1 to 1900)
  AUTHORS   York,J.D., Veile,R.A., Donis-Keller,H. and Majerus,P.W.
  TITLE     Cloning, heterologous expression, and chromosomal localization of
            human inositol polyphosphate 1-phosphatase
  JOURNAL   Proc Natl Acad Sci U S A 90 (12), 5833-5837 (1993)
   PUBMED   8390685
REFERENCE   10 (bases 1 to 1900)
  AUTHORS   Majerus,P.W., Ross,T.S., Cunningham,T.W., Caldwell,K.K.,
            Jefferson,A.B. and Bansal,V.S.
  TITLE     Recent insights in phosphatidylinositol signaling
  JOURNAL   Cell 63 (3), 459-465 (1990)
   PUBMED   2225061
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BQ100772.1, AI680695.1,
            DA272809.1, BC106006.1 and AW015766.1.
            
            On May 31, 2019 this sequence version replaced NM_002194.3.
            
            Summary: This gene encodes the enzyme inositol
            polyphosphate-1-phosphatase, one of the enzymes involved in
            phosphatidylinositol signaling pathways. This enzyme removes the
            phosphate group at position 1 of the inositol ring from the
            polyphosphates inositol 1,4-bisphosphate and inositol
            1,3,4-trisphophosphate. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1 and 2 encode the same isoform.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.120148.1,
                                           SRR1803616.191235.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-26                BQ100772.1         181-206             c
            27-32               AI680695.1         191-196             c
            33-337              DA272809.1         9-313
            338-1821            BC106006.1         1-1484
            1822-1900           AW015766.1         17-95               c
FEATURES             Location/Qualifiers
     source          1..1900
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q32.2"
     gene            1..1900
                     /gene="INPP1"
                     /note="inositol polyphosphate-1-phosphatase"
                     /db_xref="GeneID:3628"
                     /db_xref="HGNC:HGNC:6071"
                     /db_xref="MIM:147263"
     exon            1..373
                     /gene="INPP1"
                     /inference="alignment:Splign:2.1.0"
     exon            374..641
                     /gene="INPP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             438..1637
                     /gene="INPP1"
                     /EC_number="3.1.3.57"
                     /note="IPP; IPPase"
                     /codon_start=1
                     /product="inositol polyphosphate 1-phosphatase"
                     /protein_id="NP_002185.1"
                     /db_xref="CCDS:CCDS2305.1"
                     /db_xref="GeneID:3628"
                     /db_xref="HGNC:HGNC:6071"
                     /db_xref="MIM:147263"
                     /translation="MSDILRELLCVSEKAANIARACRQQEALFQLLIEEKKEGEKNKK
                     FAVDFKTLADVLVQEVIKQNMENKFPGLEKNIFGEESNEFTNDWGEKITLRLCSTEEE
                     TAELLSKVLNGNKVASEALARVVHQDVAFTDPTLDSTEINVPQDILGIWVDPIDSTYQ
                     YIKGSADIKSNQGIFPCGLQCVTILIGVYDIQTGVPLMGVINQPFVSRDPNTLRWKGQ
                     CYWGLSYMGTNMHSLQLTISRRNGSETHTGNTGSEAAFSPSFSAVISTSEKETIKAAL
                     SRVCGDRIFGAAGAGYKSLCVVQGLVDIYIFSEDTTFKWDSCAAHAILRAMGGGIVDL
                     KECLERNPETGLDLPQLVYHVENEGAAGVDRWANKGGLIAYRSRKRLETFLSLLVQNL
                     APAETHT"
     exon            642..702
                     /gene="INPP1"
                     /inference="alignment:Splign:2.1.0"
     exon            703..903
                     /gene="INPP1"
                     /inference="alignment:Splign:2.1.0"
     exon            904..1078
                     /gene="INPP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1079..1900
                     /gene="INPP1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1796..1801
                     /regulatory_class="polyA_signal_sequence"
                     /gene="INPP1"
                     /note="hexamer: AATAAA"
     polyA_site      1818
                     /gene="INPP1"
                     /note="major polyA site"
     regulatory      1882..1887
                     /regulatory_class="polyA_signal_sequence"
                     /gene="INPP1"
                     /note="hexamer: AATAAA"
     polyA_site      1900
                     /gene="INPP1"
ORIGIN      
        1 acttgtgacg tcgcggacgc ccggctcggg caggcgtggg gggcccgcgc gtcccgggag
       61 ccccgaggcg gcagcgcgcg tttccacgcc gcggtcccgc gggaaagccg ggggcggcgg
      121 cctggctgag gccaagctcg gatccggtgc cgagccaagc ggggccgtgc gtcgccgggg
      181 cttcgccttc gctcgcgtga cctccgccgt cctccccaac cctcgtcctc tggccgcgcc
      241 tgcggccgca cgcccagcgc ccctcgccta acctcgcgcc cgggccgcgc ctcctcctcc
      301 tcctgctccc cgccgcttcc gtttctcgag ggaaaggctg ctgcctcctg ctctgtcctc
      361 atccccggct tagctgacgg cccagagggt gggtgccaat tccaccagca gctgcaactg
      421 aaaagcaagg ttcagaaatg tcagatatcc tccgggagct gctctgtgtc tctgagaagg
      481 ctgctaacat tgcccgggcg tgcagacagc aggaagccct cttccagctg ctgatcgaag
      541 aaaagaaaga gggagaaaag aacaagaagt ttgcagttga cttcaagacg ctggctgatg
      601 tactggtaca ggaagttata aaacagaata tggagaacaa gtttccaggc ttggaaaaaa
      661 atatttttgg agaagaatcc aatgagttta ctaatgactg gggggaaaag attaccttga
      721 ggttgtgttc aacagaggag gaaacagcag agcttcttag caaagtcctc aatggtaaca
      781 aggtggcatc tgaagcatta gccagggttg ttcatcagga tgttgccttt actgacccaa
      841 ctctggattc cacagagatc aatgttccac aggacatttt gggaatttgg gtggacccca
      901 tagattcaac ttatcagtat ataaaaggtt ctgctgacat taaatccaac cagggaatct
      961 tcccctgtgg acttcagtgt gtcaccattt taattggtgt ctatgacata cagacagggg
     1021 ttcccctgat gggagtcatc aatcaacctt ttgtgtcacg agatccaaac accctcaggt
     1081 ggaaaggaca gtgctattgg ggcctttctt acatggggac caacatgcat tcactacagc
     1141 tcaccatctc tagaagaaac ggcagtgaaa cacacactgg aaacaccggc tctgaggcag
     1201 cattctcccc cagtttttca gccgtaatta gtacaagtga aaaggagact atcaaagctg
     1261 cattgtcacg tgtgtgtgga gatcgcatat ttggggcagc tggggctggt tataagagcc
     1321 tatgtgttgt ccaaggcctc gttgacattt acatcttttc agaagatacc acattcaaat
     1381 gggactcttg tgctgctcat gccatactga gggccatggg tgggggaata gtagacttga
     1441 aagaatgctt agaaagaaat ccagaaacag ggcttgattt gccacagttg gtgtaccacg
     1501 tggaaaatga gggtgctgct ggggtggatc ggtgggccaa caagggagga ctcattgcat
     1561 acagatccag gaagcggctg gagacattcc tgagcctcct ggtccaaaac ctggcacctg
     1621 cagagacgca tacctagagg aactctaacc ccggtgtacc tgtataaact gaactgtgaa
     1681 actgtttcgg ttatctctgt cttttgagga tggctttgtc ctgttgctgg ttaacattca
     1741 ccttcctctt ttgaggagta tttttccatt atgtattcat aataatgtta atttcaataa
     1801 atgacattca tgcagcaatt atattggtgt atgaaattct tacagtgaat attgtgctgt
     1861 tagtgctgct tgaaacattt caataaaata ttgaccagga
//
