LOCUS       NM_001128928            2044 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens inositol polyphosphate-1-phosphatase (INPP1),
            transcript variant 1, mRNA.
ACCESSION   NM_001128928
VERSION     NM_001128928.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2044)
  AUTHORS   Bozorgmehr,A., Ghadirivasfi,M., Tavakoli,M., Rahmani,H., Heydari,F.
            and Shahsavand Ananloo,E.
  TITLE     Integrated analysis of the genetic basis of suicidal behavior: what
            has been shown by structural genetic studies so far
  JOURNAL   Psychiatr Genet 28 (2), 31-37 (2018)
   PUBMED   29381655
  REMARK    GeneRIF: We found the suicide-associated gene coexpression network.
            The reconstructed network consisted of 104 genes. Topological
            analysis showed that in total, CCK, INPP1, DDC, and NPY genes are
            the most fundamental hubs in the network
REFERENCE   2  (bases 1 to 2044)
  AUTHORS   Yang,X., Coulombe-Huntington,J., Kang,S., Sheynkman,G.M., Hao,T.,
            Richardson,A., Sun,S., Yang,F., Shen,Y.A., Murray,R.R., Spirohn,K.,
            Begg,B.E., Duran-Frigola,M., MacWilliams,A., Pevzner,S.J.,
            Zhong,Q., Wanamaker,S.A., Tam,S., Ghamsari,L., Sahni,N., Yi,S.,
            Rodriguez,M.D., Balcha,D., Tan,G., Costanzo,M., Andrews,B.,
            Boone,C., Zhou,X.J., Salehi-Ashtiani,K., Charloteaux,B., Chen,A.A.,
            Calderwood,M.A., Aloy,P., Roth,F.P., Hill,D.E., Iakoucheva,L.M.,
            Xia,Y. and Vidal,M.
  TITLE     Widespread Expansion of Protein Interaction Capabilities by
            Alternative Splicing
  JOURNAL   Cell 164 (4), 805-817 (2016)
   PUBMED   26871637
REFERENCE   3  (bases 1 to 2044)
  AUTHORS   Benjamin,D.I., Louie,S.M., Mulvihill,M.M., Kohnz,R.A., Li,D.S.,
            Chan,L.G., Sorrentino,A., Bandyopadhyay,S., Cozzo,A., Ohiri,A.,
            Goga,A., Ng,S.W. and Nomura,D.K.
  TITLE     Inositol phosphate recycling regulates glycolytic and lipid
            metabolism that drives cancer aggressiveness
  JOURNAL   ACS Chem Biol 9 (6), 1340-1350 (2014)
   PUBMED   24738946
  REMARK    GeneRIF: High INPP1 expression is associated with cancer
            aggressiveness.
REFERENCE   4  (bases 1 to 2044)
  AUTHORS   Corominas,R., Yang,X., Lin,G.N., Kang,S., Shen,Y., Ghamsari,L.,
            Broly,M., Rodriguez,M., Tam,S., Wanamaker,S.A., Fan,C., Yi,S.,
            Tasan,M., Lemmens,I., Kuang,X., Zhao,N., Malhotra,D.,
            Michaelson,J.J., Vacic,V., Calderwood,M.A., Roth,F.P.,
            Tavernier,J., Horvath,S., Salehi-Ashtiani,K., Korkin,D., Sebat,J.,
            Hill,D.E., Hao,T., Vidal,M. and Iakoucheva,L.M.
  TITLE     Protein interaction network of alternatively spliced isoforms from
            brain links genetic risk factors for autism
  JOURNAL   Nat Commun 5, 3650 (2014)
   PUBMED   24722188
  REMARK    Erratum:[Nat Commun. 2023 Feb 2;14(1):569. doi:
            10.1038/s41467-023-36264-y.. PMID: 36732511]
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2044)
  AUTHORS   Jimenez,E., Arias,B., Mitjans,M., Goikolea,J.M., Roda,E.,
            Saiz,P.A., Garcia-Portilla,M.P., Buron,P., Bobes,J., Oquendo,M.A.,
            Vieta,E. and Benabarre,A.
  TITLE     Genetic variability at IMPA2, INPP1 and GSK3beta increases the risk
            of suicidal behavior in bipolar patients
  JOURNAL   Eur Neuropsychopharmacol 23 (11), 1452-1462 (2013)
   PUBMED   23453640
  REMARK    GeneRIF: results suggest that genetic variability at
            rs669838-IMPA2,rs4853694-INPP1, rs1732170-GSK3b and
            rs11921360-GSK3b genes is associated with a higher risk of
            attempting suicide in bipolar patients.
REFERENCE   6  (bases 1 to 2044)
  AUTHORS   Lovlie,R., Gulbrandsen,A.K., Molven,A. and Steen,V.M.
  TITLE     Genomic structure and sequence analysis of a human inositol
            polyphosphate 1-phosphatase gene (INPP1)
  JOURNAL   Pharmacogenetics 9 (4), 517-528 (1999)
   PUBMED   10780272
REFERENCE   7  (bases 1 to 2044)
  AUTHORS   Steen,V.M., Lovlie,R., Osher,Y., Belmaker,R.H., Berle,J.O. and
            Gulbrandsen,A.K.
  TITLE     The polymorphic inositol polyphosphate 1-phosphatase gene as a
            candidate for pharmacogenetic prediction of lithium-responsive
            manic-depressive illness
  JOURNAL   Pharmacogenetics 8 (3), 259-268 (1998)
   PUBMED   9682271
REFERENCE   8  (bases 1 to 2044)
  AUTHORS   Zhang,X. and Majerus,P.W.
  TITLE     Phosphatidylinositol signalling reactions
  JOURNAL   Semin Cell Dev Biol 9 (2), 153-160 (1998)
   PUBMED   9599410
  REMARK    Review article
REFERENCE   9  (bases 1 to 2044)
  AUTHORS   York,J.D., Veile,R.A., Donis-Keller,H. and Majerus,P.W.
  TITLE     Cloning, heterologous expression, and chromosomal localization of
            human inositol polyphosphate 1-phosphatase
  JOURNAL   Proc Natl Acad Sci U S A 90 (12), 5833-5837 (1993)
   PUBMED   8390685
REFERENCE   10 (bases 1 to 2044)
  AUTHORS   Majerus,P.W., Ross,T.S., Cunningham,T.W., Caldwell,K.K.,
            Jefferson,A.B. and Bansal,V.S.
  TITLE     Recent insights in phosphatidylinositol signaling
  JOURNAL   Cell 63 (3), 459-465 (1990)
   PUBMED   2225061
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BQ100772.1, AI680695.1,
            DA272809.1, AC092178.4 and AW015766.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001128928.1.
            
            Summary: This gene encodes the enzyme inositol
            polyphosphate-1-phosphatase, one of the enzymes involved in
            phosphatidylinositol signaling pathways. This enzyme removes the
            phosphate group at position 1 of the inositol ring from the
            polyphosphates inositol 1,4-bisphosphate and inositol
            1,3,4-trisphophosphate. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Variants 1 and 2 encode the same isoform.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.751416.1,
                                           SRR1803612.106008.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000392329.7/ ENSP00000376142.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-26                BQ100772.1         181-206             c
            27-32               AI680695.1         191-196             c
            33-335              DA272809.1         9-311
            336-373             AC092178.4         80429-80466
            374-517             AC092178.4         85393-85536
            518-785             AC092178.4         96544-96811
            786-846             AC092178.4         99132-99192
            847-1047            AC092178.4         103200-103400
            1048-1222           AC092178.4         105608-105782
            1223-2015           AC092178.4         107349-108141
            2016-2044           AW015766.1         17-45               c
FEATURES             Location/Qualifiers
     source          1..2044
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q32.2"
     gene            1..2044
                     /gene="INPP1"
                     /note="inositol polyphosphate-1-phosphatase"
                     /db_xref="GeneID:3628"
                     /db_xref="HGNC:HGNC:6071"
                     /db_xref="MIM:147263"
     exon            1..373
                     /gene="INPP1"
                     /inference="alignment:Splign:2.1.0"
     exon            374..517
                     /gene="INPP1"
                     /inference="alignment:Splign:2.1.0"
     exon            518..785
                     /gene="INPP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             582..1781
                     /gene="INPP1"
                     /EC_number="3.1.3.57"
                     /note="IPP; IPPase"
                     /codon_start=1
                     /product="inositol polyphosphate 1-phosphatase"
                     /protein_id="NP_001122400.1"
                     /db_xref="CCDS:CCDS2305.1"
                     /db_xref="GeneID:3628"
                     /db_xref="HGNC:HGNC:6071"
                     /db_xref="MIM:147263"
                     /translation="MSDILRELLCVSEKAANIARACRQQEALFQLLIEEKKEGEKNKK
                     FAVDFKTLADVLVQEVIKQNMENKFPGLEKNIFGEESNEFTNDWGEKITLRLCSTEEE
                     TAELLSKVLNGNKVASEALARVVHQDVAFTDPTLDSTEINVPQDILGIWVDPIDSTYQ
                     YIKGSADIKSNQGIFPCGLQCVTILIGVYDIQTGVPLMGVINQPFVSRDPNTLRWKGQ
                     CYWGLSYMGTNMHSLQLTISRRNGSETHTGNTGSEAAFSPSFSAVISTSEKETIKAAL
                     SRVCGDRIFGAAGAGYKSLCVVQGLVDIYIFSEDTTFKWDSCAAHAILRAMGGGIVDL
                     KECLERNPETGLDLPQLVYHVENEGAAGVDRWANKGGLIAYRSRKRLETFLSLLVQNL
                     APAETHT"
     exon            786..846
                     /gene="INPP1"
                     /inference="alignment:Splign:2.1.0"
     exon            847..1047
                     /gene="INPP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1048..1222
                     /gene="INPP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1223..2044
                     /gene="INPP1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1940..1945
                     /regulatory_class="polyA_signal_sequence"
                     /gene="INPP1"
                     /note="hexamer: AATAAA"
     polyA_site      1962
                     /gene="INPP1"
                     /note="major polyA site"
     regulatory      2026..2031
                     /regulatory_class="polyA_signal_sequence"
                     /gene="INPP1"
                     /note="hexamer: AATAAA"
     polyA_site      2044
                     /gene="INPP1"
ORIGIN      
        1 acttgtgacg tcgcggacgc ccggctcggg caggcgtggg gggcccgcgc gtcccgggag
       61 ccccgaggcg gcagcgcgcg tttccacgcc gcggtcccgc gggaaagccg ggggcggcgg
      121 cctggctgag gccaagctcg gatccggtgc cgagccaagc ggggccgtgc gtcgccgggg
      181 cttcgccttc gctcgcgtga cctccgccgt cctccccaac cctcgtcctc tggccgcgcc
      241 tgcggccgca cgcccagcgc ccctcgccta acctcgcgcc cgggccgcgc ctcctcctcc
      301 tcctgctccc cgccgcttcc gtttctcgag ggaaaggctg ctgcctcctg ctctgtcctc
      361 atccccggct tagtccttca gagcttacat catgtggccg agtttatata cctgattggc
      421 aaaacagagc ctaagaacca gctctcctgt atcccaagca aggctctttc taccgcacac
      481 cctgcaggcc catccaggcc catccagaca ataaacactg acggcccaga gggtgggtgc
      541 caattccacc agcagctgca actgaaaagc aaggttcaga aatgtcagat atcctccggg
      601 agctgctctg tgtctctgag aaggctgcta acattgcccg ggcgtgcaga cagcaggaag
      661 ccctcttcca gctgctgatc gaagaaaaga aagagggaga aaagaacaag aagtttgcag
      721 ttgacttcaa gacgctggct gatgtactgg tacaggaagt tataaaacag aatatggaga
      781 acaagtttcc aggcttggaa aaaaatattt ttggagaaga atccaatgag tttactaatg
      841 actgggggga aaagattacc ttgaggttgt gttcaacaga ggaggaaaca gcagagcttc
      901 ttagcaaagt cctcaatggt aacaaggtgg catctgaagc attagccagg gttgttcatc
      961 aggatgttgc ctttactgac ccaactctgg attccacaga gatcaatgtt ccacaggaca
     1021 ttttgggaat ttgggtggac cccatagatt caacttatca gtatataaaa ggttctgctg
     1081 acattaaatc caaccaggga atcttcccct gtggacttca gtgtgtcacc attttaattg
     1141 gtgtctatga catacagaca ggggttcccc tgatgggagt catcaatcaa ccttttgtgt
     1201 cacgagatcc aaacaccctc aggtggaaag gacagtgcta ttggggcctt tcttacatgg
     1261 ggaccaacat gcattcacta cagctcacca tctctagaag aaacggcagt gaaacacaca
     1321 ctggaaacac cggctctgag gcagcattct cccccagttt ttcagccgta attagtacaa
     1381 gtgaaaagga gactatcaaa gctgcattgt cacgtgtgtg tggagatcgc atatttgggg
     1441 cagctggggc tggttataag agcctatgtg ttgtccaagg cctcgttgac atttacatct
     1501 tttcagaaga taccacattc aaatgggact cttgtgctgc tcatgccata ctgagggcca
     1561 tgggtggggg aatagtagac ttgaaagaat gcttagaaag aaatccagaa acagggcttg
     1621 atttgccaca gttggtgtac cacgtggaaa atgagggtgc tgctggggtg gatcggtggg
     1681 ccaacaaggg aggactcatt gcatacagat ccaggaagcg gctggagaca ttcctgagcc
     1741 tcctggtcca aaacctggca cctgcagaga cgcataccta gaggaactct aaccccggtg
     1801 tacctgtata aactgaactg tgaaactgtt tcggttatct ctgtcttttg aggatggctt
     1861 tgtcctgttg ctggttaaca ttcaccttcc tcttttgagg agtatttttc cattatgtat
     1921 tcataataat gttaatttca ataaatgaca ttcatgcagc aattatattg gtgtatgaaa
     1981 ttcttacagt gaatattgtg ctgttagtgc tgcttgaaac atttcaataa aatattgacc
     2041 agga
//
